Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.
Copenhagen, Denmark. In Hum Mol Genet, Feb 2016
In total, 15 loci reached genome-wide significance (P-value < 5 × 10(-8)) in the joint discovery and replication analysis, of which 12 are previously identified loci in or close to ADCY3, GNPDA2, TMEM18, SEC16B, FAIM2, FTO, TFAP2B, TNNI3K, MC4R, GPR61, LMX1B and OLFM4 associated with adult body mass index or childhood obesity.
A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors.
Dortmund, Germany. In Arch Toxicol, Sep 2015
Finally, optimization of the classifier based on 100 probe sets showed that eight genes (F2RL2, TFAP2B, EDNRA, FOXD3, SIX3, MT1E, ETS1 and LHX2) are sufficient to separate HDACi from mercurials.
6C.04: INTEGRATED SNP ANALYSIS AND METABOLOMIC PROFILES OF METABOLIC SYNDROME.
Valencia, Spain. In J Hypertens, Jun 2015
The combined analysis of metabolomics and SNP data revealed an association between the metabolic profile of MS and genes polymorphism involved in the adiposity regulation and fatty acids metabolism: rs2272903_TT (TFAP2B), rs3803_TT (GATA2), rs174589_CC (FADS2) and rs174577_AA (FADS2).
Core promoter short tandem repeats as evolutionary switch codes for primate speciation.
Tehrān, Iran. In Am J Primatol, 2015
The identified genes are involved in important evolutionary and developmental processes, such as normal craniofacial development (TFAP2B), regulation of cell shape (PALMD), learning and long-term memory (RGS14), nervous system development (GFRA2), embryonic limb morphogenesis (PBX2), and forebrain development (APAF1).
What model organisms and interactomics can reveal about the genetics of human obesity.
Uppsala, Sweden. In Cell Mol Life Sci, 2012
Here, we searched biological databases and discovered 33 additional genes associated with human obesity (CADM2, GIPR, GPCR5B, LRP1B, NEGR1, NRXN3, SH2B1, FANCL, GNPDA2, HMGCR, MAP2K5, NUDT3, PRKD1, QPCTL, TNNI3K, MTCH2, DNAJC27, SLC39A8, MTIF3, RPL27A, SEC16B, ETV5, HMGA1, TFAP2B, TUB, ZNF608, FAIM2, KCTD15, LINGO2, POC5, PTBP2, TMEM18, TMEM160).
[Role of TFAP2B and WntSB in adipose tissue].
Japan. In Nihon Rinsho, 2011
It causes accumulation of neutral fats and causes insulin resistance through exaggerated glucose uptake independent of insulin and induces abnormal adipokine secretion, fat cell enlargement and insulin resistance.
Seattle, United States. In Unknown Journal, 2003
TFAP2B is the only gene in which mutations are known to cause Char syndrome.