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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Jan 2016.

Alpha-2-macroglobulin

alpha2-macroglobulin, MAM, A2M, alpha2M
Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, fibrillin-1, AGE
Papers on alpha2-macroglobulin
Proteome profiles of HDL particles of patients with chronic heart failure are associated with immune response and also include bacteria proteins.
New
Jehmlich et al., Leipzig, Germany. In Clin Chim Acta, 01 Mar 2016
ITGA2, APBA1 or A2M) varied in level.
Structural Basis for Latency and Function of Immune Inhibitor A Metallopeptidase, a Modulator of the Bacillus anthracis Secretome.
New
Gomis-Rüth et al., Barcelona, Spain. In Structure, 05 Feb 2016
Immune inhibitor A(InhA)-type metallopeptidases are potential virulence factors secreted by members of the Bacillus cereus group.
Molecularly imprinted polymer for caffeic acid by precipitation polymerization and its application to extraction of caffeic acid and chlorogenic acid from Eucommia ulmodies leaves.
New
Haginaka et al., Nishinomiya, Japan. In J Pharm Biomed Anal, 30 Jan 2016
UNASSIGNED: Molecularly imprinted polymers (MIPs) for caffeic acid (CA) were prepared using 4-vinylpyridine and methacrylamide (MAM) as functional monomers, divinylbenzene as a crosslinker and acetonitrile-toluene (3:1, v/v) as a porogen by precipitation polymerization.
iTRAQ-based quantitative proteomic analysis of Macrobrachium rosenbergii hemocytes during Spiroplasma eriocheiris infection.
New
Meng et al., Nanjing, China. In J Proteomics, 30 Jan 2016
Up-regulated proteins included vertebrate gliacolin-like protein, vitellogenin, Gram-negative binding protein 1, alpha2 macroglobulin isoform 2 (a2M), etc. Down-regulated proteins, involved with beta-1,3-glucan-binding protein (BGBP), immunoglobulin like, Rab7, lipopolysaccharide and β-1,3-glucan (LGBP), actin-related protein, etc. Selected bioactive factors (tachylectin, α2M and vitellogenin, BGBP, C-type lectin, LGBP and Rab7) were verified by their immune roles in the S. eriocheiris infection using real-time PCR.
Innate immune response against an oomycete pathogen Aphanomyces invadans in common carp (Cyprinus carpio), a fish resistant to epizootic ulcerative syndrome.
New
Jena et al., Lucknow, India. In Acta Trop, 29 Jan 2016
On the other hand, some parameters such as myeloperoxidase, lysozyme and alpha-2 macroglobulin activities were not altered.
An orphaned Mce-associated membrane protein of Mycobacterium tuberculosis is a virulence factor that stabilizes Mce transporters.
New
Braunstein et al., Virginia, South Africa. In Mol Microbiol, 29 Jan 2016
These results indicate a function of OmamA in multiple Mce transporters and one that may be analogous to the role of VirB8 in stabilizing Type IV secretion systems, as structural similarities between Mam proteins and VirB8 proteins are predicted by the Phyre 2 program.
Reactive oxygen species and anti-proteinases.
New
Khan et al., New Delhi, India. In Arch Physiol Biochem, 23 Jan 2016
Studies have shown that ROS damages anti-proteinase shield of the body by inactivating key members such as alpha-2-macroglobulin, alpha-1-antitrypsin.
Gene expression profiling of prostate cancer-associated genes identifies fibromodulin as potential novel biomarker for prostate cancer.
New
Reyes et al., Cartagena, Colombia. In Int J Biol Markers, 14 Jan 2016
Genes evaluated were ESM-1, SERPINE2, CLU, BGN, A2M, PENK, FMOD, CD81, DCN, TSPAN8, KBTBD10, F2RL1, TMSB4X, SNCG, CXXC5, FOXQ1, PDPN, SPN, CAV1, CD24 and KLK3.
The expression of heterologous MAM-7 in Lactobacillus rhamnosus reduces its intrinsic capacity to inhibit colonization of pathogen Vibrio parahaemolyticus in vitro.
