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Syntrophin, alpha 1

alpha1-syntrophin, Syntrophin
Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. The protein encoded by this gene is a peripheral membrane protein found associated with dystrophin and dystrophin-related proteins. This gene is a member of the syntrophin gene family, which contains at least two other structurally-related genes. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Alpha-1, CD45, CAN, iNOS, Utrophin
Papers using alpha1-syntrophin antibodies
Genome regulation by polycomb and trithorax proteins.
Supplier
Tarnopolsky Mark A., In PLoS ONE, 2006
... α-Syntrophin-specific siRNA and control siRNA were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Dystrophin-associated protein A0 is a homologue of the Torpedo87K protein
Supplier
Froehner Stanley C. et al., In The Journal of Cell Biology, 1994
... Mouse β1-Syntrophin cDNA IsolationA λgt11 mouse liver cDNA library (Clontech ...
Papers on alpha1-syntrophin
Nav1.5 N-Terminal Domain Binding to α1-Syntrophin Increases Membrane Density of Human Kir2.1, Kir2.2 and Nav1.5 Channels.
New
Delpón et al., Madrid, Spain. In Cardiovasc Res, Feb 2016
METHODS AND RESULTS: The results demonstrate that there is an unexpected "internal" PDZ-like binding domain located at the N-terminus of the Nav1.5 channel that mediates its binding to α1-syntrophin.
LXR Agonism Upregulates the Macrophage ABCA1/Syntrophin Protein Complex That Can Bind ApoA-I and Stabilized ABCA1 Protein, but Complex Loss Does Not Inhibit Lipid Efflux.
New
Fitzgerald et al., Boston, United States. In Biochemistry, Dec 2015
However, many of the data assessing the function of the ABCA1-syntrophin interaction are based on overexpression in nonmacrophage cells.
Identification of Dp71 Isoforms Expressed in PC12 Cells: Subcellular Localization and Colocalization with β-Dystroglycan and α1-Syntrophin.
New
Montañez et al., Mexico. In J Mol Neurosci, Oct 2015
In undifferentiated and nerve growth factor-differentiated PC12 Tet-ON cells, Dp71a, Dp71ab, and Dp71e were found to localize and colocalize with β-dystroglycan and α1-syntrophin in the periphery/cytoplasm, while Dp71c and Dp71ec were mainly localized in the cell periphery and showed less colocalization with β-dystroglycan and α1-syntrophin.
Quantification of the transferability of a designed protein specificity switch reveals extensive epistasis in molecular recognition.
Kortemme et al., San Francisco, United States. In Proc Natl Acad Sci U S A, 2014
Here, we test this strategy by designing a pair of mutations that modulates peptide recognition specificity in the Syntrophin PDZ domain, confirming the designed interaction biochemically and structurally, and then transplanting the mutations into the context of five related PDZ domain-peptide complexes.
Systematic family-wide analysis of sodium bicarbonate cotransporter NBCn1/SLC4A7 interactions with PDZ scaffold proteins.
Choi et al., Nashville, United States. In Physiol Rep, 2014
We then focused on syntrophin γ2 to examine the molecular and functional interaction between NBCn1 and one of the identified binding partners in the Xenopus oocyte expression system.
α1-Syntrophin-deficient mice exhibit impaired muscle force recovery after osmotic shock.
Takeda et al., Edmonton, Canada. In Muscle Nerve, 2014
INTRODUCTION: α1-syntrophin, a member of the dystrophin complex, recruits membrane molecules, including aquaporin-4, at the sarcolemma.
Nuclear recruitment of neuronal nitric-oxide synthase by α-syntrophin is crucial for the induction of mitochondrial biogenesis.
Ciriolo et al., Roma, Italy. In J Biol Chem, 2014
We demonstrate that α-Syntrophin, which resides in nuclei of myocytes, functions as the upstream mediator of nuclear nNOS translocation and nNOS-dependent mitochondrial biogenesis.
Characterization of H460R, a Radioresistant Human Lung Cancer Cell Line, and Involvement of Syntrophin Beta 2 (SNTB2) in Radioresistance.
Hong et al., Seoul, South Korea. In Genomics Inform, 2013
Among DEGs, syntrophin beta 2 (SNTB2) significantly increased in H460R cells in response to IR. Knockdown of SNTB2 by siRNA was more sensitive than the control after IR exposure in H460, H460R, and H1299 cells.
