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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 30 Mar 2015.

Alpha-2-macroglobulin

alpha2-macroglobulin, MAM, A2M, alpha2M
Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, AGE, fibrillin-1
Papers on alpha2-macroglobulin
Contribution of mitochondria and endoplasmic reticulum dysfunction in insulin resistance: Distinct or interrelated roles?
Review
New
Rieusset, Lyon, France. In Diabetes Metab, 19 Apr 2015
More important, mitochondrial dysfunction and ER stress are both closely associated with hepatic and skeletal muscle insulin resistance, thereby playing crucial roles in altered glucose homoeostasis in type 2 diabetes mellitus (T2DM).
Molecular and Histopathological Study on the Ameliorative Effects of Curcumin Against Lead Acetate-Induced Hepatotoxicity and Nephrototoxicity in Wistar Rats.
New
Yassin et al., Turabah, Saudi Arabia. In Biol Trace Elem Res, 11 Apr 2015
LA groups showed decrease in messenger RNA (mRNA) expression of catalase, SOD, GST, GPx, and alpha-1 acid glycoprotein (AGP), while the gene expression of desmin, vimentin, transforming growth factor-β1 (TGF-β1), monocyte chemoattractant protein-1 (MCP-1), and alpha-2 macroglobulin (α-2M) was increased.
A Synthetic Cannabinoid MAM-2201 Potently Suppresses Synaptic Transmission via Activation of Presynaptic CB1 Receptors and Reduces Synaptically-Evoked Intracellular Ca(2+) Transients in Cerebellar Purkinje Cells.
New
Sekino et al., Tokyo, Japan. In Neuropharmacology, 04 Apr 2015
Nevertheless, the pharmacological actions of MAM-2201 on cannabinoid receptor type 1 (CB1R) and neuronal functions have not been elucidated.
Complexes between insulin-like growth factor binding proteins and alpha-2-macroglobulin in patients with tumor.
New
Nedić et al., Belgrade, Serbia. In Exp Mol Pathol, 03 Apr 2015
UNASSIGNED: The intention of this work was to systematically study the presence of insulin-like growth factor-binding protein 1 and 2 (IGFBP-1 and IGFBP-2) complexes with alpha-2-macroglobulin (α2M) in the circulation of patients with various types of cancer.
The involvement of the sigma-1 receptor in neurodegeneration and neurorestoration.
Review
New
Wieloch et al., Lund, Sweden. In J Pharmacol Sci, Jan 2015
UNASSIGNED: The sigma-1 receptor (Sig-1R) is a single 25 kD polypeptide and a chaperone protein immersed in lipid rafts of the endoplasmic reticulum (ER) where it interacts with mitochondria at the mitochondria-associated ER membrane domain (MAM).
Sigma-1 receptor: The novel intracellular target of neuropsychotherapeutic drugs.
Review
New
Hayashi, Hamada, Japan. In J Pharmacol Sci, Jan 2015
Sigma-1 receptors are localized at the endoplasmic reticulum (ER) membranes that are physically associated with the mitochondria (MAM: mitochondria-associated ER membrane).
Human Myeloma Immunoglobulins of the Fourth Subclass (IgG4 MAM) Contain a Fraction with Different Properties of CH2 Domains.
New
Tischenko, Moscow, Russia. In Biochemistry (mosc), Jan 2015
A long-lived metastable minor fraction has been detected and characterized in myeloma protein IgG4 MAM by hydro- and thermodynamic methods.
Novel subcellular localization for α-synuclein: possible functional consequences.
Review
New
Przedborski et al., New York City, United States. In Front Neuroanat, Dec 2014
Mitochondria-associated membranes (MAM) have emerged as a central endoplasmic reticulum (ER) subcellular compartments where key functions of the cell occur.
Alpha-2-macroglobulin as a radioprotective agent: a review.
Review
New
Fang et al., Guangzhou, China. In Chin J Cancer Res, Oct 2014
Recent studies have shown that alpha-2-macroglobulin (α2M) possesses radioprotective effects.
