Dynamic and extensive metabolic state-dependent regulation of cytokine expression and circulating levels.
Hopkins, United States. In Am J Physiol Regul Integr Comp Physiol, 15 Nov 2014
In the context of chronic high-fat feeding, circulating levels of CXCL1, SAA3, TIMP-1, AGP, and A2M were increased, whereas IL-12p40, CCL4, sCD30, sRAGE, CCL12, CCL20, IL-16, IL-22, and haptoglobin were decreased relative to mice fed a control low-fat diet.
Mitochondrial import and degradation of amyloid-β peptide.
Stockholm, Sweden. In Biochim Biophys Acta, Jul 2014
The γ-secretase complex was found in mitochondria-associated endoplasmic reticulum membranes (MAM) suggesting that this could be a potential site of Aβ production, from which Aβ is further transported into the mitochondria.
microRNAs affect BCL-2 family proteins in the setting of cerebral ischemia.
Stanford, United States. In Neurochem Int, Jan 2014
Recent findings suggest that many BCL-2 family members are also directly involved in controlling transmission of Ca(2+) from the endoplasmic reticulum (ER) to mitochondria through a specialization called the mitochondria-associated ER membrane (MAM).
Animal models of brain maldevelopment induced by cycad plant genotoxins.
Oregon, United States. In Birth Defects Res C Embryo Today, Dec 2013
The neuropathology of amyotrophic lateral sclerosis/parkinsonism-dementia complex includes features suggestive of brain maldevelopment, an experimentally proven property of cycasin attributable to the genotoxic action of its aglycone methylazoxymethanol (MAM).
Discovery of prognostic factors for diagnosis and treatment of epithelial-derived ovarian cancer from laying hens.
Seoul, South Korea. In J Cancer Prev, Sep 2013
Therefore, we showed in the review: 1) characterization and classification of EOC; 2) chicken models for EOC; 3) relationship estrogen with EOC; 4) candidate prognostic factors for EOC including serpin peptidase inhibior, clade B (ovalbumin), member 3 (SERPINB3), SERPINB11, gallicin 11 (GAL11), secreted phosphoprotein 1 (SPP1) and alpha 2 macroglobulin (A2M) in normal and cancerous ovaries of laying hens; 5) biological roles of microRNAs in development of EOC.
The Notch transcription activation complex makes its move.
Baltimore, United States. In Cell, 2006
These structures show that the ANK domain of Notch is an integral part of the transcription complex and supports MAM binding, whereas the RAM domain may trigger allosteric changes in the structure needed for the derepression of transcription.