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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Synuclein, alpha

alpha-Synuclein, Fyn, PDI, protein disulfide isomerase
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009] (from NCBI)
Top mentioned proteins: CAN, V1a, Src, ACID, HAD
Papers using alpha-Synuclein antibodies
Substrate specificity of the TIM22 mitochondrial import pathway revealed with small molecule inhibitor of protein translocation
Swanton Eileithyia et al., In Biochemical Journal, 2009
... Derlin-1 and PDI (protein disulfide-isomerase) polyclonal rabbit antisera were made by Eurogentec.
Crk and CrkL adaptor proteins: networks for physiological and pathological signaling
Gallay Philippe, In PLoS ONE, 2008
... Anti-Myc mAb and anti-Fyn antibody were obtained from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Association of simian virus 40 vp1 with 70-kilodalton heat shock proteins and viral tumor antigens.
Galloway Denise, In PLoS Pathogens, 2008
... Polyclonal antibodies against Hsp90 and PDI were purchased from Santa Cruz Biotechnology, monoclonal antibodies against PDI ...
Calcium elevation in mitochondria is the main Ca2+ requirement for mitochondrial permeability transition pore (mPTP) opening
Pandol Stephen J. et al., In Pflugers Archiv, 2008
... p44/42 MAP kinase (ERK1/2) were from Cell Signalling (Beverly, MA); Bax and protein disulfide isomerise (PDI) from Santa Cruz Biotechnology (Santa Cruz, CA); COX ...
Cellular chemomechanics at interfaces: sensing, integration and response
Pollack Steven K et al., In Medical Devices (Auckland, N.Z.), 2006
... Medical grade sodium hyaluronate (NaHA) of molecular weight = 0.99 MDa and PDI = 1.3 (Lifecore Biomedical Inc., Chaska, MN) ...
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Papers on alpha-Synuclein
KLF5 promotes cell migration by up-regulating FYN in bladder cancer cells.
Guo et al., Xi'an, China. In Febs Lett, Feb 2016
We found that KLF5 increases cell migration and lamellipodia formation, expression of FYN and phosphorylation of FAK in bladder cancer cells.
Peri/Epicellular Protein Disulfide Isomerase Sustains Vascular Lumen Caliber Through an Anticonstrictive Remodeling Effect.
Laurindo et al., São Paulo, Brazil. In Hypertension, Feb 2016
We hypothesized that the cell-surface pool of the endoplasmic reticulum redox chaperone protein disulfide isomerase-A1 (peri/epicellular=pecPDI), which is known to support thrombosis, also regulates disease-associated vascular architecture.
Impact of PEG and PEG-b-PAGE modified PLGA on nanoparticle formation, protein loading and release.
Lehr et al., Saarbrücken, Germany. In Int J Pharm, Feb 2016
The double emulsion technique yielded spherical NPs in the size range from 170 to 220 nm (PDI < 0.15) for all the differently modified polymers, allowing to directly compare protein loading of and release.
Lysines, Achilles' heel in alpha-synuclein conversion to a deadly neuronal endotoxin.
Bubacco et al., Padova, Italy. In Ageing Res Rev, Jan 2016
UNASSIGNED: Alpha-synuclein aggregation is associated with Parkinson's disease and other neurodegenerative disorders termed synucleinopathies.
Sodium Butyrate Induces Endoplasmic Reticulum Stress and Autophagy in Colorectal Cells: Implications for Apoptosis.
Sun et al., Guangzhou, China. In Plos One, Dec 2015
Furthermore, sodium butyrate treatment markedly enhanced the expression of endoplasmic reticulum stress-associated proteins, including BIP, CHOP, PDI, and IRE-1a.
Combined ligand-observe (19)F and protein-observe (15)N,(1)H-HSQC NMR suggests phenylalanine as the key Δ-somatostatin residue recognized by human protein disulfide isomerase.
Howard et al., Canterbury, United Kingdom. In Sci Rep, Dec 2015
Human protein disulphide isomerase (hPDI) is an endoplasmic reticulum (ER) based isomerase and folding chaperone.
Sorting Out Release, Uptake and Processing of Alpha-Synuclein During Prion-Like Spread of Pathology.
Brundin et al., Grand Rapids, United States. In J Neurochem, Dec 2015
UNASSIGNED: Parkinson's disease is a progressive neurological disorder that is characterized by the formation of intracellular protein inclusion bodies composed primarily of a misfolded and aggregated form of the protein α-synuclein.
Integrated molecular analysis of adult T cell leukemia/lymphoma.
