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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Jun proto-oncogene

AP-1, c-Jun, Jun, activator protein-1
This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: JNK, V1a, p38, MAPK, CAN
Papers using AP-1 antibodies
Divergent Sp1 protein levels may underlie differential expression of UDP-glucose dehydrogenase by fibroblasts: Role in susceptibility to orbital Graves disease.
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Ludgate Marian, In PLoS ONE, 2010
... Polyclonal anti-IGF-1Rα and an anti-c-Jun Abs were from Santa Cruz Biotechnology (Santa Cruz, CA) while ...
Association of osteopontin regulatory polymorphisms with systemic sclerosis.
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Monsonego-Ornan Efrat, In PLoS ONE, 2010
... Akt, c-Src, p-c-Jun, c-Jun, and the small interfering RNAs (siRNAs) against c-Met, p85, Akt, c-Src, c-Jun, and a control for experiments using targeted siRNA transfection (each consists of a scrambled sequence that does not lead to specific degradation of any known cellular mRNA) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Gene discovery in rheumatoid arthritis highlights the CD40/NF-kappaB signaling pathway in disease pathogenesis.
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Ko Ben C.B., In PLoS ONE, 2009
... (forward and reverse primers from MWG (Eurofins MWG Operon, Ebersberg, Germany); NFAT/AP-1 5′-CGCCCAAAGAGGAAAATTTGTTTCATA-3′ (Santa-Cruz/Insight Biotechnology, Wembley, UK) ...
EV71 induces COX-2 expression via c-Src/PDGFR/PI3K/Akt/p42/p44 MAPK/AP-1 and NF-κB in rat brain astrocytes
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Yang Chuen-Mao et al., In Journal of Neuroinflammation, 2009
... Phospho-c-Src (#2120), Phospho-EGFR (#2231), Phospho-Akt (#9271), Phospho-ERK1/2 (#9101), Phospho-p38 (#9211), Phospho-JNK1/2 (#9255), and Phospho-c-Jun (#2361) antibodies were from Cell Signaling (Danver, MA) ...
A liver-derived secretory protein, selenoprotein P, causes insulin resistance.
Supplier
Chandra Dhyan, In PLoS ONE, 2009
... Antibodies against GSK-3 and phospho-c-Jun were obtained from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
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Papers on AP-1
c-Jun N-terminal Kinase-Dependent Endoplasmic Reticulum Stress Pathway is Critically Involved in Arjunic Acid Induced Apoptosis in Non-Small Cell Lung Cancer Cells.
New
Kim et al., Suwŏn, South Korea. In Phytother Res, Feb 2016
Consistently, arjunic acid cleaved poly (ADP-ribose) polymerase (PARP), activated Bax, and phosphorylation of c-Jun N-terminal kinases (JNK), and also attenuated the expression of pro-caspase-3 and Bcl-2 in A549 and H460 cells.
DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia.
New
Impact
Plass et al., Heidelberg, Germany. In Nat Genet, Feb 2016
Instead, we identified a potential pathogenic role for transcription factor dysregulation in CLL, where excess programming by EGR and NFAT with reduced EBF and AP-1 programming imbalances the normal B cell epigenetic program.
Glyoxalase I drives epithelial-to-mesenchymal transition via argpyrimidine-modified Hsp70, miR-21 and SMAD signalling in human bronchial cells BEAS-2B chronically exposed to crystalline silica Min-U-Sil 5: transformation into a neoplastic-like phenotype.
New
Talesa et al., Perugia, Italy. In Free Radic Biol Med, Feb 2016
By using gene silencing/overexpression and scavenging/inhibitory agents, we demonstrated that MS5 induced hydrogen peroxide-mediated c-Jun-dependent Glo1 up-regulation which resulted in a decrease in the Argpyrimidine-modified Hsp70 protein level which triggered EMT in a novel mechanism involving miR-21 and SMAD signalling.
Assessment of costimulation and coinhibition in a triple parameter T cell reporter line: Simultaneous measurement of NF-κB, NFAT and AP-1.
New
Steinberger et al., Vienna, Austria. In J Immunol Methods, Feb 2016
Three transcription factors, namely NF-κB, NFAT and AP-1, have a major role in inducing the transcriptional program that is required for T cell activation and differentiation.
HOXB13-mediated suppression of p21WAF1/CIP1 regulates JNK/c-Jun signaling in prostate cancer cells.
