Iwakura et al., Tokyo, Japan. In Neuroscience, 2011
sustained activation of IL-1 signaling....affects the expression of the ARalpha(1A) subtype..and that modification of adrenergic signaling by the IL-1 system may ultimately cause significant psychiatric abnormalities such as depression
Hadchouel et al., Paris, France. In Hypertension, 2011
Findings uncover a vascular signaling pathway linking alpha(1)-adrenergic receptors and pressure to WNK1, SPAK, and NKCC1 and may, thus, significantly broaden the comprehension of the regulatory mechanisms of vascular tone in arterial hypertension.
Wylegala et al., Katowice, Poland. In Cent European J Urol, 2010
Cataract is treated surgically and it has been reported that there may be an association between use of alpha-blockers for BPH, particularly alpha1A-adrenergic receptor selective drugs, and complications of cataract surgery known as Intraoperative Floppy Iris Syndrome (IFIS).
Woodcock et al., Melbourne, Australia. In Clin Sci (lond), 2008
Reperfusion of ischaemic rat or mouse hearts causes NE [noradrenaline ('norepinephrine')] release, stimulation of alpha(1)-ARs (alpha(1)-adrenergic receptors), PLC (phospholipase C) activation, Ins(1,4,5)P(3) generation and the development of arrhythmias.
Two phase III studies with tamsulosin, a selective alpha1A-adrenergic receptor antagonist, were conducted to evaluate the safety and efficacy of the standard treatment doses of 0.4 mg/day and 0.8 mg/day in patients with symptoms of benign prostatic hyperplasia (BPH).