Ogawa et al., Kyoto, Japan. In Nat Genet, Nov 2015
Other notable features include a predominance of activating mutations (in PLCG1, PRKCB, CARD11, VAV1, IRF4, FYN, CCR4 and CCR7) and gene fusions (CTLA4-CD28 and ICOS-CD28).
The Interaction of Alpha-synuclein with Membranes and its Implication in Parkinson's Disease: A Literature Review.
Gonzalez-Horta, In Nat Prod Commun, Oct 2015
Alpha-synuclein belongs to the class of intrinsically disordered proteins lacking a well-folded structure under physiological conditions.
IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction.
Nold et al., Melbourne, Australia. In Nat Immunol, Apr 2015
Proteomic and transcriptomic investigations revealed that IL-37 used IL-1R8 to harness the anti-inflammatory properties of the signaling molecules Mer, PTEN, STAT3 and p62(dok) and to inhibit the kinases Fyn and TAK1 and the transcription factor NF-κB, as well as mitogen-activated protein kinases.
Alpha-synuclein Toxicity in the Early Secretory Pathway: How It Drives Neurodegeneration in Parkinsons Disease.
Hay et al., Missoula, United States. In Front Neurosci, 2014
Alpha-synuclein is a predominant player in the pathogenesis of Parkinson's Disease.
The Unfolded Protein Response and the Role of Protein Disulfide Isomerase in Neurodegeneration.
Atkin et al., Melbourne, Australia. In Front Cell Dev Biol, 2014
Protein Disulfide Isomerase (PDI) is an ER chaperone induced during ER stress that is responsible for the formation of disulfide bonds in proteins.
A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis.
MacBeath et al., Boston, United States. In Cell, 2014
Pharmacologic and genetic perturbations reveal that Fzd2 drives EMT and cell migration through a previously unrecognized, noncanonical pathway that includes Fyn and Stat3.
Costimulatory molecule DNAM-1 is essential for optimal differentiation of memory natural killer cells during mouse cytomegalovirus infection.
Lanier et al., San Francisco, United States. In Immunity, 2014
Src-family tyrosine kinase Fyn and serine-threonine protein kinase C isoform eta (PKCη) signaling through DNAM-1 played distinct roles in the generation of MCMV-specific effector and memory NK cells.
Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas.
Ferrando et al., New York City, United States. In Nat Genet, 2014
In addition, we describe new and recurrent, albeit less frequent, genetic defects including mutations in FYN, ATM, B2M and CD58 implicating SRC signaling, impaired DNA damage response and escape from immune surveillance mechanisms in the pathogenesis of PTCL.
Programmed death-1 gene polymorphism (PD-1.5 C/T) is associated with colon cancer.
Ghaderi et al., Shīrāz, Iran. In Gene, 2012
Programmed death-1 gene polymorphism is associated with colon cancer.
Phosphorylation of α-synuclein is crucial in compensating for proteasomal dysfunction.
Suh et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2012
This study provides evidence that the regulation of Y136 phosphorylation of alpha-synuclein can improve behavioral performance and protect against neuronal death by promoting the turnover of lysosomal degradation of alpha-synuclein.
Viral acute lower respiratory infections impair CD8+ T cells through PD-1.
Williams et al., Nashville, United States. In J Clin Invest, 2012
Inhibition of PD-1 signaling using monoclonal antibody blockade prevented TCD8 impairment, reduced viral titers during primary infection, and enhanced protection of immunized mice against challenge infection.
The promiscuous binding of the Fyn SH3 domain to a peptide from the NS5A protein.
Camara-Artigas et al., Almería, Spain. In Acta Crystallogr D Biol Crystallogr, 2012
analysis of binding of the Fyn SH3 domain to a peptide from the NS5A protein
Soluble α-synuclein is a novel modulator of Alzheimer's disease pathophysiology.
Lesné et al., Minneapolis, United States. In J Neurosci, 2012
our data reveal an unexpected role for soluble, intraneuronal alphaSyn in AD pathophysiology.
More papers using alpha-Synuclein antibodies
Mechanotransduction in an extracted cell model: Fyn drives stretch- and flow-elicited PECAM-1 phosphorylation
Fujiwara Keigi et al., In The Journal of Cell Biology, 2006
... monoclonal antibodies were purchased: anti–protein phosphotyrosine (clone 4G10) and anti-Src (clone GD11; Millipore); anti-c-Yes and anti-Fyn (BD Biosciences); and anti-actin (clone AC-40; ...
Lipid rafts, detergent-resistant membranes, and raft targeting signals
Hueber A-O et al., In Cell Death & Disease, 2005
... Ab-3 (Calbiochem/Merck Chemicals, Nottingham, UK, referred to as Ab-3 in the manuscript), anti-FLAG (M2, Sigma), anti-Fyn (Santa Cruz Biotechnology, Santa Cruz, CA, USA), ...