New
Kim et al., Kwangju, South Korea. In Oncol Rep, Feb 2016
HOXB13 also inhibited AP-1 signals via suppressed expression of JNK/c-Jun.
Lack of association between the Angiogenin (ANG) rs11701 polymorphism and amyotrophic lateral sclerosis risk: a meta-analysis.
Review
New
Ding et al., Yichun, China. In Neurol Sci, Feb 2016
A literature search of PubMed, Embase, Web of Science, Chinese National Knowledge Infrastructure, Wanfang and SinoMed was conducted for eligible studies published up to Jun 5, 2015.
Cyclin-Dependent Kinases as Coregulators of Inflammatory Gene Expression.
Review
New
Kracht et al., Gießen, Germany. In Trends Pharmacol Sci, Jan 2016
This process involves the cytokine-induced recruitment of CDK6 to the nuclear chromatin fraction where it associates with transcription factors of the NF-κB, STAT, and AP-1 families.
Poly(I:C) increases the expression of mPGES-1 and COX-2 in rat primary microglia.
New
Fiebich et al., Belo Horizonte, Brazil. In J Neuroinflammation, Dec 2015
Protein levels of COX-2 and mPGES-1 were reduced by SB203580, SP600125, and SC514 (p38 mitogen-activated protein kinase (MAPK), c-Jun N-terminal kinase (JNK), and IκB kinase (IKK) inhibitors, respectively), as well as by PD98059 and PD0325901 (mitogen-activated protein kinase kinase (MEK) inhibitors).
Immunoregulation in human malaria: the challenge of understanding asymptomatic infection.
Review
New
Barral-Netto et al., Araripina, Brazil. In Mem Inst Oswaldo Cruz, Dec 2015
Furthermore, molecules involved in the haem detoxification pathway (such as haptoglobin and haeme oxygenase-1) and iron metabolism (ferritin and activated c-Jun N-terminal kinase) have emerged in recent years as potential biomarkers and thus are helping to unravel the immune response underlying asymptomatic Plasmodium infection.
Reversible Human TGF-β Signal Shifting between Tumor Suppression and Fibro-Carcinogenesis: Implications of Smad Phospho-Isoforms for Hepatic Epithelial-Mesenchymal Transitions.
Review
New
Okazaki et al., Hirakata, Japan. In J Clin Med, Dec 2015
As the TGF-β receptors, c-Jun N-terminal kinase and cyclin-dependent kinase, differentially phosphorylate Smad2/3, we have generated numerous antibodies against linker (L) and C-terminal (C) phosphorylation sites in Smad2/3 and identified four types of phosphorylated forms: cytostatic COOH-terminally-phosphorylated Smad3 (pSmad3C), mitogenic pSmad3L (Ser-213) signaling, fibrogenic pSmad2L (Ser-245/250/255)/C signaling and migratory pSmad2/3L (Thr-220/179)/C signaling.
The microRNA miR-22 inhibits the histone deacetylase HDAC4 to promote T(H)17 cell-dependent emphysema.
New
Impact
Corry et al., Houston, United States. In Nat Immunol, Nov 2015
We further found that miR-22 controlled the activation of APCs and T(H)17 responses through the activation of AP-1 transcription factor complexes and the histone deacetylase HDAC4.
HIV-1 Nef hijacks clathrin coats by stabilizing AP-1:Arf1 polygons.
New
Impact
Hurley et al., Berkeley, United States. In Science, Nov 2015
The lentiviral Nef protein helps viruses evade innate and adaptive immune defenses by hijacking the adaptor protein 1 (AP-1) and AP-2 clathrin adaptors.
Role of TNF in mast cell neuroinflammation and pain.
Review
New
Conti et al., Zhengzhou, China. In J Biol Regul Homeost Agents, Oct 2015
Activation of MCs leads to NF-κB and AP1 generation with release of many cytokines including TNF, IL-33 and IL-1.
Secreted and O-GlcNAcylated MIF binds to the human EGF receptor and inhibits its activation.
New
Impact
Lu et al., Houston, United States. In Nat Cell Biol, Oct 2015
The naturally secreted and O-GlcNAcylated MIF binds to EGFR, thereby inhibiting the binding of EGF to EGFR and EGF-induced EGFR activation, phosphorylation of ERK and c-Jun, cell invasion, proliferation and brain tumour formation.
Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth.
