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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Adrenergic receptor, alpha 2a

Papers on alpha2A
Contributions of A2A and A2B adenosine receptors in coronary flow responses in relation to the KATP channel using A2B and A2A/2B double-knockout mice.
Mustafa et al., Morgantown, United States. In Am J Physiol Heart Circ Physiol, 2011
Demonstrate that both A(2A)ARs and A(2B)ARs induce coronary flow changes through K(ATP) channels.
The antidepressant desipramine is an arrestin-biased ligand at the α(2A)-adrenergic receptor driving receptor down-regulation in vitro and in vivo.
Wang et al., Birmingham, United States. In J Biol Chem, 2011
direct DMI-driven arrestin-mediated alpha(2A)AR down-regulation accounts for the therapeutically desirable but mechanistically unexplained adaptive alterations in receptor expression associated with this antidepressant.
Double disruption of α2A- and α2C-adrenoceptors results in sympathetic hyperactivity and high-bone-mass phenotype.
Gouveia et al., São Paulo, Brazil. In J Bone Miner Res, 2011
These findings suggest that beta(2)-AR is not the single adrenoceptor involved in bone turnover regulation and show that alpha(2)-AR signaling also may mediate the sympathetic nervous system actions in the skeleton.
Sympathetic alpha(2)-adrenoceptors prevent cardiac hypertrophy and fibrosis in mice at baseline but not after chronic pressure overload.
Hein et al., Freiburg, Germany. In Cardiovasc Res, 2010
Adra2a in adrenergic cells are essential feedback inhibitors of sympathetic norepinephrine release to prevent cardiac hypertrophy/fibrosis. Adra2a desensitization by chronic pressure overload may contribute to the pathogenesis of this condition.
The role of the alpha 2A-adrenoceptor in mouse stress-coping behaviour.
Ohl et al., Utrecht, Netherlands. In Psychoneuroendocrinology, 2010
The involvement of the alpha 2A-adrenoceptor, located on mouse chromosome 19, on anxiety-related behaviour remains unclear and will possibly not play a main role in the development of anxiety-related behaviour in mice.
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