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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 21 May 2016.

Annexin A1

Annexin A1, annexin I, lipocortin, annexin 1, lipocortin 1, lipocortin I
Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, fibrillin-1, HAD, ACID, V1a
Papers on Annexin A1
Annexin A1 localization and its relevance to cancer.
Review
New
Degoul et al., Clermont-Ferrand, France. In Clin Sci (lond), Mar 2016
Annexin A1 (ANXA1) is a Ca(2+)-regulated phospholipid-binding protein involved in various cell processes.
Genetic overexpression of Serpina3n attenuates muscular dystrophy in mice.
New
Molkentin et al., Cincinnati, United States. In Hum Mol Genet, Feb 2016
Mechanistically, we show that increased Serpina3n promotes increased sarcolemma membrane integrity and stability in dystrophic mouse models in association with greater membrane residence of the integrins, the dystrophin/utrophin-glycoprotein complex of proteins, and annexin A1.
Annexin A1 sustains tumor metabolism and cellular proliferation upon stable loss of HIF1A.
New
Cramer et al., Berlin, Germany. In Oncotarget, Jan 2016
Strikingly, simultaneous knock-down of HIF-1α and Annexin A1 (ANXA1), one of the identified genes, resulted in complete cessation of proliferation.
Study of the Annexin A1 and Its Associations with Carcinoembryonic Antigen and Mismatch Repair Proteins in Colorectal Cancer.
New
Damazo et al., Cuiabá, Brazil. In J Gastrointest Cancer, Jan 2016
PURPOSE: Annexin-A1 (ANXA1) has been implicated in various tumor types, but few studies have investigated its involvement in colorectal cancer.
Inhibition of PDE4 During Pneumococcal Pneumonia Reduces Inflammation and Lung Injury in Mice.
New
Sousa et al., Belo Horizonte, Brazil. In Am J Respir Cell Mol Biol, Jan 2016
Combined ROL and ceftriaxone treatment decreased lethality rates and was more efficient in reducing inflammation, by increasing pro-resolving protein Annexin A1 expression, and bacterial burden by enhancing phagocytosis.
Bone marrow and splenic histology in hairy cell leukaemia.
Review
New
Sena Teixeira Mendes et al., London, United Kingdom. In Best Pract Res Clin Haematol, Dec 2015
The cells stain for B-cell related antigens as well as with antibodies against tartrate-resistant acid phosphatase, DBA44 (CD72), CD11c, CD25, CD103, CD123, cyclin D1 and annexin A1.
Effect analysis of early bedside hemo-filtration in treatment of severe pneumonia with acute renal failure of children.
New
Li et al., Xuzhou, China. In Eur Rev Med Pharmacol Sci, Dec 2015
After treatment for 7 days, IL-6 and TNF-α, YKL-40 and Annexin A1 levels of the experimental group were significantly lower than those of the control group.
Wound repair: role of immune-epithelial interactions.
Review
New
Nusrat et al., München, Germany. In Mucosal Immunol, Sep 2015
This process is highly regulated by proteins and lipids, proresolving mediators such as Annexin A1 protein and resolvins released into the epithelial milieu by the epithelium itself and infiltrating innate immune cells including neutrophils and macrophages.
The resolution of inflammation: Principles and challenges.
Review
New
Norling et al., London, United Kingdom. In Semin Immunol, May 2015
These mediators are diverse in nature, and include specialized lipid mediators (lipoxins, resolvins, protectins and maresins) proteins (annexin A1, galectins) and peptides, gaseous mediators including hydrogen sulphide, a purine (adenosine), as well as neuromodulator release under the control of the vagus nerve.
Targeting pro-resolution pathways to combat chronic inflammation in COPD.
Review
Vlahos et al., Melbourne, Australia. In J Thorac Dis, 2014
In this perspective, we discuss an alternative view on why inflammation persists with a focus on why pro-resolution mediators such as lipoxin A4 (LXA4), D-series resolving and Annexin A1 fail to effectively switch off inflammation in COPD.
In vivo proteomic imaging analysis of caveolae reveals pumping system to penetrate solid tumors.
Impact
Schnitzer et al., San Diego, United States. In Nat Med, 2014
A post-translationally modified form of annexin A1 (AnnA1) is selectively concentrated in human and rodent tumor caveolae.
Annexin-1-mediated endothelial cell migration and angiogenesis are regulated by vascular endothelial growth factor (VEGF)-induced inhibition of miR-196a expression.
GeneRIF
Huot et al., Québec, Canada. In J Biol Chem, 2012
VEGF-induced decrease of miR-196a expression may participate to the angiogenic switch by maintaining the expression of ANXA1 to levels required to enable p38-ANXA1-dependent endothelial cell migration and angiogenesis in response to VEGF.
Endothelial microparticle uptake in target cells is annexin I/phosphatidylserine receptor dependent and prevents apoptosis.
GeneRIF
Werner et al., Bonn, Germany. In Arterioscler Thromb Vasc Biol, 2012
Endothelial microparticles are incorporated by endothelial cells in an annexin I/phosphatidylserine receptor-dependent manner and protect target cells against apoptosis.
Annexin A1 interaction with the FPR2/ALX receptor: identification of distinct domains and downstream associated signaling.
GeneRIF
Flower et al., London, United Kingdom. In J Biol Chem, 2012
N-terminal region was dispensable for AnxA1-induced FPR2/ALX down-regulation in both the homologous and heterologous desensitization modes.
The role of annexin A1 in expression of matrix metalloproteinase-9 and invasion of breast cancer cells.
GeneRIF
Jang et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2012
these results indicate that ANXA1 functions as a positive regulator of MMP-9 expression and invasion of breast cancer cells through specific activation of the NF-kappaB signaling pathway.
[Hypoxia upregulates the expression of annexin A1 in lung adenocarcinoma a549 cells].
GeneRIF
Guan et al., Wuhan, China. In Zhongguo Fei Ai Za Zhi, 2012
Data show that hypoxia upregulates the expression of Annexin A1 in lung adenocarcinoma A549 cells, in which process reactive oxygen species (ROS)-NF-kappaB may paticipate in.
International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family.
Review
Impact
Murphy et al., Chicago, United States. In Pharmacol Rev, 2009
Surprisingly, the endogenous anti-inflammatory peptide annexin 1 and its N-terminal fragments also bind human FPR1 and FPR2/ALX, and the anti-inflammatory eicosanoid lipoxin A4 is an agonist at FPR2/ALX.
Annexin A1 and glucocorticoids as effectors of the resolution of inflammation.
Review
Impact
GeneRIF
D'Acquisto et al., London, United Kingdom. In Nat Rev Immunol, 2009
glucocorticoids regulate the expression and function of annexin A1 in opposing ways in innate and adaptive immune cells to mediate the resolution of inflammation. Review.
Occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera.
Impact
GeneRIF
Hanash et al., Seattle, United States. In J Clin Oncol, 2008
Report the occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera.
Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy.
Impact
Schnitzer et al., San Diego, United States. In Nature, 2004
Expression profiling and gamma-scintigraphic imaging with antibodies establishes two of these proteins, aminopeptidase-P and annexin A1, as selective in vivo targets for antibodies in lungs and solid tumours, respectively.
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