New
Impact
Piccolo et al., Padova, Italy. In Nat Cell Biol, Sep 2015
By ChIP-seq analyses in breast cancer cells, we discovered that the YAP/TAZ transcriptional response is pervasively mediated by a dual element: TEAD factors, through which YAP/TAZ bind to DNA, co-occupying chromatin with activator protein-1 (AP-1, dimer of JUN and FOS proteins) at composite cis-regulatory elements harbouring both TEAD and AP-1 motifs.
Pdcd4 knockdown up-regulates MAP4K1 expression and activation of AP-1 dependent transcription through c-Myc.
GeneRIF
Yang et al., Lexington, United States. In Biochim Biophys Acta, 2012
Pdcd4 knockdown up-regulates MAP kinase kinase kinase kinase 1 (MAP4K1) expression and increases phosphorylation of c-Jun.
Interplay between AP-1 and estrogen receptor α in regulating gene expression and proliferation networks in breast cancer cells.
GeneRIF
Zhao et al., Huddinge, Sweden. In Carcinogenesis, 2012
identify a novel ERalpha/AP-1 target, PKIB (cAMP-dependent protein kinase inhibitor-beta), which is overexpressed in ERalpha-positive breast cancer tissues
c-Jun reprograms Schwann cells of injured nerves to generate a repair cell essential for regeneration.
GeneRIF
Jessen et al., London, United Kingdom. In Neuron, 2012
This study demonistrated that absence of c-Jun results in the formation of a dysfunctional repair cell, striking failure of functional recovery, and neuronal death.
c-Jun in Schwann cells promotes axonal regeneration and motoneuron survival via paracrine signaling.
GeneRIF
Behrens et al., London, United Kingdom. In J Cell Biol, 2012
The results revealed an unexpected function for c-Jun in Shwann cells in response to axonal injury, and identified paracrine Ret signaling as an important mediator of c-Jun function in Schwann cells during regeneration.
Cultivated ginseng suppresses ultraviolet B-induced collagenase activation via mitogen-activated protein kinases and nuclear factor κB/activator protein-1-dependent signaling in human dermal fibroblasts.
GeneRIF
Jeong et al., Taejŏn, South Korea. In Nutr Res, 2012
Cultivated ginseng inhibits UVB-induced collagenolytic MMP production by interfering with MAPK/AP-1 and NF-kappaB signaling.
More papers using AP-1 antibodies
SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages.
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Huang Chuanshu et al., In Environmental Health Perspectives, 2009
... purchased antibodies specific for IκBα [inhibitor of transcription factor NFκB-α), phosphorylated IκBα (P-IκBα), c-Jun, phosphorylated c-Jun (P-c-Jun73), and IκB kinase β (IKKβ) from Cell Signaling Technology (Beverly, MA, USA); ...
The Monascus metabolite monacolin K reduces tumor progression and metastasis of Lewis lung carcinoma cells
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Pan Tzu-Ming et al., In International Journal of Biological Sciences, 2008
... MMP-7, c-Fos, c-Jun, and the anti-mouse IgG horseradish peroxidase (HRP)-linked and anti-rabbit IgG HRP-linked secondary antibodies were obtained from Santa Cruz Biotechnology, Inc ...
Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3
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Baumgrass Ria et al., In Frontiers in Immunology, 2006
... IL-17-PE (eBioscience), IFN-γ-Pacific orange (own in-house antibody), NFATc2-FITC (own antibody, BD), c-Fos-A488 (Santa Cruz Biotechnology), phospho-c-Jun-A488 (Santa Cruz Biotechnology), NF-κBp65-A488 (Santa Cruz Biotechnology), ...
Knocking out peroxisome proliferator-activated receptor (PPAR) alpha inhibits radiation-induced apoptosis in the mouse kidney through activation of NF-kappaB and increased expression of IAPs.
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Ulasov Ilya, In PLoS ONE, 2006
... The antibodies for JNK (#9258), phosphorylated JNK (Thr/183/Thr185, #9255), cyclin D1 (#2926) and phosphorylated c-Jun (Ser63, #2361) were purchased from Cell Signaling Technology (Beverly, MA) ...
A disease- and phosphorylation-related nonmechanical function for keratin 8
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Omary M. Bishr et al., In The Journal of Cell Biology, 2004
... (human T359/S363 and mouse T348/S352), phospho-NF-κB p65 (human S536 and mouse S534), phospho-p42, JNK, and c-Jun (Cell Signaling Technology); to Fas for ...
