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Adaptor-related protein complex 1, sigma 1 subunit

AP1S1, sigma1A, API-SI, SigmaIA
The protein encoded by this gene is part of the clathrin coat assembly complex which links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. This protein, as well as beta-prime-adaptin, gamma-adaptin, and the medium (mu) chain AP47, form the AP-1 assembly protein complex located at the Golgi vesicle. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: AP-1, sigma1B, ATP7B, p15, ACID
Papers on AP1S1
σ1B adaptin regulates adipogenesis by mediating the sorting of sortilin in adipose tissue.
Schu et al., Göttingen, Germany. In J Cell Sci, 2014
Vertebrates express three AP1 σ1 subunit isoforms - σ1A, σ1B and σ1C (also known as AP1S1, AP1S2 and AP1S3, respectively).
AP1S1 defect causing MEDNIK syndrome: a new adaptinopathy associated with defective copper metabolism.
Dionisi-Vici et al., Roma, Italy. In Ann N Y Acad Sci, 2014
MEDNIK syndrome is caused by mutation of the AP1S1 gene, which codes for the σ1A subunit of adaptor protein complex 1, and directs intracellular trafficking of copper pumps ATP7A and ATP7B.
MEDNIK syndrome: a novel defect of copper metabolism treatable by zinc acetate therapy.
Dionisi-Vici et al., Roma, Italy. In Brain, 2013
MEDNIK syndrome-acronym for mental retardation, enteropathy, deafness, neuropathy, ichthyosis, keratodermia-is caused by AP1S1 gene mutations, encoding σ1A, the small subunit of the adaptor protein 1 complex, which plays a crucial role in clathrin coat assembly and mediates trafficking between trans-Golgi network, endosomes and the plasma membrane.
Combined zebrafish-yeast chemical-genetic screens reveal gene-copper-nutrition interactions that modulate melanocyte pigmentation.
Patton et al., Edinburgh, United Kingdom. In Dis Model Mech, 2010
Yeast chemical-genetic interactions revealed that defects in intracellular trafficking pathways cause sensitivity to low-copper conditions; partial knockdown of the analogous Ap3s1 and Ap1s1 trafficking components in zebrafish sensitized developing melanocytes to hypopigmentation in low-copper environmental conditions.
AP-1/sigma1B-adaptin mediates endosomal synaptic vesicle recycling, learning and memory.
Schu et al., Münster, Germany. In Embo J, 2010
The ubiquitously expressed AP-1-sigma1A complex mediates protein sorting between the trans-Golgi network and early endosomes.
Disruption of AP1S1, causing a novel neurocutaneous syndrome, perturbs development of the skin and spinal cord.
GeneRIF
Cossette et al., Montréal, Canada. In Plos Genet, 2008
A splice mutation in AP1S1 was found in four families with a neurocutaneous syndrome.
Internal controls for quantitative polymerase chain reaction of swine mammary glands during pregnancy and lactation.
Loor et al., Piacenza, Italy. In J Dairy Sci, 2008
Initial analysis revealed TBK1, PCSK2, PTBP1, API5, VAPB, QTRT1, TRIM41, TMEM24, PPP2R5B, and AP1S1 as the most stable genes (sample/reference = 1 +/- 0.2).
Clinical, cellular, and neuropathological consequences of AP1S2 mutations: further delineation of a recognizable X-linked mental retardation syndrome.
Colleaux et al., Paris, France. In Hum Mutat, 2008
Mutations in the AP1S2 gene, encoding the sigma1B subunit of the clathrin-associated adaptor protein complex (AP)-1, have been recently identified in five X-linked mental retardation (XLMR) families, including the original family with Fried syndrome.
Airway wall thickness in cigarette smokers: quantitative thin-section CT assessment.
Laurent et al., Bordeaux, France. In Radiology, 2005
For each patient, summation of WA to summation of IA (SigmaWA/SigmaIA) ratio, which reflected normalized airway wall thickness, was calculated.
Identification and characterization of novel clathrin adaptor-related proteins.
Nakayama et al., Tsukuba, Japan. In J Biol Chem, 1998
Analysis using a yeast two-hybrid system has revealed that, similarly to gamma1-adaptin, gamma2-adaptin is capable of interacting not only with the sigma1 chain (called as sigma1A in this paper), the small chain of the AP-1 complex, but also with a novel sigma1-like protein, designated as sigma1B, which shows an 87% amino acid identity to sigma1A; and that, unlike gamma1-adaptin, it is unable to interact with beta1-adaptin, another large chain of the AP-1 complex.
AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast.
GeneRIF
Tubb et al., Boston, United States. In J Biol Chem, 1991
Isolation and description of the rat and mouse genes.
Reproducibility of API Staph-Ident system identifications of coagulase-negative staphylococci isolated from blood.
Overley et al., Lexington, United States. In J Clin Microbiol, 1990
Fifty-five isolates of coagulase-negative staphylococci from blood were identified four times each by using the API Staph-Ident (API-SI) system to determine the identification reproducibility of the system.
On the determination of input sound frequencies by the auditory central processor.
Deutsch, Tampa, United States. In Ieee Trans Biomed Eng, 1990
Synthetic AP ISI histograms are derived for a) unstimulated; b) fully synchronized; c) low-frequency; and d) high-frequency audio input conditions.
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