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Ankyrin repeat and kinase domain containing 1

ANKK1, PKK2, ankyrin repeat and kinase domain containing 1
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and protein kinase superfamily involved in signal transduction pathways. This gene is closely linked to DRD2 gene (GeneID:1813) on chr 11, and a well studied restriction fragment length polymorphism (RFLP) designated TaqIA, was originally associated with the DRD2 gene, however, later was determined to be located in exon 8 of ANKK1 gene (PMIDs: 18621654, 15146457), where it causes a nonconservative amino acid substitution. It is not clear if this gene plays any role in neuropsychiatric disorders previously associated with Taq1A RFLP. [provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: DRD2, HAD, Catechol O-Methyltransferase, AGE, cytokeratin
Papers on ANKK1
Longitudinal predictors of cannabis use and dependence in offspring from families at ultra high risk for alcohol dependence and in control families.
Stiffler et al., Pittsburgh, United States. In Am J Med Genet B Neuropsychiatr Genet, Feb 2016
The association between young adult patterns of cannabis use or cannabis abuse/dependence was tested with genetic variation in the cannabinoid gene, CNR1, the ANKK1-DRD2 gene, and childhood developmental trajectories of P300.
Altered brain activation in a reversal learning task unmasks adaptive changes in cognitive control in writer's cramp.
Witt et al., Kiel, Germany. In Neuroimage (amst), Dec 2015
We further linked the DRD2/ANKK1-TaqIa polymorphism, which is associated with 30% reduction of the striatal dopamine receptor density with reward-based learning and assumed impaired reversal learning in A + subjects.
On the genetics of loss aversion: An interaction effect of BDNF Val66Met and DRD2/ANKK1 Taq1a.
Reuter et al., Ulm, Germany. In Behav Neurosci, Dec 2015
In a behavioral experiment with N = 143 subjects, the present study investigates the influence of 2 functional single-nucleotide polymorphisms on the BDNF gene (BDNF Val66Met polymorphism) and ANKK1 gene (DRD2 Taq1a/ANKK1 polymorphism), that are known to affect the dopamine system, on loss aversion.
Sport physiology, dopamine and nitric oxide - Some speculations and hypothesis generation.
Esch et al., Chaniá, Greece. In Med Hypotheses, Dec 2015
Polymorphisms affecting dopamine (especially DRD2/ANKK1-Taq1a which leads to lower density of dopamine D2 receptors in the striatum, leading to increased striatal dopamine synthesis) and COMT val 158 met (which prolongs the action of dopamine in the cortex) feature both in the time interval estimation and the executive skills literatures.
A Dopamine Pathway Gene Risk Score for Cognitive Recovery Following Traumatic Brain Injury: Methodological Considerations, Preliminary Findings, and Interactions With Sex.
Wagner et al., Pittsburgh, United States. In J Head Trauma Rehabil, Dec 2015
RESULTS: A significant sex × gene interaction was observed at 6 and 12 months for ANKK1 rs1800497 (6M: P = .002,
An initial investigation of associations between dopamine-linked genetic variation and smoking motives in African Americans.
MacKillop et al., Boulder, United States. In Pharmacol Biochem Behav, Nov 2015
Associations among haplotypes in the NCAM1-TTC12-ANKK1-DRD2 gene cluster, a dopamine-related gene region associated with ND, PDM intermediate phenotypes, and ND were examined.
The ANKK1/DRD2 locus is a genomic substrate for affective priming and recognition of angry faces.
Huertas et al., Madrid, Spain. In Brain Behav, Nov 2015
INTRODUCTION: Ankyrin repeat and kinase domain containing I (ANKK1) and dopamine D2 receptor (DRD2) genes have been associated with psychopathic traits in clinical samples.
Addiction pharmacogenetics: a systematic review of the genetic variation of the dopaminergic system.
Nielsen et al., Houston, United States. In Psychiatr Genet, Oct 2015
Polymorphisms of the DRD2, ANKK1, DAT1, DBH, and DRD4 genes have been found to moderate the effects of pharmacotherapy of alcohol, opioid, and cocaine use disorders.
Genetic Risk Determinants for Cigarette Smoking Dependence in Mexican Mestizo Families.
Mutchinick et al., Mexico. In Nicotine Tob Res, Oct 2015
METHODS: Three hundred sixty-four Mexican Mestizo Mexico City residents from 87 families with at least one smoker were assessed for association of 12 gene variants of six candidate genes (CHRNA4, CHRNB2, DRD2, ANKK1, SLC6A3, and CYP2A6) with cigarette consumption, age of initiation and smoking duration.
