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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 02 Oct 2014.

Alpha-2-macroglobulin

alpha2-macroglobulin, MAM, A2M, alpha2M
Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, Alpha-1, AGE
Papers on alpha2-macroglobulin
Identification of α2-macroglobulin as a master inhibitor of cartilage-degrading factors that attenuates the progression of posttraumatic osteoarthritis.
New
Wei et al., Providence, United States. In Arthritis Rheumatol, Jul 2014
In vivo effects on cartilage degeneration and matrix metalloproteinase 13 (MMP-13) concentration were evaluated in male rats (n = 120) randomized to 1 of 4 treatments: 1) anterior cruciate ligament transection (ACLT) and saline injections, 2) ACLT and 1 IU/kg injections of α2 M, 3) ACLT and 2 IU/kg injections of α2 M, or 4) sham operation and saline injections.
Mitochondrial import and degradation of amyloid-β peptide.
Review
New
Glaser et al., Stockholm, Sweden. In Biochim Biophys Acta, Jul 2014
The γ-secretase complex was found in mitochondria-associated endoplasmic reticulum membranes (MAM) suggesting that this could be a potential site of Aβ production, from which Aβ is further transported into the mitochondria.
Reaction pathways and free energy profiles for cholinesterase-catalyzed hydrolysis of 6-monoacetylmorphine.
New
Zhan et al., Dalian, China. In Org Biomol Chem, May 2014
As the most active metabolite of heroin, 6-monoacetylmorphine (6-MAM) can penetrate into the brain for the rapid onset of heroin effects.
MAM (mitochondria-associated membranes) in mammalian cells: lipids and beyond.
Review
New
Vance, Edmonton, Canada. In Biochim Biophys Acta, May 2014
One mechanism by which communication between the endoplasmic reticulum (ER) and mitochondria is achieved is by close juxtaposition between these organelles via mitochondria-associated membranes (MAM).
Import of desired nucleic acid sequences using addressing motif of mitochondrial ribosomal 5S-rRNA for fluorescent in vivo hybridization of mitochondrial DNA and RNA.
New
Ježek et al., Praha, Czech Republic. In J Bioenerg Biomembr, Apr 2014
Based on the matrix-addressing sequence of mitochondrial ribosomal 5S-rRNA (termed MAM), which is naturally imported into mitochondria, we have constructed an import system for in vivo targeting of mitochondrial DNA (mtDNA) or mt-mRNA, in order to provide fluorescence hybridization of the desired sequences.
Influence of domestication process on immune response to repeated emersion stressors in Eurasian perch (Perca fluviatilis, L.).
New
Kestemont et al., Namur, Belgium. In Comp Biochem Physiol A Mol Integr Physiol, Apr 2014
Domestication also resulted in the up-regulation of five a2M isoforms and down-regulation of complement C3 and Ig light chain proteins, independently of any stressor exposure.
Progressive brain damage, synaptic reorganization and NMDA activation in a model of epileptogenic cortical dysplasia.
New
Battaglia et al., Milano, Italy. In Plos One, Dec 2013
We previously demonstrated in a rat model of acquired focal cortical dysplasia, the methylazoxymethanol/pilocarpine - MAM/pilocarpine - rats, that the occurrence of status epilepticus (SE) and subsequent seizures fostered a pathologic process capable of modifying the morphology of cortical pyramidal neurons and NMDA receptor expression/localization.
Intrinsic epileptogenicity of dysplastic cortex: converging data from experimental models and human patients.
Review
New
Nobili et al., Milano, Italy. In Epilepsia, Sep 2013
To investigate cellular and molecular bases of epileptogenic mechanisms and possible effect of severe epilepsy on the malformed cortex we have here performed a parallel analysis of a rat model of acquired cortical dysplasia previously established in our laboratory, i.e., the methylazoxymethanol/pilocarpine (MAM-PILO) rats, and surgical samples from patients with type IIB FCD.
Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels.
New
Impact
Reue et al., Los Angeles, United States. In Cell Metab, Jul 2013
Diet1 encodes a 236 kD protein consisting of tandem low-density lipoprotein receptor and MAM (meprin-A5-protein tyrosine phosphatase mu) domains and is expressed in the enterocytes of the small intestine.
