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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Angiopoietin 1

Angpt1, angiopoietin-1, angiopoietin
Top mentioned proteins: vascular endothelial growth factor, TIE-2, HAD, CAN, V1a
Papers on Angpt1
Endothelial hyperpermeability after cardiac surgery with cardiopulmonary bypass as assessed using an in vitro bioassay for endothelial barrier function.
New
Boer et al., Amsterdam, Netherlands. In Br J Anaesth, Feb 2016
RESULTS: Cardiopulmonary bypass was associated with increased P-selectin, vascular cell adhesion molecule-1, and von Willebrand factor plasma concentrations and an increase in the angiopoietin-2 to angiopoietin-1 ratio, irrespective of the flow profile.
Hydrogen sulfide ameliorates acute lung injury induced by infrarenal aortic cross-clamping by inhibiting inflammation and angiopoietin 2 release.
New
Sun et al., Harbin, China. In J Vasc Surg, Feb 2016
In exploration of the mechanisms, we found that IAC increased the release of angiopoietin 2 (Ang2) and its expression in lung tissues.
Circulating angiopoietin-1 and -2 in patients with stable and exacerbated asthma.
New
Jang et al., Puch'ŏn, South Korea. In Ann Allergy Asthma Immunol, Feb 2016
BACKGROUND: Angiopoietin (Ang)-1 and -2 are involved in the pathogenesis of asthma and have been identified as markers of asthma severity.
Non-statin Treatments for Managing LDL Cholesterol and Their Outcomes.
Review
New
Stein et al., Cincinnati, United States. In Clin Ther, Jan 2016
Additional agents are being developed as orphan indications expressly for patients with homozygous familial hypercholesterolemia, including peroxisome proliferator activated receptor-δ agonists, angiopoietin-like protein 3 inhibitors, and gene therapy.
Novel therapeutics in hypertriglyceridemia.
New
Hegele et al., London, Canada. In Curr Opin Lipidol, Dec 2015
Other potential therapies include small molecule inhibitors of microsomal triglyceride transfer protein (lomitapide) and diacylglycerol acyltransferase-1 (pradigastat), and a monoclonal antibody against angiopoietin-like protein 3 (REGN1500).
Ocular Angiogenesis: Vascular Endothelial Growth Factor and Other Factors.
Review
New
Adamis et al., In Dev Ophthalmol, Dec 2015
Additional proangiogenic targets that have emerged as potential mediators of ocular neovascularization include hypoxia-inducible factor-1, angiopoietin-2, platelet-derived growth factor-B and components of the alternative complement pathway.
Gene-based therapies in lipidology: current status and future challenges.
New
Brisson et al., Montréal, Canada. In Curr Opin Lipidol, Dec 2015
Most advanced antisense oligonucleotide drugs target apolipoprotein C-III, apolipoprotein (a), angiopoietin-like 3, and diacylglycerol o-acyltransferase-2.
Influenza lung injury: mechanisms and therapeutic opportunities.
Review
New
Kobzik et al., Ban Mae Chan, Thailand. In Am J Physiol Lung Cell Mol Physiol, Dec 2015
Damage to the alveolar-capillary barrier has been quantified in mice, and agents have been identified that can help to preserve barrier integrity, such as vasculotide, angiopoietin-like 4 neutralization, and sphingosine 1-phosphate mimics.
Update on the molecular biology of dyslipidemias.
Review
New
Ramasamy, Worcester, United Kingdom. In Clin Chim Acta, Dec 2015
Mutations in the genes APOB, and ANGPTL3 and ANGPTL4 (that encode angiopoietin-like proteins which inhibit lipoprotein lipase activity) can further cause low levels of apoB containing lipoproteins.
Trebananib (AMG 386) in Combination With Sunitinib in Patients With Metastatic Renal Cell Cancer: An Open-Label, Multicenter, Phase II Study.
New
Impact
Ravaud et al., Bordeaux, France. In J Clin Oncol, Nov 2015
PURPOSE: Trebananib, an investigational recombinant peptide-Fc fusion protein, neutralizes the receptor-ligand interaction between Tie2 and angiopoietin-1/2.
Predictive biomarkers of sorafenib efficacy in advanced hepatocellular carcinoma: Are we getting there?
Review
New
Cheng et al., Taipei, Taiwan. In World J Gastroenterol, Oct 2015
Studies based on patient cohorts identified the potential of blood levels of angiopoietin-2, hepatocyte growth factor, insulin-like growth factor-1, and transforming growth factor-β1 for predicting sorafenib efficacy.
Analysis of circulating DNA and protein biomarkers to predict the clinical activity of regorafenib and assess prognosis in patients with metastatic colorectal cancer: a retrospective, exploratory analysis of the CORRECT trial.
New
Impact
Van Cutsem et al., Barcelona, Spain. In Lancet Oncol, Aug 2015
We also measured the concentration of 15 proteins of interest-angiopoietin 2, interleukin 6, interleukin 8, placental growth factor, soluble TIE-1, soluble VEGFR1, VEGF-A, VEGF-C, VEGF-D, VEGF-A isoform 121, bone morphogenetic protein 7, macrophage colony-stimulating factor, stromal cell-derived factor-1, tissue inhibitor of metalloproteinase 2, and von Willebrand factor-in plasma samples from 611 patients.
Postsurgical adjuvant tumor therapy by combining anti-angiopoietin-2 and metronomic chemotherapy limits metastatic growth.
Impact
Augustin et al., Heidelberg, Germany. In Cancer Cell, 2015
Antiangiogenic tumor therapy has failed in the adjuvant setting.
ANGPTL8/betatrophin does not control pancreatic beta cell expansion.
Impact
Gromada et al., United States. In Cell, 2014
Recently, it was reported that angiopoietin-like protein 8 (ANGPTL8) was the long-sought "betatrophin" that could control pancreatic beta cell proliferation.
Anti-angiopoietin therapy with trebananib for recurrent ovarian cancer (TRINOVA-1): a randomised, multicentre, double-blind, placebo-controlled phase 3 trial.
Impact
Oza et al., Phoenix, United States. In Lancet Oncol, 2014
BACKGROUND: Angiogenesis is a valid target in the treatment of epithelial ovarian cancer.
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