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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Islet amyloid polypeptide

amylin, DAP, IAPP
Islet, or insulinoma, amyloid polypeptide is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. While the association of amylin with the development of type II diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Studies suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes. [provided by RefSeq, Apr 2011] (from NCBI)
Top mentioned proteins: Insulin, CAN, ACID, V1a, HAD
Papers using amylin antibodies
Endoplasmic reticulum stress plays a central role in development of leptin resistance
Supplier
Mantzoros Christos S. et al., In Diabetes Care, 2008
... Amylin human recombinants were purchased from Phoenix Pharmaceuticals (Burlingame, CA) ...
One-year treatment with exenatide improves beta-cell function, compared with insulin glargine, in metformin-treated type 2 diabetes patients: a randomized, controlled trial
Supplier
Glass Leonard C. et al., In Diabetes Care, 2008
... has received grants from Bristol Myers Squibb, Amylin, Eli Lilly, Novartis, Pfizer, Takeda, Roche, and Merck; participates in the speaker's ...
Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis
Supplier
Chen Roland S. et al., In Diabetes Care, 2006
... Lilly, Novartis, Pfizer, Takeda, Roche, and Johnson & Johnson and grant support from Bristol-Myers Squibb, Amylin, Eli Lilly, Novartis, Pfizer, Takeda, Roche, and Merck.
GenoLink: discovering drug target proteins by exploring networks of heterogeneous biological data
Supplier
Médigue Claudine et al., In Nucleic Acids Research, 2004
... diaminopimelate (DAP) biosynthesis locus identifies dapC, a novel ...
Abnormal cardiac inflow patterns during postnatal development in a mouse model of Holt-Oram syndrome
Supplier
Drucker Daniel J. et al., In Diabetes, 2004
... has served as an advisor or consultant within the past 12 months to Amylin Pharmaceuticals, Arena Pharmaceuticals, Arisaph Pharmaceuticals, Eli Lilly, GlaxoSmithKline, Glenmark Pharmaceuticals, Hoffman LaRoche, Isis Pharmaceuticals, Merck Research Laboratories, Metabolex, Novartis ...
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Papers on amylin
Differential activation of innate immune pathways by distinct islet amyloid polypeptide (IAPP) aggregates.
New
Verchere et al., Canada. In J Biol Chem, Feb 2016
UNASSIGNED: Aggregation of islet amyloid polypeptide (IAPP) contributes to beta cell dysfunction in type 2 diabetes and islet transplantation.
Pramlintide Antagonizes Beta Amyloid (Aβ)- and Human Amylin-Induced Depression of Hippocampal Long-Term Potentiation.
New
Jhamandas et al., Onoda, Japan. In Mol Neurobiol, Feb 2016
We have previously demonstrated that electrophysiological and neurotoxic effects of Aβ and human amylin are expressed via the amylin receptor.
Prenatal exposure to persistent organic pollutants and organophosphate pesticides, and markers of glucose metabolism at birth.
New
Cordier et al., Rennes, France. In Environ Res, Feb 2016
METHODS: Dialkylphosphate (DAP) metabolites of organophosphate pesticides were measured in maternal urine collected at the beginning of pregnancy.
Targeting Insulin-Degrading Enzyme to Treat Type 2 Diabetes Mellitus.
Review
New
Tang, Chicago, United States. In Trends Endocrinol Metab, Jan 2016
Insulin-degrading enzyme (IDE) selectively degrades peptides, such as insulin, amylin, and amyloid β (Aβ) that form toxic aggregates, to maintain proteostasis.
GLP-1 and Amylin in the Treatment of Obesity.
Review
New
Vilsbøll et al., Copenhagen, Denmark. In Curr Diab Rep, Jan 2016
Among these are the beta-cell hormone amylin and the intestinal L cell hormone glucagon-like peptide-1 (GLP-1).
Effects of intrathecal amylin on formalin-induced nociception and on cAMP accumulation in the rat embryonic spinal cells.
New
Owji et al., Shīrāz, Iran. In Neuropeptides, Jan 2016
UNASSIGNED: Amylin (AMY) is a member of calcitonin family of peptides.
Hypothalamic Amylin Acts in Concert with Leptin to Regulate Food Intake.
New
Impact
Friedman et al., New York City, United States. In Cell Metab, Jan 2016
Profiling of hypothalamic neurons revealed that islet amyloid polypeptide (Iapp, precursor to amylin) is expressed in neurons in the lateral hypothalamus, arcuate nucleus, medial preoptic area, and elsewhere.
Stabilizing Off-pathway Oligomers by Polyphenol Nanoassemblies for IAPP Aggregation Inhibition.
New
Ding et al., United States. In Sci Rep, Dec 2015
Here, we use discrete molecular dynamics (DMD) simulations and high-throughput dynamic light scattering (DLS) experiments to study the anti-aggregation effects of two polyphenols, curcumin and resveratrol, on the aggregation of islet amyloid polypeptide (IAPP or amylin).
