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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 26 Oct 2014.

Annexin A1

Annexin A1, annexin I, lipocortin, annexin 1, lipocortin 1, lipocortin I
Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, fibrillin-1, ACID, HAD, V1a
Papers on Annexin A1
Expression of the Annexin A1 gene is associated with suppression of growth, invasion and metastasis of nasopharyngeal carcinoma.
New
Cheng et al., Hengyang, China. In Mol Med Report, 31 Dec 2014
A previous study by our group showed that Annexin A1 was decreased in NPC tissue as compared with normal adjacent tissue.
Investigation of circulating antibodies to ANXA1 in breast cancer.
New
Wei et al., Dongguan, China. In Tumour Biol, 25 Nov 2014
UNLABELLED: Our recent work demonstrated that circulating levels of IgG antibody to linear peptide antigens derived from annexin A1 (ANXA1) were significantly increased in lung cancer.
Proteomic and Mitochondrial Genomic Analyses of Pediatric Brain Tumors.
New
Roy et al., Miami, United States. In Mol Neurobiol, 25 Nov 2014
Proteins down-regulated in brain tumors compared to controls were heat shock protein 90 kDa beta, BiP; guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1, isoform CRA_d; histone H2B.1; neurofilament, light polypeptide 68 kDa; Annexin I; and RAN.
Human Annexins A1, A2, and A8 as Potential Molecular Targets for Ni(II) Ions.
New
Frączyk et al., Warsaw, Poland. In Chem Res Toxicol, 20 Nov 2014
To test if these proteins are potential molecular targets for nickel toxicity we characterized the binding of Ni(II) ions and hydrolysis of peptides Ac-KALTGHLEE-am (A1-1), Ac-TKYSKHDMN-am (A1-2), and Ac-GVGTRHKAL-am (A1-3), from annexin A1, Ac-KMSTVHEIL-am (A2-1) and Ac-SALSGHLET-am (A2-2), from annexin A2, and Ac-VKSSSHFNP-am (A8-1), from annexin A8, using UV-vis and circular dichroism (CD) spectroscopies, potentiometry, isothermal titration calorimetry, high-performance liquid chromatography (HPLC), and electrospray ionization mass spectrometry (ESI-MS).
In vivo proteomic imaging analysis of caveolae reveals pumping system to penetrate solid tumors.
New
Impact
Schnitzer et al., San Diego, United States. In Nat Med, 30 Sep 2014
A post-translationally modified form of annexin A1 (AnnA1) is selectively concentrated in human and rodent tumor caveolae.
The complex understanding of Annexin A1 phosphorylation.
Review
New
Ruml et al., Praha, Czech Republic. In Cell Signal, Jan 2014
Annexin A1 (ANXA1) is the first characterized member of the annexins superfamily.
[Participation of annexins in endocytosis and EGFR-mediated signal transduction].
Review
New
Bandorowicz-Pikuła et al., In Postepy Biochem, Dec 2013
In this review we describe a role of some members of the annexin family, annexin A1 (AnxA1), annexin A2 (AnxA2), annexin A6 (AnxA6) and annexin A8 (AnxA8) in the epidermal growth factor (EGF) signal transduction pathway.
Correlation of ANXA1 expression with drug resistance and relapse in bladder cancer.
New
Zhang et al., Beijing, China. In Int J Clin Exp Pathol, Dec 2013
OBJECTIVE: To investigate the expression of annexin a1 (ANXA1) in adriamycin-resistant human bladder cancer cell line (pumc-91/ADM) compared with the parental cell line (pumc-91) and its relevance to the drug resistance of bladder cancer, as well as explore the relevance of ANXA1 in recurrent bladder cancer tissues as pertinent to relapse.
Annexin A1: potential for glucocorticoid sparing in RA.
Review
New
Leech et al., Australia. In Nat Rev Rheumatol, Oct 2013
Annexin A1 is a glucocorticoid-induced molecule that is known to replicate many of the described anti-inflammatory effects of glucocorticoids.
