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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Angiomotin

angiomotin, Amot
This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: YAP, amotl1, Actin, V1a, Amotl2
Papers on angiomotin
mRNA and protein expression of the angiogenesis-related genes EDIL3, AMOT and ECM1 in mesenchymal stem cells in psoriatic dermis.
New
Zhang et al., Taiyuan, China. In Clin Exp Dermatol, Jan 2016
Our previous microarray study showed that the angiogenesis-related genes EDIL3 (epidermal growth factor-like repeats and discoidin I-like domains 3), AMOT (angiomotin) and ECM1 (extracellular matrix protein 1), had high expression levels in dermal mesenchymal stem cells (DMSCs) from psoriatic skin lesions.
Position- and polarity-dependent Hippo signaling regulates cell fates in preimplantation mouse embryos.
Review
New
Sasaki, Suita, Japan. In Semin Cell Dev Biol, Dec 2015
At the molecular level, phosphorylation of the Hippo-pathway component angiomotin at adherens junctions (AJs) in the inner (apolar) cells activates the Lats protein kinase and triggers Hippo signaling.
Long non-coding RNA small nucleolar RNA host gene 12 (SNHG12) promotes cell proliferation and migration by upregulating angiomotin gene expression in human osteosarcoma cells.
New
Li et al., Tianjin, China. In Tumour Biol, Nov 2015
Angiomotin, encoded by the AMOT gene, is a protein that regulates the migration and organization of endothelial cells.
Tankyrase Inhibitors Target YAP by Stabilizing Angiomotin Family Proteins.
New
Chen et al., Houston, United States. In Cell Rep, Nov 2015
This effect is mediated by anigomotin (AMOT) family proteins.
Atypical protein kinase C induces cell transformation by disrupting Hippo/Yap signaling.
New
McCaffrey et al., Montréal, Canada. In Mol Biol Cell, Nov 2015
In MDCK cells, Yap1 was sequestered to cell-cell junctions by Amot, and aPKC overexpression resulted in loss of Amot expression and a spindle-like cell phenotype.
MicroRNA-205 inhibits the proliferation and invasion of breast cancer by regulating AMOT expression.
New
Fan et al., Zhengzhou, China. In Oncol Rep, Oct 2015
It has been reported that the expression of angiomotin (AMOT) is upregulated in breast cancer.
Novel genetic causes for cerebral visual impairment.
New
de Vries et al., Nijmegen, Netherlands. In Eur J Hum Genet, Oct 2015
In addition, in 11 patients (44%) with CVI, variants in one or more candidate genes were identified (ACP6, AMOT, ARHGEF10L, ATP6V1A, DCAF6, DLG4, GABRB2, GRIN1, GRIN2B, KCNQ3, KCTD19, RERE, SLC1A1, SLC25A16, SLC35A2, SOX5, UFSP2, UHMK1, ZFP30).
Endosomal regulation of contact inhibition through the AMOT:YAP pathway.
New
Wilson et al., Tucson, United States. In Mol Biol Cell, Aug 2015
In addition to phosphorylation-dependent regulation of YAP, the integral membrane protein angiomotin (AMOT) and AMOT family members control YAP through direct binding.
Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway.
New
Zhang et al., Hong Kong, Hong Kong. In Cell Res, Jul 2015
Angiomotin binding releases the auto-inhibition and promotes Merlin's binding to Lats1/2.
Merlin's wizardry guides cohesive migration.
New
Impact
Morrison et al., Jena, Germany. In Nat Cell Biol, Mar 2015
The collective migration of epithelial cell sheets is now shown to be mediated by a signalling axis that involves the merlin tumour-suppressor protein, the tight-junction-associated angiomotin-Rich1 complex and the Rac1 small GTPase.
Influence of Sex on Basal and Dickkopf-1 Regulated Gene Expression in the Bovine Morula.
Hansen et al., Araçatuba, Brazil. In Plos One, 2014
Expression of all genes tested that were affected by sex in experiment 1 was affected in a similar manner in Experiment 2. In contrast, effects of DKK1 on gene expression were largely not repeatable in Experiment 2. The exception was for the Hippo signaling gene AMOT, which was inhibited by DKK1.
Angiomotin'g YAP into the nucleus for cell proliferation and cancer development.
Review
Hong, Singapore, Singapore. In Sci Signal, 2013
Scaffold proteins angiomotin (Amot) and angiomotin-related AmotL1 and AmotL2 were recently identified as negative regulators of YAP and TAZ by preventing their nuclear translocation.
The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation.
GeneRIF
Yu et al., Shanghai, China. In Biochem J, 2012
Three L/P-PXY motifs of AMOT/p130 and the WW domains of Nedd4 mediate the interaction of Nedd4, Nedd4-2 and Itch.
A vaccine targeting angiomotin induces an antibody response which alters tumor vessel permeability and hampers the growth of established tumors.
GeneRIF
Cavallo et al., Torino, Italy. In Angiogenesis, 2012
A vaccine targeting angiomotin induces an antibody response which alters tumor vessel permeability and hampers the growth of established tumors.
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
Review
Citi et al., Genève, Switzerland. In Essays Biochem, 2011
angiomotin, α-catenin and cingulin, are believed to act by sequestering either transcription factors, such as YAP (Yes-associated protein), or regulators of small GTPases, such as GEF (guanine-nucleotide-exchange factor)-H1, at junctions.
A tight junction-associated Merlin-angiomotin complex mediates Merlin's regulation of mitogenic signaling and tumor suppressive functions.
Impact
GeneRIF
Kissil et al., Philadelphia, United States. In Cancer Cell, 2011
ADepletion of Angiomotin in Nf2(-/-) Schwann cells attenuates the Ras-MAPK signaling pathway, impedes cellular proliferation in vitro and tumorigenesis in vivo
The adaptor protein AMOT promotes the proliferation of mammary epithelial cells via the prolonged activation of the extracellular signal-regulated kinases.
GeneRIF
Wells et al., Indianapolis, United States. In Cancer Res, 2011
Data show that Amot expression is required for proliferation of breast cancer cells in specific microenvironmental contexts that require ERK1/2 signaling.
Hippo pathway-independent restriction of TAZ and YAP by angiomotin.
GeneRIF
Hong et al., Singapore, Singapore. In J Biol Chem, 2011
novel mechanism to restrict the activity of TAZ and YAP through physical interaction with Amot and AmotL1
A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells.
Impact
Pawson et al., Toronto, Canada. In Cell, 2006
Rich1 binds the scaffolding protein angiomotin (Amot) and is thereby targeted to a protein complex at tight junctions (TJs) containing the PDZ-domain proteins Pals1, Patj, and Par-3.
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