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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Angiopoietin-like 5

ANGPTL5, angiopoietin-like 5
Top mentioned proteins: Angpt1, ANGPTL3, ANGPTL4, NOD, thrombopoietin
Papers on ANGPTL5
Comparison of Different Cytokine Conditions Reveals Resveratrol as a New Molecule for Ex Vivo Cultivation of Cord Blood-Derived Hematopoietic Stem Cells.
New
Schiedlmeier et al., Langen, Germany. In Stem Cells Transl Med, Sep 2015
The cultivation in resveratrol preserved the CB-HSC phenotype in vitro most efficiently and was ∼2 times more potent than commonly used cytokine conditions (including stem cell factor, thrombopoietin, Fms-related tyrosine kinase 3 ligand, interleukin-6) and the recently established serum-free culture, including IGFBP2 and angiopoietin-like 5. Serial transplantation studies further confirmed resveratrol to support robust multilineage engraftment in primary and secondary NSG recipients.
Identification of stage-specific biomarkers in lung adenocarcinoma based on RNA-seq data.
New
Liu et al., Qingdao, China. In Tumour Biol, Aug 2015
ANGPTL5, C7orf16, EDN3, LOC150622, HOXA11AS, IL1F5, and USH1G significantly distinguished stage III from stages I and II.
Co-expression of immunoglobulin-like transcript 4 and angiopoietin-like proteins in human non-small cell lung cancer.
New
Sun et al., Jinan, China. In Mol Med Report, Apr 2015
ILT4 and ANGPTL2 or ANGPTL5 were found to be co‑expressed in the five NSCLC cell lines that were investigated at the mRNA and protein level.
PRC2 inhibition counteracts the culture-associated loss of engraftment potential of human cord blood-derived hematopoietic stem and progenitor cells.
Müller et al., Würzburg, Germany. In Sci Rep, 2014
Human CB-derived CD34+ cells were cultured in serum-free medium together with SCF, TPO, FGF, with or without Igfbp2 and Angptl5 (STF/STFIA cocktails).
Angptl4 maintains in vivo repopulation capacity of CD34+ human cord blood cells.
Karlsson et al., Lund, Sweden. In Eur J Haematol, 2012
Specifically, Angptl5 has been implicated in the expansion of human NOD/SCID-repopulating cells (SRCs) ex vivo.
A novel genome-information content-based statistic for genome-wide association analysis designed for next-generation sequencing data.
Xiong et al., Houston, United States. In J Comput Biol, 2012
Finally, we apply the seven statistics to published resequencing dataset from ANGPTL3, ANGPTL4, ANGPTL5, and ANGPTL6 genes in the Dallas Heart Study.
Synergistic effects of growth factors and mesenchymal stromal cells for expansion of hematopoietic stem and progenitor cells.
Wagner et al., Aachen, Germany. In Exp Hematol, 2011
MATERIALS AND METHODS: Twenty different combinations of growth factors (stem cell factor [SCF], thrombopoietin [TPO], fibroblast growth factor-1 [FGF-1], angiopoietin-like 5, and insulin-like growth factor-binding protein 2), either with or without MSC coculture were systematically compared for their ability to support HPC expansion.
Human CD34+ CD133+ hematopoietic stem cells cultured with growth factors including Angptl5 efficiently engraft adult NOD-SCID Il2rγ-/- (NSG) mice.
GeneRIF
Chen et al., Cambridge, United States. In Plos One, 2010
CD34+ CD133+ hematopoietic stem cells cultured with growth factors including Angptl5 efficiently engraft adult NOD-SCID Il2rgamma-/- (NSG) mice
Impacts of angiopoietin-like proteins on lipoprotein metabolism and cardiovascular events.
Review
Hirayama et al., Tokyo, Japan. In Curr Opin Lipidol, 2010
RECENT FINDINGS: Population-based studies have indicated that loss-of-function mutations of Angptl3, Angptl4, and Angptl5 are associated with a low triglyceride concentration.
Ontogeny of angiopoietin-like protein 1, 2, 3, 4, 5, and 7 genes during chick embryonic development.
Yokouchi et al., Kumamoto, Japan. In Dev Growth Differ, 2009
Angiopoietin-like proteins (ANGPTLs) are secreted proteins possessing an amino-terminal coiled-coil domain and a carboxyl-terminal fibrinogen-like domain and are known as angiogenic factors.
Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans.
Cohen et al., Dallas, United States. In J Clin Invest, 2009
A total of 1% of the Dallas Heart Study population and 4% of those participants with a plasma TG in the lowest quartile had a rare loss-of-function mutation in ANGPTL3, ANGPTL4, or ANGPTL5.
Angiopoietin-like 5 and IGFBP2 stimulate ex vivo expansion of human cord blood hematopoietic stem cells as assayed by NOD/SCID transplantation.
Lodish et al., Cambridge, United States. In Blood, 2008
Addition of either angiopoietin-like 5 or IGF-binding protein 2 to the cultures led to a sizable expansion of HSC numbers, as assayed by NOD/SCID transplantation.
Comparative integromics on Angiopoietin family members.
Katoh et al., Japan. In Int J Mol Med, 2006
Angiopoietin family consists of ANGPT1, ANGPT2, ANGPT4, ANGPTL1 (ANGPT3), ANGPTL2, ANGPTL3 (ANGPT5), ANGPTL4, ANGPTL5, ANGPTL6 and ANGPTL7.
Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells.
Impact
Lodish et al., Cambridge, United States. In Nat Med, 2006
Furthermore, angiopoietin-like 5, angiopoietin-like 7 and microfibril-associated glycoprotein 4 also supported expansion of HSCs in culture.
Identification of a novel human angiopoietin-like gene expressed mainly in heart.
GeneRIF
Mao et al., Shanghai, China. In J Hum Genet, 2002
Maps to 11q22, mainly expressed in adult human heart.
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