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Protein kinase, AMP-activated, alpha 2 catalytic subunit

AMPK, AMP-activated protein kinase
protein kinase that phosphorylates and inhibits acetyl-CoA carboxylase (ACC); rate-limiting enzyme in malonyl-CoA synthesis [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: V1a, ACID, Insulin, mTOR, CAN
Papers using AMPK antibodies
Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth
Lisanti Michael P. et al., In Cell Cycle, 2010
... (#ab10433; Abcam), anti-Cathepsin B (#sc-13985 (FL-339); Santa Cruz Biotech), anti-OXPHOS (#MS601; Mitosciences), anti-β actin (#A5441, Sigma), anti-phospho-AMPK (#2531, Cell Signaling), anti-AMPK (#2532, Cell Signaling), ...
Autophagy negatively regulates keratinocyte inflammatory responses via scaffolding protein p62/SQSTM1
Koya Daisuke et al., In Experimental Diabetes Research, 2010
... (Thr172) and anti-AMPKα (23A3) antibodies were obtained from Cell Signaling Technology (Beverly, MA) ...
Resveratrol ameliorates vasculopathy in STZ-induced diabetic rats: role of AGE-RAGE signalling
Yagasaki Kazumi et al., In Journal of Clinical Biochemistry and Nutrition, 2009
... The anti-phospho-AMPKα (Thr172) and anti-AMPK antibodies were obtained from Cell Signaling Technology, Inc., (Beverly, MA) ...
Protective effect of berberine on beta cells in streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats
Roh Gu Seob et al., In Anatomy & Cell Biology, 2008
... Antibodies against p-AMPK, total AMPK, p-ACC, and total ACC were obtained from Cell Signaling Technology (Danvers, MA, USA) ...
Inactivation of AMPK alters gene expression and promotes growth of prostate cancer cells
Luo Zhijun et al., In Journal of Molecular Signaling, 2008
... Antibodies against phospho- and nonphospho-proteins of Akt, S6K1, S6, AMPK, and ACC were purchased from Cell Signaling Technology (Danvers, MA) ...
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Papers on AMPK
SIRT6 protects cardiomyocytes against ischemia/reperfusion injury by augmenting FoxO3α-dependent antioxidant defense mechanisms.
Jiang et al., Chengdu, China. In Basic Res Cardiol, Mar 2016
Intriguingly, SIRT6 was noticed to up-regulate AMP/ATP and then activate the adenosine 5'-monophosphate-activated protein kinase (AMPK)-forkhead box O3α (FoxO3α) axis and further initiated the downstream antioxidant-encoding gene expression (manganese superoxide dismutase and catalase), thereby decreasing cellular levels of oxidative stress and mediating cardioprotection in the ischemic heart.
Intermedin/Adrenomedullin 2 polypeptide promotes adipose tissue browning and reduces high-fat diet-induced obesity and insulin resistance in mice.
Wang et al., Beijing, China. In Int J Obes (lond), Feb 2016
These effects may be due to increased AMP-activated protein kinase (AMPK) phosphorylation and reduced peroxisome proliferator-activated receptor gamma co-activator 1α (PGC1α) acetylation, which result in interactions between PGC1α and PR domain containing 16 (PRDM16) and then promote uncoupling protein 1 (UCP1) expression in adipocytes.
Leptin signalling pathways in hypothalamic neurons.
Kim et al., Seoul, South Korea. In Cell Mol Life Sci, Feb 2016
The signaling pathways known to mediate the actions of leptin include JAK-STAT signaling, PI3K-Akt-FoxO1 signaling, SHP2-ERK signaling, AMPK signaling, and mTOR-S6K signaling.
Changes in one-carbon metabolism after duodenal-jejunal bypass surgery.
Hwang et al., Dublin, Ireland. In Am J Physiol Endocrinol Metab, Feb 2016
In particular, the AMP:ATP ratio and phosphorylation of AMP-activated protein kinase increased after DJB surgery, which led to enhanced energy production and increased catabolic pathway activity, such as fatty acid oxidation and glucose transport.
Targeting AMPK signaling in combating ovarian cancers: opportunities and challenges.
Chan et al., Hong Kong, Hong Kong. In Acta Biochim Biophys Sin (shanghai), Feb 2016
Targeting cancer cell metabolism by the application of AMP-activated protein kinase (AMPK)-activating agents is believed to be one of the most plausible attempts.
Current understanding of metformin effect on the control of hyperglycemia in diabetes.
He et al., Baltimore, United States. In J Endocrinol, Feb 2016
However, its mechanism of action remains partially understood and controversial, especially in regards to the role of AMPK in metformin's action and the mechanism of AMPK activation.
AMPK in cardiac fibrosis and repair: Actions beyond metabolic regulation.
