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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Annexin A4

Annexin A4
an annexin; may be involved in exocytosis in apical regions of polarized cells [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: fibrillin-1, ToF, CAN, Actin, HAD
Papers on Annexin A4
Overexpression of annexin A4 indicates poor prognosis and promotes tumor metastasis of hepatocellular carcinoma.
Liu et al., Fuzhou, China. In Tumour Biol, Feb 2016
In the current study, annexin A4, a calcium-dependent phospholipid-binding protein, has been found to be significantly elevated in HCC patients with early recurrence/metastasis, and had a strong correlation with portal vein tumor thrombosis (p = 0.03) and advanced BCLC stage (p = 0.002).
VvpE mediates the intestinal colonization of Vibrio vulnificus by the disruption of tight junctions.
Han et al., Seoul, South Korea. In Int J Med Microbiol, Jan 2016
In addition, the results of a LC-MS/MS analysis showed that VvpE contributes to WT pathogenesis in multiple ways by interacting with intestinal proteins, including β-globin, Annexin A2, Annexin A4, F-actin, and intelectin-1b.
Annexin A4 is a novel direct regulator of adenylyl cyclase type 5.
Müller et al., Münster, Germany. In Faseb J, Sep 2015
Annexin A4 (AnxA4), a Ca(2+)- and phospholipid-binding protein, is up-regulated in the human failing heart.
Annexin A4 and cancer.
Sun et al., Dalian, China. In Clin Chim Acta, Aug 2015
Annexin A4 (Anxa4) is one of the Ca(2+)-regulated and phospholipid-binding annexin superfamily proteins.
Proteomic analysis of porcine endometrial tissue during peri-implantation period reveals altered protein abundance.
Wasielak et al., Olsztyn, Poland. In J Proteomics, Aug 2015
Endometrial proteins that increased from Day 9 to Day 12 of cycle included annexin A4, beta-actin, apolipoprotein, ceruloplasmin and afamin.
The Proteomic Analysis of Human Placenta with Pre-eclampsia and Normal Pregnancy.
Kim et al., Suwŏn, South Korea. In J Korean Med Sci, Jun 2015
The 11 up-regulated proteins were fibrinogen gamma, cardiac muscle alpha actin proprotein, cytokeratin 8, calumenin, fibrinogen fragment D, F-actin capping protein alpha-1 subunit, Hsp 27, Hsp 40, annexin A4, enoyl-CoA delta isomerase and programmed cell death protein 6.
Cystatin B as a potential diagnostic biomarker in ovarian clear cell carcinoma.
Naito et al., Tokyo, Japan. In Int J Oncol, Apr 2015
Based on hierarchical clustering that revealed a marked distinction in the expression levels of cystatin B (CYTB) and Annexin A4 (ANXA4) in CCC relative to the other subtypes, we focused the study on CYTB and ANXA4 expression in EOCs by IHC, RT-qPCR and western blot analyses using tissue specimens and cultured cells.
Identification of O-Linked Glycoproteins Binding to the Lectin Helix pomatia Agglutinin as Markers of Metastatic Colorectal Cancer.
Dwek et al., London, United Kingdom. In Plos One, 2014
The results were validated using a further independent set of specimens and this showed a significant association between the staining score for annexin 4 and HPA and the time to metastasis; independently (annexin A4: Chi square 11.45, P = 0.0007; HPA: Chi square 9.065, P = 0.0026) and in combination (annexin 4 and HPA combined: Chi square 13.47; P = 0.0002).
Potential targets for ovarian clear cell carcinoma: a review of updates and future perspectives.
Kimura et al., Suita, Japan. In Cancer Cell Int, 2014
In particular, we focus on the mechanism of platinum resistance in clear cell carcinoma, including the role of annexin A4, one of the most investigated factors of platinum resistance, as well as the mutant genes and overexpressed proteins such as VEGF, PI3K/AKT/mTOR signaling pathway, ARID1A, hepatocyte nuclear factor-1β, ZNF217.
Role of calcium-binding sites in calcium-dependent membrane association of annexin A4.
Fukuoka et al., Nishinomiya, Japan. In Biosci Biotechnol Biochem, 2014
Annexin A4 (Anx4) is a cytosolic calcium-binding protein with four repeat domains, each containing one calcium-binding site (CBS).
Annexin A4 induces platinum resistance in a chloride-and calcium-dependent manner.
Naka et al., Ōsaka, Japan. In Oncotarget, 2014
We previously reported that enhanced annexin A4 (ANXA4) expression, a Ca2+-regulated phospholipid-binding protein, induces chemoresistance to platinum-based drugs.
Identification of differential proteins in colorectal cancer cells treated with caffeic acid phenethyl ester.
Wu et al., Wanxian, China. In World J Gastroenterol, 2014
The identified up-regulated proteins were Annexin A4, glyceraldehyde-3-phosphate dehydrogenase, Glucosamine-6-phosphate deaminase 1 (GNPDA1), and Glutathione peroxidase (GPX-1).
Annexin A4 is a promising therapeutic target for the treatment of platinum-resistant cancers.
Naka et al., Suita, Japan. In Expert Opin Ther Targets, 2014
INTRODUCTION: Platinum drugs are widely used for the treatment of testicular, bladder, ovarian, colorectal, lung and prostate cancers.
Gestational diabetes is characterized by reduced mitochondrial protein expression and altered calcium signaling proteins in skeletal muscle.
Friedman et al., Melbourne, Australia. In Plos One, 2013
Quantitative proteomic analysis in rectus abdominus skeletal muscle tissue collected at delivery revealed reduced protein content of mitochondrial complex I (C-I) subunits (NDUFS3, NDUFV2) and altered content of proteins involved in calcium homeostasis/signaling (calcineurin A, α1-syntrophin, annexin A4) in OGDM (n = 6) vs. ONGT (n = 6).
Targeting annexin A4 to counteract chemoresistance in clear cell carcinoma of the ovary.
Naka et al., Ibaraki, Japan. In Expert Opin Ther Targets, 2010
AREAS COVERED IN THIS REVIEW: An overview of the clinical characteristics of ovarian CCC; the role of annexin family proteins in tumor development and progression; the role of annexin A4 in enhancing cellular drug resistance; recent studies linking annexin A4 overexpression to chemoresistance in tumors of ovarian CCC.
Crystal structures of sodium-bound annexin A4.
Arii et al., Sagamihara, Japan. In Biosci Biotechnol Biochem, 2009
In this study, we resolved two crystal structures of the Na(+)-bound form of annexin A4.
Identification of a novel protein complex containing annexin A4, rabphilin and synaptotagmin.
Gawler et al., Liverpool, United Kingdom. In Febs Lett, 2004
the rabphilin C2B domain interacts directly with the N-terminus of annexin A4 and mediates the co-complexing of these two proteins which co-localise at the plasma membrane annexin; A4 may play a role in synaptic exocytosis.
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