GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Runt-related transcription factor 1
AML1, GSK-3beta, RUNX1, glycogen synthase kinase 3beta
Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from
NCBI)
Papers on
AML1
RUNX1/AML1 mutant collaborates with BMI1 overexpression in the development of human and murine myelodysplastic syndromes.
New
Hiroshima, Japan. In Blood, 07 Apr 2013
Key points BMI1 overexpression is one of the second hit partner genes of RUNX1 mutations that contribute to the development of MDS.
A Rare Cytogenetic Presentation of Acute Myeloid Leukemia (AML-M2).
New
Bengaluru, India. In Acta Med Iran, Dec 2012
Acute myeloid leukemia (AML) with t(8;21)(q22;q22) generating the AML1/ETO fusion gene on 8q22 is a distinct type of AML t(8;21) category (WHO)/AML-M2 (FAB), generally associated with a favourable prognosis.
HDAC inhibitors induce tumor-cell-selective pro-apoptotic transcriptional responses.
New
Melbourne, Australia. In Cell Death Dis, Dec 2012
This notion is supported by biochemical studies demonstrating aberrant recruitment of epigenetic enzymes such as histone deacetylases (HDACs) and histone methyltransferases to promoter regions through association with oncogenic fusion proteins such as PML-RARα and AML1-ETO.
OP9 Bone Marrow Stroma Cells Differentiate into Megakaryocytes and Platelets.
New
Tokyo, Japan. In Plos One, Dec 2012
The gene expressions of p45NF-E2, FOG, Fli1, GATA2, RUNX1, thrombopoietin, and c-mpl were observed during the MK differentiation.
[Involvement of Wnt signaling in hippocampal plasticity].
New
In Ross Fiziol Zh Im I M Sechenova, Dec 2012
A special attention is devoted to glycogen synthase kinase 3beta (GSK-3beta), one of most important from both plasticity and pathology perspectives component of the canonical Wnt pathway.
NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-θ and reactive oxygen species.
New
Impact
Vancouver, Canada. In Nat Med, Nov 2012
We also show that PKC-θ is regulated by a new pathway in which NOTCH1 induces runt-related transcription factor 3 (RUNX3), RUNX3 represses RUNX1 and RUNX1 induces PKC-θ.
[Transcription factor RUNX1].
Review
New
In Mol Biol (mosk), Nov 2012
Transcription factor RUNX1 is one of the key regulatory proteins in vertebrates.
Comparative analysis of different approaches to measure treatment response in acute myeloid leukemia.
New
Impact
Memphis, United States. In J Clin Oncol, Nov 2012
However, only 19 (9.6%) of the 197 PCR-positive samples were flow cytometry positive, with analyses of AML1-ETO and CBFβ-MYH11 accounting for most discrepancies, whereas eight of 13 MLL-positive samples had detectable MRD by flow cytometry.
Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes.
New
Impact
Boston, United States. In J Clin Oncol, Oct 2012
OBJECTIVE: A subset of patients with myelodysplastic syndromes (MDS) who are predicted to have lower-risk disease as defined by the International Prognostic Scoring System (IPSS) demonstrate more aggressive disease and shorter overall survival than expected.
RUNX1 mutations are associated with poor outcome in younger and older patients with cytogenetically normal acute myeloid leukemia and with distinct gene and MicroRNA expression signatures.
New
Impact
Columbus, United States. In J Clin Oncol, Oct 2012
OBJECTIVE: To determine the association of RUNX1 mutations with therapeutic outcome in younger and older patients with primary cytogenetically normal acute myeloid leukemia (CN-AML) and with gene/microRNA expression signatures.
Epigenetic mechanisms in leukemia.
Review
New
Worcester, United States. In Adv Biol Regul, Sep 2012
For example, the oncogenic AML1-ETO protein, which results from a chromosomal translocation between chromosomes 8 and 21, is expressed in nearly 25% of all acute myelogenous leukemias, disrupts Runx1 subnuclear localization during interphase and compromises transcriptional regulation.
AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches.
Review
New
New York City, United States. In Front Med, Sep 2012
The AML1-ETO fusion transcription factor is generated by the t(8;21) translocation, which is present in approximately 4%-12% of adult and 12%-30% of pediatric acute myeloid leukemia (AML) patients.
Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia.
New
Impact
Boston, United States. In Cancer Cell, Sep 2012
Here we identify the core transcriptional regulatory circuit controlled by TAL1 and its regulatory partners HEB, E2A, LMO1/2, GATA3, and RUNX1.
Targeted therapy: The new lease on life for acute promyelocytic leukemia, and beyond.
Review
New
Shanghai, China. In Iubmb Life, Aug 2012
The t(15;17) which generates PML-RARα, t(8;21) that produces AML1-ETO, and t(9;22) which generates BCR-ABL are the three most frequently seen chromosomal translocations in myeloid leukemia.
Re-expression of miR-199a suppresses renal cancer cell proliferation and survival by targeting GSK-3β.
New
GeneRIF
Yamagata, Japan. In Cancer Lett, Mar 2012
demonstrate low miR-199a expression as a feature of advanced RCCs, identify miR-199a as a negative regulator of GSK-3beta
Akt induces osteoclast differentiation through regulating the GSK3β/NFATc1 signaling cascade.
GeneRIF
Kwangju, South Korea. In J Immunol, 2012
the PI3K/Akt/GSK3beta/NFATc1 signaling axis plays an important role in RANKL-induced osteoclastogenesis.
Myeloid cell IL-10 production in response to leishmania involves inactivation of glycogen synthase kinase-3β downstream of phosphatidylinositol-3 kinase.
GeneRIF
Vancouver, Canada. In J Immunol, 2012
Thus, GSK-3beta negatively regulates myeloid cell IL-10 production in response to leishmania.
The kinase Sgg modulates temporal development of macrochaetes in Drosophila by phosphorylation of Scute and Pannier.
GeneRIF
Cambridge, United Kingdom. In Development, 2012
The kinase Sgg modulates temporal development of macrochaetes in Drosophila by phosphorylation of Scute and Pannier.
Myeloid malignancies: mutations, models and management.
Review
Marseille, France. In Bmc Cancer, 2011
CEBPA, ETV6, RUNX1), epigenetic regulators (e.g.
Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity.
GeneRIF
Tokyo, Japan. In J Exp Med, 2011
Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity.
