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Angiotensinogen

Angiotensin II, Angiotensin, Ang II, angiotensin I
The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Renin, AT1, V1a, HAD, CAN
Papers using Angiotensin II antibodies
A G protein-coupled receptor at work: the rhodopsin model.
Supplier
Koch Karl-Wilhelm, In PLoS ONE, 2008
... Ang II was from Sigma Aldrich.
NAD(+), sirtuins, and cardiovascular disease
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Rosenthal Nadia et al., In Aging (Albany NY), 2008
... Angiotensin II Tocris Biosciences ...
Detection of reactive oxygen species in isolated, perfused lungs by electron spin resonance spectroscopy
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Dietrich Alexander et al., In Nature Communications, 2004
... Endothelial Nox2 overexpression potentiates vascular oxidative stress and hemodynamic response to angiotensin II: studies in endothelial-targeted Nox2 transgenic mice ...
Mechanical stress-activated PKCdelta regulates smooth muscle cell migration.
Supplier
Kiechl Stefan, In PLoS ONE, 2002
... Ang II, Ang-(1-7), losartan, Dulbecco's modified Eagle's medium (DMEM), penicillin and streptomycin were obtained from Sigma Aldrich.
Troglitazone induces GLUT4 translocation in L6 myotubes.
Supplier
Parise Gianni, In PLoS ONE, 2000
... Ang II was from Bachem, myricetin, SIN-1 and nitro-l-arginine-methyl-ester ...
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Papers on Angiotensin II
Selective small molecule angiotensin II type 2 receptor antagonists for neuropathic pain: preclinical and clinical studies.
New
Rice et al., London, United Kingdom. In Pain, Feb 2016
One notable exception is the angiotensin II type 2 (AT2) receptor that has clinical validity on the basis of a successful double-blind, randomized, placebo-controlled, clinical trial of EMA401, a highly selective, orally active, peripherally restricted AT2 receptor antagonist in patients with postherpetic neuralgia.
Neuregulin-1 attenuates development of nephropathy in a type 1 diabetes mouse model with high cardiovascular risk.
New
De Keulenaer et al., Antwerp, Belgium. In Am J Physiol Endocrinol Metab, Feb 2016
Regarding the renal effects of rhNRG-1, further analysis showed that rhNRG-1 inhibited collagen synthesis of glomerular mesangial cells in vitro, but did not affect Ang II-induced vasoconstriction of glomerular arterioles.
Epidermal Growth Factor Receptor Transactivation: Mechanisms, Pathophysiology, and Potential Therapies in the Cardiovascular System.
New
Impact
Eguchi et al., Australia. In Annu Rev Pharmacol Toxicol, Feb 2016
The capacity of G protein-coupled receptor (GPCR) agonists, such as angiotensin II (AngII), to promote EGFR signaling is called transactivation and is well described, yet delineating the molecular processes and functional relevance of this crosstalk has been challenging.
[Renal artery injury caused by Kawasaki disease].
Review
New
Peng et al., Guangzhou, China. In Zhongguo Dang Dai Er Ke Za Zhi, Jan 2016
The diameter of the origin of the main renal artery, hemodynamic parameters of the main renal artery and the renal interlobar artery, rennin activity, and levels of angiotensin II and aldosterone were compared between groups.
The Role of CNS in the Effects of Salt on Blood Pressure.
Review
New
Fujita et al., Tokyo, Japan. In Curr Hypertens Rep, Jan 2016
Several other factors such as mineralocorticoid receptors, aldosterone, corticosterone, epithelial sodium channels, and angiotensin II also play important roles in central sympathetic activation, some of which can be associated with brain oxidative stress.
Interleukin-1 Receptor Activation Potentiates Salt Reabsorption in Angiotensin II-Induced Hypertension via the NKCC2 Co-transporter in the Nephron.
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Impact
Crowley et al., Durham, United States. In Cell Metab, Jan 2016
While the efficacy of renin angiotensin system (RAS) blockade in lowering blood pressure illustrates that the RAS is broadly activated in human hypertension, the frequent failure of RAS inhibition to prevent or reverse hypertensive organ damage highlights the need for novel therapies to combat RAS-dependent hypertension.
Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension.
New
Nishida et al., Okazaki, Japan. In Sci Signal, Dec 2015
The angiotensin (Ang) type 1 receptor (AT1R) promotes functional and structural integrity of the arterial wall to contribute to vascular homeostasis, but this receptor also promotes hypertension.
Effects of tempol on altered metabolism and renal vascular responsiveness in fructose-fed rats.
New
Johns et al., Cork, Ireland. In Appl Physiol Nutr Metab, Dec 2015
UNASSIGNED: This study investigated the effect of tempol (a superoxide dismutase mimetic) on renal vasoconstrictor responses to angiotensin II (Ang II) and adrenergic agonists in fructose-fed Sprague-Dawley rats (a model of metabolic syndrome).
