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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 Mar 2014.

Annexin A1

Annexin A1, annexin I, lipocortin, annexin 1, lipocortin 1, lipocortin I
Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, fibrillin-1, HAD, V1a
Papers on Annexin A1
Endogenous annexin A1 IS a novel protective determinant in nonalcoholic steatohepatitis (NASH).
New
Perretti et al., Novara, Italy. In Hepatology, 25 Apr 2014
UNLABELLED: Annexin A1 (AnxA1) is an effector of the resolution of inflammation highly effective in terminating acute inflammatory responses.
Cytokine/chemokine secretion and proteomic identification of upregulated annexin A1 from peripheral blood mononuclear cells co-cultured with the liver fluke, Opisthorchis viverrini.
New
Pinlaor et al., Khon Kaen, Thailand. In Infect Immun, 10 Apr 2014
Selected for further study, immunoblotting of annexin A1 (ANXA1) showed upregulation in PBMCs after 12 and 24 h co-cultured with liver flukes.
Serial changes in plasma annexin A1 and cortisol levels in sepsis patients.
New
Shih et al., Taipei, Taiwan. In Chin J Physiol, 28 Mar 2014
Annexin A1 (AnxA1), originally identified as a glucocorticoid-regulated protein, is an impor- tant endogenous anti-inflammatory mediator during the resolution phase of inflammation, and its cir- culating level has been rarely studied in sepsis patients.
Analysis of skin and secretions of Dybowski's frogs (Rana dybowskii) exposed to Staphylococcus aureus or Escherichia coli identifies immune response proteins.
New
Xu et al., Harbin, China. In Vet J, 03 Mar 2014
Proteins with a potential function in the immune response were identified, such as stathmin 1a, annexin A1, superoxide dismutase A, C-type lectin, lysozyme, antimicrobial peptides, cofilin-1-B, mannose receptor, histone H4, prohormone convertase 1, carbonyl reductase 1 and some components of the Toll-like receptor (TLR) signalling pathway.
Urine annexin A1 as an index for glomerular injury in patients.
New
Chen et al., Taipei, Taiwan. In Dis Markers, Dec 2013
We recently demonstrated high urine levels of annexin A1 (ANXA1) protein in a mouse Adriamycin-induced glomerulopathy (ADG) model.
Resolution of inflammation: mechanisms and opportunity for drug development.
Review
New
Teixeira et al., Edinburgh, United Kingdom. In Pharmacol Ther, Aug 2013
Successful resolution requires activation of endogenous programs with switch from production of pro-inflammatory towards pro-resolving molecules, such as specific lipid mediators and annexin A1, and the non-phlogistic elimination of granulocytes by apoptosis with subsequent removal by surrounding macrophages.
New pathways to control inflammatory responses in adipose tissue.
Review
New
Fantuzzi et al., Chicago, United States. In Curr Opin Pharmacol, Aug 2013
Specifically, we discuss evidence on the role of the inflammasome and its downstream products as a potential target for anti-inflammatory strategies as well as T regulatory (Treg) cells and mediators involved in the resolution phase of inflammation such as resolvins, protectins, annexin A1 (ANXA1) and galectins as potential targets for novel agonist therapies.
Annexin-1-mediated endothelial cell migration and angiogenesis are regulated by vascular endothelial growth factor (VEGF)-induced inhibition of miR-196a expression.
GeneRIF
Huot et al., Qu├ębec, Canada. In J Biol Chem, 2012
VEGF-induced decrease of miR-196a expression may participate to the angiogenic switch by maintaining the expression of ANXA1 to levels required to enable p38-ANXA1-dependent endothelial cell migration and angiogenesis in response to VEGF.
Endothelial microparticle uptake in target cells is annexin I/phosphatidylserine receptor dependent and prevents apoptosis.
GeneRIF
Werner et al., Bonn, Germany. In Arterioscler Thromb Vasc Biol, 2012
Endothelial microparticles are incorporated by endothelial cells in an annexin I/phosphatidylserine receptor-dependent manner and protect target cells against apoptosis.
Annexin A1: novel roles in skeletal muscle biology.
Review
Parente et al., Salerno, Italy. In J Cell Physiol, 2012
Annexin A1 (ANXA1, lipocortin-1) is the first characterized member of the annexin superfamily of proteins, so called since their main property is to bind (i.e., to annex) to cellular membranes in a Ca(2+) -dependent manner.
Anti-inflammatory drugs, eicosanoids and the annexin A1/FPR2 anti-inflammatory system.
Review
Flower et al., London, United Kingdom. In Prostaglandins Other Lipid Mediat, 2012
The action of anti-inflammatory and anti-allergic drugs on the eicosanoid system is briefly reviewed.
Annexin A1 interaction with the FPR2/ALX receptor: identification of distinct domains and downstream associated signaling.
GeneRIF
Flower et al., London, United Kingdom. In J Biol Chem, 2012
N-terminal region was dispensable for AnxA1-induced FPR2/ALX down-regulation in both the homologous and heterologous desensitization modes.
The role of annexin A1 in expression of matrix metalloproteinase-9 and invasion of breast cancer cells.
GeneRIF
Jang et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2012
these results indicate that ANXA1 functions as a positive regulator of MMP-9 expression and invasion of breast cancer cells through specific activation of the NF-kappaB signaling pathway.
[Hypoxia upregulates the expression of annexin A1 in lung adenocarcinoma a549 cells].
GeneRIF
Guan et al., Wuhan, China. In Zhongguo Fei Ai Za Zhi, 2012
Data show that hypoxia upregulates the expression of Annexin A1 in lung adenocarcinoma A549 cells, in which process reactive oxygen species (ROS)-NF-kappaB may paticipate in.
Microparticles: a critical component in the nexus between inflammation, immunity, and thrombosis.
Review
Toti et al., Strasbourg, France. In Semin Immunopathol, 2011
Because of their multiple properties that are characteristic of a private response of the parental cell, MPs could act as cytoprotective and anti-inflammatory agents through the delivery of activated protein C or annexin 1 and could contribute to the limitation of vascular hyporeactivity.
International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family.
Review
Impact
Murphy et al., Chicago, United States. In Pharmacol Rev, 2009
Surprisingly, the endogenous anti-inflammatory peptide annexin 1 and its N-terminal fragments also bind human FPR1 and FPR2/ALX, and the anti-inflammatory eicosanoid lipoxin A4 is an agonist at FPR2/ALX.
Annexin A1 and glucocorticoids as effectors of the resolution of inflammation.
Review
Impact
GeneRIF
D'Acquisto et al., London, United Kingdom. In Nat Rev Immunol, 2009
glucocorticoids regulate the expression and function of annexin A1 in opposing ways in innate and adaptive immune cells to mediate the resolution of inflammation. Review.
Occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera.
Impact
GeneRIF
Hanash et al., Seattle, United States. In J Clin Oncol, 2008
Report the occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera.
Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy.
Impact
Schnitzer et al., San Diego, United States. In Nature, 2004
Expression profiling and gamma-scintigraphic imaging with antibodies establishes two of these proteins, aminopeptidase-P and annexin A1, as selective in vivo targets for antibodies in lungs and solid tumours, respectively.
Simple diagnostic assay for hairy cell leukaemia by immunocytochemical detection of annexin A1 (ANXA1).
Impact
Pileri et al., Perugia, Italy. In Lancet, 2004
Through gene expression profiling, annexin A1 (ANXA1) has been identified as a gene that is upregulated in hairy cell leukaemia.
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