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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 12 Nov 2015.


alpha2-macroglobulin, MAM, A2M, alpha2M
Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, fibrillin-1, AGE
Papers on alpha2-macroglobulin
Direct and indirect immunofluorescence staining patterns in the diagnosis of paraneoplastic pemphigus.
Diercks et al., Groningen, Netherlands. In Br J Dermatol, 11 Dec 2015
In addition, the desmosomal proteins desmoglein (Dsg) 3 and less frequently Dsg 1 are targeted, as well as the protease inhibitor alpha-2-macroglobulin-like antigen-1 (A2ML1).(1-4)
Human plasma protein N-glycosylation.
Wuhrer et al., Leiden, Netherlands. In Glycoconj J, 10 Dec 2015
Thus, as the assessment of protein glycosylation is becoming a major element in clinical and biopharmaceutical research, this review aims to convey the current state of knowledge on the N-glycosylation of the major plasma glycoproteins alpha-1-acid glycoprotein, alpha-1-antitrypsin, alpha-1B-glycoprotein, alpha-2-HS-glycoprotein, alpha-2-macroglobulin, antithrombin-III, apolipoprotein B-100, apolipoprotein D, apolipoprotein F, beta-2-glycoprotein 1, ceruloplasmin, fibrinogen, immunoglobulin (Ig) A, IgG, IgM, haptoglobin, hemopexin, histidine-rich glycoprotein, kininogen-1, serotransferrin, vitronectin, and zinc-alpha-2-glycoprotein. In addition, the less abundant immunoglobulins D and E are included because of their major relevance in immunology and biopharmaceutical research.
Protein Folding and Misfolding, Endoplasmic Reticulum Stress in Neurodegenerative Diseases: in Trace of Novel Drug Targets.
Fülöp et al., Szeged, Hungary. In Curr Protein Pept Sci, 01 Dec 2015
MT and ER are tightly coupled both physically and functionally with a special lipid raft called mitochondria-associated ER-membrane (MAM).
Contribution of mitochondria and endoplasmic reticulum dysfunction in insulin resistance: Distinct or interrelated roles?
Rieusset, Lyon, France. In Diabetes Metab, 30 Nov 2015
More important, mitochondrial dysfunction and ER stress are both closely associated with hepatic and skeletal muscle insulin resistance, thereby playing crucial roles in altered glucose homoeostasis in type 2 diabetes mellitus (T2DM).
Donor platelet plasma components inactivate sensitive and multidrug resistant Acinetobacter baumannii isolates.
Heller et al., Norfolk, United States. In Pathog Dis, 23 Nov 2015
Instead, the donor plasma components complement and alpha-2 macroglobulin are implicated.
The involvement of the sigma-1 receptor in neurodegeneration and neurorestoration.
Wieloch et al., Lund, Sweden. In J Pharmacol Sci, Jan 2015
The sigma-1 receptor (Sig-1R) is a single 25 kD polypeptide and a chaperone protein immersed in lipid rafts of the endoplasmic reticulum (ER) where it interacts with mitochondria at the mitochondria-associated ER membrane domain (MAM).
Renoprotective Mechanism of Remote Ischemic Preconditioning Based on Transcriptomic Analysis in a Porcine Renal Ischemia Reperfusion Injury Model.
Han et al., Seoul, South Korea. In Plos One, Dec 2014
Furthermore, alpha 2 macroglobulin, tissue plasminogen activator, uterine plasmin trypsin inhibitor, and arginase-1 mRNA levels were elevated in the rIPCl group.
Stress responses from the endoplasmic reticulum in cancer.
Nishitoh et al., Miyazaki, Japan. In Front Oncol, Dec 2014
More recently, the mitochondria-associated ER membrane (MAM), which is a site of close contact between the ER and mitochondria, has been shown to function as a platform for various intracellular stress responses including apoptotic signaling, inflammatory signaling, the autophagic response, and the UPR.
Novel subcellular localization for α-synuclein: possible functional consequences.
