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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Amphiregulin

amphiregulin, AREG
The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This encoded protein is associated with a psoriasis-like skin phenotype. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Epidermal Growth Factor, EGFR, epiregulin, CAN, TGF-alpha
Papers on amphiregulin
Different EGF Receptor Agonists Produce Unique Signatures for the Recruitment of Downstream Signaling Protein.
New
Pike et al., Washington, D.C., United States. In J Biol Chem, Feb 2016
Ensemble clustering of the overall response to the different growth factors suggests that these EGF receptor ligands fall into two major groups: i) EGF, AREG and EPR; and ii) BTC, TGFα, and EPG.
Sprouty4 mediates amphiregulin-induced down-regulation of E-cadherin and cell invasion in human ovarian cancer cells.
New
Leung et al., Vancouver, Canada. In Tumour Biol, Feb 2016
Amphiregulin (AREG) binds exclusively to the epidermal growth factor receptor (EGFR) and has been considered to be a dominant autocrine/paracrine EGFR ligand in ovarian cancer.
Growth Arrest Specific-1 (GAS1) Is a C/EBP Target Gene That Functions in Ovulation and Corpus Luteum Formation in Mice.
New
Richards et al., In Biol Reprod, Feb 2016
Female Gas1 mutant mice are fertile, exhibit enhanced rates of ovulation, increased fertility, and higher levels of Areg and Lhcgr mRNA in granulosa cells.
Acquired resistance of pancreatic cancer cells to treatment with gemcitabine and HER-inhibitors is accompanied by increased sensitivity to STAT3 inhibition.
New
Modjtahedi et al., Vienna, Austria. In Int J Oncol, Feb 2016
Acquisition of resistance to these agents was accompanied by upregulation of p-c-MET, p-STAT3, CD44, increased autocrine production of EGFR ligand amphiregulin and differential activation status of EGFR tyrosine residues as well as downregulation of total and p-SRC.
Xenograft of Human Umbilical Mesenchymal Stem Cells from Wharton's Jelly as a Potential Therapy for Rat Pilocarpine-Induced Epilepsy.
New
Lin et al., Taipei, Taiwan. In Brain Behav Immun, Jan 2016
Implanted HUMSCs survived in the hippocampus and released cytokines, including FGF-6, amphiregulin, glucocorticoid-induced tumor necrosis factors receptor (GITR), MIP-3β, and osteoprotegerin.
RYR2, PTDSS1 and AREG genes are implicated in a Lebanese population-based study of copy number variation in autism.
New
Boustany et al., Beirut, Lebanon. In Sci Rep, Dec 2015
The novel potential autism susceptibility genes PTDSS1 and AREG were uncovered and warrant further genetic and functional analyses.
New findings on primary and acquired resistance to anti-EGFR therapy in metastatic colorectal cancer: do all roads lead to RAS?
Review
New
Russo et al., Palermo, Italy. In Oncotarget, Oct 2015
Many biomarkers, including KRAS and NRAS mutations, BRAF mutations, PIK3CA mutations, PTEN loss, AREG and EREG expression, and HER-2 amplification have already been identified to select responders to anti-EGFR agents.
A Distinct Function of Regulatory T Cells in Tissue Protection.
New
Impact
Rudensky et al., New York City, United States. In Cell, Sep 2015
Here, we demonstrate that selective Treg cell deficiency in amphiregulin leads to severe acute lung damage and decreased blood oxygen concentration during influenza virus infection without any measureable alterations in Treg cell suppressor function, antiviral immune responses, or viral load.
Emerging functions of amphiregulin in orchestrating immunity, inflammation, and tissue repair.
Review
New
Impact
Artis et al., Newark, United States. In Immunity, Mar 2015
Emerging data suggest that in addition to characteristic type 2-associated cytokines, the epidermal growth factor (EGF)-like molecule Amphiregulin (AREG) might be a critical component of type 2-mediated resistance and tolerance.
Interactions of signaling proteins, growth factors and other proteins with heparan sulfate: mechanisms and mysteries.
