Origin and Diversification of Meprin Proteases.
Valencia, Spain. In Plos One, Dec 2014
Meprins are astacin metalloproteases with a characteristic, easily recognizable structure, given that they are the only proteases with both MAM and MATH domains plus a transmembrane region.
Stress responses from the endoplasmic reticulum in cancer.
Miyazaki, Japan. In Front Oncol, Dec 2014
More recently, the mitochondria-associated ER membrane (MAM), which is a site of close contact between the ER and mitochondria, has been shown to function as a platform for various intracellular stress responses including apoptotic signaling, inflammatory signaling, the autophagic response, and the UPR.
The Notch transcription activation complex makes its move.
Baltimore, United States. In Cell, 2006
These structures show that the ANK domain of Notch is an integral part of the transcription complex and supports MAM binding, whereas the RAM domain may trigger allosteric changes in the structure needed for the derepression of transcription.