A new dynamic Bayesian network (DBN) approach for identifying gene regulatory networks from time course microarray data
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Hubank Michael et al., In Molecular Systems Biology, 2004
... 4874) and anti-c-Jun (Santa Cruz Biotechnology, H-79) ...
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
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Borthwick Lee A. et al., In The American Journal of Pathology, 2004
... Cell Signaling), phospho-ERK-1/2 (4370; Cell Signaling), phospho-Iκ-Bα (9246; Cell Signaling), Iκ-Bα (sc-1643; Santa Cruz Biotechnology), phospho-c-Jun (2361; Cell Signaling), c-Jun (9165; Cell Signaling), ...
Nuclear Dvl, c-Jun, β-catenin, and TCF form a complex leading to stabiLization of β-catenin–TCF interaction
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Li Lin et al., In The Journal of Cell Biology, 2003
... were: β-catenin (14/β-catenin; BD Biosciences), TCF-4 (6H5-3; Millipore), Dvl-2 (10B5; Santa Cruz Biotechnology, Inc.), and c-Jun (H-79; Santa Cruz Biotechnology, Inc.) ...
MAP kinases and cell migration
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Yang Chuen-Mao et al., In Journal of Neuroinflammation, 2003
... Phospho-CaMKII, phospho-JNK, and phospho-c-Jun antibody kits were from Cell Signaling (Danver, MA, USA) ...
Paeoniflorin: an antihyperlipidemic agent from Paeonia lactiflora
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Yokozawa Takako et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2003
... Rabbit polyclonal antibodies against c-Jun N-terminal kinase (JNK) and phosphor-JNK (p-JNK), and mouse monoclonal c-Jun were purchased from Cell Signaling Technology (Beverly, MA, USA) ...
A novel role for c-Jun N-terminal kinase and phosphoinositide 3-kinase in the liver X receptor-mediated induction of macrophage gene expression
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Ramji Dipak P. et al., In Cellular Signalling, 2003
... The antisera were obtained from Biogenesis (ApoE), Abcam (ABCA1), Sigma (β-actin), Santa-Cruz Biotechnology [c-Jun (H-89), phospho-c-Jun (Ser63; KM-1)] and Cell Signaling Technology [AKT, phospho-AKT (Ser473), ...
In vitro chemo- and radio-resistance in small cell lung cancer correlates with cell adhesion and constitutive activation of AKT and MAP kinase pathways
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Song Gang et al., In OncoTargets and therapy, 2001
... Mouse anti-phospho-ERK1/2, rabbit anti-ERK1/2, anti-phospho-p38, anti-p38, anti-phospho-c-Jun, and anti-c-Jun were purchased from Cell Signaling Technology (Danvers, MA) ...
PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells
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Huang Chuanshu et al., In The Journal of Cell Biology, 2001
... The antibodies to Fra-1, Fra-2, Fos B, Jun B, and Jun D were obtained from Santa Cruz Biotechnology, Inc ...
Rapid tyrosine phosphorylation of neuronal proteins including tau and focal adhesion kinase in response to amyloid-beta peptide exposure: involvement of Src family protein kinases.
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Rubinsztein David C., In PLoS ONE, 2001
... polyclonal antibody, anti-phospho-AKT monoclonal antibody, anti-phospho-CREB polyclonal antibody, anti-monoclonal CREB antibody, anti-AKT polyclonal antibody and anti-phospho-c-Jun polyclonal antibody were purchased from Cell Signaling (Beverly, MA) ...
Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes.
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Chadwick Brian P., In PLoS ONE, 2001
... sequence of C-JUN.Horseradish peroxidase (HPR)-conjugated secondary antibodies used in this study were from Santa Cruz Biotechnology.
Mutation of the matrix metalloproteinase 2 gene (MMP2) causes a multicentric osteolysis and arthritis syndrome
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Koch Alisa E et al., In Arthritis Research & Therapy, 2000
... (Thr638/641), PKCδ (Tyr311), PKCδ (Thr505), stress-activated protein kinase SAPK/JNK (Thr183/Tyr185), and c-Jun (Ser63) antibodies were obtained from Cell Signaling Technology (Beverly, MA, USA) ...
Δ9-tetrahydrocannabinol increases nerve growth factor production by prostate PC-3 cells: involvement of CB1 cannabinoid receptor and Raf-1
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Gorman Adrienne M. et al., In International Journal of Cell Biology, 2000
... Mouse monoclonal antibody against p-c-Jun was from Santa Cruz Biotechnology.
c-Jun is a negative regulator of myelination
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Jessen Kristján R. et al., In The Journal of Cell Biology, 2000
... Serine-63 phospho–c-Jun polyclonal antibody was obtained from Cell Signaling Technology ...
Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, β cell dysfunction, and type 2 diabetes
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Chan Catherine B et al., In Journal of Molecular Endocrinology, 2000
... Antibodies to iNOS (BD Biosciences, Mississauga, Ontario, Canada), NF-κB (C-20), TNFAIP3 (H-100 and A-12), JUN (Santa Cruz Biotechnology, Santa Cruz, CA, USA) ...
Predominant intracellular localization of the type I transforming growth factor-β receptor and increased nuclear accumulation after growth arrest
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Maher Pamela A. et al., In The Journal of Cell Biology, 1999
... epitope tag, EGFR, c-Jun, c-Fos, c-Myc, cyclin E, and importin β (Santa Cruz Biotechnology, Inc.), phospho-c-Jun (New England Biolabs, Inc.), cyclin D1 and ...
Role of caspases in N-methyl-D-aspartate-induced apoptosis in cerebrocortical neurons
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Greene Lloyd A. et al., In Cell research, 1997
... JNK, phospho MKK4 (Ser257/Thr261), MKK4, phospho MKK7 (Ser271/Thr275), MKK7, phospho c-Jun (Ser63 and Ser73), and c-Jun antibodies were from Cell Signaling (Beverly, MA) ...
Phosphatidylinositol 3-kinase gamma mediates shear stress-dependent activation of JNK in endothelial cells
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Walzel H et al., In Cell Death & Disease, 1997
... gene constructs, pAP1(PMA)-TA-Luc and pTA-Luc, were from Clontech (Heidelberg, Germany) and actin (1-19) pAb, double-stranded AP-1 consensus (sc-2501), and the mutant (sc-2514) oligonucleotide were from Santa Cruz Biotechnology (Heidelberg, Germany) ...
Apoptosis signaling pathway in T cells is composed of ICE/Ced-3 family proteases and MAP kinase kinase 6b
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Simon Hans-Uwe et al., In The Journal of Experimental Medicine, 1996
... -dihydroceramide, DAG (1,2-dioctanoyl-sn-glycerol), IBMX (3-isobutyl-1-methylxanthine), LY 83583 (6-anilinoquinoline-5,8-quinone), and GST-fusion protein of c-Jun (GST-c-Jun, 1–79) were from Biomol (Plymouth Meeting, PA) ...
TGF beta 1 inhibits NF-kappa B/Rel activity inducing apoptosis of B cellstranscriptional activation of I kappa B alpha
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Topper James N. et al., In The Journal of Experimental Medicine, 1995
... The simplified NFκB promoter and the Gal4-Jun fusion constructs were obtained from CLONTECH Laboratories, Inc ...
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
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Fan Chung K et al., In Respiratory Research, 1993
... Nuclear extract kit and TransAM AP-1 family kit were from Active Motif (Rixensart, Belgium) ...
Direct in vivo VH to JH rearrangement violating the 12/23 rule
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Rajewsky Klaus et al., In The Journal of Experimental Medicine, 1993
... rearranged IgH allele of the LN1 mouse, a “pan”-PCR genome walking strategy was performed using adaptor AP1 and adaptor specific primers A1 and A2 (GenomeWalker Kit; CLONTECH Laboratories, Inc.) as described ...
Increased proliferation of adventitial fibroblasts from spontaneously hypertensive rat aorta.
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Pesce Maurizio, In PLoS ONE, 1990
... Anti-c-Jun, anti-c-Fos, anti-Phospho-c-Jun (Ser63), anti-Phospho-c-Jun (Ser73) antibodies were purchased from Cell Signaling Technology (Cell Signaling, CA, ...
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
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Moilanen Eeva et al., In BMC Pharmacology, 1975
... (Santa Cruz Biotechnology Inc.), rabbit polyclonal p38 MAPK, phospho-p38 MAPK (Thr180/Tyr182), p38α, phospho-SAPK/JNK (Thr183/Tyr185) and phospho-c-Jun (Ser63) II antibodies (Cell Signaling technology) ...
A rapid method of total lipid extraction and purification
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Diabaté Silvia et al., In Particle and Fibre Toxicology, 1958
... ), and anti-c-Jun were obtained from Cell Signaling (New England Biolabs, Frankfurt, ...
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