Przedborski et al., New York City, United States. In Front Neuroanat, Dec 2014
Mitochondria-associated membranes (MAM) have emerged as a central endoplasmic reticulum (ER) subcellular compartments where key functions of the cell occur.
The different facets of organelle interplay-an overview of organelle interactions.
Islinger et al., Aveiro, Portugal. In Front Cell Dev Biol, Dec 2014
Such membrane associations between the mitochondria and a specialized site of the ER, the mitochondria associated-membrane (MAM), as well as between the ER and the plasma membrane (PAM) have been partially characterized at the molecular level.
Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels.
Reue et al., Los Angeles, United States. In Cell Metab, 2013
Diet1 encodes a 236 kD protein consisting of tandem low-density lipoprotein receptor and MAM (meprin-A5-protein tyrosine phosphatase mu) domains and is expressed in the enterocytes of the small intestine.
Clinicopathological characteristics of androgen-dependent advanced prostate cancer patients with α2-macroglobulin deficiency.
Akahoshi et al., Sagamihara, Japan. In Int J Oncol, 2012
alpha-2-macroglobulin (a2M) deficiency develops from catabolism of a2M in androgen-dependent advanced prostate cancer patients
Diagnostic value of multiple biomarker panel for prediction of significant fibrosis in chronic hepatitis C.
Kim et al., Pusan, South Korea. In Clin Biochem, 2011
We observed that the most informative biomarkers for predicting significant liver fibrosis in chronic hepatitis C patients were blood levels of alpha2-macroglobulin and hyaluronic acid
Expression, purification and structural analysis of recombinant rBdh-2His₆, a spermadhesin from buck (Capra hircus) seminal plasma.
Cavada et al., Fortaleza, Brazil. In Reprod Fertil Dev, 2011
investigation of secondary structure and thermal stability of recombinant bodhesin 2, a spermadhesin from seminal plasma
Requirements for mediator complex subunits distinguish three classes of notch target genes at the Drosophila wing margin.
Treisman et al., New York City, United States. In Dev Dyn, 2011
Genes activated by Notch signaling at the dorsal-ventral boundary of wing disc fall into classes affected differently by the loss of kinase module subunits. The distinctions do not result from different requirements for Groucho.
Relationship between production of acute-phase proteins and strength of inflammatory stimulation in rats.
Yamamoto et al., Sagamihara, Japan. In Lab Anim, 2011
Peak serum levels of alpha(2)-macroglobulin and alpha(1)-acid glycoprotein injected at 0.05 mL/rat were significantly lower than those at 0.2 or 0.4 mL/rat. No significant differences were observed for peak serum levels at 0.2 and 0.4 mL/rat.
Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival.
Su et al., Baltimore, United States. In Cell, 2007
The ER supplies Ca(2+) directly to mitochondria via inositol 1,4,5-trisphosphate receptors (IP3Rs) at close contacts between the two organelles referred to as mitochondrion-associated ER membrane (MAM).
The Notch transcription activation complex makes its move.
Kopan et al., Baltimore, United States. In Cell, 2006
These structures show that the ANK domain of Notch is an integral part of the transcription complex and supports MAM binding, whereas the RAM domain may trigger allosteric changes in the structure needed for the derepression of transcription.
Structures of complement component C3 provide insights into the function and evolution of immunity.
Gros et al., Utrecht, Netherlands. In Nature, 2005
The structures reveal thirteen domains, nine of which were unpredicted, and suggest that the proteins of the alpha2-macroglobulin family evolved from a core of eight homologous domains.
Conserved role of a complement-like protein in phagocytosis revealed by dsRNA knockout in cultured cells of the mosquito, Anopheles gambiae.
Kafatos et al., Heidelberg, Germany. In Cell, 2001
It shows substantial structural and functional similarities, including the highly conserved thioester motif, to both a central component of mammalian complement system, factor C3, and to a pan-protease inhibitor, alpha2-macroglobulin.
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