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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.


This gene encodes a member of the histidine triad (HIT) superfamily. The encoded protein may play a role in single-stranded DNA repair through its nucleotide-binding activity and its diadenosine polyphosphate hydrolase activity. Mutations in this gene have been associated with ataxia-ocular apraxia. Alternatively spliced transcript variants have been identified for this gene.[provided by RefSeq, Aug 2010] (from NCBI)
Top mentioned proteins: ACID, HAD, CAN, POLYMERASE, STEP
Papers on AOA
Spatial and temporal dynamics of ammonia oxidizers in the sediments of the Gulf of Finland, Baltic Sea.
Leskinen et al., Helsinki, Finland. In Mar Environ Res, Feb 2016
The diversity and dynamics of ammonia-oxidizing bacteria (AOB) and archaea (AOA) nitrifying communities in the sediments of the eutrophic Gulf of Finland (GoF) were investigated.
Prognostic significance of histomolecular subgroups of adult anaplastic (WHO Grade III) gliomas: applying the 'integrated' diagnosis approach.
Santosh et al., Bengaluru, India. In J Clin Pathol, Feb 2016
AIMS: Anaplastic gliomas (AGs; WHO Grade III) include anaplastic astrocytoma (AA), anaplastic oligodendroglioma (AO) and anaplastic oligoastrocytoma (AOA) and are known to have variable prognosis.
Epidermal growth factor receptor (EGFR) gene amplification in high-grade gliomas: Western Indian tertiary cancer center experience.
Jalali et al., Mumbai, India. In Neurol India, Jan 2016
258 patients were having a GBM [including 31 with a GBM with oligodendroglioma component (GBM-O)], 31 with a gliosarcoma, 13 with an anaplastic astrocytoma (AA), 12 with an anaplastic oligodendroglioma (AO), and 10 with an anaplastic oligoastrocytoma (AOA).
High occurrence of Pacearchaeota and Woesearchaeota (Archaea superphylum DPANN) in the surface waters of oligotrophic high-altitude lakes.
Casamayor et al., Blanes, Spain. In Environ Microbiol Rep, Jan 2016
Micrarchaeota-Diapherotrites (formerly Euryarchaeota MEG cluster), Methanomicrobia, Thermoplasmata, and AOA showed relative abundances between 1-3% and occurrences between 14-26%.
Artificial oocyte activation to improve reproductive outcomes in women with previous fertilization failure: a systematic review and meta-analysis of RCTs.
Martins et al., Athens, Greece. In Hum Reprod, Aug 2015
STUDY QUESTION: In couples with previous fertilization failure, are reproductive outcomes improved using ICSI followed by artificial oocyte activation (ICSI-AOA) compared with conventional ICSI?
[Cultivation and characterization of an ammonia oxidizing archaeon enriched from wastewater treatment plant].
Shen et al., In Wei Sheng Wu Xue Bao, Aug 2015
OBJECTIVES: To enrich ammonia-oxidizing archaeon (AOA) from wastewater treatment plants, identify its phylogenetic status, morphology and determine its growth and ammonia oxidation rates.
Molecular underpinnings of Aprataxin RNA/DNA deadenylase function and dysfunction in neurological disease.
Williams et al., United States. In Prog Biophys Mol Biol, Mar 2015
Aprataxin (APTX), a protein altered in the heritable neurological disorder Ataxia with Oculomotor Apraxia 1 (AOA1), acts as a DNA ligase "proofreader" to directly reverse AMP-modified nucleic acid termini in DNA- and RNA-DNA damage responses.
Sedimentary archaeal amoA gene abundance reflects historic nutrient level and salinity fluctuations in Qinghai Lake, Tibetan Plateau.
Wu et al., Wuhan, China. In Sci Rep, 2014
However, it is poorly known that whether the DNA and lipids of microbial functional aerobes (such as ammonia-oxidizing archaea: AOA) can be used for reconstructing past environmental conditions.
Osteoarthritis: From Palliation to Prevention: AOA Critical Issues.
Olson et al., Durham, United States. In J Bone Joint Surg Am, 2014
Osteoarthritis is a leading cause of disability.
Assisted oocyte activation following ICSI fertilization failure.
De Sutter et al., Gent, Belgium. In Reprod Biomed Online, 2014
Assisted oocyte activation (AOA) is being increasingly applied in human assisted reproduction to restore fertilization and pregnancy rates in couples with a history of ICSI fertilization failure.
Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity.
Williams et al., United States. In Nature, 2014
Aprataxin (APTX) reverses DNA adenylation but the context for deadenylation repair is unclear.
Mitochondrial dysfunction in a novel form of autosomal recessive ataxia.
Lavin et al., Brisbane, Australia. In Mitochondrion, 2013
These results describe a patient with an apparently novel form of AOA characterised by a defect at the level of the mitochondrion.
Structure of an aprataxin-DNA complex with insights into AOA1 neurodegenerative disease.
Williams et al., United States. In Nat Struct Mol Biol, 2011
Data suggest that mutations affecting protein folding, the active site pocket and the pivot motif underlie aprataxin dysfunction in the neurodegenerative disorder ataxia with oculomotor apraxia 1 (AOA1).
Ataxia with oculomotor apraxia type1 (AOA1): novel and recurrent aprataxin mutations, coenzyme Q10 analyses, and clinical findings in Italian patients.
Gellera et al., Milano, Italy. In Neurogenetics, 2011
The clinical phenotype was homogeneous, irrespectively of the type and location of the APTX mutation, and it was mainly characterized by early-onset cerebellar signs, sensory neuropathy, cognitive decline, and oculomotor deficits.
Aprataxin localizes to mitochondria and preserves mitochondrial function.
Wilson et al., Baltimore, United States. In Proc Natl Acad Sci U S A, 2011
Aprataxin localizes to mitochondria and preserves mitochondrial function.
Genotype-phenotype correlations in early onset ataxia with ocular motor apraxia and hypoalbuminaemia.
Onodera et al., Niigata, Japan. In Brain, 2011
The patients with early onset ataxia with ocular motor apraxia and hypoalbuminaemia homozygous for the c.689_690insT mutation(APTX) show a more severe phenotype than those with a p.Pro206Leu or p.Val263Gly mutation.
A novel nonsense mutation in the APTX gene associated with delayed DNA single-strand break removal fails to enhance sensitivity to different genotoxic agents.
Bassi et al., Italy. In Hum Mutat, 2011
Aprataxin is required for the normal repair rate of DNA single-strand breaks induced by genotoxic agents.
The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates.
West et al., London, United Kingdom. In Nature, 2006
neurological disorders associated with APTX mutations may be caused by the gradual accumulation of unrepaired DNA strand breaks resulting from abortive DNA ligation events
Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene.
Tsuji et al., Niigata, Japan. In Nat Genet, 2001
We have called its product aprataxin; the gene symbol is APTX.
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