New pathways to control inflammatory responses in adipose tissue.
Review
New
Fantuzzi et al., Chicago, United States. In Curr Opin Pharmacol, Aug 2013
Specifically, we discuss evidence on the role of the inflammasome and its downstream products as a potential target for anti-inflammatory strategies as well as T regulatory (Treg) cells and mediators involved in the resolution phase of inflammation such as resolvins, protectins, annexin A1 (ANXA1) and galectins as potential targets for novel agonist therapies.
Resolution of inflammation: mechanisms and opportunity for drug development.
Review
New
Teixeira et al., Edinburgh, United Kingdom. In Pharmacol Ther, Aug 2013
Successful resolution requires activation of endogenous programs with switch from production of pro-inflammatory towards pro-resolving molecules, such as specific lipid mediators and annexin A1, and the non-phlogistic elimination of granulocytes by apoptosis with subsequent removal by surrounding macrophages.
Annexin-1-mediated endothelial cell migration and angiogenesis are regulated by vascular endothelial growth factor (VEGF)-induced inhibition of miR-196a expression.
GeneRIF
Huot et al., Québec, Canada. In J Biol Chem, 2012
VEGF-induced decrease of miR-196a expression may participate to the angiogenic switch by maintaining the expression of ANXA1 to levels required to enable p38-ANXA1-dependent endothelial cell migration and angiogenesis in response to VEGF.
Endothelial microparticle uptake in target cells is annexin I/phosphatidylserine receptor dependent and prevents apoptosis.
GeneRIF
Werner et al., Bonn, Germany. In Arterioscler Thromb Vasc Biol, 2012
Endothelial microparticles are incorporated by endothelial cells in an annexin I/phosphatidylserine receptor-dependent manner and protect target cells against apoptosis.
Annexin A1 interaction with the FPR2/ALX receptor: identification of distinct domains and downstream associated signaling.
GeneRIF
Flower et al., London, United Kingdom. In J Biol Chem, 2012
N-terminal region was dispensable for AnxA1-induced FPR2/ALX down-regulation in both the homologous and heterologous desensitization modes.
The role of annexin A1 in expression of matrix metalloproteinase-9 and invasion of breast cancer cells.
GeneRIF
Jang et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2012
these results indicate that ANXA1 functions as a positive regulator of MMP-9 expression and invasion of breast cancer cells through specific activation of the NF-kappaB signaling pathway.
[Hypoxia upregulates the expression of annexin A1 in lung adenocarcinoma a549 cells].
GeneRIF
Guan et al., Wuhan, China. In Zhongguo Fei Ai Za Zhi, 2012
Data show that hypoxia upregulates the expression of Annexin A1 in lung adenocarcinoma A549 cells, in which process reactive oxygen species (ROS)-NF-kappaB may paticipate in.
International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family.
Review
Impact
Murphy et al., Chicago, United States. In Pharmacol Rev, 2009
Surprisingly, the endogenous anti-inflammatory peptide annexin 1 and its N-terminal fragments also bind human FPR1 and FPR2/ALX, and the anti-inflammatory eicosanoid lipoxin A4 is an agonist at FPR2/ALX.
Annexin A1 and glucocorticoids as effectors of the resolution of inflammation.
Review
Impact
GeneRIF
D'Acquisto et al., London, United Kingdom. In Nat Rev Immunol, 2009
glucocorticoids regulate the expression and function of annexin A1 in opposing ways in innate and adaptive immune cells to mediate the resolution of inflammation. Review.
Occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera.
Impact
GeneRIF
Hanash et al., Seattle, United States. In J Clin Oncol, 2008
Report the occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera.
Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy.
Impact
Schnitzer et al., San Diego, United States. In Nature, 2004
Expression profiling and gamma-scintigraphic imaging with antibodies establishes two of these proteins, aminopeptidase-P and annexin A1, as selective in vivo targets for antibodies in lungs and solid tumours, respectively.
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