[Variability of healthy human proteome].
Review
Larina et al., In Biomed Khim, 2012
On the contrary, proteins and peptides characterized by insignificant dispersion in healthy population (such as albumin--coefficient of variation (CV) 9%; transferrin--CV14%; C3c complement--CV 17%, alpha-1 acid glycoprotein--CV 21%, alpha2-macroglobulin--CV 20%; transthyretin fragment--CV 28,3% and beta-chain alpha2-HS-glycoprotein--CV 29,7%) can provide us with important information about state of health.
Clinicopathological characteristics of androgen-dependent advanced prostate cancer patients with α2-macroglobulin deficiency.
GeneRIF
Akahoshi et al., Sagamihara, Japan. In Int J Oncol, 2012
alpha-2-macroglobulin (a2M) deficiency develops from catabolism of a2M in androgen-dependent advanced prostate cancer patients
[Macroglobulin signaling system].
Review
Zorina et al., In Biomed Khim, 2012
This review will focus on the systematization of knowledge about structure of macroglobulin signaling system, which includes macroglobulin family proteins (alpha-2-macroglobulin, alpha-2-glycoprotein, pregnancy associated plasma protein A), their receptors (LRP, grp78), ligands (proteinases, cytokines, hormones, lipids, et al.) transforming and transcriptional factors for regulation of macroglobulins synthesis.
Diagnostic value of multiple biomarker panel for prediction of significant fibrosis in chronic hepatitis C.
GeneRIF
Kim et al., Pusan, South Korea. In Clin Biochem, 2011
We observed that the most informative biomarkers for predicting significant liver fibrosis in chronic hepatitis C patients were blood levels of alpha2-macroglobulin and hyaluronic acid
Expression, purification and structural analysis of recombinant rBdh-2His₆, a spermadhesin from buck (Capra hircus) seminal plasma.
GeneRIF
Cavada et al., Fortaleza, Brazil. In Reprod Fertil Dev, 2011
investigation of secondary structure and thermal stability of recombinant bodhesin 2, a spermadhesin from seminal plasma
Requirements for mediator complex subunits distinguish three classes of notch target genes at the Drosophila wing margin.
GeneRIF
Treisman et al., New York City, United States. In Dev Dyn, 2011
Genes activated by Notch signaling at the dorsal-ventral boundary of wing disc fall into classes affected differently by the loss of kinase module subunits. The distinctions do not result from different requirements for Groucho.
Relationship between production of acute-phase proteins and strength of inflammatory stimulation in rats.
GeneRIF
Yamamoto et al., Sagamihara, Japan. In Lab Anim, 2011
Peak serum levels of alpha(2)-macroglobulin and alpha(1)-acid glycoprotein injected at 0.05 mL/rat were significantly lower than those at 0.2 or 0.4 mL/rat. No significant differences were observed for peak serum levels at 0.2 and 0.4 mL/rat.
Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival.
Impact
Su et al., Baltimore, United States. In Cell, 2007
The ER supplies Ca(2+) directly to mitochondria via inositol 1,4,5-trisphosphate receptors (IP3Rs) at close contacts between the two organelles referred to as mitochondrion-associated ER membrane (MAM).
The Notch transcription activation complex makes its move.
Impact
Kopan et al., Baltimore, United States. In Cell, 2006
These structures show that the ANK domain of Notch is an integral part of the transcription complex and supports MAM binding, whereas the RAM domain may trigger allosteric changes in the structure needed for the derepression of transcription.
Structures of complement component C3 provide insights into the function and evolution of immunity.
Impact
Gros et al., Utrecht, Netherlands. In Nature, 2005
The structures reveal thirteen domains, nine of which were unpredicted, and suggest that the proteins of the alpha2-macroglobulin family evolved from a core of eight homologous domains.
Conserved role of a complement-like protein in phagocytosis revealed by dsRNA knockout in cultured cells of the mosquito, Anopheles gambiae.
Impact
Kafatos et al., Heidelberg, Germany. In Cell, 2001
It shows substantial structural and functional similarities, including the highly conserved thioester motif, to both a central component of mammalian complement system, factor C3, and to a pan-protease inhibitor, alpha2-macroglobulin.
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