Prognostic score including gene mutations in chronic myelomonocytic leukemia.
Villejuif, France. In J Clin Oncol, Aug 2013
METHODS: We genotyped ASXL1 and up to 18 other genes including epigenetic (TET2, EZH2, IDH1, IDH2, DNMT3A), splicing (SF3B1, SRSF2, ZRSF2, U2AF1), transcription (RUNX1, NPM1, TP53), and signaling (NRAS, KRAS, CBL, JAK2, FLT3) regulators in 312 patients with CMML.
A role for RUNX1 in hematopoiesis and myeloid leukemia.
Tokyo, Japan. In Int J Hematol, Jun 2013
Since its discovery from a translocation in leukemias, the runt-related transcription factor 1/acute myelogenous leukemia-1 (RUNX1/AML1), which is widely expressed in hematopoietic cells, has been extensively studied.
Modulation of Epidermal Transcription Circuits in Psoriasis: New Links between Inflammation and Hyperproliferation.
Ann Arbor, United States. In Plos One, Dec 2012
These DEMs were associated with regulatory axes involving cytokines (e.g., IFN-γ, IL-17A, TNF-α), transcription factors (e.g., STAT1, NF-κB, E2F, RUNX1) and chromatin modifiers (SETDB1).