gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 26 Aug 2015.

Runt-related transcription factor 1

AML1, GSK-3beta, RUNX1, glycogen synthase kinase 3beta
Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ETO, HAD, CAN, ETV6, MLL
Papers on AML1
Prognostification of ALL by Cytogenetics.
Review
New
Lone et al., Srīnagar, India. In Indian J Hematol Blood Transfus, 30 Sep 2015
Some chromosomal abnormalities are associated with more favorable outcomes, such as high hyperdiploidy (51-65 chromosomes) and the ETV6-RUNX1 fusion.
High Frequency and Poor Prognosis of Late Childhood BCR-ABL-Positive and MLL-AF4-Positive ALL Define the Need for Advanced Molecular Diagnostics and Improved Therapeutic Strategies in Pediatric B-ALL in Pakistan.
New
Irfan et al., Riyadh, Saudi Arabia. In Mol Diagn Ther, 13 Sep 2015
The most common FOs are BCR-ABL, MLL-AF4, ETV6-RUNX1, and TCF3-PBX1, all of which have important prognostic and drug selection implications.
Prevalence of common fusion transcripts in acute lymphoblastic leukemia: A report of 304 cases.
New
Kumar et al., New Delhi, India. In Asia Pac J Clin Oncol, 12 Sep 2015
This study was conducted to determine the frequency of common fusion transcripts BCR-ABL, TEL-AML1, MLL-AF4 and E2A-PBX1 for B-ALL and SIL-TAL1 for T-ALL as seen at a tertiary care center in India.
Resistance in the Ribosome: RUNX1, pre-LSCs, and HSPCs.
New
Impact
Ito et al., United States. In Cell Stem Cell, 06 Sep 2015
(2015) show that loss-of-function mutations in RUNX1 reduce ribosome biogenesis and provide pre-LSCs a selective advantage over normal hematopoietic cells through increased stress resistance.
Runx1 Deficiency Decreases Ribosome Biogenesis and Confers Stress Resistance to Hematopoietic Stem and Progenitor Cells.
New
Impact
Speck et al., Philadelphia, United States. In Cell Stem Cell, 06 Sep 2015
The transcription factor RUNX1 is frequently mutated in myelodysplastic syndrome and leukemia.
Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment.
New
Impact
Zon et al., Boston, United States. In Nature, 23 Aug 2015
The pro-haematopoietic effects of EETs were conserved in the developing zebrafish embryo, where 11,12-EET promoted HSPC specification by activating a unique activator protein 1 (AP-1) and runx1 transcription program autonomous to the haemogenic endothelium.
Mutations in the BCR-ABL1 Kinase Domain and Elsewhere in Chronic Myeloid Leukemia.
Review
New
Martinelli et al., Bologna, Italy. In Clin Lymphoma Myeloma Leuk, Jun 2015
Mutations in genes other than BCR-ABL1 include ASXL1, TET2, RUNX1, DNMT3A, EZH2, and TP53 in chronic phase patients and RUNX1, ASXL1, IKZF1, WT1, TET2, NPM1, IDH1, IDH2, NRAS, KRAS, CBL, TP53, CDKN2A, RB1, and GATA-2 mutations in advanced phase patients.
Targeted gene correction of RUNX1 in induced pluripotent stem cells derived from familial platelet disorder with propensity to myeloid malignancy restores normal megakaryopoiesis.
Review
New
Kurokawa et al., Tokyo, Japan. In Exp Hematol, Jun 2015
UNASSIGNED: Familial platelet disorder with propensity to myeloid malignancy (FPD/AML) is an autosomal dominant disease associated with germline mutation in RUNX1 gene and characterized by thrombocytopenia and an increased risk for developing myeloid malignancies.
Chemical biology. A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice.
New
Impact
Bushweller et al., Charlottesville, United States. In Science, Mar 2015
The transcription factor fusion CBFβ-SMMHC (core binding factor β and the smooth-muscle myosin heavy chain), expressed in AML with the chromosome inversion inv(16)(p13q22), outcompetes wild-type CBFβ for binding to the transcription factor RUNX1, deregulates RUNX1 activity in hematopoiesis, and induces AML.
Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element.
New
Impact
Look et al., Boston, United States. In Science, Jan 2015
MYB binds to this new site and recruits its H3K27 acetylase-binding partner CBP, as well as core components of a major leukemogenic transcriptional complex that contains RUNX1, GATA-3, and TAL1 itself.
Harnessing the Therapeutic Potential of Th17 Cells.
Review
New
Mageed et al., Arbīl, Iraq. In Mediators Inflamm, Dec 2014
For development, Th17 cells require activation of the transcription factors STAT3 and RORγt while RUNX1, c-Maf, and Aiolos are involved in changes of phenotype/functions.
Hematopoietic transcription factor mutations and inherited platelet dysfunction.
Review
New
Rao et al., Philadelphia, United States. In F1000prime Rep, Dec 2014
These hematopoietic transcription factors include RUNX1, FLI1, GATA-1, and GFI1B.
Incidence and Prognostic Value of Known Genetic Aberrations in Patients with Acute Myeloid Leukemia -  a Two Year Study.
New
Karabinos et al., In Klin Onkol, Dec 2014
Moreover, we found a favorable clinical outcome in patients expressing fusion genes AML1- ETO or PMLRARA in contrast to an adverse clinical outcome with few remissions and death in AML patients with MLL, - 5q/ - 5 and - 7q/ 7- .
Microarray and Proteomic Analyses of Myeloproliferative Neoplasms with a Highlight on the mTOR Signaling Pathway.
New
Schechter et al., Belgrade, Serbia. In Plos One, Dec 2014
Thirty-six genes (including RUNX1, TNFRSF19) were persistently highly expressed, while 42 genes (including FOXD4, PDE4A) were underexpressed both in CD34+ cells and granulocytes.
Somatic drivers of B-ALL in a model of ETV6-RUNX1; Pax5(+/-) leukemia.
New
Adams et al., Cambridge, United Kingdom. In Bmc Cancer, Dec 2014
Its most common chromosomal aberration is the ETV6-RUNX1 fusion gene, with ~25% of ETV6-RUNX1 patients also carrying PAX5 alterations.
Hypothalamic glycogen synthase kinase 3β has a central role in the regulation of food intake and glucose metabolism.
GeneRIF
Tups et al., Marburg an der Lahn, Germany. In Biochem J, 2012
increased hypothalamic GSK3beta signalling contributes to deleterious effects of leptin deficiency and exacerbates high-fat diet-induced weight gain and glucose intolerance
Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity.
Impact
GeneRIF
Jenuwein et al., Freiburg, Germany. In Cell, 2012
Data identify Prdm3 and Prdm16 as H3K9me1 methyltransferases and expose a functional framework in which anchoring to the nuclear periphery helps maintain the integrity of mammalian heterochromatin.
Epithelial cell adhesion molecules and epithelial mesenchymal transition (EMT) markers in Ewing's sarcoma family of tumors (ESFTs). Do they offer any prognostic significance?
GeneRIF
Llombart-Bosch et al., Valencia, Spain. In Virchows Arch, 2012
Desmoplakin and pGSK3beta constitute independent good prognostic factors for progression free survival in Ewing Sarcoma patients.
GSK3β/axin-1/β-catenin complex is involved in semaphorin3A signaling.
GeneRIF
Goshima et al., Yokohama, Japan. In J Neurosci, 2012
Semaphorin (Sema)3A induces formation of the GSK3beta/axin-1/beta-catenin complex, which regulates the signaling cascade of Sema3A via an endocytotic mechanism in dorsal root ganglion neurons.
Regulation of postnatal forebrain amoeboid microglial cell proliferation and development by the transcription factor Runx1.
GeneRIF
Stifani et al., Montréal, Canada. In J Neurosci, 2012
This study demonistrated that Runx1 regulate postnatal forebrain amoeboid microglial cell proliferation and development in mice.
share on facebooktweetadd +1mail to friends