Post-Traumatic Brain Injury: Genetic Susceptibility to Outcome.
Bendena et al., Toronto, Canada. In Neuroscientist, Aug 2015
To provide health care workers with the basic information for clinical management we summarize and compare the data on post-TBI outcome with regard to the impact of genetic variation: apolipoprotein E (APOE), brain-derived neurotrophic factor (BDNF), calcium channel, voltage dependent P/Q type, catechol-O-methyltransferase (COMT), dopamine receptor D2 and ankyrin repeat and kinase domain containing 1 (DRD2 and ANKK1), interleukin-1 (IL-1), interleukin-6 (IL-6), kidney and brain expressed protein (KIBRA), neurofilament, heavy polypeptide (NEFH), endothelial nitric oxide synthase 3 (NOS3), poly (ADP-ribose) polymerase-1 (PARP-1), protein phosphatase 3, catalytic subunit, gamma isozyme (PPP3CC), the serotonin transporter (5-HTT) gene solute carrier family 6 member (SLC6A4) and tumor protein 53 (TP53).
[A genetic view of addiction].
Gorwood et al., Paris, France. In Med Sci (paris), Apr 2015
Finally, DRD2 and ANKK1 genes, involved in the dopaminergic pathway, and which were initially associated with AD, are now considered to be involved in a broader phenotype (addiction to psychoactive substances) including opiates.
Association between DRD2 (rs1799732 and rs1801028) and ANKK1 (rs1800497) polymorphisms and schizophrenia: a meta-analysis.
Wang et al., Shenyang, China. In Am J Med Genet B Neuropsychiatr Genet, 2015
The role of dopamine D2 receptor (DRD2) polymorphisms in schizophrenia remains controversial.
The significant association of Taq1A genotypes in DRD2/ANKK1 with smoking cessation in a large-scale meta-analysis of Caucasian populations.
Li et al., Hangzhou, China. In Transl Psychiatry, 2014
Although a number of studies have analyzed the relation between the DRD2/ANKK1 gene Taq1A polymorphism and smoking cessation, the results remain controversial.
Pharmacogenetics of nicotine addiction: role of dopamine.
Sofuoglu et al., West Haven, United States. In Pharmacogenomics, 2014
Genetic variants in DRD2, DRD4, ANKK1, DAT1, COMT and DBH genes show some promise in informing personalized prescribing of smoking cessation pharmacotherapies.
DRD2/ANKK1 TaqI A genotype moderates the relationship between alexithymia and the relative value of alcohol among male college binge drinkers.
Mackillop et al., Lincoln, United States. In Pharmacol Biochem Behav, 2012
The A1 allele of DRD2/ANKK1 TaqI A interacts with hypoemotionality to predict a novel index of problem drinking
DRD2/ANKK1 TaqIA and SLC6A3 VNTR polymorphisms in alcohol dependence: association and gene-gene interaction study in a population of Central Italy.
Ceccanti et al., Italy. In Neurosci Lett, 2012
Our study extends and confirms previous results and, for the first time, tested the gene-gene interaction between SLC6A3 and DRD2 in alcohol dependence.
Pharmacogenomic associations with weight gain in olanzapine treatment of patients without schizophrenia.
Fijal et al., Indianapolis, United States. In J Clin Psychiatry, 2012
The association between 5 ANKK1, 54 DRD2, and 11 HTR2C SNPs and weight change during 8 weeks of olanzapine treatment was assessed in 4 pooled studies.
A DRD2 and ANKK1 haplotype is associated with nicotine dependence.
Morris et al., Brisbane, Australia. In Psychiatry Res, 2012
The results of this study suggested that the DRD2 C957T polymorphism and the ANKK1 TaqIA polymorphism are key contributors to the genetic susceptibility to nicotine dependence.
[ANKK1 gene in psychiatry].
Samochowiec et al., Laizhou, China. In Psychiatr Pol, 2011
It seems accurate to search for associations of polymorphisms in ANKK1 gene with dopaminergic system disorders.
Comment on "Genetically determined differences in learning from errors".
Rosskopf et al., Stralsund, Germany. In Science, 2008
We raise the concern that this polymorphism resides in the gene for the kinase ANKK1, where it causes a nonconservative amino acid exchange.
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