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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Annexin A11

annexin XI, annexin A11, annexin 11, ANXA11, Anx11
This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain the calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: calcyclin, ACID, Phosphogluconate Dehydrogenase, ALG-2, OUT
Papers on annexin XI
Granuloma genes in sarcoidosis: what is new?
Review
New
Rybicki et al., Detroit, United States. In Curr Opin Pulm Med, Sep 2015
With relevance to granuloma formation, genes involved in apoptotic processes and immune cell activation were further confirmed (ANXA11 and BTNL2) in multiple ethnicities; others were newly identified (XAF1).
Prostate cancer-associated autoantibodies in serum against tumor-associated antigens as potential new biomarkers.
New
Balabanov et al., Hamburg, Germany. In J Proteomics, May 2015
Autoantibody response to antigens PRDX2, PRDX6 and ANXA11 in PCa patient's sera was confirmed using recombinant antigens.
Annexin A11 knockdown inhibits in vitro proliferation and enhances survival of Hca-F cell via Akt2/FoxO1 pathway and MMP-9 expression.
New
Sun et al., Dalian, China. In Biomed Pharmacother, Mar 2015
Annexin A11 (Anxa11), a Ca(2+)-regulated phospholipid-binding protein, is involved in cell apoptosis, differentiation, vesicle trafficking, cancer progression and autoimmune diseases.
A new role for annexin A11 in the early secretory pathway via stabilizing Sec31A protein at the endoplasmic reticulum exit sites (ERES).
New
Maki et al., London, United Kingdom. In J Biol Chem, Mar 2015
In this study, we show that another calcium-binding protein, annexin A11 (AnxA11), physically associates with Sec31A by the adaptor function of ALG-2.
Antigen-Antibody Affinity for Dry Eye Biomarkers by Label Free Biosensing. Comparison with the ELISA Technique.
Casquel et al., Madrid, Spain. In Sensors (basel), 2014
Different proteins involved with dry eye dysfunction: ANXA1, ANXA11, CST4, PRDX5, PLAA and S100A6; were validated as biomarkers.
Annexin A11 in disease.
Review
Greenaway et al., Dalian, China. In Clin Chim Acta, 2014
Ubiquitously expressed in many cell types, annexin A11 (Anxa11) is a member of the multigene family of Ca(2+)-regulated phospholipid-dependent and membrane-binding annexin proteins.
Annexin A11 (ANXA11) gene polymorphisms are associated with sarcoidosis in a Han Chinese population: a case-control study.
Zhang et al., Xinxiang, China. In Bmj Open, 2013
OBJECTIVES: To further identify the single-nucleotide polymorphisms (SNPs) that contribute to the genetic susceptibility to sarcoidosis, we examined the potential association between sarcoidosis and 15 SNPs of the ANXA11 gene.
Aberrant differentiation of urothelial cells in patients with ureteropelvic junction obstruction.
Han et al., Wuhan, China. In Int J Clin Exp Pathol, 2013
The expression of Annexin A7, Annexin A11, EGFR, Keratin 5, uroplakin III, and SMA in the urothelium of obstructed UPJ segment and of the normal ureter below the obstructed segment were determined by immunofluorescence.
Annexin A11 gene polymorphism (R230C variant) and sarcoidosis in a Portuguese population.
Delgado et al., Porto, Portugal. In Tissue Antigens, 2013
A recent genome-wide association study detected a protective effect for the annexin A11 rs1049550*T allele (R230Cvariant) in susceptibility to sarcoidosis.
Proteomic analysis of synovial fibroblast-like synoviocytes from rheumatoid arthritis.
Luo et al., Nanjing, China. In Clin Exp Rheumatol, 2013
annexin 11, peroxiredoxin 1, TrpRS), heat-shock/chaperone proteins (e.g.
Feasibility of proposed single-nucleotide polymorphisms as predictive markers for targeted regimens in metastatic colorectal cancer.
Kim et al., Seoul, South Korea. In Br J Cancer, 2013
For bevacizumab regimens, patients homozygous for the minor alleles (TT) of ANXA11 rs1049550 exhibited an ORR twice as high as those homozygous or heterozygous for the ancestral allele (CC and CT; P=0.031).
Tear proteome and protein network analyses reveal a novel pentamarker panel for tear film characterization in dry eye and meibomian gland dysfunction.
Suárez et al., Spain. In J Proteomics, 2013
A further validation study using multiplexed-like ELISA assays in tear samples collected with both sponge and capillary confirmed the high discriminatory power of five biomarkers: S100A6, annexin A1 (ANXA1), annexin A11 (ANXA11), cystatin-S (CST4), and phospholipase A2-activating protein (PLAA) with an area under ROC curve (AUC)≥ 97.9% (sensitivity ≥ 94.3%; specificity ≥ 97.6%) when comparing dry eye and control individuals.
IL12RB2 gene is associated with the age of type 1 diabetes onset in Croatian family Trios.
Zemunik et al., Split, Croatia. In Plos One, 2011
METHODS AND FINDINGS: We genotyped four genetic variants (rs2358817, rs1049550, rs6679356, rs9865818) within VTCN1, ANXA11, IL12RB2 and LPP genes respectively, in 265 T1DM family trios in Croatian population.
Functional variant ANXA11 R230C: true marker of protection and candidate disease modifier in sarcoidosis.
GeneRIF
Petrek et al., Olomouc, Czech Republic. In Genes Immun, 2011
ANXA11 rs1049550 single nucleotide polymorphism is the susceptibility marker in sarcoidosis, at least in Caucasians.
Anti-annexins autoantibodies: their role as biomarkers of autoimmune diseases.
Review
Doria et al., Padova, Italy. In Autoimmun Rev, 2011
Annexin XI is involved in several biological pathways, particularly apoptosis and cell proliferation.
First independent replication study confirms the strong genetic association of ANXA11 with sarcoidosis.
GeneRIF
Wollnik et al., In Thorax, 2010
Data confirm the strong association between variations in ANXA11 and sarcoidosis and support the hypothesis that ANXA11 represents a strong genetic risk factor for sarcoidosis.
Suppression of annexin A11 in ovarian cancer: implications in chemoresistance.
GeneRIF
Zhang et al., Baltimore, United States. In Neoplasia, 2009
Immunohistochemistry analyses indicated that annexin A11 immunointensity inversely correlated with HMOX1 immunoreactivity in 142 ovarian cancer patients.
Characterisation of the sarcoidosis-associated variant of annexin A11.
GeneRIF
Moss et al., London, United Kingdom. In Gen Physiol Biophys, 2008
analysis of the sarcoidosis-associated variant of annexin A11
Novel protein ligands of the annexin A7 N-terminal region suggest pro-beta helices engage one another with high specificity.
GeneRIF
Creutz, Charlottesville, United States. In Gen Physiol Biophys, 2008
A7 and A11 have sequence repeats that form novel structures, called YP pro-beta helices, that are characterized by an ability to interact with one another
Genome-wide association study identifies ANXA11 as a new susceptibility locus for sarcoidosis.
Impact
GeneRIF
Schreiber et al., Kiel, Germany. In Nat Genet, 2008
The strongest association signal maps to the ANXA11 (annexin A11) gene on chromosome 10q22.3.
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