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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Ankyrin repeat domain 2

Ankrd2, Arpp
ANKRD2 belongs to the conserved muscle ankyrin repeat protein (MARP) family. Expression of MARPs is induced in response to physiologic stress, injury, and hypertrophy (Miller et al., 2003 [PubMed 14583192]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: CARP, cyclic AMP-regulated phosphoprotein, ACID, titin, CAN
Papers on Ankrd2
Profiling of skeletal muscle Ankrd2 protein in human cardiac tissue and neonatal rat cardiomyocytes.
New
Kojic et al., Belgrade, Serbia. In Histochem Cell Biol, Jun 2015
Muscle-specific mechanosensors Ankrd2/Arpp (ankyrin repeat protein 2) and Ankrd1/CARP (cardiac ankyrin repeat protein) have an important role in transcriptional regulation, myofibrillar assembly, cardiogenesis and myogenesis.
The mitotic PP2A regulator ENSA/ARPP-19 is remarkably conserved across plants and most eukaryotes.
New
Moorhead et al., Calgary, Canada. In Biochem Biophys Res Commun, Apr 2015
PP2A containing the B55 subunit is a key regulator of mitosis and must be inhibited by phosphorylated α-endosulfine (ENSA) or cyclic AMP-regulated 19 kDa phosphoprotein (ARPP-19) to allow passage through mitosis.
MicroRNA-320a sensitizes tamoxifen-resistant breast cancer cells to tamoxifen by targeting ARPP-19 and ERRγ.
Sun et al., Hefei, China. In Sci Rep, 2014
Re-expression of miR-320a was sufficient to sensitize TamR cells to tamoxifen by targeting cAMP-regulated phosphoprotein (ARPP-19) and estrogen-related receptor gamma (ERRγ) as well as their downstream effectors, c-Myc and Cyclin D1.
Induction of Ankrd1 in Dilated Cardiomyopathy Correlates with the Heart Failure Progression.
Labeit et al., Mannheim, Germany. In Biomed Res Int, 2014
Expression patterns of 8 mechanoptotic machinery-associated titin ligands (ANKRD1, ANKRD2, TRIM63, TRIM55, NBR1, MLP, FHL2, and TCAP) were quantitated in endomyocardial biopsies from 25 patients with advanced IDCM.
Increased ARPP-19 expression is associated with hepatocellular carcinoma.
Ji et al., Shanghai, China. In Int J Mol Sci, 2014
The cAMP-regulated phosphoprotein 19 (ARPP-19) plays a key role in cell mitotic G2/M transition.
Regulation of α-endosulfine, an inhibitor of protein phosphatase 2A, by multisite phosphorylation.
Mochida, Kumamoto, Japan. In Febs J, 2014
α-endosulfine (ENSA)/cyclic AMP-regulated 19 kDa phosphoprotein (ARPP-19) family proteins phosphorylated at S67 by Greatwall kinase bind and inhibit PP2A-B55.
Comparative genetic analysis of PP2A-Cdc55 regulators in budding yeast.
Yoshida et al., Waltham, United States. In Cell Cycle, 2013
In animal cells, highly conserved ENSA/ARPP-19 family proteins bind and inhibit PP2A-B55 activity for mitotic entry.
The muscle ankyrin repeat proteins CARP, Ankrd2, and DARP are not essential for normal cardiac development and function at basal conditions and in response to pressure overload.
Chen et al., Milano, Italy. In Plos One, 2013
Ankrd1/CARP, Ankrd2/Arpp, and Ankrd23/DARP belong to a family of stress inducible ankyrin repeat proteins expressed in striated muscle (MARPs).
Crosstalk between NSL histone acetyltransferase and MLL/SET complexes: NSL complex functions in promoting histone H3K4 di-methylation activity by MLL/SET complexes.
Jin et al., Changchun, China. In Plos Genet, 2013
In genomic experiments, we identified a set of genes including ANKRD2, that are affected by knockdown of both NSL and MLL/SET subunits, suggested they are co-regulated by NSL and MLL/SET complexes.
Identification and validation of differentially expressed genes from pig skeletal muscle.
Guimarães et al., Viçosa, Brazil. In J Anim Breed Genet, 2013
From this, the expression profile of 13 genes was measured, to confirm their relationship with myogenesis like ANKRD2, MYBPC1, NEB and MYL2.
On the regulation of protein phosphatase 2A and its role in controlling entry into and exit from mitosis.
Review
Hunt, Schwäbisch Hall, Germany. In Adv Biol Regul, 2013
Control of this phosphatase is achieved by an inhibitor protein (α-endosulfine or ARPP-19) that becomes inhibitory when phosphorylated by a protein kinase called Greatwall, which is itself a substrate of CDK1.
Bod1 regulates protein phosphatase 2A at mitotic kinetochores.
Swedlow et al., Dundee, United Kingdom. In Nat Commun, 2012
Two proteins, Ensa and Arpp-19, were recently identified as specific inhibitors of PP2A-B55 and are critical for allowing full activity of Cdk1/cyclin B and entry into mitosis.
Muscle ankyrin repeat proteins: their role in striated muscle function in health and disease.
Review
GeneRIF
Faulkner et al., Belgrade, Serbia. In Crit Rev Clin Lab Sci, 2011
Although analyzed in a limited number of patients, there is a considerable body of evidence that MARP proteins could be suitable candidates for prognostic and diagnostic biomarkers.
Ankrd2/ARPP is a novel Akt2 specific substrate and regulates myogenic differentiation upon cellular exposure to H(2)O(2).
GeneRIF
Marmiroli et al., Bologna, Italy. In Mol Biol Cell, 2011
Ankrd2 is a novel Akt2 specific substrate and regulates myogenic differentiation
Multi-tasking role of the mechanosensing protein Ankrd2 in the signaling network of striated muscle.
GeneRIF
Faulkner et al., Trieste, Italy. In Plos One, 2010
Ankrd2 is a potent regulator in muscle cells affecting a multitude of pathways and processes
Greatwall kinase, ARPP-19 and protein phosphatase 2A: shifting the mitosis paradigm.
Review
Jessus et al., Paris, France. In Results Probl Cell Differ, 2010
PP2A-B55δ is the major phosphatase controlling exit from mitosis; it is negatively regulated by the kinase Greatwall that phosphorylates the small protein ARPP-19 and converts it into a potent PP2A inhibitor.
Arpp/Ankrd2, a member of the muscle ankyrin repeat proteins (MARPs), translocates from the I-band to the nucleus after muscle injury.
GeneRIF
Moriyama et al., Ōita, Japan. In Histochem Cell Biol, 2008
The Ankrd2 accumulated in the nuclei of myofibers located adjacent to severely damaged myofibers after muscle injury. Ankrd2 may translocate from the I-band to the nucleus in response to muscle damage and in the regulation of gene expression.
Structural and regulatory roles of muscle ankyrin repeat protein family in skeletal muscle.
GeneRIF
Lieber et al., San Diego, United States. In Am J Physiol Cell Physiol, 2007
Ankrd2 plays important structural and gene regulatory roles in skeletal muscle.
Potent and specific inhibitors of mammalian phosphoribosylpyrophosphate (PRPP) synthetase.
Review
Robins et al., Costa Mesa, United States. In Adv Enzyme Regul, 1988
beta-ARPP is a substrate, albeit poor, for adenosine deaminase and solutions of the beta-anomer of this nucleoside and its monophosphate anomerize over time to give alpha- and beta-mixtures.
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