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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Adrenergic receptor, alpha 2c

alpha2C
Top mentioned proteins: alpha2A, alpha2B, ADRA2C, HAD, Alpha-1
Papers on alpha2C
Detecting a dexmedetomidine-evoked reduction of noradrenaline release in the human brain with the alpha2C-adrenoceptor PET ligand [(11) C]ORM-13070.
New
Scheinin et al., Turku, Finland. In Synapse, Feb 2016
PET imaging can for some neurotransmitters be used to measure synaptic neurotransmitter concentrations.
Brexpiprazole for the Treatment of Schizophrenia: A Review of this Novel Serotonin-Dopamine Activity Modulator.
Review
New
Citrome et al., In Clin Schizophr Relat Psychoses, Dec 2015
Brexpiprazole acts as a partial agonist at dopamine D2 and serotonin 5-HT1A receptors, and as an antagonist at serotonin 5-HT2A and at adrenergic alpha1B and alpha2C receptors.
Validation of [(11) C]ORM-13070 as a PET tracer for alpha2c -adrenoceptors in the human brain.
New
Scheinin et al., Turku, Finland. In Synapse, Mar 2015
This study explored the use of the α2C -adrenoceptor PET tracer [(11) C]ORM-13070 to monitor α2C -AR occupancy in the human brain.
Lurasidone in the treatment of schizophrenia: a critical evaluation.
Review
Tandon et al., Gainesville, United States. In Expert Opin Pharmacother, 2014
EXPERT OPINION: Lurasidone is a benzoisothiazole with potent dopamine D2 and serotonin 5HT2A antagonist and serotonin 5HT1A partial agonist properties (like other second-generation antipsychotic agents) with additional potent 5HT7 and alpha2C noradrenergic antagonism.
Anti-Parkinson effects of a selective alpha2C-adrenoceptor antagonist in the MPTP marmoset model.
Drinkenburg et al., Rijswijk, Netherlands. In Behav Brain Res, 2014
Here the putative anti-Parkinson effects of the oral selective alpha2C-adrenoceptor antagonist (JNJ27063699 0.1-10mg/kg p.o.) and of vehicle (fruit syrup) were evaluated in the MPTP-marmoset model.
Alpha2C-adrenoceptors play a prominent role in sympathetic constriction of porcine pulmonary arteries.
Pertz et al., Berlin, Germany. In Naunyn Schmiedebergs Arch Pharmacol, 2012
Enhanced pulmonary vasoconstriction in response to injuries of the central nervous system and hypoxia result in pulmonary edema due to increased sympathetic activation.
α2-Adrenergic receptor distribution and density within the nucleus tractus solitarii of normotensive and hypertensive rats during development.
GeneRIF
Fior-Chadi et al., Santo André, Brazil. In Auton Neurosci, 2012
In summary, our results highlight the importance of alpha(2R) distribution within the NTS regarding the neural control of blood pressure and the development of hypertension.
A QSAR study using MTD method and Dragon descriptors for a series of selective ligands of α2C adrenoceptor.
Mracec et al., Timişoara / Temesvár, Romania. In Eur J Med Chem, 2011
A QSAR (quantitative structure-activity relationship) analysis of the binding affinities for a series of 43 quinoline derivatives active against the alpha2C adrenergic receptor was performed.
Double disruption of α2A- and α2C-adrenoceptors results in sympathetic hyperactivity and high-bone-mass phenotype.
GeneRIF
Gouveia et al., São Paulo, Brazil. In J Bone Miner Res, 2011
These findings suggest that beta(2)-AR is not the single adrenoceptor involved in bone turnover regulation and show that alpha(2)-AR signaling also may mediate the sympathetic nervous system actions in the skeleton.
Interaction between alpha(1)- and alpha(2)-adrenoreceptors contributes to enhanced constrictor effects of norepinephrine in mesenteric veins compared to arteries.
GeneRIF
Galligan et al., Praha, Czech Republic. In Eur J Pharmacol, 2010
Data indicate that alpha2C- and alpha1D- adrenoceptors interact to enhance adrenergic reactivity (norepinephrine-induced constriction) of mesenteric veins but not in mesenteric arteries.