New
Trombert et al., Santiago, Chile. In Biol Res, 31 Dec 2015
Thus, we aimed to express MAM-7 V. parahaemolyticus adhesion protein in Lactobacillus sp. to generate an RL that prevents pathogen colonization.
A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model.
Cook et al., Milwaukee, United States. In Int J Med Chem, 2014
In addition, a chiral positive allosteric modulator (PAM), SH-053-2'F-R-CH3 (2), has been shown to reverse the deleterious effects in the MAM-model of schizophrenia as well as alleviate constriction in airway smooth muscle.
Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels.
Impact
Reue et al., Los Angeles, United States. In Cell Metab, 2013
Diet1 encodes a 236 kD protein consisting of tandem low-density lipoprotein receptor and MAM (meprin-A5-protein tyrosine phosphatase mu) domains and is expressed in the enterocytes of the small intestine.
Clinicopathological characteristics of androgen-dependent advanced prostate cancer patients with α2-macroglobulin deficiency.
GeneRIF
Akahoshi et al., Sagamihara, Japan. In Int J Oncol, 2012
alpha-2-macroglobulin (a2M) deficiency develops from catabolism of a2M in androgen-dependent advanced prostate cancer patients
Diagnostic value of multiple biomarker panel for prediction of significant fibrosis in chronic hepatitis C.
GeneRIF
Kim et al., Pusan, South Korea. In Clin Biochem, 2011
We observed that the most informative biomarkers for predicting significant liver fibrosis in chronic hepatitis C patients were blood levels of alpha2-macroglobulin and hyaluronic acid
Expression, purification and structural analysis of recombinant rBdh-2His₆, a spermadhesin from buck (Capra hircus) seminal plasma.
GeneRIF
Cavada et al., Fortaleza, Brazil. In Reprod Fertil Dev, 2011
investigation of secondary structure and thermal stability of recombinant bodhesin 2, a spermadhesin from seminal plasma
Requirements for mediator complex subunits distinguish three classes of notch target genes at the Drosophila wing margin.
GeneRIF
Treisman et al., New York City, United States. In Dev Dyn, 2011
Genes activated by Notch signaling at the dorsal-ventral boundary of wing disc fall into classes affected differently by the loss of kinase module subunits. The distinctions do not result from different requirements for Groucho.
Relationship between production of acute-phase proteins and strength of inflammatory stimulation in rats.
GeneRIF
Yamamoto et al., Sagamihara, Japan. In Lab Anim, 2011
Peak serum levels of alpha(2)-macroglobulin and alpha(1)-acid glycoprotein injected at 0.05 mL/rat were significantly lower than those at 0.2 or 0.4 mL/rat. No significant differences were observed for peak serum levels at 0.2 and 0.4 mL/rat.
Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival.
Impact
Su et al., Baltimore, United States. In Cell, 2007
The ER supplies Ca(2+) directly to mitochondria via inositol 1,4,5-trisphosphate receptors (IP3Rs) at close contacts between the two organelles referred to as mitochondrion-associated ER membrane (MAM).
The Notch transcription activation complex makes its move.
Impact
Kopan et al., Baltimore, United States. In Cell, 2006
These structures show that the ANK domain of Notch is an integral part of the transcription complex and supports MAM binding, whereas the RAM domain may trigger allosteric changes in the structure needed for the derepression of transcription.
Structures of complement component C3 provide insights into the function and evolution of immunity.
Impact
Gros et al., Utrecht, Netherlands. In Nature, 2005
The structures reveal thirteen domains, nine of which were unpredicted, and suggest that the proteins of the alpha2-macroglobulin family evolved from a core of eight homologous domains.
Conserved role of a complement-like protein in phagocytosis revealed by dsRNA knockout in cultured cells of the mosquito, Anopheles gambiae.
Impact
Kafatos et al., Heidelberg, Germany. In Cell, 2001
It shows substantial structural and functional similarities, including the highly conserved thioester motif, to both a central component of mammalian complement system, factor C3, and to a pan-protease inhibitor, alpha2-macroglobulin.
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