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Alpha-1-microglobulin/bikunin precursor

alpha1-microglobulin, protein HC, AMBP
This gene encodes a complex glycoprotein secreted in plasma. The precursor is proteolytically processed into distinct functioning proteins: alpha-1-microglobulin, which belongs to the superfamily of lipocalin transport proteins and may play a role in the regulation of inflammatory processes, and bikunin, which is a urinary trypsin inhibitor belonging to the superfamily of Kunitz-type protease inhibitors and plays an important role in many physiological and pathological processes. This gene is located on chromosome 9 in a cluster of lipocalin genes. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Alpha-1, Serum albumin, HAD, AGE, ACID
Papers on alpha1-microglobulin
Urinary microprotein concentrations in the long-term follow-up of dilating vesicoureteral reflux patients who underwent medical or surgical treatment.
New
Rao et al., Shanghai, China. In Int Urol Nephrol, Jan 2016
The patients' clinical features and clinical outcomes, as well as the urinary activities of albumin (ALB), transferrin (TRF), immunoglobulin G (IgG), alpha-1-microglobulin (α1-MG), and N-acetyl-β-glucosaminidase (NAG), were retrospectively analyzed.
Low Mass Blood Peptides Discriminative of Inflammatory Bowel Disease (IBD) Severity: A Quantitative Proteomic Perspective.
New
Leong et al., Australia. In Mol Cell Proteomics, Jan 2016
Peptides differentiating controls from IBD originate from secreted phosphoprotein 24 (SPP24, p = 0.000086, 0.009); whereas those in remission and healthy can be differentiated in UC by SPP24 (p = 0.00023, 0.001), α-1-microglobulin (AMBP, p = 0.006) and CD by SPP24 (p = 0.019, 0.05).
Heme-induced contractile dysfunction in Human cardiomyocytes caused by oxidant damage to thick filament proteins.
New
Balla et al., Debrecen, Hungary. In Free Radic Biol Med, Dec 2015
Importantly, binding of heme to hemopexin or alpha-1-microglobulin prevented its effects on cardiomyocyte contractility, suggesting an allosteric effect.
Influence of renal function on serum concentration of 1,5-anhydroglucitol in type 2 diabetic patients in CKD stages I-III: A comparative study with HbA1c and glycated albumin.
New
Kulozik et al., Heidelberg, Germany. In J Diabetes, Dec 2015
METHODS: The following parameters were measured in 377 patients with type 2 diabetes: HbA1c, serum levels of 1,5-AG, GA and creatinine, hemoglobin, urinary albumin/creatinine ratio and urinary excretion of alpha-1-microglobulin (A1M).
First trimester prediction of preeclampsia.
Review
New
Hansson et al., Lund, Sweden. In Curr Hypertens Rep, Sep 2015
New biomarkers suggest an alternative model based on free HbF and the heme scavenger alpha-1-microglobulin (A1M) with a prediction rate of 69 % at an FPR of 5 %.
[Urinary protein detection by iTRAQ® associated with renal transplant complications and its modification with therapy].
New
Cordero-Pérez et al., Monterrey, Mexico. In Cir Cir, Sep 2015
The 5 proteins with higher scores in graft rejection were: alpha-1-microglobulin, 5'-nucleotidase cytosolic III, retinol-binding protein 4, membrane protein palmitoylated 4, and serine carboxypeptidase, while post-transplant infections were: mitochondrial acetyl-coenzyme A synthetase, putative adenosyl homocysteinase 2, zinc finger protein GLIS1, putative protein FAM157B, and zinc finger protein 615.
Urine alpha1-microglobulin is a better marker for early tubular dysfunction than beta2-microglobulin among tenofovir-exposed human immunodeficiency virus-infected men who have sex with men.
New
Shang et al., Shenyang, China. In Braz J Infect Dis, Jul 2015
METHODS: In a cross-sectional study urinary alpha1-microglobulin, beta2-microglobulin, N-acetyl-β-d-glucosaminidase and albumin were measured and expressed as the ratio-to-creatinine in 239 human immunodeficiency virus-infected men who have sex with men who were treatment naïve or receiving antiretroviral therapy with tenofovir-containing or non-tenofovir-containing regimens.
Preeclampsia - will orphan drug status facilitate innovative biological therapies?
Review
Hahn, Basel, Switzerland. In Front Surg, 2014
Hence, it is with great interest to become aware of at least three novel therapeutic approaches for the treatment of this disorder: exploiting either the anticoagulant activity of antithrombin, the free radical scavenging activity of alpha-1-microglobulin, or the regenerative capacity of placenta-derived mesenchymal stem cells.
