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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Aristaless-like homeobox 3

Alx3, ALX homeobox 3
This gene encodes a nuclear protein with a homeobox DNA-binding domain that functions as a transcriptional regulator involved in cell-type differentiation and development. Preferential methylation of this gene's promoter is associated with advanced-stage neuroblastoma tumors. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, V1a, Midline, Insulin, TRAF4
Papers on Alx3
Glucose-dependent downregulation of glucagon gene expression mediated by selective interactions between ALX3 and PAX6 in mouse alpha cells.
New
Vallejo et al., Madrid, Spain. In Diabetologia, Feb 2016
Here, we investigated the role of the transcription factor aristaless-like homeobox 3 (ALX3) as a glucose-dependent modulator of PAX6 activity in alpha cells.
Catalytic behaviour in the ring-opening polymerisation of organoaluminiums supported by bulky heteroscorpionate ligands.
New
Rodríguez et al., Ciudad Real, Spain. In Dalton Trans, Aug 2015
Thus, the treatment of AlX3 (X = Me, Et) with bulky acetamide or thioacetamide heteroscorpionate ligands nbptamH (1) [nbptamH = N-naphthyl-2,2-bis(3,5-dimethylpyrazol-1-yl)thioacetamide], fbpamH (2) [fbpamH = N-fluorenyl-2,2-bis(3,5-dimethylpyrazol-1-yl)acetamide], ptbptamH (3) [ptbptamH = N-phenyl-2,2-bis(3,5-di-tert-butylpyrazol-1-yl)thioacetamide], ntbptamH (4) [ntbptamH = N-naphthyl-2,2-bis(3,5-di-tert-butylpyrazol-1-yl)thioacetamide], ptbpamH (5) [ptbpamH = N-phenyl-2,2-bis(3,5-di-tert-butylpyrazol-1-yl)acetamide] and (S)-mtbpamH (6) [(S)-mtbpamH = (S)-(−)-N-α-methylbenzyl-2,2-bis(3,5-di-tert-butylpyrazol-1-yl)acetamide] for 1 hour at 0 °C afforded the dialkyl aluminium complexes [AlX2{κ(2)-nbptam}] (X = Me 7, Et 8), [AlX2{κ(2)-fbpam}] (X = Me 9, Et 10), [AlX2{κ(2)-ptbptam}] (X = Me 11, Et 12), [AlX2{κ(2)-ntbptam}] (X = Me 13, Et 14), [AlX2{κ2(-)ptbpam}] (X = Me 15, Et 16) and [AlX2{κ(2)-(S)-mtbpam}] (X = Me 17, Et 18).
Phosphine complexes of aluminium(III) halides - preparation and structural and spectroscopic systematics.
Reid et al., Southampton, United Kingdom. In Dalton Trans, 2014
Six-coordinate pseudo-octahedral complexes trans-[AlX2(L-L)2][AlX4] (X = Cl, Br or I; L-L = o-C6H4(PMe2)2, Me2P(CH2)2PMe2) are produced from reaction of AlX3 with the diphosphine in CH2Cl2 (X = Cl) or toluene (X = Br or I) solution.
Pdx1 and USF transcription factors co-ordinately regulate Alx3 gene expression in pancreatic β-cells.
Vallejo et al., In Biochem J, 2014
The homeodomain transcription factor Alx3 (aristaless-like homeobox 3) expressed in pancreatic islets participates in the regulated expression of several islet genes, and its deficiency in mice leads to islet cell apoptosis and glucose intolerance.
LRP2 mediates folate uptake in the developing neural tube.
Hammes et al., Berlin, Germany. In J Cell Sci, 2014
Moreover, the folic-acid-dependent gene Alx3 is significantly downregulated in Lrp2 mutants.
Validation of nucleolar protein 4 as a novel methylated tumor suppressor gene in head and neck cancer.
Califano et al., İstanbul, Turkey. In Oncol Rep, 2014
In the present study, we assessed the association of epigenetic alterations of a panel of 12 genes [nucleolar protein 4 (NOL4), iroquois homeobox 1 (IRX1), SLC5A8, LRRC3B, FUSSEL18, EBF3, GBX2, HMX2, SEPT9, ALX3, SOCS3 and LHX6] with head and neck squamous cell carcinoma (HNSCC) via a candidate gene approach.
Potocki-Shaffer deletion encompassing ALX4 in a patient with frontonasal dysplasia phenotype.
