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Angiotensin II receptor, type 1b

angiotensin II type 1 receptor, angiotensin II receptor
G-protein coupled receptor for angiotensin II; has a role in blood pressure regulation, electrolyte balance and cardiac function [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Angiotensin II, AT1, Renin, HAD, ARB
Papers on angiotensin II type 1 receptor
Monocytic Angiotensin and Endothelin Receptor Imbalance Modulate Secretion of the Profibrotic Chemokine Ligand 18.
New
Riemekasten et al., Lübeck, Germany. In J Rheumatol, Feb 2016
RESULTS: Monocytes of patients with SSc presented an increased angiotensin II Type 1 receptor (AT1R)/AT2R ratio compared with those of healthy donors.
Drug-related problems vary with medication category and treatment duration in Taiwanese heart failure outpatients receiving case management.
New
Lee et al., Taipei, Taiwan. In J Formos Med Assoc, Feb 2016
The drugs most frequently causing a DRP were angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers, diuretics, warfarin, spironolactone, and β-blockers.
Recent Clinical Drug Trials Evidence in Marfan Syndrome and Clinical Implications.
Review
New
Lacro et al., Boston, United States. In Can J Cardiol, Jan 2016
The primary aims of this report were to examine the evidence related to medical therapy for Marfan syndrome, including recently completed randomized clinical trials on the efficacy of β-blockers and angiotensin II receptor blockers for the prophylactic treatment of aortic enlargement in Marfan syndrome, and to provide recommendations for medical therapy on the basis of available evidence.
The role of parvovirus B19 in the pathogenesis of autoimmunity and autoimmune disease.
Review
New
Kerr, In J Clin Pathol, Jan 2016
Documented mechanisms in B19-associated autoimmunity include molecular mimicry (IgG antibody to B19 proteins has been shown to cross react with a variety of recognised human autoantigens, including collagen II, keratin, angiotensin II type 1 receptor, myelin basic protein, cardiolipin, and platelet membrane glycoprotein IIb/IIIa), B19-induced apoptosis with presentation of self-antigens to T lymphocytes, and the phospholipase activity of the B19 unique VP1 protein.
[Drug-induced acute kidney injury].
Review
New
Derungs, Bern, Switzerland. In Ther Umsch, Dec 2015
NSAIDs, diuretics, ACE inhibitors, and angiotensin II receptor blockers (ARBs} are the most frequent prerenal causes of an acute elevation in creatinine levels.
Mitigation of myocardial fibrosis by molecular cardiac surgery-mediated gene overexpression.
New
Bridges et al., Charlotte, United States. In J Thorac Cardiovasc Surg, Dec 2015
Both the angiotensin II type 1 receptor and angiotensin II were significantly elevated in the small- and large-infarct groups, whereas gene treatment diminished this effect.
The Role of Renin Angiotensin Aldosterone System Genes in Diabetic Nephropathy.
Review
New
Rahimi, Kermānshāh, Iran. In Can J Diabetes, Dec 2015
The effects of some RAAS gene variants, including angiotensin converting enzyme (ACE), angiotensinogen (AGT) and angiotensin II type 1 receptor (AT1R), on the risk for DN have been studied more extensively, but there has been controversy.
International Union of Basic and Clinical Pharmacology. XCIX. Angiotensin Receptors: Interpreters of Pathophysiological Angiotensinergic Stimuli [corrected].
Review
New
Impact
Thomas et al., Seychelles. In Pharmacol Rev, Oct 2015
The receptors for RAS peptides consist of three G-protein-coupled receptors—the angiotensin II type 1 receptor (AT1 receptor), the angiotensin II type 2 receptor (AT2 receptor), the MAS receptor—and a type II trans-membrane zinc protein—the candidate angiotensin IV receptor (AngIV binding site).
Structure of the Angiotensin receptor revealed by serial femtosecond crystallography.
New
Impact
Cherezov et al., Los Angeles, United States. In Cell, Jun 2015
Angiotensin II type 1 receptor (AT(1)R) is a G protein-coupled receptor that serves as a primary regulator for blood pressure maintenance.
[Effect of Antihypertensive Drugs on Regression of Left Ventricular Hypertrophy].
