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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Adrenergic receptor, alpha 2b

alpha2B
Top mentioned proteins: HAD, alpha2A, Interferon-alpha, CAN, alpha2C
Papers on alpha2B
Sustained viral response and treatment-induced cytopenia correlate with SLCs and KLF12 genotypes in interferon/ribavirin-treated Chinese chronic hepatitis C patients.
New
Niu et al., Changchun, China. In J Gastroenterol Hepatol, Feb 2016
357 CHC patients received recombinant interferon-alpha2b/ribavirin (IFN-α2b/RBV) treatment and 175 patients were chosen for analysis of drug-induced cytopenia.
MULTIPLEX PCR ASSAY FOR DETECTION OF HUMAN SOMATOTROPIN AND INTERFERON ALPHA2b GENES IN PLANT MATERIAL.
New
Kuchuk et al., In Tsitol Genet, May 2015
Here we describe a multiplex PCR protocol for revealing of two human genes (encoding growth hormone and interferon alpha2b) that have been successfully introduced into plant genomes.
Immunomodulated anterior chemotherapy followed by concurrent chemoradiotherapy in locally advanced tongue cancer: An Institutional experience.
Biswas et al., Calcutta, India. In Indian J Med Paediatr Oncol, 2015
CONTEXT: Sequential induction chemotherapy with cisplatin and 5-fluorouracil (PF) along with interferon-alpha2b and concurrent chemoradiation offers superior loco-regional control for locally advanced carcinoma of oral tongue.
[Immune diagnostics of disorders in the IFN-alpha/NK-cell system in patients with frequently recurrent herpes simplex].
Karaulov et al., In Zh Mikrobiol Epidemiol Immunobiol, 2014
MC were cultivated in the presence of a recombinant human IFN-alpha2b at the concentration of 10, 100 and 1000 U/ml for 24 hours.
Superoxide dismutase activity in transgenic canola.
Slyvets et al., In Tsitol Genet, 2014
Superoxide dismutase (SOD) activity was investigated in leaves of transgenic canola plants which expressed heterologous genes of different origin, namely 1) herbicide resistance genes (bar and simultaneously bar and epsps); 2) DesC desaturase gene (desC) of cyanobacterium Synechococcus vulcanus; 3) human interferon alpha2b gene (huLFN-alpha2b); 4) esxA::fbpB(deltaTMD) fused gene, encoding ESAT-6 and Ag85b Mycobacterium tuberculosis proteins, inducing immune response against tuberculosis; 5) cyp11A1 gene of cytochrome P450(scc) from bovine adrenal cortex mitochondria.
Tuning to the significant: neural and genetic processes underlying affective enhancement of visual perception and memory.
Review
Todd et al., Canada. In Behav Brain Res, 2014
We focus on differences arising from a variant of the ADRA2b gene, which codes for the alpha2b adrenoreceptor as a way of investigating influences of NE availability on ABA in humans.
Adenosine A₂B receptor agonism inhibits neointimal lesion development after arterial injury in apolipoprotein E-deficient mice.
GeneRIF
Ijzerman et al., Leiden, Netherlands. In Arterioscler Thromb Vasc Biol, 2012
Activation of the adenosine A(2B) receptor protects against vascular injury, while it also enhances plaque stability as indicated by increased collagen content.
Contributions of A2A and A2B adenosine receptors in coronary flow responses in relation to the KATP channel using A2B and A2A/2B double-knockout mice.
GeneRIF
Mustafa et al., Morgantown, United States. In Am J Physiol Heart Circ Physiol, 2011
Demonstrate that both A(2A)ARs and A(2B)ARs induce coronary flow changes through K(ATP) channels.
[Autoimmune hemolytic anemia in a case of chronic hepatitis type C 56 weeks after initiation of second line treatment with pegylated interferon alpha2b/ribavirin combination therapy].
Review
Unoura et al., Hakui, Japan. In Nihon Shokakibyo Gakkai Zasshi, 2011
A 49-year-old man with chronic type C hepatitis had agreed to undergo pegylated interferon alpha2b/ribavirin (RBV) combination therapy during 48 weeks, but his hepatitis relapsed.
{Alpha}2B-adrenoceptor deficiency leads to postnatal respiratory failure in mice.
