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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Insulin-like growth factor binding protein, acid labile subunit

Als, IGFALS, AHAS
The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, STEP, Insulin-Like Growth Factor I
Papers on Als
Retention, molecular evolution and expression divergence of the auxin/indole acetic acid and auxin response factor gene families in Brassica rapa shed light on their evolution patterns in plants.
New
Hou et al., Nanjing, China. In Genome Biol Evol, Jan 2016
In addition, ALs existed widely and had a closer relationship with ARFs, suggesting that ALs might be the initial structure of ARFs.
Morphological characterization of the antennal lobes in the Mediterranean fruit fly Ceratitis capitata.
New
Crnjar et al., Monserrato, Italy. In J Comp Physiol A Neuroethol Sens Neural Behav Physiol, Jan 2016
The ALs in C. capitata are organized in glomeruli which are more tightly packed in the anterior part than the posterior one.
Quantitative expression of regulatory and differentiation-related genes in the key steps of human hematopoiesis: The LeukoStage Database.
New
Hrušák et al., Praha, Czech Republic. In Differentiation, Jan 2016
At various stages of maturation, the cells may change pathologically, leading to diseases including acute leukemias (ALs).
Structure and function of insulin-like growth factor acid-labile subunits in mammalian homologues.
Review
New
Jiazhong et al., Chengdu, China. In Yi Chuan, Dec 2015
However, the functional study of insulin-like growth factor acid-labile subunit (IGFALS) mainly focused on the prolonging half-life of IGFs.
Atypical defects resulting in growth hormone insensitivity.
New
de Luca et al., Leiden, Netherlands. In Growth Horm Igf Res, Dec 2015
UNASSIGNED: Besides four well-documented genetic causes of GH insensitivity (GHI) (GHR, STAT5B, IGF1, IGFALS defects), several other congenital and acquired conditions are associated with GHI.
MECHANISMS IN ENDOCRINOLOGY: Novel genetic causes of short stature.
Review
New
Kant et al., Leiden, Netherlands. In Eur J Endocrinol, Dec 2015
Besides well-defined causes of GH insensitivity (GHR, STAT5B, IGFALS, IGF1 defects), disorders of NFκB signalling, STAT3 and IGF2 have recently been discovered.
Roseovarius atlanticus sp. nov., isolated from surface seawater of the Atlantic Ocean.
New
Yan et al., Harbin, China. In Int J Syst Evol Microbiol, Dec 2015
Diphosphatidylglycerol (DPG), phosphatidylglycerol (PG), phosphatidylcholine (PC), phosphatidylethanolamine (PE), two aminolipids (ALs), two phospholipids (PLs) were present.
Systematic review of preoperative, intraoperative and postoperative risk factors for colorectal anastomotic leaks.
Review
New
Winter et al., Dublin, Ireland. In Br J Surg, Apr 2015
The objective was to perform a systematic review of the literature, focusing on the role of preoperative, intraoperative and postoperative factors in the development of colorectal ALs.
The Candida albicans agglutinin-like sequence family of adhesins: functional insights gained from structural analysis.
Review
Hoyer et al., Urbana, United States. In Future Microbiol, 2014
Candida albicans adhesion is mediated by a number of proteins including those in the Als (agglutinin-like sequence) family, which have been studied intensively.
Resistance to AHAS inhibitor herbicides: current understanding.
Review
Powles et al., Australia. In Pest Manag Sci, 2014
Acetohydroxyacid synthase (AHAS) inhibitor herbicides currently comprise the largest site-of-action group (with 54 active ingredients across five chemical groups) and have been widely used in world agriculture since they were first introduced in 1982.
Enhancement of anion binding in lanthanide optical sensors.
Impact
Ponce et al., Pasadena, United States. In Acc Chem Res, 2013
In this Account, we show that selected ALs in lanthanide/anion systems greatly improve sensor performance for medical, planetary science, and biodefense applications.
Genetic analysis of short children with apparent growth hormone insensitivity.
GeneRIF
Losekoot et al., Leiden, Netherlands. In Horm Res Paediatr, 2011
Heterozygous STAT5B mutations, with or without heterozygous IGFALS defects, may be associated with growth hormone insensitivity.
Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model.
Impact
Krainer et al., New York City, United States. In Nature, 2011
Furthermore, neonatal SMA mice had decreased hepatic Igfals expression, leading to a pronounced reduction in circulating insulin-like growth factor 1 (IGF1), and ASO-10-27 treatment restored IGF1 to normal levels.
Case report: low circulating IGF-I levels due to Acid-Labile Subunit deficiency in adulthood are not associated with early development of atherosclerosis and impaired heart function.
GeneRIF
Twickler et al., Amsterdam, Netherlands. In Growth Horm Igf Res, 2011
low circulating IGF-I levels due to Acid-Labile Subunit deficiency in adulthood are not associated with early development of atherosclerosis and impaired heart function.
Evidence for a continuum of genetic, phenotypic, and biochemical abnormalities in children with growth hormone insensitivity.
Review
Impact
Savage et al., London, United Kingdom. In Endocr Rev, 2011
The role and mechanisms of the GH-IGF-I axis in normal human growth is discussed, followed by descriptions of mutations in GHR, STAT5B, PTPN11, IGF1, IGFALS, IGF1R, and GH1 defects causing bioinactive GH or anti-GH antibodies.
D440N mutation in the acid-labile subunit of insulin-like growth factor complexes inhibits secretion and complex formation.
GeneRIF
Baxter et al., Sydney, Australia. In Mol Endocrinol, 2011
D440N mutation in ALS generates a hyperglycosylated form with impaired secretion and complex formation, potentially leading to dysregulation of endocrine IGF, thus contributing to growth retardation
Acid-labile subunit (ALS) gene expression and protein content in human placentas: differences according to birth weight.
GeneRIF
Cassorla et al., Santiago, Chile. In J Clin Endocrinol Metab, 2011
We describe that the human placenta expresses the mRNA and the protein for ALS, and we observed an increase in ALS mRNA expression and protein content in small compared with appropriate for gestational age placentas.
Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer.
GeneRIF
Kraft et al., Boston, United States. In Cancer Epidemiol Biomarkers Prev, 2010
Common genetic variation in the IGF1 and SSTR5 genes seems to influence circulating IGF-I levels
Dispelling myths in the treatment of hepatic encephalopathy.
Impact
Jalan et al., London, United Kingdom. In Lancet, 2005
Bodils Als-Nielsen and colleagues, in a systematic review of randomised trials, found insufficient evidence about whether non-absorbable disaccharides are beneficial (BMJ 2004; 328: 1046-50).
Engineering herbicide-resistant maize using chimeric RNA/DNA oligonucleotides.
Impact
Baszczynski et al., Mangochi, Malawi. In Nat Biotechnol, 2000
A precise single-point mutation was introduced into genes encoding acetohydroxyacid synthase (AHAS), at a position known to confer imidazolinone resistance.
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