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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Adrenergic receptor, alpha 2a

alpha2A
Top mentioned proteins: alpha2B, HAD, alpha2C, CAN, ADRA2A
Papers on alpha2A
Severe immune thrombocytopenia after peg-interferon-alpha2a, ribavirin and telaprevir treatment completion: A case report and systematic review of literature.
New
Mazzella et al., Bologna, Italy. In World J Hepatol, Jul 2015
Here we report the case of a patient with chronic genotype 1b hepatitis C virus (HCV) infection treated with pegylated-interferon alpha-2a, ribavirin and telaprevir for 24 wk; the patient developed severe AITP three weeks after treatment withdrawal.
9A.05: SYMPATHETIC NERVOUS SYSTEM DRIVES RENAL INFLAMMATION BY ALPHA(2A)-ADRENOCEPTORS.
New
Stegbauer et al., Durham, United States. In J Hypertens, Jun 2015
alpha2A-adrenoceptors (alpha2A-AR) in adrenergic neurons are known for regulating sympathetic tone by controlling norepinephrine (NE) release from sympathetic nerve endings by a negative feedback mechanism.
Anti-interferon alpha antibodies and autoantibodies in patients with Behçet's disease uveitis treated with recombinant human interferon alpha-2a.
New
Tugal-Tutkun et al., İstanbul, Turkey. In Graefes Arch Clin Exp Ophthalmol, Mar 2015
BACKGROUND: Recombinant human (rh) interferon alpha2a (IFN-α2a) therapy is successfully used for the treatment of Behçet's disease (BD) uveitis refractory to conventional immunosuppressive treatment.
Lurasidone in the treatment of schizophrenia: a critical evaluation.
Review
Tandon et al., Gainesville, United States. In Expert Opin Pharmacother, 2014
It has little or no activity at the alpha1 and alpha2A noradrenergic, 5HT2C serotonergic, histaminergic and cholinergic receptors.
Effects of low-dose clonidine on cardiovascular and autonomic variables in adolescents with chronic fatigue: a randomized controlled trial.
Wyller et al., Oslo, Norway. In Bmc Pediatr, 2014
We hypothesized that symptoms as well as the underlying pathophysiology might improve by treatment with the alpha2A-adrenoceptor agonist clonidine.
Update on 3-iodothyronamine and its neurological and metabolic actions.
Review
Chiellini et al., Pisa, Italy. In Front Physiol, 2013
With a lower affinity it interacts with alpha2A adrenergic receptors.
Oxidative status and the response to pegylated-interferon alpha2a plus ribavirin in chronic genotype 4 HCV hepatitis.
Gomaa et al., Cairo, Egypt. In Excli J, 2012
Oxidative stress may play a pathogenic role in chronic hepatitis C (CHC).
Guanfacine extended release as adjunctive therapy to psychostimulants in children and adolescents with attention-deficit/hyperactivity disorder.
Review
Childress, Las Vegas, United States. In Adv Ther, 2012
In these patients, clinicians frequently use a combination of psychostimulants and nonscheduled medications to manage ADHD, although published evidence supporting this practice was relatively scarce until recently.Guanfacine extended release (GXR), a selective alpha2A-adrenoceptor agonist, is approved as a monotherapy and adjunctive therapy to psychostimulant medications for ADHD in patients 6-17 years of age.
Contributions of A2A and A2B adenosine receptors in coronary flow responses in relation to the KATP channel using A2B and A2A/2B double-knockout mice.
GeneRIF
Mustafa et al., Morgantown, United States. In Am J Physiol Heart Circ Physiol, 2011
Demonstrate that both A(2A)ARs and A(2B)ARs induce coronary flow changes through K(ATP) channels.
The antidepressant desipramine is an arrestin-biased ligand at the α(2A)-adrenergic receptor driving receptor down-regulation in vitro and in vivo.
GeneRIF
Wang et al., Birmingham, United States. In J Biol Chem, 2011
direct DMI-driven arrestin-mediated alpha(2A)AR down-regulation accounts for the therapeutically desirable but mechanistically unexplained adaptive alterations in receptor expression associated with this antidepressant.
Double disruption of α2A- and α2C-adrenoceptors results in sympathetic hyperactivity and high-bone-mass phenotype.
GeneRIF
Gouveia et al., São Paulo, Brazil. In J Bone Miner Res, 2011
These findings suggest that beta(2)-AR is not the single adrenoceptor involved in bone turnover regulation and show that alpha(2)-AR signaling also may mediate the sympathetic nervous system actions in the skeleton.
Pegylated interferons alpha2a and alpha2b in the treatment of chronic hepatitis C.
Review
Colombo et al., Milano, Italy. In Nat Rev Gastroenterol Hepatol, 2010
To improve the effectiveness and tolerability of the three times per week therapeutic schedule of IFN, two forms of pegylated interferon (PEG-IFN) were developed in the early 2000s-PEG-IFN-alpha2a and PEG-IFN-alpha2b.
Sympathetic alpha(2)-adrenoceptors prevent cardiac hypertrophy and fibrosis in mice at baseline but not after chronic pressure overload.
GeneRIF
Hein et al., Freiburg, Germany. In Cardiovasc Res, 2010
Adra2a in adrenergic cells are essential feedback inhibitors of sympathetic norepinephrine release to prevent cardiac hypertrophy/fibrosis. Adra2a desensitization by chronic pressure overload may contribute to the pathogenesis of this condition.
The role of the alpha 2A-adrenoceptor in mouse stress-coping behaviour.
GeneRIF
Ohl et al., Utrecht, Netherlands. In Psychoneuroendocrinology, 2010
The involvement of the alpha 2A-adrenoceptor, located on mouse chromosome 19, on anxiety-related behaviour remains unclear and will possibly not play a main role in the development of anxiety-related behaviour in mice.
Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes.
Impact
Renström et al., Malmö, Sweden. In Science, 2010
In this locus, Adra2a, encoding the alpha2A-adrenergic receptor [alpha(2A)AR], was significantly overexpressed.
Ribavirin monitoring in chronic hepatitis C therapy: anaemia versus efficacy.
Review
François et al., Amiens, France. In Antivir Ther, 2009
The standard treatment of HCV infection with pegylated interferon-alpha2a or -alpha2b and ribavirin is effective in <50% of HCV genotype-1-infected patients.
Molecules to remember.
Impact
Romo et al., Winston-Salem, United States. In Cell, 2007
In this issue of Cell, Wang et al. (2007) now reveal how a series of molecular events involving alpha2A-adrenoceptors and a class of ion channels gated by cAMP tune the responses of neural circuits that function in working memory in mammals.
Alpha2A-adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex.
Impact
Arnsten et al., New Haven, United States. In Cell, 2007
We report that alpha2A-AR stimulation strengthens WM through inhibition of cAMP, closing Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) channels and strengthening the functional connectivity of PFC networks.
Vascular adrenoceptors: an update.
Review
Impact
Moura et al., Porto, Portugal. In Pharmacol Rev, 2001
From two types of adrenoceptors (alpha and beta), we have now nine subtypes (alpha1A, alpha1B, alpha1D, alpha2A/D, alpha2B, alpha2A/D, beta1, beta2, and beta3) and two other candidates (alpha1L and beta4), which may be conformational states of alpha1A and beta1-adrenoceptors, respectively.
Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission.
Impact
Kobilka et al., Würzburg, Germany. In Nature, 1999
Alpha2-adrenergic receptors are known to have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system; however, the individual roles of the three highly homologous alpha2-adrenergic-receptor subtypes (alpha2A, alpha2B, alpha2C) in this process are not known.
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