Molecular classification of outcomes from dengue virus -3 infections.
Galveston, United States. In J Clin Virol, 31 Mar 2015
The classifier primarily relied on acute phase (A2M), complement (CFD), platelet counts and cellular leak (TPM4) to produce an 86% accuracy of prediction with an area under the receiver operating curve of >0.9 for DHF and DFC vs DF.
Superresolution imaging of viral protein trafficking.
Washington, D.C., United States. In Med Microbiol Immunol, 28 Mar 2015
These contacts, known as mitochondria-associated membranes (MAM), facilitate calcium signaling, lipid transfer, as well as antiviral and stress responses.
Mitochondrial import and degradation of amyloid-β peptide.
Stockholm, Sweden. In Biochim Biophys Acta, Jul 2014
The γ-secretase complex was found in mitochondria-associated endoplasmic reticulum membranes (MAM) suggesting that this could be a potential site of Aβ production, from which Aβ is further transported into the mitochondria.
Discovery of prognostic factors for diagnosis and treatment of epithelial-derived ovarian cancer from laying hens.
Seoul, South Korea. In J Cancer Prev, 2013
Therefore, we showed in the review: 1) characterization and classification of EOC; 2) chicken models for EOC; 3) relationship estrogen with EOC; 4) candidate prognostic factors for EOC including serpin peptidase inhibior, clade B (ovalbumin), member 3 (SERPINB3), SERPINB11, gallicin 11 (GAL11), secreted phosphoprotein 1 (SPP1) and alpha 2 macroglobulin (A2M) in normal and cancerous ovaries of laying hens; 5) biological roles of microRNAs in development of EOC.
The Notch transcription activation complex makes its move.
Baltimore, United States. In Cell, 2006
These structures show that the ANK domain of Notch is an integral part of the transcription complex and supports MAM binding, whereas the RAM domain may trigger allosteric changes in the structure needed for the derepression of transcription.