Martinet et al., Bellinzona, Switzerland. In Am J Med Genet A, 2014
Only a small number of genes have been associated with FND phenotypes until now, the first gene being EFNB1, related to craniofrontonasal syndrome (CFNS) with craniosynostosis in addition, and more recently the aristaless-like homeobox genes ALX3, ALX4, and ALX1, which have been related with distinct phenotypes named FND1, FND2, and FND3 respectively.
Mosaic small supernumerary marker chromosome 1 at amniocentesis: prenatal diagnosis, molecular genetic analysis and literature review.
Review
Wang et al., Taipei, Taiwan. In Gene, 2013
We discuss the genotype-phenotype correlation of the involved genes of ALX3, RBM15, NTNG1, SLC25A24, GPSM2, TBX15 and NOTCH2 in this case.
Activation of H2 using P/Al based frustrated Lewis pairs and reactions with olefins.
Stephan et al., Toronto, Canada. In Dalton Trans, 2013
The activation of H2 using Mes3P-AlX3 (X = Cl, Br, I) FLPs was investigated.
One-dimensional infinite chain structures of [Al2(OH)4(H2O)4]X2 (X = I, Br, Cl): an aggregate of Al2 species and a precursor of Al(OH)3.
Wang et al., Hohhot, China. In Dalton Trans, 2013
These crystallize in the same monoclinic system and the same C2/c space group with different unit cell parameters from spontaneously hydrolyzed solutions of AlX3.
CO2 reduction via aluminum complexes of ammonia boranes.
Stephan et al., Toronto, Canada. In Dalton Trans, 2013
Reactions of amine-boranes NH3BH3, Me2NHBH3, or Me3NBH3 with AlX3 (X = Cl, Br, I, C6F5) have been examined.
Vertical transmission of a frontonasal phenotype caused by a novel ALX4 mutation.
Passos-Bueno et al., São Paulo, Brazil. In Am J Med Genet A, 2013
Its etiology is still poorly understood but recently frontonasal dysplasia phenotypes were linked to loss-of-function mutations in the ALX homeobox gene family, which comprises the ALX1, ALX3, and ALX4 genes.
Differential configurations involving binding of USF transcription factors and Twist1 regulate Alx3 promoter activity in mesenchymal and pancreatic cells.
Vallejo et al., Madrid, Spain. In Biochem J, 2013
During embryonic development, the aristaless-type homeodomain protein Alx3 is expressed in the forehead mesenchyme and contributes to the regulation of craniofacial development.
Defective neural crest migration revealed by a Zebrafish model of Alx1-related frontonasal dysplasia.
Takahashi et al., Manchester, United Kingdom. In Hum Mol Genet, 2013
In contrast, mutations of Alx3 or Alx4 cause milder forms of FND.
BMP-2 Induced Expression of Alx3 That Is a Positive Regulator of Osteoblast Differentiation.
Kamijo et al., Tokyo, Japan. In Plos One, 2012
We focused on Alx3 (aristaless-like homeobox 3) which was clearly induced during osteoblast differentiation.
Clinical and genetic characterization of frontorhiny: report of 3 novel cases and discussion of the surgical management.
GeneRIF
Tollefson et al., Sacramento, United States. In Arch Facial Plast Surg, 2011
We report a novel Y214X mutation in ALX3 in frontorhiny.
The aristaless-like homeobox protein Alx3 as an etiopathogenic factor for diabetes mellitus.
GeneRIF
Vallejo, Madrid, Spain. In Islets, 2011
ALX3 could be considered as a candidate gene for the etiopathogenesis of diabetes or its complications during embryonic or fetal development is discussed
Alx3-deficient mice exhibit decreased insulin in beta cells, altered glucose homeostasis and increased apoptosis in pancreatic islets.
GeneRIF
Vallejo et al., Madrid, Spain. In Diabetologia, 2011
ALX3 participates in the regulation of the expression of essential genes for the function of pancreatic islets, and its deficiency alters the regulation of glucose homeostasis in vivo.
Alx3-deficient mice exhibit folic acid-resistant craniofacial midline and neural tube closure defects.
GeneRIF
Vallejo et al., Madrid, Spain. In Dev Biol, 2010
Alx3-deficient mice exhibit folic acid-resistant craniofacial midline and neural tube closure defects.
Frontorhiny, a distinctive presentation of frontonasal dysplasia caused by recessive mutations in the ALX3 homeobox gene.
GeneRIF
Wilkie et al., Oxford, United Kingdom. In Am J Hum Genet, 2009
ALX3 is essential for normal facial development in humans and that deficiency causes a clinically recognizable phenotype, which we term frontorhiny.
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