Interaction with the effector dynamin-related protein 1 (Drp1) is an ancient function of Rab32 subfamily proteins.
New
Simmen et al., Edmonton, Canada. In Cell Logist, Oct 2014
UNASSIGNED: The mitochondria-associated membrane (MAM) is an endoplasmic reticulum (ER) domain that forms contacts with mitochondria and accommodates Ca(2+) transfer between the two organelles.
Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels.
Impact
Reue et al., Los Angeles, United States. In Cell Metab, 2013
Diet1 encodes a 236 kD protein consisting of tandem low-density lipoprotein receptor and MAM (meprin-A5-protein tyrosine phosphatase mu) domains and is expressed in the enterocytes of the small intestine.
Clinicopathological characteristics of androgen-dependent advanced prostate cancer patients with α2-macroglobulin deficiency.
GeneRIF
Akahoshi et al., Sagamihara, Japan. In Int J Oncol, 2012
alpha-2-macroglobulin (a2M) deficiency develops from catabolism of a2M in androgen-dependent advanced prostate cancer patients
Diagnostic value of multiple biomarker panel for prediction of significant fibrosis in chronic hepatitis C.
GeneRIF
Kim et al., Pusan, South Korea. In Clin Biochem, 2011
We observed that the most informative biomarkers for predicting significant liver fibrosis in chronic hepatitis C patients were blood levels of alpha2-macroglobulin and hyaluronic acid
Expression, purification and structural analysis of recombinant rBdh-2His₆, a spermadhesin from buck (Capra hircus) seminal plasma.
GeneRIF
Cavada et al., Fortaleza, Brazil. In Reprod Fertil Dev, 2011
investigation of secondary structure and thermal stability of recombinant bodhesin 2, a spermadhesin from seminal plasma
Requirements for mediator complex subunits distinguish three classes of notch target genes at the Drosophila wing margin.
GeneRIF
Treisman et al., New York City, United States. In Dev Dyn, 2011
Genes activated by Notch signaling at the dorsal-ventral boundary of wing disc fall into classes affected differently by the loss of kinase module subunits. The distinctions do not result from different requirements for Groucho.
Relationship between production of acute-phase proteins and strength of inflammatory stimulation in rats.
GeneRIF
Yamamoto et al., Sagamihara, Japan. In Lab Anim, 2011
Peak serum levels of alpha(2)-macroglobulin and alpha(1)-acid glycoprotein injected at 0.05 mL/rat were significantly lower than those at 0.2 or 0.4 mL/rat. No significant differences were observed for peak serum levels at 0.2 and 0.4 mL/rat.
Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival.
Impact
Su et al., Baltimore, United States. In Cell, 2007
The ER supplies Ca(2+) directly to mitochondria via inositol 1,4,5-trisphosphate receptors (IP3Rs) at close contacts between the two organelles referred to as mitochondrion-associated ER membrane (MAM).
The Notch transcription activation complex makes its move.
Impact
Kopan et al., Baltimore, United States. In Cell, 2006
These structures show that the ANK domain of Notch is an integral part of the transcription complex and supports MAM binding, whereas the RAM domain may trigger allosteric changes in the structure needed for the derepression of transcription.
Structures of complement component C3 provide insights into the function and evolution of immunity.
Impact
Gros et al., Utrecht, Netherlands. In Nature, 2005
The structures reveal thirteen domains, nine of which were unpredicted, and suggest that the proteins of the alpha2-macroglobulin family evolved from a core of eight homologous domains.
Conserved role of a complement-like protein in phagocytosis revealed by dsRNA knockout in cultured cells of the mosquito, Anopheles gambiae.
Impact
Kafatos et al., Heidelberg, Germany. In Cell, 2001
It shows substantial structural and functional similarities, including the highly conserved thioester motif, to both a central component of mammalian complement system, factor C3, and to a pan-protease inhibitor, alpha2-macroglobulin.
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