Combining genome-wide methods to investigate the genetic complexity of courtship song variation in Drosophila melanogaster.
Cochrane et al., Santa Barbara, United States. In Mol Biol Evol, 2013
Quantitative complementation at one of these loci, Syntrophin-like 1, supports a hypothesis that variation at this locus affects variation in the inter-pulse interval of courtship song.
Syntrophin proteins as Santa Claus: role(s) in cell signal transduction.
Review
Khanday et al., Jammu, India. In Cell Mol Life Sci, 2013
In our previous work, we reported a differential expression pattern of alpha-1-syntrophin (SNTA1) protein in esophageal and breast carcinomas.
Regional registration of [6-(14)C]glucose metabolism during brain activation of α-syntrophin knockout mice.
Dienel et al., Little Rock, United States. In J Neurochem, 2013
α-Syntrophin is a component of the dystrophin scaffold-protein complex that serves as an adaptor for recruitment of key proteins to the cytoplasmic side of plasma membranes.
Dp71 gene disruption alters the composition of the dystrophin-associated protein complex and neuronal nitric oxide synthase expression in the hypothalamic supraoptic and paraventricular nuclei.
GeneRIF
Hardin-Pouzet et al., Tizi Gheniff, Algeria. In J Endocrinol, 2012
Data show that in Dp71-null mice, the levels of beta-dystroglycan (beta-DG) and alpha1-syntrophin (alpha1-Syn) were lower and utrophin expression did not change, and the neuronal nitric oxide synthase (nNOS) expression and activity were increased.
Myocilin interacts with syntrophins and is member of dystrophin-associated protein complex.
GeneRIF
Tomarev et al., Bethesda, United States. In J Biol Chem, 2012
We identified alpha1-syntrophin, a component of the dystrophin-associated protein complex (DAPC), as a myocilin-binding candidate.
α-Syntrophin is required for the hepatocyte growth factor-induced migration of cultured myoblasts.
GeneRIF
Kim et al., Suwŏn, South Korea. In Exp Cell Res, 2012
Migration of myoblasts from alpha-syntrophin knockout mice could not be stimulated by HGF.
Dg-Dys-Syn1 signaling in Drosophila regulates the microRNA profile.
Shcherbata et al., Göttingen, Germany. In Bmc Cell Biol, 2011
Verification of a subset of our results was conducted via q-PCR and revealed that miR-956, miR-980 and miR-252 are regulated via a Dystroglycan-Dystrophin-Syntrophin dependent pathway.
Nicotinic acetylcholine receptor stability at the NMJ deficient in α-syntrophin in vivo.
GeneRIF
Akaaboune et al., Ann Arbor, United States. In J Neurosci, 2011
These results demonstrate that alpha-syn is required for the maturation and stability of the postsynaptic apparatus and suggest that alpha-syn may act via alpha-dbn1.
Α-syntrophin modulates myogenin expression in differentiating myoblasts.
GeneRIF
Kim et al., Suwŏn, South Korea. In Plos One, 2009
alpha-syntrophin plays an important role in regulating myogenesis by modulating myogenin expression
Transcriptional regulatory networks in lipid metabolism control ABCA1 expression.
Review
Langmann et al., Regensburg, Germany. In Biochim Biophys Acta, 2005
Although the exact mechanisms how ABC transporters mediate lipid transport are not completely resolved, recent evidence from several laboratories including ours suggests that vesicular transport processes involving different interactive proteins like beta2-syntrophin, alpha1-syntrophin, Lin7, and cdc42 are critically involved in cellular lipid homeostasis controlled by ABCA1 and ABCG1.
Association of neuronal nitric oxide synthase (nNOS) with alpha1-syntrophin at the sarcolemma.
Review
Takeda et al., Kodaira, Japan. In Microsc Res Tech, 2001
alpha1-syntrophin is a PDZ-containing dystrophin-associated protein, expressed predominantly in striated muscle and brain.
Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains.
Impact
Bredt et al., United States. In Cell, 1996
PDZ domain interactions also mediate binding of nNOS to skeletal muscle syntrophin, a dystrophin-associated protein.
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