GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Annexin A1
Annexin A1, annexin I, lipocortin, annexin 1, lipocortin 1, lipocortin I
Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity. [provided by RefSeq, Jul 2008] (from
NCBI)
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Papers on
Annexin A1
Distinguishing hairy cell leukemia variant from hairy cell leukemia: Development and validation of diagnostic criteria.
New
Tampa, United States. In Leuk Res, 30 Apr 2013
Detection of BRAFV600E mutation and annexin A1 were examined in a subset of cases to further validate FCM diagnostic criteria.
Annexin A1 is a biomarker of T-tubular repair in skeletal muscle of nonmyopathic patients undergoing statin therapy.
New
Bern, Switzerland. In Faseb J, 14 Mar 2013
Only the gene expression for annexin A1 was up-regulated, whereas the expression of other repair genes remained unchanged.
Annexin A1 down-regulation in oral squamous cell carcinoma correlates to pathological differentiation grade.
New
Shanghai, China. In Oral Oncol, 08 Mar 2013
OBJECTIVES: Functional role of Annexin A1 in tumorigenesis is poorly understood.
Down-regulation of annexin A1 in the urothelium reduces cell survival after bacterial toxin exposure.
New
Bern, Switzerland. In J Urol, 02 Mar 2013
Annexin A6 was abundant in detrusor smooth muscle, and low in urothelium, whereas annexin A1 was the highest in urothelium.
Optimization of Agrobacterium mediated genetic transformation of cotyledonary node explants of Vigna radiata.
New
Hyderābād, India. In Springerplus, Dec 2012
Double cotyledonary node (DCN) explants were inoculated with Agrobacterium tumefaciens strain LBA 4404 harboring a binary vector pCAMBIA 2301 containing neomycin phosphotransferase (npt II) gene as selectable marker, β-glucuronidase (GUS) as a reporter (uidA) gene and annexin 1 bj gene.
Anti-inflammatory drugs, eicosanoids and the annexin A1/FPR2 anti-inflammatory system.
Review
New
London, United Kingdom. In Prostaglandins Other Lipid Mediat, Aug 2012
The action of anti-inflammatory and anti-allergic drugs on the eicosanoid system is briefly reviewed.
Annexin A1: novel roles in skeletal muscle biology.
Review
New
Salerno, Italy. In J Cell Physiol, Aug 2012
Annexin A1 (ANXA1, lipocortin-1) is the first characterized member of the annexin superfamily of proteins, so called since their main property is to bind (i.e., to annex) to cellular membranes in a Ca(2+) -dependent manner.
Cleavage of annexin A1 by ADAM10 during secondary necrosis generates a monocytic "find-me" signal.
GeneRIF
Tübingen, Germany. In J Immunol, 2012
Cleavage of annexin A1 by ADAM10 during secondary necrosis generates a monocytic "find-me" signal.
Annexin 1 exerts anti-nociceptive effects after peripheral inflammatory pain through formyl-peptide-receptor-like 1 in rat dorsal root ganglion.
GeneRIF
Wuhan, China. In Br J Anaesth, 2011
Endogenous ANXA1 expression at the dorsal root ganglion level is involved in complete Freund's adjuvant-induced inflammatory pain, and intrathecal ANXA1 20 microg microl(-1) produces its anti-nociceptive effect through formyl-peptide-receptor-like 1
Activation of the annexin A1 pathway underlies the protective effects exerted by estrogen in polymorphonuclear leukocytes.
GeneRIF
United Kingdom. In Arterioscler Thromb Vasc Biol, 2011
Activation of the annexin A1 pathway underlies the protective effects exerted by estrogen in polymorphonuclear leukocytes.
Kirenol upregulates nuclear annexin-1 which interacts with NF-κB to attenuate synovial inflammation of collagen-induced arthritis in rats.
GeneRIF
Beijing, China. In J Ethnopharmacol, 2011
Kirenol upregulates nuclear Annexin-1 which interacts with NF-kappaB to inhibit NF-kappaB activity, reduce cytokine expression and thereby attenuate inflammation of arthritic joints.
Microparticles: a critical component in the nexus between inflammation, immunity, and thrombosis.
Review
Strasbourg, France. In Semin Immunopathol, 2011
Because of their multiple properties that are characteristic of a private response of the parental cell, MPs could act as cytoprotective and anti-inflammatory agents through the delivery of activated protein C or annexin 1 and could contribute to the limitation of vascular hyporeactivity.
Anti-annexins autoantibodies: their role as biomarkers of autoimmune diseases.
Review
Padova, Italy. In Autoimmun Rev, 2011
Autoantibodies directed toward annexin I, II, V and XI have been reported, but their role and their clinical correlates are controversial.
Endogenous annexin A1 counter-regulates bleomycin-induced lung fibrosis.
GeneRIF
Ribeirão Preto, Brazil. In Bmc Immunol, 2010
counter-regulates bleomycin-induced lung fibrosis
Phosphorylation of basic amino acid residues in proteins: important but easily missed.
Review
Warsaw, Poland. In Acta Biochim Pol, 2010
Beside acting as high-energy intermediates in the transfer of the phosphoryl group from donor to acceptor molecules, phosphohistidines have been found so far in histone H4, heterotrimeric G proteins, ion channel KCa3.1, annexin 1, P-selectin and myelin basic protein, as well as in recombinant thymidylate synthase expressed in bacterial cells.
International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family.
Review
Impact
Chicago, United States. In Pharmacol Rev, 2009
Surprisingly, the endogenous anti-inflammatory peptide annexin 1 and its N-terminal fragments also bind human FPR1 and FPR2/ALX, and the anti-inflammatory eicosanoid lipoxin A4 is an agonist at FPR2/ALX.
Annexin A1 and glucocorticoids as effectors of the resolution of inflammation.
Review
Impact
GeneRIF
London, United Kingdom. In Nat Rev Immunol, 2009
glucocorticoids regulate the expression and function of annexin A1 in opposing ways in innate and adaptive immune cells to mediate the resolution of inflammation. Review.
Occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera.
Impact
GeneRIF
Seattle, United States. In J Clin Oncol, 2008
Report the occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera.
Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy.
Impact
San Diego, United States. In Nature, 2004
Expression profiling and gamma-scintigraphic imaging with antibodies establishes two of these proteins, aminopeptidase-P and annexin A1, as selective in vivo targets for antibodies in lungs and solid tumours, respectively.
Simple diagnostic assay for hairy cell leukaemia by immunocytochemical detection of annexin A1 (ANXA1).
Impact
Perugia, Italy. In Lancet, 2004
Through gene expression profiling, annexin A1 (ANXA1) has been identified as a gene that is upregulated in hairy cell leukaemia.