GeneRIF
Hein et al., Freiburg, Germany. In J Biol Chem, 2010
alpha(2B)-adrenoceptors in lung epithelia play an important role in suppressing sonic hedgehog-mediated proliferation of mesenchymal cells and thus prevent respiratory failure
Pegylated interferons alpha2a and alpha2b in the treatment of chronic hepatitis C.
Review
Colombo et al., Milano, Italy. In Nat Rev Gastroenterol Hepatol, 2010
To improve the effectiveness and tolerability of the three times per week therapeutic schedule of IFN, two forms of pegylated interferon (PEG-IFN) were developed in the early 2000s-PEG-IFN-alpha2a and PEG-IFN-alpha2b.
Functional linkage as a direction for studies in oxidative stress: alpha-adrenergic receptors.
Review
Grover et al., Hamilton, Canada. In Can J Physiol Pharmacol, 2010
They are G protein-coupled receptors that may be broadly classified into alpha1 (subclasses alpha1A, alpha1B, alpha1D) and alpha2 (subclasses alpha2A, alpha2B, alpha2C).
Ribavirin monitoring in chronic hepatitis C therapy: anaemia versus efficacy.
Review
François et al., Amiens, France. In Antivir Ther, 2009
The standard treatment of HCV infection with pegylated interferon-alpha2a or -alpha2b and ribavirin is effective in <50% of HCV genotype-1-infected patients.
Hypertension in transgenic mice with brain-selective overexpression of the alpha(2B)-adrenoceptor.
GeneRIF
Gavras et al., Boston, United States. In Am J Hypertens, 2009
Overexpression of the alpha(2B)-AR gene leads to increased production of alpha(2B)-AR protein in brain regions known to regulate central sympathetic outflow, thus resulting in sustained BP elevation.
Albinterferon alpha-2b: a genetic fusion protein for the treatment of chronic hepatitis C.
Review
Impact
McHutchison et al., Rockville, United States. In Nat Biotechnol, 2007
The albumin-fusion platform takes advantage of the long half-life of human albumin to provide a new treatment approach that allows the dosing frequency of IFN-alpha to be reduced in individuals with chronic hepatitis C. Albinterferon alpha-2b (alb-IFN), a recombinant polypeptide composed of IFN-alpha2b genetically fused to human albumin, has an extended half-life and early evidence indicates that it is efficacious and well tolerated.
Upregulation of soluble vascular endothelial growth factor receptor 1 contributes to angiogenesis defects in the placenta of alpha 2B-adrenoceptor deficient mice.
GeneRIF
Hein et al., Freiburg, Germany. In Circ Res, 2007
alpha2B adrenoceptor deficient mice develop a defect in fetal and maternal vessel formation in the placenta.
Low-dose outpatient chemobiotherapy with temozolomide, granulocyte-macrophage colony stimulating factor, interferon-alpha2b, and recombinant interleukin-2 for the treatment of metastatic melanoma.
Impact
Spitler et al., San Francisco, United States. In J Clin Oncol, 2006
PURPOSE: The objective of this study was to further investigate the efficacy and safety of low-dose outpatient chemobiotherapy in patients with unresectable metastatic melanoma.
Vascular adrenoceptors: an update.
Review
Impact
Moura et al., Porto, Portugal. In Pharmacol Rev, 2001
From two types of adrenoceptors (alpha and beta), we have now nine subtypes (alpha1A, alpha1B, alpha1D, alpha2A/D, alpha2B, alpha2A/D, beta1, beta2, and beta3) and two other candidates (alpha1L and beta4), which may be conformational states of alpha1A and beta1-adrenoceptors, respectively.
Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia.
Impact
Davis et al., Houston, United States. In Nat Med, 2000
In the case of chronic myelogenous leukemia (CML), either allogeneic bone marrow transplant (BMT) or interferon-alpha2b (IFN-alpha2b) therapy can result in complete remission, but the mechanism for prolonged disease control is unknown and may involve immune anti-leukemic responses.
Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission.
Impact
Kobilka et al., Würzburg, Germany. In Nature, 1999
Alpha2-adrenergic receptors are known to have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system; however, the individual roles of the three highly homologous alpha2-adrenergic-receptor subtypes (alpha2A, alpha2B, alpha2C) in this process are not known.
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