Atypical Renal Cysts: A Morphologic, Immunohistochemical, and Molecular Study.
Indianapolis, United States. In Am J Surg Pathol, Feb 2016
We retrieved 29 cases (15 nephrectomies, 14 partial nephrectomies) from the surgical pathology files of Johns Hopkins Hospital from 1993 to 2014 and performed immunohistochemistry for CK7, alpha-methylacyl-CoA racemase (AMACR), CAIX, and CD10 and fluorescence in situ hybridization for trisomy 7 and 17 and 3p deletion.
[Related biomarkers in the diagnosis of prostate cancer].
In Zhonghua Nan Ke Xue, Oct 2015
This review focuses on some of the more promising tumor biomarkers such as prostate cancer antigen 3, early prostate cancer antigen, prostate-specific membrane antigen, alpha-methylacyl-CoA racemase, and vascular endothelial growth factor.
Seminal vesicle intraepithelial neoplasia versus basal cell hyperplasia in a seminal vesicle.
Ancona, Italy. In Eur Urol, 2014
Prostate-specific antigen, prostate-specific acid phosphatase, prostate-specific membrane antigen, prostein (P501S), alpha-methylacyl-CoA racemase, and GATA binding protein 3 (GATA3) were negative; p63, 34betaE12, cytokeratin 5/6, and p53 were positive in cells in basal and suprabasal positions, whereas CA-125 was expressed in the luminal cells.
Lipid metabolism in prostate cancer.
New York City, United States. In Am J Clin Exp Urol, 2013
A central role for fatty acid oxidation in supplying energy to the prostate cancer cell is supported by the observation that the peroxisomal enzyme, α-methylacyl-CoA racemase (AMACR), which facilitates the transformation of branched chain fatty acids to a form suitable for β-oxidation, is highly overexpressed in prostate cancer compared with normal prostate.
Identification of a cell of origin for human prostate cancer.
Los Angeles, United States. In Science, 2010
The cooperative effects of AKT, ERG, and androgen receptor in basal cells recapitulated the histological and molecular features of human prostate cancer, with loss of basal cells and expansion of luminal cells expressing prostate-specific antigen and alpha-methylacyl-CoA racemase.