Angiotensin-(1-7): new perspectives in atherosclerosis treatment.
Review
New
Chen et al., Beijing, China. In J Geriatr Cardiol, Nov 2015
Angiotensin (Ang)-(1-7) is recognized as a new bioactive peptide in renin-angiotensin system (RAS).
Efficacy and safety of a novel multi-electrode radiofrequency ablation catheter for renal sympathetic denervation in pigs.
New
Fang et al., Shanghai, China. In J Geriatr Cardiol, Nov 2015
Blood samples collected from renal arteries and veins as well as renal arteriography were performed on all animals before, immediately after, and three months after procedure to evaluate the effects of Spark on the levels of plasma renin, aldosterone, angiotensin I, and angiotensin II as well as the pathological changes of renal arteries.
International Union of Basic and Clinical Pharmacology. XCIX. Angiotensin Receptors: Interpreters of Pathophysiological Angiotensinergic Stimuli [corrected].
Review
New
Impact
Thomas et al., Seychelles. In Pharmacol Rev, Oct 2015
The receptors for RAS peptides consist of three G-protein-coupled receptors—the angiotensin II type 1 receptor (AT1 receptor), the angiotensin II type 2 receptor (AT2 receptor), the MAS receptor—and a type II trans-membrane zinc protein—the candidate angiotensin IV receptor (AngIV binding site).
Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure.
New
Impact
Di Lorenzo et al., New York City, United States. In Nat Med, Sep 2015
Mice lacking Nogo-B either systemically or specifically in endothelial cells are hypotensive, resistant to angiotensin II-induced hypertension and have preserved endothelial function and nitric oxide release.
Structure of the Angiotensin receptor revealed by serial femtosecond crystallography.
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Impact
Cherezov et al., Los Angeles, United States. In Cell, Jun 2015
Angiotensin II type 1 receptor (AT(1)R) is a G protein-coupled receptor that serves as a primary regulator for blood pressure maintenance.
New Concepts in Malaria Pathogenesis: The Role of the Renin-Angiotensin System.
Review
Pinheiro et al., Rio de Janeiro, Brazil. In Front Cell Infect Microbiol, 2014
Recent discoveries indicate the potential role of the renin-angiotensin system (RAS) in malaria infection.
Reactive Oxygen Species in the Paraventricular Nucleus of the Hypothalamus Alter Sympathetic Activity During Metabolic Syndrome.
Review
Braga et al., João Pessoa, Brazil. In Front Physiol, 2014
The PVN plays an important role in the sympathoexcitatory response to increasing circulating levels of angiotensin II (Ang-II), which activates AT1 receptors in the circumventricular organs (OCVs), mainly in the subfornical organ (SFO).
Angiotensin II induces vascular endocannabinoid release, which attenuates its vasoconstrictor effect via CB1 cannabinoid receptors.
GeneRIF
Hunyady et al., Budapest, Hungary. In J Biol Chem, 2012
Ang II stimulates vascular endocannabinoid formation, which attenuates its vasoconstrictor effect, suggesting that endocannabinoid release from the vascular wall and CB(1)R activation reduces the vasoconstrictor and hypertensive effects of Ang II.
Upregulation of ACE2-ANG-(1-7)-Mas axis in jejunal enterocytes of type 1 diabetic rats: implications for glucose transport.
GeneRIF
Leung et al., Hong Kong, Hong Kong. In Am J Physiol Endocrinol Metab, 2012
Data suggest that angiotensin I [as Ang (1-7)] is involved in regulation of glucose transport in jejunal enterocytes.
Angiotensin-II and MARCKS: a hydrogen peroxide- and RAC1-dependent signaling pathway in vascular endothelium.
GeneRIF
Michel et al., Boston, United States. In J Biol Chem, 2012
a critical role for H(2)O(2) in angiotensin-II signaling to the endothelial cytoskeleton in a novel pathway that is critically dependent on MARCKS, Rac1, and c-Abl.
Lack of association of A-6G polymorphism of AGT gene with essential hypertension in the Chinese population.
GeneRIF
Li, Nanjing, China. In J Cardiovasc Med (hagerstown), 2012
Lack of association of A-6G polymorphism of AGT gene with essential hypertension in the Chinese population.
Role of chymase in diabetic nephropathy.
GeneRIF
Boim et al., São Paulo, Brazil. In Exp Biol Med (maywood), 2012
The results indicate an important role for chymase in inducing fibrosis through TGF-beta1 activation, parallel with Ang II effects.
More papers using Angiotensin II antibodies
Growth factors and mitogen-activated protein kinases
Supplier
Stepien Henryk et al., In The Scientific World Journal, 1997
... ), angiotensin IV (ang IV, Bachem ...
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