Recent progress in therapeutic strategy for ischemic stroke.
In Cell Transplant, Feb 2016
GDNF and HGF significantly reduced infarct size, the number of microtubule-associated protein 1 light chain3 (LC3)-positive cells, and the number of terminal deoxynucleotidyl transferase-mediated dUTP-biotin in situ nick end labeling (TUNEL)-positive cells, indicating that GDNF and HGF were greatly associated with not only the antiapoptotic effect but also the antiautophagic effects.
Autophagy mediates degradation of nuclear lamina.
Philadelphia, United States. In Nature, Dec 2015
The autophagy protein LC3/Atg8, which is involved in autophagy membrane trafficking and substrate delivery, is present in the nucleus and directly interacts with the nuclear lamina protein lamin B1, and binds to lamin-associated domains on chromatin.
Decorin as a multivalent therapeutic agent against cancer.
Philadelphia, United States. In Adv Drug Deliv Rev, Nov 2015
Upon receptor binding, decorin initiates signaling pathways within endothelial cells downstream of VEGFR2 that ultimately culminate in a Peg3/Beclin 1/LC3-dependent autophagic program.
Rubicon swaps autophagy for LAP.
More papers using
Cambridge, United Kingdom. In Nat Cell Biol, Jul 2015
Phagocytic cells engulf their prey into vesicular structures called phagosomes, of which a certain proportion becomes demarcated for enhanced maturation by a process called LC3-associated phagocytosis (LAP).
Aging: past, present and future
In Cell Cycle, 2008
... Biologicals, #NBP1–00085); BNIP3 (Abcam, #ab10433); Cathepsin B (FL-339) (Santa Cruz, #sc-13985); Lamp-1 (E-5) (Santa Cruz, #sc-17768); LC3 (Abcam, ab48395); ATG16L1 (Abgent, #AP1817a); ... Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum
In The Journal of Cell Biology, 2004
... Butcher, Babraham Institute, Cambridge, England, UK), rabbit anti-GFP (Invitrogen), 9E10 mouse anti-myc, rabbit anti–MAP-LC3 (Santa Cruz Biotechnology Inc.), rabbit anti–MAP-LC3 (Sigma-Aldrich), ... Comparison of the effect of mitochondrial inhibitors on mitochondrial membrane potential in two different cell lines using flow cytometry and spectrofluorometry
In Cell Death & Disease, 2002
... IA, USA), anti-cathepsin D (Ab-2, Calbiochem, Saint Quentin en Yvelines, France), anti-p62 (SQSTM1, Enzo, Villeurbane, France), anti-LC3 (51–11, MBL International Corporation, Nanterre, France), ...