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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 23 Aug 2015.

Annexin A1

Annexin A1, annexin I, lipocortin, annexin 1, lipocortin 1, lipocortin I
Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, fibrillin-1, HAD, ACID, V1a
Papers on Annexin A1
Wound repair: role of immune-epithelial interactions.
Review
New
Nusrat et al., München, Germany. In Mucosal Immunol, 30 Sep 2015
This process is highly regulated by proteins and lipids, proresolving mediators such as Annexin A1 protein and resolvins released into the epithelial milieu by the epithelium itself and infiltrating innate immune cells including neutrophils and macrophages.
Chloral Hydrate Preconditioning Protects Against Ischemic Stroke via Upregulating Annexin A1.
New
Pei et al., Wuhan, China. In Cns Neurosci Ther, 30 Sep 2015
Annexin A1 (ANXA1) is a homeostatic antiinflammatory mediator that participates in countering against ischemic injuries.
Pituitary Dendritic Cells Communicate Immune Pathogenic Signals.
New
Bulloch et al., New York City, United States. In Brain Behav Immun, 15 Aug 2015
Pituitary CD11c/eyfp+ cells also express annexin A1 (ANXA1), indicating a role in GC signal attenuation.
The resolution of inflammation: Principles and challenges.
Review
New
Norling et al., London, United Kingdom. In Semin Immunol, May 2015
These mediators are diverse in nature, and include specialized lipid mediators (lipoxins, resolvins, protectins and maresins) proteins (annexin A1, galectins) and peptides, gaseous mediators including hydrogen sulphide, a purine (adenosine), as well as neuromodulator release under the control of the vagus nerve.
Ac2-26 Mimetic Peptide of Annexin A1 Inhibits Local and Systemic Inflammatory Processes Induced by Bothrops moojeni Venom and the Lys-49 Phospholipase A2 in a Rat Model.
New
Oliani et al., Ribeirão Preto, Brazil. In Plos One, Dec 2014
Annexin A1 (AnxA1) is an endogenous glucocorticoid regulated protein that modulates anti-inflammatory process and its therapeutic potential has recently been recognized in a range of systemic inflammatory disorders.
Annexin A1 expression in a pooled breast cancer series: association with tumor subtypes and prognosis.
New
Schmidt et al., Amsterdam, Netherlands. In Bmc Med, Dec 2014
BACKGROUND: Annexin A1 (ANXA1) is a protein related with the carcinogenesis process and metastasis formation in many tumors.
Targeting pro-resolution pathways to combat chronic inflammation in COPD.
Review
New
Vlahos et al., Melbourne, Australia. In J Thorac Dis, Nov 2014
In this perspective, we discuss an alternative view on why inflammation persists with a focus on why pro-resolution mediators such as lipoxin A4 (LXA4), D-series resolving and Annexin A1 fail to effectively switch off inflammation in COPD.
In vivo proteomic imaging analysis of caveolae reveals pumping system to penetrate solid tumors.
New
Impact
Schnitzer et al., San Diego, United States. In Nat Med, Sep 2014
A post-translationally modified form of annexin A1 (AnnA1) is selectively concentrated in human and rodent tumor caveolae.
Annexin A1 in malignant tumors: current opinions and controversies.
Review
Shuanying et al., Xi'an, China. In Int J Biol Markers, 2014
Annexin A1 is a 37 kDa calcium and phospholipid-binding protein that participates in several biological processes, such as inflammatory reactions, modulation of cell proliferation, regulation of cell death signaling, apoptosis, and, most importantly, tumor formation and development.
[Participation of annexins in endocytosis and EGFR-mediated signal transduction].
Review
Bandorowicz-Pikuła et al., In Postepy Biochem, 2013
In this review we describe a role of some members of the annexin family, annexin A1 (AnxA1), annexin A2 (AnxA2), annexin A6 (AnxA6) and annexin A8 (AnxA8) in the epidermal growth factor (EGF) signal transduction pathway.
Annexin-1-mediated endothelial cell migration and angiogenesis are regulated by vascular endothelial growth factor (VEGF)-induced inhibition of miR-196a expression.
GeneRIF
Huot et al., Québec, Canada. In J Biol Chem, 2012
VEGF-induced decrease of miR-196a expression may participate to the angiogenic switch by maintaining the expression of ANXA1 to levels required to enable p38-ANXA1-dependent endothelial cell migration and angiogenesis in response to VEGF.
Endothelial microparticle uptake in target cells is annexin I/phosphatidylserine receptor dependent and prevents apoptosis.
GeneRIF
Werner et al., Bonn, Germany. In Arterioscler Thromb Vasc Biol, 2012
Endothelial microparticles are incorporated by endothelial cells in an annexin I/phosphatidylserine receptor-dependent manner and protect target cells against apoptosis.
Annexin A1 interaction with the FPR2/ALX receptor: identification of distinct domains and downstream associated signaling.
GeneRIF
Flower et al., London, United Kingdom. In J Biol Chem, 2012
N-terminal region was dispensable for AnxA1-induced FPR2/ALX down-regulation in both the homologous and heterologous desensitization modes.
The role of annexin A1 in expression of matrix metalloproteinase-9 and invasion of breast cancer cells.
GeneRIF
Jang et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2012
these results indicate that ANXA1 functions as a positive regulator of MMP-9 expression and invasion of breast cancer cells through specific activation of the NF-kappaB signaling pathway.
[Hypoxia upregulates the expression of annexin A1 in lung adenocarcinoma a549 cells].
GeneRIF
Guan et al., Wuhan, China. In Zhongguo Fei Ai Za Zhi, 2012
Data show that hypoxia upregulates the expression of Annexin A1 in lung adenocarcinoma A549 cells, in which process reactive oxygen species (ROS)-NF-kappaB may paticipate in.
International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family.
Review
Impact
Murphy et al., Chicago, United States. In Pharmacol Rev, 2009
Surprisingly, the endogenous anti-inflammatory peptide annexin 1 and its N-terminal fragments also bind human FPR1 and FPR2/ALX, and the anti-inflammatory eicosanoid lipoxin A4 is an agonist at FPR2/ALX.
Comparative proteomic analysis of differentially expressed proteins in an in vitro cellular carcinogenesis model of oral squamous cell carcinoma.
Zhang et al., Shanghai, China. In Proteomics Clin Appl, 2009
Moreover, Annexin A1 and A2 expression levels correlated with the pathological differentiation grade of cancerous tissues.
Annexin A1 and glucocorticoids as effectors of the resolution of inflammation.
Review
Impact
GeneRIF
D'Acquisto et al., London, United Kingdom. In Nat Rev Immunol, 2009
glucocorticoids regulate the expression and function of annexin A1 in opposing ways in innate and adaptive immune cells to mediate the resolution of inflammation. Review.
Occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera.
Impact
GeneRIF
Hanash et al., Seattle, United States. In J Clin Oncol, 2008
Report the occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera.
Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy.
Impact
Schnitzer et al., San Diego, United States. In Nature, 2004
Expression profiling and gamma-scintigraphic imaging with antibodies establishes two of these proteins, aminopeptidase-P and annexin A1, as selective in vivo targets for antibodies in lungs and solid tumours, respectively.
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