Review
Pacifici et al., Philadelphia, United States. In Connect Tissue Res, 2014
In this review, we provide a description and analysis of HBDs in proteins including amphiregulin, fibroblast growth factor family members, heparanase, sclerostin and hedgehog protein family members.
Overcoming Resistance to Anti-EGFR Therapy in Colorectal Cancer.
Review
Tabernero et al., Seattle, United States. In Am Soc Clin Oncol Educ Book, 2014
Nongenetic mechanisms, including compensatory activation of receptor tyrosine kinases HER3 and MET, together with high expression of the ligands amphiregulin, transforming growth factor alpha heregulin, and hepatocyte growth factor in the tumor microenvironment also are thought to be involved in resistance.
Biomarker analyses in CLEOPATRA: a phase III, placebo-controlled study of pertuzumab in human epidermal growth factor receptor 2-positive, first-line metastatic breast cancer.
Impact
Swain et al., Barcelona, Spain. In J Clin Oncol, 2014
PATIENTS AND METHODS: Mandatory tumor and serum samples were collected (N = 808; 58% to 99.8% were assessable), and amphiregulin, betacellulin, epidermal growth factor (EGF), transforming growth factor alpha, EGF receptor, HER2, HER3, insulin-like growth factor 1 receptor, PTEN, phosphorylated AKT, PIK3CA, CMYC, serum HER2 extracellular domain (sHER2), and FCγR were assessed using appropriate assays.
ADAM17 at the interface between inflammation and autoimmunity.
Review
Sisto et al., Bari, Italy. In Immunol Lett, 2014
TGF-α and amphiregulin) and adhesion proteins (e.g.
Somatic cells regulate maternal mRNA translation and developmental competence of mouse oocytes.
Impact
Conti et al., San Francisco, United States. In Nat Cell Biol, 2013
In mice deficient in amphiregulin, decreased fecundity and oocyte developmental competence is associated with defective translation of a subset of maternal mRNAs.
Amphiregulin enhances regulatory T cell-suppressive function via the epidermal growth factor receptor.
Impact
Sijts et al., Utrecht, Netherlands. In Immunity, 2013
Stimulation with the EGF-like growth factor Amphiregulin (AREG) markedly enhanced Treg cell function in vitro, and in a colitis and tumor vaccination model we showed that AREG was critical for efficient Treg cell function in vivo.
Amphiregulin is a prognostic factor in colorectal cancer.
GeneRIF
Shirouzu et al., Kurume, Japan. In Anticancer Res, 2012
We conclude that the expression of Amphiregulin in a primary colorectal tumor is useful as an indicator of prognosis and as a predictor of recurrence.
Cell surface annexins regulate ADAM-mediated ectodomain shedding of proamphiregulin.
GeneRIF
Higashiyama et al., Japan. In Mol Biol Cell, 2012
proAREG-annexins-ADAM17 complex needs to localize at the cell surface for shedding of proAREG to occur
Nuclear envelope-localized EGF family protein amphiregulin activates breast cancer cell migration in an EGF-like domain independent manner.
GeneRIF
Hieda et al., Suita, Japan. In Biochem Biophys Res Commun, 2012
these data demonstrate a novel function mediated by the intracellular domain of proAREG and suggest a significant role for nuclear envelope-localized proAREG in driving human breast cancer progression.
Monoubiquitination of pro-amphiregulin regulates its endocytosis and ectodomain shedding.
GeneRIF
Higashiyama et al., Japan. In Biochem Biophys Res Commun, 2012
These results suggested that pro-AREG monoubiquitination and the subsequent trafficking to intracellular organelles is a novel shedding regulatory mechanism that contributes to the secretion of EGFR ligands in growth factor signaling.
Lung tumor-associated dendritic cell-derived amphiregulin increased cancer progression.
GeneRIF
Kuo et al., Kao-hsiung, Taiwan. In J Immunol, 2011
Lung tumor-associated dendritic cell-derived amphiregulin increased cancer progression.
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