A guided tour into subcellular colocalization analysis in light microscopy.
II Roy Martin Roop, In PLoS ONE, 2005
... anti-LVS (Becton Dickinson), anti-nucleolin, anti-calnexin, anti-actin, anti-histone H1 and anti-LAMP1 (Abcam); monoclonal antibodies (MoAbs) were anti-PDI (Abcam) and anti-nucleolin (clone D3) ...
Cellular localization, oligomerization, and membrane association of the hereditary spastic paraplegia 3A (SPG3A) protein atlastin
Lee Tina H. et al., In The Journal of Cell Biology, 2002
An mAb used to detect protein disulfide isomerase (Abcam) and the HA epitope ...
Protein kinase signaling in the modulation of microvascular permeability
Mehta Dolly et al., In The Journal of Experimental Medicine, 2001
... Primers for Gβ 1–5 subunits, siRNA for Gβ1, Fyn, cSrc, and control scrambled siRNA, as well as transfection reagent for siRNA, were purchased from Santa Cruz Biotechnology, Inc ...
C-Cbl binds the CSF-1 receptor at tyrosine 973, a novel phosphorylation site in the receptor's carboxy-terminus
Clurman Bruce, In PLoS Genetics, 2001
... and cleaved caspase-3 were from Cell Signaling; anti-SRC, anti-JNK (C-17), anti-MKK4, HA (Y11), anti-GFP, and anti-FYN were purchased from Santa Cruz Biotechnology Inc ...
Integration of Golgi trafficking and growth factor signaling by the lipid phosphatase SAC1
Mayinger Peter et al., In The Journal of Cell Biology, 2000
... anti-PI(4)P (Echelon), mouse monoclonal anti–β-COP (clone mAD; Abcam), rabbit polyclonal anti-SEC23 (COP-II; Abcam), mouse monoclonal anti-PDI (clone RL90; Affinity BioReagents), goat polyclonal anti-Sec61α (Santa Cruz Biotechnology, Inc.), and sheep polyclonal ...
Negative Regulation of T Cell Receptor–Lipid Raft Interaction by Cytotoxic T Lymphocyte–associated Antigen 4
Bluestone Jeffrey A. et al., In The Journal of Experimental Medicine, 1999
Santa Cruz Biotechnology, Inc.), anti-Fyn (Fyn3; Santa Cruz Biotechnology), anti-phosphotyrosine (4G10: Upstate Biotechnology), ...
Activation of oligodendroglial Fyn kinase enhances translation of mRNAs transported in hnRNP A2–dependent RNA granules
Trotter Jacqueline et al., In The Journal of Cell Biology, 1998
... Polyclonal antibodies against Fyn, hnRNP E1 (Santa Cruz Biotechnology, Inc.), and Src-pY418, which ...
Negative Regulation of Immunoglobulin E–dependent Allergic Responses by Lyn Kinase
Rivera Juan et al., In The Journal of Experimental Medicine, 1996
... The rabbit phospho-Src (Y418) and phospho-Lyn (Y507) antibodies, which also recognize Fyn (Y417) and (Y528), were from Biosource International and Cell Signaling Technologies, respectively ...
Peptidase inhibitors improve recovery of substance P and calcitonin gene-related peptide release from rat spinal cord slices
Hingtgen Cynthia M et al., In Molecular Pain, 1995
... 1:500 titer, Cell Signaling Technologies; c-Src: mouse monoclonal primary antibody, 1:500 titer, Santa Cruz Biotechnology; Fyn: mouse monoclonal primary antibody, 1:300 titer, Santa Cruz Biotechnology.
The phosphorylation state of the microtubule-associated protein tau as affected by glutamate, colchicine and beta-amyloid in primary rat cortical neuronal cultures
Reynolds C Hugh et al., In Molecular Neurodegeneration, 1994
... Lck protein was purified using a cobalt containing matrix (Talon, Clontech, Palo Alto, CA, USA) and Fyn by an immunoaffinity column using Fyn3 antibody (Santa Cruz Biotechnology, Santa Cruz, CA, USA) ...
Changes in protein phosphorylation in Rous sarcoma virus-transformed chicken embryo cells.
Fujita Donald J et al., In BMC Biochemistry, 1980
... raised against amino acids 23–247 mapping within the extracellular domain of Flt-1 of human origin, α-Fyn (FYN3), and α-Yes (3) were purchased from Santa Cruz Biotechnology.
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