Horman et al., Brussels, Belgium. In J Mol Cell Cardiol, Feb 2016
The AMP-activated protein kinase (AMPK) is a ubiquitously expressed cellular energy sensor and an essential component of the adaptive response to cardiomyocyte stress that occurs during ischemia.
Inhibitory effects of nicotine derived from cigarette smoke on thymic stromal lymphopoietin production in epidermal keratinocytes.
Hirasawa et al., Sendai, Japan. In Cell Immunol, Feb 2016
Nicotine inhibition of TSLP production was abolished by pretreatments with α7 nicotinic acetylcholine receptor (α7 nAChR) antagonists, AMP-activated protein kinase (AMPK) inhibitor, and phosphoinositide 3-kinase (PI3K) inhibitors.
Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion.
Cahill et al., Boston, United States. In Cancer Cell, Jan 2016
NAD+ depletion activated the intracellular energy sensor AMPK, triggered autophagy, and resulted in cytotoxicity.
A MYC-Driven Change in Mitochondrial Dynamics Limits YAP/TAZ Function in Mammary Epithelial Cells and Breast Cancer.
Eilers et al., Würzburg, Germany. In Cancer Cell, Jan 2016
MYC-dependent growth strains cellular energy resources and stimulates AMP-activated kinase (AMPK).
Glucose Alters Per2 Rhythmicity Independent of AMPK, Whereas AMPK Inhibitor Compound C Causes Profound Repression of Clock Genes and AgRP in mHypoE-37 Hypothalamic Neurons.
Belsham et al., Toronto, Canada. In Plos One, Dec 2015
Glucose had no significant effect on phospho-GSK3β, whereas AMPK phosphorylation was altered.
Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation.
He et al., Chicago, United States. In Nat Chem, Dec 2015
The reduced level of ATP results in activation of the AMP-activated protein kinase that leads to reduced lipogenesis.
Polyphenols and Glycemic Control.
Clifton et al., Adelaide, Australia. In Nutrients, Dec 2015
Polyphenols may also enhance insulin-dependent glucose uptake, activate 5' adenosine monophosphate-activated protein kinase (AMPK), modify the microbiome and have anti-inflammatory effects.
AMPK Keeps Tumor Cells from Starving to Death.
Shaw, Los Angeles, United States. In Cell Stem Cell, Dec 2015
They find that inhibition of the metabolic stress sensor AMP-activated protein kinase (AMPK) led to deranged glucose metabolism and redox homeostasis, resulting in reduced leukemic progression that was further attenuated by dietary restriction.
Atg5-independent autophagy regulates mitochondrial clearance and is essential for iPSC reprogramming.
Ding et al., San Francisco, United States. In Nat Cell Biol, Nov 2015
Furthermore, AMPK seems to be upstream of this autophagic pathway and can be targeted by small molecules to modulate mitochondrial clearance during metabolic reprogramming.
The role of AMPK/mTOR/S6K1 signaling axis in mediating the physiological process of exercise-induced insulin sensitization in skeletal muscle of C57BL/6 mice.
Fu et al., Tianjin, China. In Biochim Biophys Acta, 2012
Our results provide new insights into the mechanism by which AMPK/mTOR/S6K1 signaling axis mediates the physiological process of exercise-induced insulin sensitization.
Endothelium-selective activation of AMP-activated protein kinase prevents diabetes mellitus-induced impairment in vascular function and reendothelialization via induction of heme oxygenase-1 in mice.
Xu et al., Hong Kong, Hong Kong. In Circulation, 2012
Endothelium-specific AMPK activation is sufficient to protect against diabetes mellitus-induced aggravation of vascular injury by promoting endothelial function and reendothelialization via upregulation of heme oxygenase-1 and SDF-1alpha.
AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells.
Ching et al., Hong Kong, Hong Kong. In Cancer Res, 2012
underexpression of AMPK is frequently observed in HCC, and that inactivation of AMPK promotes hepatocarcinogenesis by destabilizing p53 in a SIRT1-dependent manner.
AMPK regulates mitotic spindle orientation through phosphorylation of myosin regulatory light chain.
Marcus et al., Atlanta, United States. In Mol Cell Biol, 2012
AMPK mediates spindle pole-associated pMRLC(ser19) to control spindle orientation via regulation of actin cortex-astral microtubule attachments
AMP-activated protein kinase-α1 as an activating kinase of TGF-β-activated kinase 1 has a key role in inflammatory signals.
Lee et al., Suwŏn, South Korea. In Cell Death Dis, 2011
AMPK-alpha1 as an activating kinase of TAK1 has a key role in mediating inflammatory signals triggered by TLR4 and TNF-alpha.
More papers using AMPK antibodies
Inactivation of AMPK alters gene expression and promotes growth of prostate cancer cells
Luo Zhijun et al., In Oncogene, 2008
... Antibodies for total and phospho-T172 of AMPK alpha subunit were from Cell Signaling Technology, Inc ...
LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis.
Gottardi Cara, In PLoS ONE, 2007
... NICHD and maintained by The University of Iowa, Department of Biology; Iowa City, Iowa, USA), anti-AMPK-alpha (Santa Cruz Biotechnology, Santa Cruz, CA, USA), ...
Thiazolidinedione ameliorates renal injury in experimental diabetic rats through anti-inflammatory effects mediated by inhibition of NF-κB activation
Fantus I. George et al., In Experimental Diabetes Research, 2006
... The rabbit polyclonal antibodies against phospho- and total-AMPK alpha were purchased from Cell Signaling Technology, Inc ...
Nucleocytoplasmic shuttling of the zinc finger protein EZI is mediated by importin-7-dependent nuclear import and CRM1-independent export mechanisms
Schneider Martin F. et al., In Journal of Biomedicine and Biotechnology, 2006
... -D-riboside), anti-p38 MAPK, anti-phospho-p38 MAPK (Thr180/Tyr182), anti-AMPK, and anti-phospho-AMPK (Thr172) antibodies were purchased from Cell Signaling Technology (Boston, MA) ...
COPI activity coupled with fatty acid biosynthesis is required for viral replication.
Evans David Hugh, In PLoS Pathogens, 2005
... Eisenberg), anti-Rac1 (Millipore),and anti-AMPK (Cell Signaling Technology) ...
G-Quadruplexes Induce ATM/JNK-Dependent Apoptosis.
Fugmann Sebastian D., In PLoS ONE, 2005
... Antibodies against AMPK α and phosphorylated ATM at Ser1981, p53 at Ser15, AMPK at Thr172 and ACC at Ser79 were purchased from Cell Signaling (Danvers, MA) ...
MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
Morton Nicholas M. et al., In Diabetes, 2005
... Akt, phospho-Akt (Ser 473), phospho-tyrosine, AMP-activated protein kinase (AMPK)α, phospho-AMPK (Thr 172), horseradish peroxidase anti-rabbit, and anti-mouse IgG were obtained from Cell Signaling Technology (Beverly, MA) ...
Dibasic phosphorylation sites in the R domain of CFTR have stimulatory and inhibitory effects on channel activation
Zielenkiewicz Piotr et al., In Journal of Molecular Modeling, 2003
... For AMPK β1, the structures of the yeast proteins SPCC1919.03c
Mitochondrial disorders
Zeviani Massimo et al., In Cell Metabolism, 2003
... Anti-PGC-1α antibody was from Abcam; anti-AMPK and anti-AMPK-P antibodies were from Cell Signaling; anti-COI and -COX5a were ...
Zebrafish-based small molecule discovery
Werb Zena et al., In Nature chemical biology, 2002
... AMPK agonist A-766962 was from Tocris Bioscience ...
Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase
Heiss Elke H. et al., In Free Radical Biology & Medicine, 2002
... , AMPK, and horseradish peroxidase-conjugated goat anti-rabbit secondary antibody from Cell Signaling (USA); anti-tubulin from Santa ...
Hepatocyte growth factor activates several transduction pathways in rat pancreatic acini.
Zang Mengwei, In PLoS ONE, 2002
... -AMPK antibody was from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants.
Xu Aimin, In PLoS ONE, 2001
... Nuclear respiratory factor (NRF)1 and mitochondrial transcription factor A (mtTFA) antibodies, and the specific siRNA for AMPK were purchased from Santa Cruz Biotechnology Inc ...
A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain.
Sethi Jaswinder K., In PLoS ONE, 2001
... Cruz (Santa Cruz, CA), antibodies against PAS, ERK, phospho-ERK, Akt, phospho-Akt (T308 and S473), AMPK, phospho-AMPK, and phosphotyrosine from Cell Signaling Technology (Danvers, MA), anti-AS160 ...
Aspirin inhibits in vitro maturation and in vivo immunostimulatory function of murine myeloid dendritic cells
Freund Gregory G et al., In BMC Immunology, 2000
... Anti-AMPKα 1/2 (Cat# sc-25792), anti-phoso AMPK (Threonine 172) (Cat# sc-33524-R) and Culture Micro Slides (sc-24978) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Overexpression of Rad inhibits glucose uptake in cultured muscle and fat cells.
Orsulic Sandra, In PLoS ONE, 1995
... IR, IRS1 were purchased from Upstate Biotechnology (Lake Placid, NY), pAkt (Ser473), pErk, pAMPK (Thr172), AMPK, pACC (Ser79), ACC were purchased from Cell Signaling Technology (Beverly, MA), LKB1, ...
Regulation of cholesterol biosynthesis
Wu Chieh-Hsi et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 1985
... Anti-phospho-ACC (#3661) and anti-phospho-AMPKα (#2531s) were obtained from Cell signaling Technology, Inc ...
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