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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Angiopoietin-like 4

ANGPTL4, NL1, Arp4, angiopoietin-like 4, zinc metallopeptidase, NL2
This gene is a member of the angiopoietin/angiopoietin-like gene family and encodes a glycosylated, secreted protein with a fibrinogen C-terminal domain. This gene is induced under hypoxic conditions in endothelial cells and is the target of peroxisome proliferation activators. The encoded protein is a serum hormone directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity and also acts as an apoptosis survival factor for vascular endothelial cells. The encoded protein may play a role in several cancers and it also has been shown to prevent the metastatic process by inhibiting vascular activity as well as tumor cell motility and invasiveness. Decreased expression of this protein has been associated with type 2 diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Angpt1, CAN, ACID, HAD, V1a
Papers using ANGPTL4 antibodies
Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP
Supplier
Wong Rachel OL et al., In Neural Development, 1999
... Thy1-YFP-NL2 transgenic mice ...
Papers on ANGPTL4
Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin.
New
Impact
Eroglu et al., Basel, Switzerland. In Cell, Feb 2016
Proper establishment of synapses is critical for constructing functional circuits.
Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma.
New
Sodhi et al., Baltimore, United States. In Oncotarget, Feb 2016
Here we evaluate the contribution of HIF-1, VEGF, and a second HIF-1-regulated gene product, angiopoietin-like 4 (ANGPTL4), to angiogenesis in UM.
Kinetic and structural characterisation of amyloid-β peptides hydrolysis by human angiotensin-1-converting enzyme.
New
Sturrock et al., Cape Town, South Africa. In Febs J, Feb 2016
UNASSIGNED: Angiotensin-1 converting enzyme (ACE), a zinc metallopeptidase, consists of two homologous catalytic domains (N and C) with different substrate specificities.
Aqueous Angiopoietin-Like 4 Levels Correlate With Nonperfusion Area and Macular Edema in Branch Retinal Vein Occlusion.
New
Park et al., In Invest Ophthalmol Vis Sci, Feb 2016
PURPOSE: To investigate whether macular edema (ME) due to branch retinal vein occlusion (BRVO) associates with retinal overexpression of angiopoietin-like 4 (ANGPTL4).
Influenza lung injury: mechanisms and therapeutic opportunities.
Review
New
Kobzik et al., Ban Mae Chan, Thailand. In Am J Physiol Lung Cell Mol Physiol, Dec 2015
Damage to the alveolar-capillary barrier has been quantified in mice, and agents have been identified that can help to preserve barrier integrity, such as vasculotide, angiopoietin-like 4 neutralization, and sphingosine 1-phosphate mimics.
Update on the molecular biology of dyslipidemias.
Review
New
Ramasamy, Worcester, United Kingdom. In Clin Chim Acta, Dec 2015
Mutations in the genes APOB, and ANGPTL3 and ANGPTL4 (that encode angiopoietin-like proteins which inhibit lipoprotein lipase activity) can further cause low levels of apoB containing lipoproteins.
Pathogenesis of childhood idiopathic nephrotic syndrome: a paradigm shift from T-cells to podocytes.
Review
New
Kato et al., Hirakata, Japan. In World J Pediatr, Feb 2015
However, recent findings are changing this paradigm, i.e., visceral glomerular epithelial cells (podocytes) may be involved via expression of molecules such as CD80 and angiopoietin-like 4. CONCLUSIONS: Recent evidence suggests that minimal-change disease results from interactions between humoral factors and dysfunctional podocytes.
Significance of Tissue Expression and Serum Levels of Angiopoietin-like Protein 4 in Breast Cancer Progression: Link to NF-κB /P65 Activity and Pro-Inflammatory Cytokines.
El-Gendy et al., Ţanţā, Egypt. In Asian Pac J Cancer Prev, 2014
MATERIALS AND METHODS: Angiopoietin-like protein 4 (ANGPTL4) mRNA expressions were evaluated using quantitative real time PCR and its protein expression by immunohistochemistry.
