gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Phosphoribosyl pyrophosphate amidotransferase

Amidophosphoribosyltransferase, Prat, ADE4
The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. It is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosythetic pathway. This gene and PAICS/AIRC gene, a bifunctional enzyme catalyzing steps six and seven of this pathway, are located in close proximity on chromosome 4, and divergently transcribed from an intergenic region. [provided by RefSeq, Mar 2011] (from NCBI)
Top mentioned proteins: ACID, STEP, CAN, HAD, ade2
Papers on Amidophosphoribosyltransferase
Functional complementation analyses reveal that the single PRAT family protein of trypanosoma brucei is a divergent homolog of Tim17 in saccharomyces cerevisiae.
Chaudhuri et al., Nashville, United States. In Eukaryot Cell, Mar 2015
Trypanosoma brucei, a parasitic protozoan that causes African trypanosomiasis, possesses a single member of the presequence and amino acid transporter (PRAT) protein family, which is referred to as TbTim17.
Identification of cancer mechanisms through computational systems modeling.
Voit et al., Atlanta, United States. In Transl Cancer Res, 2014
In fact, only three enzymatic steps emerge with statistical confidence as most likely being affected, namely: amidophosphoribosyltransferase (ATASE), 5'-nucleotidase (5NUC), and the xanthine oxidase/dehydrogenase (XD) reactions.
Three proteins mediate import of transit sequence-less precursors into the inner envelope of chloroplasts in Arabidopsis thaliana.
Reinbothe et al., Grenoble, France. In Proc Natl Acad Sci U S A, 2014
A family of 17 putative preprotein and amino acid transporters designated PRAT has been identified in Arabidopsis thaliana, comprising PRAT proteins in mitochondria and chloroplasts.
[Antimutagenesis of multiphytoadaptogene in yeast saccharomyces].
Korolev et al., In Genetika, 2013
MPA decreased the direct mutations frequency in ADE4-ADE8 loci induced by UV radiation and nitrous acid by 3.7 and 33 times, respectively.
New functions of the chloroplast Preprotein and Amino acid Transporter (PRAT) family members in protein import.
Reinbothe et al., Grenoble, France. In Plant Signal Behav, 2013
Three members of the family of preprotein and amino acid transporters, PRAT, were identified in chloroplasts that mediate the uptake of transit sequence-less proteins into the inner plastid envelope membrane.
Multi-locus candidate gene analyses of lipid levels in a pediatric Turkish cohort: lessons learned on LPL, CETP, LIPC, ABCA1, and SHBG.
Williams et al., İstanbul, Turkey. In Omics, 2013
We observed an association between CETP variant rs708272 and low HDL-C (allelic p=0.020, genotypic p=0.046), which was supported by an independent analysis, PRAT (PRAT control p=0.027).
Surface hydrophobicity and roughness influences the morphology and biochemistry of streptomycetes during attached growth and differentiation.
Weiser et al., Praha, Czech Republic. In Fems Microbiol Lett, 2013
Comparison of young mycelium (6 h) proteomes, obtained from the cultures attached to the glass and zirconia/silica beads, revealed three proteins with altered expression levels (dihydrolipoamide dehydrogenase, amidophosphoribosyltransferase and cystathionine beta-synthase) and one unique protein (glyceraldehyde-3-phosphate dehydrogenase) that was present only in cells grown on glass beads.
Transcriptional regulation of the purine de novo synthesis gene Prat in Drosophila melanogaster.
Clark et al., Fredericton, Canada. In Gene, 2013
The first step of the purine de novo synthesis pathway is catalyzed by amidophosphoribosyltransferase (E.C. which is encoded by two Prat genes in D. melanogaster, Prat and Prat2.
A molecular link between mitochondrial preprotein transporters and respiratory chain complexes.
Whelan et al., Australia. In Plant Signal Behav, 2012
In Arabidopsis, Tim17 and Tim23 belong to a large gene family consisting of 16 members termed the Preprotein and Amino acid transporters (PRAT).
Identification of seven Xanthomonas oryzae pv. oryzicola genes potentially involved in pathogenesis in rice.