Review
Shatunova et al., In Kardiologiia, 2014
We also demonstrate benefits of the use of fixed combinations of drugs for the treatment of patients with arterial hypertension including those with left ventricular hypertrophy, and stress advantages of angiotensin II receptor blockers characterized by low risk of unfavorable effects and high compliance to treatment over other classes of antihypertensive drugs.
Association between the AGTR1 A1166C polymorphism and risk of IgA nephropathy: a meta-analysis.
Wang et al., Jinan, China. In Genet Mol Res, 2014
Numerous studies have evaluated the association between the A1166C polymorphism in the angiotensin II type 1 receptor (AGTR1) gene and immunoglobulin A nephropathy (IgAN) risk.
Efficacy and safety of nebivolol and valsartan as fixed-dose combination in hypertension: a randomised, multicentre study.
Impact
NAC-MD-01 Study Investigators et al., New Orleans, United States. In Lancet, 2014
We assessed the efficacy and safety of a fixed-dose combination of a vasodilating β blocker (nebivolol) and an angiotensin II receptor blocker (valsartan) in adults with hypertension.
Influence of angiotensin II receptor blocker combination tablet prescription on drug number and cost.
Tsuchiya et al., Gifu, Japan. In Sage Open Med, 2013
OBJECTIVES: Combination therapy using an angiotensin II receptor blocker is expected to promote medication adherence and alleviate economic burden among patients by reducing the number of drugs taken, and thereby to lower associated medical costs.
Use of β-blockers, angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, and risk of breast cancer recurrence: a Danish nationwide prospective cohort study.
Impact
Ahern et al., Århus, Denmark. In J Clin Oncol, 2013
PURPOSE: To estimate associations between use of β-blockers, angiotensin-converting enzyme (ACE) inhibitors, or angiotensin receptor blockers (ARBs) and breast cancer recurrence in a large Danish cohort.
A systematic comparison of the properties of clinically used angiotensin II type 1 receptor antagonists.
Review
Impact
Liu et al., Nieder-Ingelheim, Germany. In Pharmacol Rev, 2013
Angiotensin II type 1 receptor antagonists (ARBs) have become an important drug class in the treatment of hypertension and heart failure and the protection from diabetic nephropathy.
Altered functioning of both renal dopamine D1 and angiotensin II type 1 receptors causes hypertension in old rats.
GeneRIF
Asghar et al., Houston, United States. In Hypertension, 2012
alterations in both D1R (diminished) and AT(1)R (exaggerated) functions are necessary for the development of age-associated hypertension, as seen in old FBN rats.
AT1 receptors in the paraventricular nucleus mediate the hyperthermia-induced reflex reduction of renal blood flow in rats.
GeneRIF
Badoer et al., Melbourne, Australia. In Am J Physiol Regul Integr Comp Physiol, 2011
Results suggest that endogenous ANG II acts on AT1 receptors in the PVN to mediate the reduction in RBF induced by hyperthermia.
Influence of myocardial infarction on changes in the expression of angiotensin type 1 receptor in the rat prostate.
GeneRIF
Ochędalski et al., Łódź, Poland. In Folia Histochem Cytobiol, 2010
Data demonstrate tissue-specific changes in AT1a-b and AT2 receptor expression after myocardial infarction, and show that MI has a strong influence on the expression of angiotensin receptor type AT1 in the prostate at the protein and mRNA level.
Cardiomyocyte autophagy is regulated by angiotensin II type 1 and type 2 receptors.
GeneRIF
Delbridge et al., Melbourne, Australia. In Autophagy, 2009
Angiotensin II (AngII) increases autophagosome formation via the AngII type I (AT1) receptor and that this response is constitutively antagonized by co-expression of the AngII type 2 (AT2) receptor in neonatal cardiomyocytes.
Increased perfusion pressure enhances the expression of endothelin (ETB) and angiotensin II (AT1, AT2) receptors in rat mesenteric artery smooth muscle cells.
GeneRIF
Edvinsson et al., Lund, Sweden. In Blood Press, 2008
AT1 receptor mRNA and protein were up-regulated at 17 h of high perfusion pressure.
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