Aerobic exercise training improves skeletal muscle function and Ca2+ handling-related protein expression in sympathetic hyperactivity-induced heart failure.
Brum et al., São Paulo, Brazil. In J Appl Physiol, 2010
A cohort of male 5-mo-old wild-type (WT) and congenic alpha2A/alpha2C adrenoceptor knockout (ARKO) mice in a C57BL/6J genetic background were randomly assigned into untrained and trained groups.
Functional linkage as a direction for studies in oxidative stress: alpha-adrenergic receptors.
Review
Grover et al., Hamilton, Canada. In Can J Physiol Pharmacol, 2010
They are G protein-coupled receptors that may be broadly classified into alpha1 (subclasses alpha1A, alpha1B, alpha1D) and alpha2 (subclasses alpha2A, alpha2B, alpha2C).
Exercise training reduces cardiac angiotensin II levels and prevents cardiac dysfunction in a genetic model of sympathetic hyperactivity-induced heart failure in mice.
GeneRIF
Brum et al., São Paulo, Brazil. In Eur J Appl Physiol, 2009
Exercise training decreased alpha(2A)/alpha(2C)adrenoceptor lacking mice's cardiac angiotensin II levels and angiotensin-converting enzyme activity.
Alpha2-adrenoceptor subtypes--unexpected functions for receptors and ligands derived from gene-targeted mouse models.
Review
Hein et al., Freiburg, Germany. In Neurochem Int, 2007
Studies with gene-targeted mice carrying deletions in the genes encoding alpha2A-, alpha2B- or alpha2C-adrenoceptors have provided new insight into adrenergic receptor biology: (1) In principle, all three alpha2-receptor subtypes may operate as presynaptic inhibitory feedback receptors to control the release of noradrenaline and adrenaline or other transmitters from neurons.
Role of alpha2C-adrenoceptors in the reduction of skin blood flow induced by local cooling in mice.
GeneRIF
Ishikawa et al., Shizuoka, Japan. In Br J Pharmacol, 2007
Local cooling-induced reduction of skin blood flow in mice primarily results from increased reactivity of alpha (2C)-adrenoceptors to circulating catecholamines, in which the Rho/Rho kinase pathway is involved.
[Development of heart failure in the course of coronary artery disease--the role of genetic factors].
Review
Musiał et al., Białystok, Poland. In Kardiol Pol, 2005
Other genetic factors, which may affect are different gene variants of adrenergic receptors (beta1, beta2, alpha2C), AMP deaminase-1, endothelin-1, endothelial nitric oxide syntase, precursors of natriuretic peptides and inflammatory factors (TNF-alpha, IL-6, MCP-1, TGF, MMP-2).
Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure.
Impact
Liggett et al., Cincinnati, United States. In N Engl J Med, 2002
In transfected cells, a polymorphic alpha2C-adrenergic receptor (alpha2CDel322-325) has decreased function, and a variant of the beta1-adrenergic receptor (beta1Arg389) has increased function.
Vascular adrenoceptors: an update.
Review
Impact
Moura et al., Porto, Portugal. In Pharmacol Rev, 2001
Instead, the endothelium is an important organ possessing at least five different adrenoceptor subtypes (alpha2A/D, alpha2C, beta1, beta2, and beta3), which either directly or through the release of nitric oxide actively participate in the regulation of the vascular tone.
Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission.
Impact
Kobilka et al., Würzburg, Germany. In Nature, 1999
Alpha2-adrenergic receptors are known to have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system; however, the individual roles of the three highly homologous alpha2-adrenergic-receptor subtypes (alpha2A, alpha2B, alpha2C) in this process are not known.
Cardiovascular regulation in mice lacking alpha2-adrenergic receptor subtypes b and c.
Impact
Kobilka et al., Stanford, United States. In Science, 1996
The role of specific alpha2AR subtypes (alpha2a, alpha2b, and alpha2c) was characterized with hemodynamic measurements obtained from strains of genetically engineered mice deficient in either alpha2b or alpha2c receptors.
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