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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 04 Sep 2015.

Alpha-2-macroglobulin

alpha2-macroglobulin, MAM, A2M, alpha2M
Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, fibrillin-1, AGE
Papers on alpha2-macroglobulin
Pharmacogenetic Study on the Impact of Rivastigmine Concerning Genetic Variants of A2M and IL-6 Genes on Iranian Alzheimer's Patients.
New
Tavasoli et al., Tehrān, Iran. In Mol Neurobiol, 21 Sep 2015
Increasing evidence indicates that many genes including interleukin-6 (IL-6) and alpha 2-macroglobulin (A2M) may contribute to the pathogenesis of AD.
PDGFRβ(+) cells in human and experimental neuro-vascular dysplasia and seizures.
New
Marchi et al., Milano, Italy. In Neuroscience, 14 Sep 2015
An in vivo rat model of neuro-vascular dysplasia was obtained by pre-natal exposure to methyl-axozy methanoic acid (MAM).
Contribution of mitochondria and endoplasmic reticulum dysfunction in insulin resistance: Distinct or interrelated roles?
Review
New
Rieusset, Lyon, France. In Diabetes Metab, Apr 2015
More important, mitochondrial dysfunction and ER stress are both closely associated with hepatic and skeletal muscle insulin resistance, thereby playing crucial roles in altered glucose homoeostasis in type 2 diabetes mellitus (T2DM).
The involvement of the sigma-1 receptor in neurodegeneration and neurorestoration.
Review
New
Wieloch et al., Lund, Sweden. In J Pharmacol Sci, Jan 2015
The sigma-1 receptor (Sig-1R) is a single 25 kD polypeptide and a chaperone protein immersed in lipid rafts of the endoplasmic reticulum (ER) where it interacts with mitochondria at the mitochondria-associated ER membrane domain (MAM).
Sigma-1 receptor: the novel intracellular target of neuropsychotherapeutic drugs.
Review
New
Hayashi, Hamada, Japan. In J Pharmacol Sci, Jan 2015
Sigma-1 receptors are localized at the endoplasmic reticulum (ER) membranes that are physically associated with the mitochondria (MAM: mitochondria-associated ER membrane).
Origin and Diversification of Meprin Proteases.
New
Marín, Valencia, Spain. In Plos One, Dec 2014
Meprins are astacin metalloproteases with a characteristic, easily recognizable structure, given that they are the only proteases with both MAM and MATH domains plus a transmembrane region.
Novel subcellular localization for α-synuclein: possible functional consequences.
Review
New
Przedborski et al., New York City, United States. In Front Neuroanat, Dec 2014
Mitochondria-associated membranes (MAM) have emerged as a central endoplasmic reticulum (ER) subcellular compartments where key functions of the cell occur.
Stress responses from the endoplasmic reticulum in cancer.
Review
New
Nishitoh et al., Miyazaki, Japan. In Front Oncol, Dec 2014
More recently, the mitochondria-associated ER membrane (MAM), which is a site of close contact between the ER and mitochondria, has been shown to function as a platform for various intracellular stress responses including apoptotic signaling, inflammatory signaling, the autophagic response, and the UPR.
Isolation of Endoplasmic Reticulum, Mitochondria, and Mitochondria-Associated Membrane and Detergent Resistant Membrane Fractions from Transfected Cells and from Human Cytomegalovirus-Infected Primary Fibroblasts.
New
Colberg-Poley et al., Ioánnina, Greece. In Curr Protoc Cell Biol, Dec 2014
The mitochondria-associated membrane (MAM) fraction provides direct physical contact between the ER and mitochondria.
Alpha-2-Macroglobulin Levels in Gingival Crevicular Fluid Pre- and Post-scaling and Root Planing with Adjunctive Tetracycline Fibers in Chronic Periodontitis: A Randomized Controlled Trial.
New
Juneja et al., Ghāziābād, India. In J Contemp Dent Pract, Dec 2014
BACKGROUND: This split-mouth clinical study aimed to investigate levels of alpha-2-macroglobulin (a2M) in gingival crevicular fluid (GCF) of chronic periodontitis patients pre- and post-scaling and root planing (SRP) with or without adjunctive use of tetracycline fibers.
Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels.
Impact
Reue et al., Los Angeles, United States. In Cell Metab, 2013
Diet1 encodes a 236 kD protein consisting of tandem low-density lipoprotein receptor and MAM (meprin-A5-protein tyrosine phosphatase mu) domains and is expressed in the enterocytes of the small intestine.
Clinicopathological characteristics of androgen-dependent advanced prostate cancer patients with α2-macroglobulin deficiency.
GeneRIF
Akahoshi et al., Sagamihara, Japan. In Int J Oncol, 2012
alpha-2-macroglobulin (a2M) deficiency develops from catabolism of a2M in androgen-dependent advanced prostate cancer patients
Diagnostic value of multiple biomarker panel for prediction of significant fibrosis in chronic hepatitis C.
GeneRIF
Kim et al., Pusan, South Korea. In Clin Biochem, 2011
We observed that the most informative biomarkers for predicting significant liver fibrosis in chronic hepatitis C patients were blood levels of alpha2-macroglobulin and hyaluronic acid
Expression, purification and structural analysis of recombinant rBdh-2His₆, a spermadhesin from buck (Capra hircus) seminal plasma.
GeneRIF
Cavada et al., Fortaleza, Brazil. In Reprod Fertil Dev, 2011
investigation of secondary structure and thermal stability of recombinant bodhesin 2, a spermadhesin from seminal plasma
Requirements for mediator complex subunits distinguish three classes of notch target genes at the Drosophila wing margin.
GeneRIF
Treisman et al., New York City, United States. In Dev Dyn, 2011
Genes activated by Notch signaling at the dorsal-ventral boundary of wing disc fall into classes affected differently by the loss of kinase module subunits. The distinctions do not result from different requirements for Groucho.
Relationship between production of acute-phase proteins and strength of inflammatory stimulation in rats.
GeneRIF
Yamamoto et al., Sagamihara, Japan. In Lab Anim, 2011
Peak serum levels of alpha(2)-macroglobulin and alpha(1)-acid glycoprotein injected at 0.05 mL/rat were significantly lower than those at 0.2 or 0.4 mL/rat. No significant differences were observed for peak serum levels at 0.2 and 0.4 mL/rat.
Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival.
Impact
Su et al., Baltimore, United States. In Cell, 2007
The ER supplies Ca(2+) directly to mitochondria via inositol 1,4,5-trisphosphate receptors (IP3Rs) at close contacts between the two organelles referred to as mitochondrion-associated ER membrane (MAM).
The Notch transcription activation complex makes its move.
Impact
Kopan et al., Baltimore, United States. In Cell, 2006
These structures show that the ANK domain of Notch is an integral part of the transcription complex and supports MAM binding, whereas the RAM domain may trigger allosteric changes in the structure needed for the derepression of transcription.
Structures of complement component C3 provide insights into the function and evolution of immunity.
Impact
Gros et al., Utrecht, Netherlands. In Nature, 2005
The structures reveal thirteen domains, nine of which were unpredicted, and suggest that the proteins of the alpha2-macroglobulin family evolved from a core of eight homologous domains.
Conserved role of a complement-like protein in phagocytosis revealed by dsRNA knockout in cultured cells of the mosquito, Anopheles gambiae.
Impact
Kafatos et al., Heidelberg, Germany. In Cell, 2001
It shows substantial structural and functional similarities, including the highly conserved thioester motif, to both a central component of mammalian complement system, factor C3, and to a pan-protease inhibitor, alpha2-macroglobulin.
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