A biosensor platform for rapid detection of E. coli in drinking water.
Tempe, United States. In Enzyme Microb Technol, Feb 2016
Non-target substrates that included 4-methylumbelliferyl-β-d-galactopyranoside (MUGal) and l-leucine β-naphthylamide aminopeptidase (LLβ-N) were also investigated to identify nonspecific patterns of enzymatic activities in E. coli.
Aminoacyl β-naphthylamides as substrates and modulators of AcrB multidrug efflux pump.
Monserrato, Italy. In Proc Natl Acad Sci U S A, Feb 2016
Because the hydrolysis of PAβN in Escherichia coli was nearly entirely dependent on an aminopeptidase, PepN, expression of PepN in periplasm allowed us to carry out a quantitative determination of PAβN efflux kinetics through the determination of its periplasmic concentrations by quantitation of the first hydrolysis product, phenylalanine, after a short period of treatment.
Advances in the study of Lynch syndrome in China.
Beijing, China. In World J Gastroenterol, Jul 2015
In addition to frequently altered MMR genes, such as MLH1, MSH2, MSH6, and MLH3, other MMR-associated genes, such as those encoding human exonuclease 1, transforming growth factor β receptor 2, and alanine aminopeptidase, metastasis-associated protein 2, adenomatosis polyposis coli down-regulated 1, and hepatic and glial cell adhesion molecule have also been implicated in Chinese Lynch syndrome.
Assessment of spinal pain.
Herne, Germany. In Best Pract Res Clin Rheumatol, 2014
HLA B27 has the strongest contribution to the total genetic burden, but other major contributors such as endoplasmic reticulum aminopeptidase (ERAP)-1 and interleukin (IL)-23R have also been identified.
Potential Use of Calpain Inhibitors as Brain Injury Therapy
Boca Raton, United States. In Unknown Journal, 0001
We saw the development of a serine aminopeptidase inhibitor, vildagliptin, as a therapy for type 2 diabetes (Deacon and Holst, 2006), and another ACE inhibitor (Aliskiren) that is an alternative to the current ACE inhibitor drugs (Stanton, 2003).