Long-Term Feeding of Chitosan Ameliorates Glucose and Lipid Metabolism in a High-Fructose-Diet-Impaired Rat Model of Glucose Tolerance.
Chiang et al., Taipei, Taiwan. In Mar Drugs, 2014
Plasma angiopoietin-like 4 (ANGPTL4) protein expression was not affected by the HF diet, but it was significantly increased in chitosan-supplemented, HF-diet-fed rats.
[Novel adipokines: their potential role in the pathogenesis of obesity and metabolic disorders].
Review
Krauss et al., Laizhou, China. In Postepy Hig Med Dosw (online), 2014
This paper presents the current state of knowledge about retinol binding protein 4 (RBP-4), fasting-induced adipose factor/angiopoietin-like protein 4 (FIAF/ANGPTL4), fibroblast growth factor-21 (FGF21), dipeptidyl peptidase-4 (DPP-4), irisin and their potential role in the pathogenesis of metabolic disorders associated with obesity.
The interplay between synaptic activity and neuroligin function in the CNS.
Review
Xu et al., Hangzhou, China. In Biomed Res Int, 2014
Consistent with their localization, NL1 and NL3 selectively affect excitatory synapses, whereas NL2 specifically affects inhibitory synapses.
Quantum imaging with undetected photons.
Impact
Zeilinger et al., Vienna, Austria. In Nature, 2014
Our experiment uses two separate down-conversion nonlinear crystals (numbered NL1 and NL2), each illuminated by the same pump laser, creating one pair of photons (denoted idler and signal).
Circulating angiopoietin-like 4 links proteinuria with hypertriglyceridemia in nephrotic syndrome.
Impact
Chugh et al., Birmingham, United States. In Nat Med, 2014
We show in the present study that plasma angiopoietin-like 4 (Angptl4) links proteinuria with hypertriglyceridemia through two negative feedback loops.
GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression.
Impact
Werb et al., San Francisco, United States. In Nat Cell Biol, 2013
Mechanistically, miR-29b inhibits metastasis by targeting a network of pro-metastatic regulators involved in angiogenesis, collagen remodelling and proteolysis, including VEGFA, ANGPTL4, PDGF, LOX and MMP9, and targeting ITGA6, ITGB1 and TGFB, thereby indirectly affecting differentiation and epithelial plasticity.
Angptl4 maintains in vivo repopulation capacity of CD34+ human cord blood cells.
GeneRIF
Karlsson et al., Lund, Sweden. In Eur J Haematol, 2012
Angptls would be useful in instances where there is a need to maintain HSCs ex vivo, such as during transduction for gene therapy applications
Fatty acids bind tightly to the N-terminal domain of angiopoietin-like protein 4 and modulate its interaction with lipoprotein lipase.
GeneRIF
Lookene et al., Tallinn, Estonia. In J Biol Chem, 2012
Fatty acids bind tightly to the N-terminal domain of angiopoietin-like protein 4 and modulate its interaction with lipoprotein lipase.
Organotypic coculture preparation for the study of developmental synapse elimination in mammalian brain.
GeneRIF
Kano et al., Tokyo, Japan. In J Neurosci, 2012
This study demonistrated that neuroligin-2 as a novel molecule that promotes climbing fibers synapse elimination in postsynaptic Purkinje cells in mice.
Emerging roles of angiopoietin-like 4 in human cancer.
Review
GeneRIF
Tan et al., Singapore, Singapore. In Mol Cancer Res, 2012
Studies indicate ANGPTL4 as a promising candidate for clinical intervention in the fight against cancer.
Angiopoietin like protein 4 expression is decreased in activated macrophages.
GeneRIF
Grunfeld et al., San Francisco, United States. In Biochem Biophys Res Commun, 2012
The effect of Toll-like Receptor activation on the expression of macrophage ANGPTL4 was studied.
Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-):H2O2 ratio and confers anoikis resistance to tumors.
Impact
GeneRIF
Tan et al., Singapore, Singapore. In Cancer Cell, 2011
Data show that that elevated ANGPTL4 expression is widespread in tumors, and its suppression impairs tumor growth associated with enhanced apoptosis.
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