Proteomic analysis indicates that overexpression and nuclear translocation of lactoylglutathione lyase (GLO1) is associated with tumor progression in murine fibrosarcoma.
Ube, Japan. In Electrophoresis, 16 Mar 2014
Seven up-regulated proteins were identified in QRsP-11 compared to QR-32 cells, namely GLO1, annexin A1, adenylate kinase isoenzyme 1, transcription factor BTF3, myosin light polypeptide 6, low molecular weight phosphotyrosine protein phosphatase and nucleoside diphosphate kinase B. Heat shock protein beta-1 (HspB1), a methylglyoxal-adducted protein, is concomitantly over-expressed in QRsP-11 as compared to QR-32 cells.
Detection of circulating antibodies to linear peptide antigens derived from ANXA1 and DDX53 in lung cancer.
Changchun, China. In Tumour Biol, 23 Feb 2014
To confirm whether the antibody test developed with linear peptide antigens has a similar power to that developed with the whole protein molecules, the present work was then undertaken to develop an in-house enzyme-linked immunosorbent assay with linear peptide antigens derived from annexin A1 (ANXA1) and DEAD box protein 53 (DDX53), which have been used to develop the EarlyCDT®-Lung test.
Resolution of inflammation: mechanisms and opportunity for drug development.
Edinburgh, United Kingdom. In Pharmacol Ther, Aug 2013
Successful resolution requires activation of endogenous programs with switch from production of pro-inflammatory towards pro-resolving molecules, such as specific lipid mediators and annexin A1, and the non-phlogistic elimination of granulocytes by apoptosis with subsequent removal by surrounding macrophages.
New pathways to control inflammatory responses in adipose tissue.
Chicago, United States. In Curr Opin Pharmacol, Aug 2013
Specifically, we discuss evidence on the role of the inflammasome and its downstream products as a potential target for anti-inflammatory strategies as well as T regulatory (Treg) cells and mediators involved in the resolution phase of inflammation such as resolvins, protectins, annexin A1 (ANXA1) and galectins as potential targets for novel agonist therapies.
Annexin A1: novel roles in skeletal muscle biology.
Salerno, Italy. In J Cell Physiol, 2012
Annexin A1 (ANXA1, lipocortin-1) is the first characterized member of the annexin superfamily of proteins, so called since their main property is to bind (i.e., to annex) to cellular membranes in a Ca(2+) -dependent manner.