New pathways to control inflammatory responses in adipose tissue.
Chicago, United States. In Curr Opin Pharmacol, Aug 2013
Specifically, we discuss evidence on the role of the inflammasome and its downstream products as a potential target for anti-inflammatory strategies as well as T regulatory (Treg) cells and mediators involved in the resolution phase of inflammation such as resolvins, protectins, annexin A1 (ANXA1) and galectins as potential targets for novel agonist therapies.
Resolution of inflammation: mechanisms and opportunity for drug development.
Edinburgh, United Kingdom. In Pharmacol Ther, Aug 2013
Successful resolution requires activation of endogenous programs with switch from production of pro-inflammatory towards pro-resolving molecules, such as specific lipid mediators and annexin A1, and the non-phlogistic elimination of granulocytes by apoptosis with subsequent removal by surrounding macrophages.