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Chromosome 5 open reading frame 39

Annexin II receptor, annexin II receptor on
Top mentioned proteins: V1a, CAN, fucosyltransferase, caspase-8, bcl-2
Papers on Annexin II receptor
SiRNA directed against annexin II receptor inhibits angiogenesis via suppressing MMP2 and MMP9 expression.
Zhao et al., Shanghai, China. In Cell Physiol Biochem, 2014
BACKGROUND/AIMS: Annexin II receptor (AXIIR) is able to mediate Annexin II signal and induce apoptosis, but its role in angiogenesis remains unclear.
Annexin II receptor induces apoptosis independent of Annexin II.
Chen et al., Beijing, China. In Apoptosis, 2013
Annexin II receptor (AXIIR) is also known as chromosome 5 open reading frame 39 (C5orf39), it was originally identified as a cell surface receptor for Annexin II.
Annexin II interactions with the annexin II receptor enhance multiple myeloma cell adhesion and growth in the bone marrow microenvironment.
Roodman et al., Pittsburgh, United States. In Blood, 2012
Results show that AXII and AXIIR play important roles in multiple myeloma (MM) and that targeting the AXII/AXIIR axis may be a novel therapeutic approach for MM.
GAS6/AXL axis regulates prostate cancer invasion, proliferation, and survival in the bone marrow niche.
Taichman et al., Ann Arbor, United States. In Neoplasia, 2010
Similarly, prostate cancer (PCa) cells express the annexin II receptor and seem to use the stem cell niche for homing to the bone marrow.
Annexin II/annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancer.
Taichman et al., Ann Arbor, United States. In J Cell Biochem, 2008
annexin II and its receptor axis play a central role in prostate cancer metastasis, and prostate cancer utilizes the hematopoietic stem cell homing mechanisms to gain access to the niche.
Cloning and characterization of the annexin II receptor on human marrow stromal cells.
Roodman et al., Pittsburgh, United States. In J Biol Chem, 2006
analysis of the annexin II receptor on human marrow stromal cells
Endothelium as a target for antiphospholipid antibodies.
Meroni et al., Milano, Italy. In Immunobiology, 2002
Beta 2 glycoprotein I can adhere to endothelial cell surface through the Annexin II receptor and through negatively charged structures (heparin-like molecules) that are bound by the phospholipid-binding site of the molecule.
Angiostatin binds to tyrosine kinase substrate annexin II through the lysine-binding domain in endothelial cells.
Sharma et al., Philadelphia, United States. In Microvasc Res, 2002
Similarly, saturating the annexin II receptor by plasminogen in endothelial cells also blocks angiostatin's activity.
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