Validation of potential candidate biomarkers of drug-induced nephrotoxicity and allodynia in medication-overuse headache.
Pini et al., Modena, Italy. In J Headache Pain, 2014
In this study, four proteins that were found differentially expressed in urine, and, on the basis of the literature review, resulted related to kidney diseases, were verified by Western Blot and Enzyme-linked Immunosorbent Assay (ELISA); Prostaglandin-H2 D-synthase (PTGDS), uromodulin (UROM), alpha-1-microglobulin (AMBP) and cystatin-C (CYSC).
Proteomic studies in endemic nephropathy.
Review
Dihazi et al., Niš, Serbia. In Prilozi, 2013
Urine beta2-microglobulin (B2M) was mainly used as a tubular marker of EN but recently alpha1-microglobulin (AMBP) was proposed for the diagnosis of EN.
Fetal hemoglobin in preeclampsia: a new causative factor, a tool for prediction/diagnosis and a potential target for therapy.
Review
Akerström et al., Lund, Sweden. In Curr Opin Obstet Gynecol, 2013
This review summarizes the present knowledge of a new potential cause of the disease and suggests a method for its prediction/diagnosis and a possible treatment, both based on the recent findings on the involvement of fetal hemoglobin (HbF) and the heme and radical scavenging protein A1M (alpha-1-microglobulin). RECENT FINDINGS: Gene and protein profiling studies have independently shown that increased amount of free HbF is accumulated in the preeclampsia placenta.
PP010. Alpha-1-microglobulin protects from heme induced placenta and kidney damage in a pregnant ewe model for preeclampsia.
Gram et al., In Pregnancy Hypertens, 2013
OBJECTIVE: To study alpha-1-microglobulin (A1M), an endogenous radical scavenger and heme-binder, as a potential treatment for preeclampsia using the pregnant ewe preeclampsia model.
PP006. Gene expression profiling of first trimester placentas from pregnancies at high risk of developing preeclampsia.
Hansson et al., In Pregnancy Hypertens, 2013
OBJECTIVE: Was to study first trimester placental gene expression in patients identified as high risk for PE by either Doppler ultrasound or the biochemical markers cell free fetal hemoglobin (HbF) and alpha-1-microglobulin (A1M).
Cloning, purification, crystallization and preliminary X-ray studies of human α1-microglobulin.
GeneRIF
Wang et al., Chongqing, China. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012
crystal of alpha1-microglobulin belonged to space group P4(3), with unit-cell parameters a = b = 36.45, c = 112.68 A
The critical role of adrenomedullin and its binding protein, AMBP-1, in neuroprotection.
Review
Wang et al., North Bay Shore, United States. In Biol Chem, 2012
The evolutionarily conserved neuropeptide, adrenomedullin (AM), and its binding protein, AMBP-1, also known as complement factor H, play important roles in brain physiology, and their expression is altered in brain pathology.
Bikunin and α1-microglobulin/bikunin precursor (AMBP) gene mutational screening in patients with kidney stones: a case-control study.
GeneRIF
Demiryurek et al., Gaziantep, Turkey. In Scand J Urol Nephrol, 2010
These findings suggest that there was no significant association in genotype distribution of Init-2 polymorphism of the AMBP gene between patients with kidney stones and healthy controls.
Beta2-microglobulin and alpha1-microglobulin as markers of Balkan endemic nephropathy, a worldwide disease.
GeneRIF
Djordjević et al., Niš, Serbia. In Ren Fail, 2010
urinary marker for the differential diagnosis of Balkan endemic nephropathy
Up-regulation of A1M/α1-microglobulin in skin by heme and reactive oxygen species gives protection from oxidative damage.
GeneRIF
Akerström et al., Lund, Sweden. In Plos One, 2010
The results suggest that A1M may have a physiological role in protection of skin cells and matrix against oxidative damage following bleeding.
Bystander cell death and stress response is inhibited by the radical scavenger α(1)-microglobulin in irradiated cell cultures.
GeneRIF
Akerström et al., Lund, Sweden. In Radiat Res, 2010
the cell-protective effects of alpha(1)-microglobulin during alpha-particle irradiation
Homology of beta-lactoglobulin, serum retinol-binding protein, and protein HC.
Impact
Brew et al., In Science, 1985
Such comparisons revealed that beta-lactoglobulin is similar to human serum retinol-binding protein and to another human protein of unknown function known as complex-forming glycoprotein heterogeneous in charge (protein HC).
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