The glomerular permeability factors in idiopathic nephrotic syndrome.
Amsterdam, Netherlands. In Pediatr Nephrol, Feb 2016
Podocyte metabolism modifications-leading to the overexpression of the podocyte B7-1antigen (CD 80), hypoactivity of the podocyte enzyme sphingomyelin phosphodiesterase acid-like 3 b (SMPDL3b), and to the podocyte production of a hyposialylated form of the angiopoietin-like 4 (Angptl4)-are mechanisms possibly involved in the changes in the podocyte cytoskeleton leading to SSNS and or SRNS.
Influenza lung injury: mechanisms and therapeutic opportunities.
Ban Mae Chan, Thailand. In Am J Physiol Lung Cell Mol Physiol, Dec 2015
Damage to the alveolar-capillary barrier has been quantified in mice, and agents have been identified that can help to preserve barrier integrity, such as vasculotide, angiopoietin-like 4 neutralization, and sphingosine 1-phosphate mimics.
Update on the molecular biology of dyslipidemias.
Worcester, United Kingdom. In Clin Chim Acta, Dec 2015
Mutations in the genes APOB, and ANGPTL3 and ANGPTL4 (that encode angiopoietin-like proteins which inhibit lipoprotein lipase activity) can further cause low levels of apoB containing lipoproteins.
[Novel adipokines: their potential role in the pathogenesis of obesity and metabolic disorders].
Laizhou, China. In Postepy Hig Med Dosw (online), 2014
This paper presents the current state of knowledge about retinol binding protein 4 (RBP-4), fasting-induced adipose factor/angiopoietin-like protein 4 (FIAF/ANGPTL4), fibroblast growth factor-21 (FGF21), dipeptidyl peptidase-4 (DPP-4), irisin and their potential role in the pathogenesis of metabolic disorders associated with obesity.
Quantum imaging with undetected photons.
Vienna, Austria. In Nature, 2014
Our experiment uses two separate down-conversion nonlinear crystals (numbered NL1 and NL2), each illuminated by the same pump laser, creating one pair of photons (denoted idler and signal).
GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression.
San Francisco, United States. In Nat Cell Biol, 2013
Mechanistically, miR-29b inhibits metastasis by targeting a network of pro-metastatic regulators involved in angiogenesis, collagen remodelling and proteolysis, including VEGFA, ANGPTL4, PDGF, LOX and MMP9, and targeting ITGA6, ITGB1 and TGFB, thereby indirectly affecting differentiation and epithelial plasticity.