New Insights from Sum Frequency Generation Vibrational Spectroscopy into the Interactions of Islet Amyloid Polypeptides with Lipid Membranes.
Review
New
Yan et al., Richland, United States. In J Diabetes Res, Dec 2015
Here, we review the most recent applications of sum frequency generation (SFG) vibrational spectroscopy applied in conjunction with computational modeling techniques, a joint experimental and computational methodology that has provided valuable insights into the aggregation of islet amyloid polypeptide (IAPP) on membrane surfaces.
Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology.
Review
New
Raleigh et al., Stony Brook, United States. In J Diabetes Res, Dec 2015
The hormone islet amyloid polypeptide (IAPP, or amylin) plays a role in glucose homeostasis but aggregates to form islet amyloid in type-2 diabetes.
Amylin: Pharmacology, Physiology, and Clinical Potential.
Review
New
Impact
Roth et al., Zürich, Switzerland. In Pharmacol Rev, Jul 2015
Amylin is a pancreatic β-cell hormone that produces effects in several different organ systems.
The impact of diabetes and diabetes medications on bone health.
Review
New
Impact
Pratley et al., Orlando, United States. In Endocr Rev, Apr 2015
Animal models also have demonstrated a role for amylin in bone metabolism, but clinical trials in patients with type 1 diabetes with an amylin analog (pramlintide) have not shown a significant impact on bone metabolism.
IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo.
New
Impact
Flores et al., Houston, United States. In Nature, Mar 2015
Here we show that deletion of the ΔN isoforms of p63 or p73 leads to metabolic reprogramming and regression of p53-deficient tumours through upregulation of IAPP, the gene that encodes amylin, a 37-amino-acid peptide co-secreted with insulin by the β cells of the pancreas.
Causative factors for formation of toxic islet amyloid polypeptide oligomer in type 2 diabetes mellitus.
Review
An et al., South Korea. In Clin Interv Aging, 2014
Human islet amyloid polypeptide (h-IAPP) is a peptide hormone that is synthesized and cosecreted with insulin from insulin-secreting pancreatic β-cells.
Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones.
Impact
Liu et al., Cambridge, United States. In Nature, 2014
Treatment of lean and obese mice with this inhibitor shows that IDE regulates the abundance and signalling of glucagon and amylin, in addition to that of insulin.
Binding of islet amyloid polypeptide to supported lipid bilayers and amyloid aggregation at the membranes.
GeneRIF
Hamada et al., Kōbe, Japan. In Biochemistry, 2012
The results obtained in this study using model membranes reveal that membrane-bound IAPP species display a pronounced membrane perturbation ability and suggest the potential involvement of the oligomeic forms of IAPP in membrane dysfunction.
Nucleobindin 1 caps human islet amyloid polypeptide protofibrils to prevent amyloid fibril formation.
GeneRIF
Sakmar et al., New York City, United States. In J Mol Biol, 2012
postulate that the engineered forms of NUCB1 prevent hIAPP fibril formation by a mechanism where protofibril-like species are "capped" to prevent further fibril assembly and maturation
The occurrence of islet amyloid polypeptide amyloidosis in Japanese subjects.
GeneRIF
Ando et al., In Pancreas, 2012
Letter: report islet amyloid polypeptide amyloidosis in Japanese subjects with/without type 2 diabetes mellitus.
Two-dimensional infrared spectroscopy reveals the complex behaviour of an amyloid fibril inhibitor.
Impact
GeneRIF
Zanni et al., Madison, United States. In Nat Chem, 2012
at 8 h after mixing, rat amylin blocks the N-terminal beta-sheet of fibrils. At 24 h after mixing, rat amylin blocks neither beta-sheet and forms its own beta-sheet
Lipid interaction and membrane perturbation of human islet amyloid polypeptide monomer and dimer by molecular dynamics simulations.
GeneRIF
Wei et al., Shanghai, China. In Plos One, 2011
insight into the hIAPP-membrane interaction and the molecular mechanism of membrane disruption by hIAPP oligomers
More papers using amylin antibodies
Functional genomics and expression analysis of the Corynebacterium glutamicum fpr2-cysIXHDNYZ gene cluster involved in assimilatory sulphate reduction.
Supplier
Valdivia Raphael, In PLoS ONE, 2004
... , 400 µg/ml diaminopimelic acid (DAP) (Sigma Aldrich, St Louis, MO) was ...
Role of ERAB/L-3-hydroxyacyl-coenzyme A dehydrogenase type II activity in Abeta-induced cytotoxicity.
Supplier
El Khoury Joseph, In PLoS ONE, 1998
... Aβ42, human amylin (HA), biotinylated Aβ42 and biotinylated HA were purchased from Bachem (Germany) (H-1368, H-7905, H-5642 ...
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