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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Actin, alpha, cardiac muscle 1

alpha-cardiac actin, Actc-1
Top mentioned proteins: Actin, CAN, HAD, alpha-actin, Desmin
Papers on alpha-cardiac actin
E101K and M123V alpha-cardiac actin gene mutations are not associated with cardiomyopathy in Iranian population.
Behmanesh et al., Tehrān, Iran. In Arya Atheroscler, Sep 2015
ACTC1 is one of the main sarcomere components in heart muscle.
A Novel Alpha Cardiac Actin (ACTC1) Mutation Mapping to a Domain in Close Contact with Myosin Heavy Chain Leads to a Variety of Congenital Heart Defects, Arrhythmia and Possibly Midline Defects.
Bouvagnet et al., Lyon, France. In Plos One, 2014
The haplotype analysis delineated a 7.7 meganucleotides genomic interval which included the alpha-cardiac actin gene (ACTC1) among 36 other protein coding genes.
Cardiomyocyte differentiation induced in cardiac progenitor cells by cardiac fibroblast-conditioned medium.
Zhang et al., Shanghai, China. In Exp Biol Med (maywood), 2014
The expression of cardiomyocyte-associated genes, such as alpha-cardiac actin, cardiac troponin T, and beta-myosin heavy chain (MHC), was increased in the CPCs that had undergone cardiomyogenic differentiation compared with untreated cells.
Exome sequencing identifies a novel variant in ACTC1 associated with familial atrial septal defect.
Gerull et al., Calgary, Canada. In Can J Cardiol, 2014
RESULTS: Whole-exome sequencing of 2 affected family members identified 44 rare shared variants, including a nonsynonymous mutation (c.532A>T, p.M178L, NM_005159.4) in alpha-cardiac actin (ACTC1).
A cocktail method for promoting cardiomyocyte differentiation from bone marrow-derived mesenchymal stem cells.
Fan et al., Tianjin, China. In Stem Cells Int, 2013
Real-time qPCR and Western blotting analyses showed that cTnT, alpha-cardiac actin, mef-2c, Cx43, and GSK-3beta expression increased while beta-catenin expression decreased.
Polymorphism in the alpha cardiac muscle actin 1 gene is associated to susceptibility to chronic inflammatory cardiomyopathy.
Chevillard et al., São Paulo, Brazil. In Plos One, 2012
Since mutations in multiple sarcomeric genes, including alpha-cardiac actin (ACTC1) have been involved in hereditary dilated cardiomyopathy, we investigated the involvement of the ACTC1 gene in CCC pathogenesis.
Intracoronary artery transplantation of cardiomyoblast-like cells from human adipose tissue-derived multi-lineage progenitor cells improve left ventricular dysfunction and survival in a swine model of chronic myocardial infarction.
Matsuyama et al., Suita, Japan. In Biochem Biophys Res Commun, 2012
Histological studies at week 12 post-transplantation demonstrated engraftment of the pre DiI-stained hCLCs into the scarred myocardium and their expression of human specific alpha-cardiac actin.
Molecular mechanism of the E99K mutation in cardiac actin (ACTC Gene) that causes apical hypertrophy in man and mouse.
Marston et al., London, United Kingdom. In J Biol Chem, 2011
propose that the ACTC E99K mutation causes higher myofibrillar Ca(2+) sensitivity that is responsible for the sudden cardiac death, apical hypertrophy, and subsequent development of heart failure in humans and mice.
Characterization of Fetal Tissue-derived Mesenchymal Stem Cells.
Kim et al., Seoul, South Korea. In Int J Stem Cells, 2009
The hfMSCs were able to undergo PCR up to 20 times without displaying significant changes in morphology or expression of various stemness markers (Nanog and human telomerase reverse transcriptase [hAFP]), including germ layer markers (hNF68, alpha-cardiac actin, and hAFP).
Characterization of a cardiac-specific enhancer, which directs {alpha}-cardiac actin gene transcription in the mouse adult heart.
Buckingham et al., Paris, France. In J Biol Chem, 2005
there is a cardiac-specific enhancer located within -2.354/-1.36 kbp of Actc1
A novel complex regulates cardiac actin gene expression through interaction of Emb, a class VI POU domain protein, MEF2D, and the histone transacetylase p300.
Buckingham et al., Paris, France. In Mol Cell Biol, 2004
These results demonstrate the importance of the Emb-MEF2D-histone transacetylase p300 complex in the transcriptional regulation of the cardiac actin gene and suggest a potential role in chromatin remodeling associated with muscle gene activation.
Cellular disorganization and extensive apoptosis in the developing heart of mice that lack cardiac muscle alpha-actin: apparent cause of perinatal death.
Jokinen et al., Turku, Finland. In Pediatr Res, 2004
Other actin isoforms cannot compensate for the lack of cardiac alpha-actin, and this seems to induce apoptosis in defective cardiac myocytes, which are not able to cope with the increased workload in the perinatal phase.
Cardiomyopathy: molecular and immunological aspects (review).
Takeda, Tokyo, Japan. In Int J Mol Med, 2003
In familial hypertrophic cardiomyopathy, nine gene abnormalities have been discovered in the sarcomere, i.e. the genes of beta cardiac myosin heavy chain, cardiac troponin T, alpha-tropomyosin, cardiac myosin binding protein-C, essential or regulatory myosin light chain, cardac troponin I, alpha-cardiac actin, and titin.
Aetiology and pathogenesis of hypertrophic cardiomyopathy.
Betocchi et al., Napoli, Italy. In Acta Paediatr Suppl, 2001
Other genes involved are alpha-tropomyosin, cardiac troponin-I, essential and regulatory light chains, alpha-cardiac actin, titin, and alpha-myosin heavy chain.
Genetic complementation reveals a novel regulatory role for 3' untranslated regions in growth and differentiation.
Blau et al., Stanford, United States. In Cell, 1993
The complementing cDNAs were identified as muscle structural genes, troponin I, tropomyosin, and alpha-cardiac actin, and their activity was mapped to the 3' untranslated region (3'UTR).
Chromosomal localization of muscle nicotinic acetylcholine receptor genes in the mouse.
Changeux et al., In Science, 1986
Analysis of the progeny of the interspecies mouse backcross (DBA/2 X SPE) X DBA/2 showed that the alpha-subunit gene cosegregates with the alpha-cardiac actin gene on chromosome 17, that the beta-subunit gene is located on chromosome 11, and that the gamma- and delta-subunit genes cosegregate and are located on chromosome 1.
The pattern of actin expression in human fibroblast x mouse muscle heterokaryons suggests that human muscle regulatory factors are produced.
Blau et al., In Cell, 1986
In addition, the usual decline in the level of mouse alpha-cardiac actin transcripts was not observed; instead, after fusion with human fibroblasts the levels increased.
Cell type-specific activation of actin genes in the early amphibian embryo.
Gurdon et al., In Nature, 1984
Gene-specific probes show that alpha-skeletal and alpha-cardiac actin genes start to be transcribed simultaneously at the end of gastrulation, but only in those regions of the mesoderm that subsequently form embryonic muscle.
alpha-Cardiac actin is the major sarcomeric isoform expressed in embryonic avian skeletal muscle.
Eldridge et al., In Science, 1984
alpha-Cardiac actin mRNA accounts for more than 90 percent of the sarcomeric actin transcripts expressed in avian embryonic breast muscle.
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