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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Cholinergic receptor, nicotinic, alpha polypeptide 7

Top mentioned proteins: CAN, V1a, beta2, HAD, ACID
Papers on alpha7
The many neuroprogressive actions of tryptophan catabolites (TRYCATs) that may be associated with the pathophysiology of neuro-immune disorders.
Maes et al., Geelong, Australia. In Curr Pharm Des, Jan 2016
The neuroprotective functions of this TRYCAT are likely exercised via engagement with alpha7 nicotinic acetylcholine and aryl hydrocarbon receptors but the neuroprotective effects stemming from elevated kynurenic acid levels come at the price of severely compromised neurocognitive function and emotional processing.
The Dietary Flavonoid Rhamnetin Inhibits Both Inflammation and Excitotoxicity During Ethanol Withdrawal in Rat Organotypic Hippocampal Slice Cultures.
Littleton et al., Lexington, United States. In Alcohol Clin Exp Res, Dec 2015
The aim of this study was to evaluate the anti-inflammatory and neuroprotective potential of rhamnetin, a dietary flavonoid with alpha7 nAChR selective activity, in an in vitro model of EtOH-induced neurotoxicity.
Effect of GTS-21, An Alpha7 Nicotinic Acetylcholine Receptor Agonist, on Clp-Induced Inflammatory, Gastrointestinal Motility and Colonic Permeability Changes in Mice.
De Winter et al., Leuven, Belgium. In Shock, Dec 2015
In this respect, selective alpha7 nicotinic acetylcholine receptor (α7nAChR) agonists have shown anti-inflammatory properties in several animal models of inflammation.
The keystone of Alzheimer pathogenesis might be sought in Aβ physiology.
Palmeri et al., Catania, Italy. In Neuroscience, Nov 2015
Here we propose a model interpreting AD pathogenesis as an alteration of the negative feedback loop between Aβ and its physiological receptors, focusing on alpha7 nicotinic acetylcholine receptors (α7-nAchRs).
Anti-inflammatory role of microglial alpha7 nAChRs and its role in neuroprotection.
Lopez et al., Madrid, Spain. In Biochem Pharmacol, Nov 2015
Nicotinic acetylcholine receptors (nAChRs) are widely distributed throughout the central nervous system, being expressed in neurons and non-neuronal cells, where they participate in a variety of physiological responses like memory, learning, locomotion, attention, among others.
Neuroprotective effect of cellular prion protein (PrPC) is related with activation of alpha7 nicotinic acetylcholine receptor (α7nAchR)-mediated autophagy flux.
Park et al., Chŏnju, South Korea. In Oncotarget, Oct 2015
Activation of the alpha7 nicotinic acetylcholine receptor (α7nAchR) is regulated by prion protein (PrPC) expression and has a neuroprotective effect by modulating autophagic flux.
Schizophrenia drug discovery and development in an evolving era: are new drug targets fulfilling expectations?
Brandon et al., Cambridge, United States. In J Psychopharmacol, Feb 2015
Specifically, compounds selectively targeting the metabotropic glutamate receptor 2/3 subtype, phosphodiesterase subtype 10, glycine transporter subtype 1 and the alpha7 nicotinic acetylcholine receptor have been the subject of intense drug discovery and development efforts.
Dose-dependent protective effect of nicotine in a murine model of viral myocarditis induced by coxsackievirus B3.
Yue-Chun et al., Wenzhou, China. In Sci Rep, 2014
The alpha 7 nicotinic acetylcholine receptor (alpha7 nAChR) was recently described as an anti-inflammatory target in various inflammatory diseases.
Alpha7 neuronal nicotinic receptor: a pluripotent target for diseases of the central nervous system.
Stachowiak et al., Winston-Salem, United States. In Cns Neurol Disord Drug Targets, 2013
In addition research and development of novel drugs has also promoted an intense debate on the role of activation, desensitization, β -amyloid oligomers, glutamate, and alpha7 nAChR, in cognition, neuronal survival, and neurodegeneration.
Beyond acetylcholinesterase inhibitors for treating Alzheimer's disease: α7-nAChR agonists in human clinical trials.
Cesario et al., Roma, Italy. In Curr Pharm Des, 2013
The neuronal nicotinic alpha7-acetylcholine receptor (α7-nAChR) is a promising and attractive drug target for improving cognitive deficits in neuropsychiatric and neurological disorders such as Alzheimer's disease (AD).
Cholinergic coordination of presynaptic and postsynaptic activity induces timing-dependent hippocampal synaptic plasticity.
Yakel et al., United States. In J Neurosci, 2012
Correlated Chrna7 input coordinates presynaptic and postsynaptic activities to induce timing-dependent synaptic plasticity, providing a novel mechanism by which neuromodulators precisely modulate network activity and plasticity.
The effect of crebanine on memory and cognition impairment via the alpha-7 nicotinic acetylcholine receptor.
Vajragupta et al., Bangkok, Thailand. In Life Sci, 2012
analysis of the effect of crebanine on memory and cognition impairment via the alpha-7 nicotinic acetylcholine receptor
Stroke-induced activation of the α7 nicotinic receptor increases Pseudomonas aeruginosa lung injury.
Pittet et al., San Francisco, United States. In Faseb J, 2012
genetic deletion of the alpha7nAChR significantly (P<0.05) attenuates the effect of prior stroke on lung injury and mortality caused by P. aeruginosa pneumonia
Sperm epidermal growth factor receptor (EGFR) mediates α7 acetylcholine receptor (AChR) activation to promote fertilization.
Breitbart et al., Ramat Gan, Israel. In J Biol Chem, 2012
activation of alpha7 by ZP leads to SFK-dependent EGFR activation, Ca(2+) influx, and the acrosome reaction
Nicotinic receptor Alpha7 expression during tooth morphogenesis reveals functional pleiotropy.
Gahring et al., Salt Lake City, United States. In Plos One, 2011
distinct and varied spatiotemporal expression of alpha7 during tooth development
The vagus nerve and the nicotinic anti-inflammatory pathway.
Ulloa, North Bay Shore, United States. In Nat Rev Drug Discov, 2005
Recent studies indicate that the vagus nerve (which is the longest of the cranial nerves and innervates most of the peripheral organs) can modulate the immune response and control inflammation through a 'nicotinic anti-inflammatory pathway' dependent on the alpha7-nicotinic acetylcholine receptor (alpha7nAChR).
Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway.
Boeckxstaens et al., Amsterdam, Netherlands. In Nat Immunol, 2005
the vagal anti-inflammatory pathway acts by alpha7 subunit-mediated Jak2-STAT3 activation
Evidence for ectopic neurotransmission at a neuronal synapse.
Sejnowski et al., Los Angeles, United States. In Science, 2005
At cholinergic synapses in the chick ciliary ganglion, however, membrane formations and physiological measurements suggest that release distant from postsynaptic densities can activate the predominantly extrasynaptic alpha7 nicotinic receptor subtype.
Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics.
Springer et al., Boston, United States. In Nature, 2004
Allostery in the beta3 I domain alters three metal binding sites, associated loops and alpha1- and alpha7-helices.
Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis.
Ulloa et al., North Bay Shore, United States. In Nat Med, 2004
Nicotinic stimulation prevents activation of the NF-kappaB pathway and inhibits HMGB1 secretion through a specific 'nicotinic anti-inflammatory pathway' that requires the alpha7 nicotinic acetylcholine receptor (alpha7nAChR).
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