Chen et al., Nanjing, China. In Microbiology, 2012
The 13 Vir(-)/HR(+) mutants included tal-C10c-like (a transcriptional activator-like TAL effector), rpfC (regulator of pathogenicity factors), oxyR (oxidative stress transcriptional regulator), dsbC (disulfide isomerase), opgH (glucan biosynthesis glucosyltransferase H), rfbA (glucose-1-phosphate thymidylyltransferase), amtR (aminotransferase), purF (amidophosphoribosyltransferase), thrC (threonine synthase), trpA (tryptophan synthase alpha subunit) and three genes encoding hypothetical proteins (Xoryp_02235, Xoryp_00885 and Xoryp_22910).
Stable isotope dilution mass spectrometric assay for PRPP using enzymatic procedures.
Ichida et al., Tokyo, Japan. In Nucleosides Nucleotides Nucleic Acids, 2011
A method for the measurement of PRPP in erythrocytes was designed, which is based on the determination of [(13)C(5)]glutamate derived from [(13)C(5)]glutamine following the utilization of PRPP by the action of amidophosphoribosyltransferase.
[High efficient gene knockout in Verticillium dahliae].
Dai et al., Beijing, China. In Wei Sheng Wu Xue Bao, 2011
RESULTS: Gene knockout frequency for ADE4 and ChsV was 87% and 44% , respectively.
A link between impaired purine nucleotide synthesis and apoptosis in Drosophila melanogaster.
Clark et al., Fredericton, Canada. In Genetics, 2011
Data show the presence of apoptosis at the cellular level in both ade2 and Prat mutants, and the upregulated gene HtrA2, which encodes an apoptosis effector and is thus a candidate for initiating apoptosis in response to purine depletion.
The plant PRAT proteins - preprotein and amino acid transport in mitochondria and chloroplasts.
Philippar et al., Martinsried, Germany. In Plant Biol (stuttg), 2010
The membrane proteins of the plant preprotein and amino acid transporter (PRAT) superfamily all share common structural elements, such as four membrane-spanning alpha-helices.
Modifiers of Prat, a de novo purine synthesis gene, in Drosophila melanogaster.
Clark et al., Fredericton, Canada. In Genome, 2009
whereas Mod(Prat:bw)3-5 suppresses Prat in all stages and tissues examined for both sexes.
Expression pattern diversity and functional conservation between retroposed PRAT genes from Drosophila melanogaster and Drosophila virilis.
Clark et al., Fredericton, Canada. In J Mol Evol, 2008
Data show that the requirement for both Prat and Prat2 in Drosophila is not simply due to differences in protein function. Both genes have developed nonoverlapping patterns of expression, which correlate with their respective loss-of-function phenotypes.
Chemical genetic identification of glutamine phosphoribosylpyrophosphate amidotransferase as the target for a novel bleaching herbicide in Arabidopsis.
Davies et al., Indianapolis, United States. In Plant Physiol, 2007
DAS734 is a potent, slow-binding inhibitor.
The purine synthesis gene Prat2 is required for Drosophila metamorphosis, as revealed by inverted-repeat-mediated RNA interference.
Clark et al., Fredericton, Canada. In Genetics, 2006
Use of Prat and Prat2 double RNA interference causes more severe pupal lethal phenotypes and suggests that Prat and Prat2 have partially additive functions during Drosophila metamorphosis.
The preprotein translocase of the mitochondrial inner membrane: function and evolution.
Soll et al., Freiburg, Germany. In J Mol Biol, 1999
Moreover, they show a sequence similarity to OEP16, a channel-forming amino acid transporter in the outer envelope of chloroplasts, and to LivH, a component of a prokaryotic amino acid permease, defining a new PRAT-family of preprotein and amino acid transporters.
[Metabolism of purine nucleotides and the production of uric acid].
Itakura et al., Tokushima, Japan. In Nihon Rinsho, 1996
The metabolic rate of purine nucleotide biosynthesis is chiefly determined by the regulation of the de novo pathway, especially amidophosphoribosyltransferase and PRPP synthetase, and the accumulation of uric acid results from the acceleration of de novo biosynthesis and catabolism of purine nucleotide or the decrease in urinary excretion of uric acid.
share on facebooktweetadd +1mail to friends