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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.


Antennapedia, Antp, Hoxa7, ANT-C
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, HOXA9, Scr, Polycomb
Papers on Antennapedia
CRISPR/Cas9 Mutagenesis Reveals Versatile Roles of Hox Genes in Crustacean Limb Specification and Evolution.
Patel et al., Berkeley, United States. In Curr Biol, Feb 2016
In the thorax, Ubx is necessary for gill development and for repression of gnathal fate, and Antp dictates claw morphology.
An Organizational Hub of Developmentally Regulated Chromatin Loops in the Drosophila Antennapedia Complex.
Cai et al., Athens, United States. In Mol Cell Biol, Jan 2016
Chromatin boundary elements (CBEs) are widely distributed in the genome and mediate formation of chromatin loops, but their roles in gene regulation remain poorly understood.
Hox miRNA regulation within the Drosophila Bithorax complex: Patterning behavior.
Lai et al., New York City, United States. In Mech Dev, Nov 2015
The study of Drosophila Hox genes, located in the Antennapedia complex (ANT-C) and Bithorax complex (BX-C), has provided fundamental insights into mechanisms of how the segments of the animal body plan are specified.
Homeodomain proteins: an update.
Affolter et al., Basel, Switzerland. In Chromosoma, Nov 2015
In animals, there are 16 major classes, ANTP, PRD, PRD-LIKE, POU, HNF, CUT (with four subclasses: ONECUT, CUX, SATB, and CMP), LIM, ZF, CERS, PROS, SIX/SO, plus the TALE superclass with the classes IRO, MKX, TGIF, PBC, and MEIS.
The homeodomain transcription factors antennapedia and POU-M2 regulate the transcription of the steroidogenic enzyme gene Phantom in the silkworm.
Xia et al., Chongqing, China. In J Biol Chem, Nov 2015
In silico analysis predicted several potential cis-regulatory elements (CREs) for the homeodomain transcription factors Antennapedia (Antp) and POU-M2 in the proximal promoters of steroidogenic enzyme genes.
Entropic Enhancement of Protein-DNA Affinity by Oxygen-to-Sulfur Substitution in DNA Phosphate.
Iwahara et al., Galveston, United States. In Biophys J, Oct 2015
We mechanistically characterized this phenomenon for the Antennapedia homeodomain-DNA complex by integrated use of fluorescence, isothermal titration calorimetry, NMR spectroscopy, and x-ray crystallography.
Penetratin Story: An Overview.
Joliot et al., Paris, France. In Methods Mol Biol, 2014
Interestingly, the two most used CPPs, TAT and penetratin peptides, are derived from natural proteins, HIV Tat and Antennapedia homeoprotein, respectively.
Did homeobox gene duplications contribute to the Cambrian explosion?
Holland, Oxford, United Kingdom. In Zoological Lett, 2014
I describe how ANTP-class homeobox genes, which encode transcription factors involved in body patterning, increased in number in the bilaterian stem lineage and earlier.
Calcisponges have a ParaHox gene and dynamic expression of dispersed NK homeobox genes.
Adamska et al., Bergen, Norway. In Nature, 2014
Sponges are simple animals with few cell types, but their genomes paradoxically contain a wide variety of developmental transcription factors, including homeobox genes belonging to the Antennapedia (ANTP) class, which in bilaterians encompass Hox, ParaHox and NK genes.
Evolution of homeobox genes.
Holland, Oxford, United Kingdom. In Wiley Interdiscip Rev Dev Biol, 2013
The largest group in animals is the ANTP class which includes the well-known Hox genes, plus other genes implicated in development including ParaHox (Cdx, Xlox, Gsx), Evx, Dlx, En, NK4, NK3, Msx, and Nanog.
Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML.
Chen et al., Chicago, United States. In Blood, 2012
Data show that up-regulation of the HOXA7, HOXA9, HOXA11, and PBX3 resulting from the down-regulation of miR-181 family members probably contribute to the poor prognosis of patients with nonfavorable cytogenetically abnormal AML (CA-AML).
Inhibition of PCGF2 enhances granulocytic differentiation of acute promyelocytic leukemia cell line HL-60 via induction of HOXA7.
Chung et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2012
Taken together, these results support the notion that down-regulation of PCGF2 is sufficient to induce granulocytic differentiation of HL-60 cells via de-repression of HOXA7 gene expression.
NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights.
Aplan et al., Bethesda, United States. In Blood, 2012
Several of the NUP98 fusions, including NUP98-homeobox (HOX)A9, NUP98-HOXD13, and NUP98-JARID1A, have been used to generate animal models of both lymphoid and myeloid malignancy; these models typically up-regulate HOXA cluster genes, including HOXA5, HOXA7, HOXA9, and HOXA10.
The noncoding RNA Mistral activates Hoxa6 and Hoxa7 expression and stem cell differentiation by recruiting MLL1 to chromatin.
Sauer et al., Riverside, United States. In Mol Cell, 2011
The long, noncoding RNA (lncRNA) Mistral (Mira) activates transcription of the homeotic genes Hoxa6 and Hoxa7 in mouse embryonic stem cells (mESC) by recruiting MLL1 to chromatin.
Functional synthetic Antennapedia genes and the dual roles of YPWM motif and linker size in transcriptional activation and repression.
Gehring et al., Basel, Switzerland. In Proc Natl Acad Sci U S A, 2011
Functional synthetic Antennapedia genes and the YPWM motif play dual roles in transcriptional activation and repression.
Functional crosstalk between Bmi1 and MLL/Hoxa9 axis in establishment of normal hematopoietic and leukemic stem cells.
So et al., London, United Kingdom. In Cell Stem Cell, 2011
In contrast, MLL-AF9, which drives expression of Hoxa7 and Hoxa9, readily transformed Bmi1(-/-) cells.
Down-regulation of homeobox genes MEIS1 and HOXA in MLL-rearranged acute leukemia impairs engraftment and reduces proliferation.
Canaani et al., Israel. In Proc Natl Acad Sci U S A, 2011
Several targets of MLL fusions, MEIS1, HOXA7, HOXA9, and HOXA10 are functionally related and have been implicated in leukemias. Each of the four genes was knocked down separately in the precursor B-cell leukemic line RS4;11 expressing MLL-AF4.
Polycomb-dependent regulatory contacts between distant Hox loci in Drosophila.
Cavalli et al., Montpellier, France. In Cell, 2011
In Drosophila melanogaster, Hox genes are organized in an anterior and a posterior cluster, called Antennapedia complex and bithorax complex, located on the same chromosome arm and separated by 10 Mb of DNA.
NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis.
Kamps et al., San Diego, United States. In Nat Cell Biol, 2007
We demonstrate that NUP98-NSD1 induces AML in vivo, sustains self-renewal of myeloid stem cells in vitro, and enforces expression of the HoxA7, HoxA9, HoxA10 and Meis1 proto-oncogenes.
A Hedgehog- and Antennapedia-dependent niche maintains Drosophila haematopoietic precursors.
Banerjee et al., Los Angeles, United States. In Nature, 2007
the posterior signalling centre is specified early in the embryo by the homeotic gene Antennapedia (Antp) and expresses the signalling molecule Hedgehog
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