First trimester prediction of preeclampsia.
Lund, Sweden. In Curr Hypertens Rep, Sep 2015
New biomarkers suggest an alternative model based on free HbF and the heme scavenger alpha-1-microglobulin (A1M) with a prediction rate of 69 % at an FPR of 5 %.
[Urinary protein detection by iTRAQ® associated with renal transplant complications and its modification with therapy].
Monterrey, Mexico. In Cir Cir, Sep 2015
The 5 proteins with higher scores in graft rejection were: alpha-1-microglobulin, 5'-nucleotidase cytosolic III, retinol-binding protein 4, membrane protein palmitoylated 4, and serine carboxypeptidase, while post-transplant infections were: mitochondrial acetyl-coenzyme A synthetase, putative adenosyl homocysteinase 2, zinc finger protein GLIS1, putative protein FAM157B, and zinc finger protein 615.
Preeclampsia - will orphan drug status facilitate innovative biological therapies?
Basel, Switzerland. In Front Surg, 2014
Hence, it is with great interest to become aware of at least three novel therapeutic approaches for the treatment of this disorder: exploiting either the anticoagulant activity of antithrombin, the free radical scavenging activity of alpha-1-microglobulin, or the regenerative capacity of placenta-derived mesenchymal stem cells.
Proteomic studies in endemic nephropathy.
Niš, Serbia. In Prilozi, 2013
Urine beta2-microglobulin (B2M) was mainly used as a tubular marker of EN but recently alpha1-microglobulin (AMBP) was proposed for the diagnosis of EN.
Fetal hemoglobin in preeclampsia: a new causative factor, a tool for prediction/diagnosis and a potential target for therapy.
Lund, Sweden. In Curr Opin Obstet Gynecol, 2013
This review summarizes the present knowledge of a new potential cause of the disease and suggests a method for its prediction/diagnosis and a possible treatment, both based on the recent findings on the involvement of fetal hemoglobin (HbF) and the heme and radical scavenging protein A1M (alpha-1-microglobulin). RECENT FINDINGS: Gene and protein profiling studies have independently shown that increased amount of free HbF is accumulated in the preeclampsia placenta.
The critical role of adrenomedullin and its binding protein, AMBP-1, in neuroprotection.
North Bay Shore, United States. In Biol Chem, 2012
The evolutionarily conserved neuropeptide, adrenomedullin (AM), and its binding protein, AMBP-1, also known as complement factor H, play important roles in brain physiology, and their expression is altered in brain pathology.