Wang et al., Birmingham, United States. In J Biol Chem, 2011
direct DMI-driven arrestin-mediated alpha(2A)AR down-regulation accounts for the therapeutically desirable but mechanistically unexplained adaptive alterations in receptor expression associated with this antidepressant.
Gouveia et al., São Paulo, Brazil. In J Bone Miner Res, 2011
These findings suggest that beta(2)-AR is not the single adrenoceptor involved in bone turnover regulation and show that alpha(2)-AR signaling also may mediate the sympathetic nervous system actions in the skeleton.
Hein et al., Freiburg, Germany. In Cardiovasc Res, 2010
Adra2a in adrenergic cells are essential feedback inhibitors of sympathetic norepinephrine release to prevent cardiac hypertrophy/fibrosis. Adra2a desensitization by chronic pressure overload may contribute to the pathogenesis of this condition.
Ohl et al., Utrecht, Netherlands. In Psychoneuroendocrinology, 2010
The involvement of the alpha 2A-adrenoceptor, located on mouse chromosome 19, on anxiety-related behaviour remains unclear and will possibly not play a main role in the development of anxiety-related behaviour in mice.