MEC-17 is an alpha-tubulin acetyltransferase.
Athens, United States. In Nature, 2010
Acetylation of the epsilon-amino group of K40 on alpha-tubulin is a conserved PTM on the luminal side of microtubules that was discovered in the flagella of Chlamydomonas reinhardtii.
Elongator bridges tubulin acetylation and neuronal migration.
San Francisco, United States. In Cell, 2009
In this issue, Creppe et al. (2009) now show that the multisubunit histone acetyltransferase Elongator may regulate migration and branch formation of cortical neurons in the developing mouse brain by acetylating alpha-tubulin.
Capturing protein tails by CAP-Gly domains.
Switzerland. In Trends Biochem Sci, 2008
A prominent function of CAP-Gly domains is to bind to C-terminal EEY/F-COO(-) sequence motifs present in alpha-tubulin and in some microtubule-associated protein tails; however, CAP-Gly domains also interact with other structural elements including end-binding homology domains, zinc-finger motifs and proline-rich sequences.