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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Actinin, alpha 1

alpha-Actinin, alpha-actinin-1, ACTN1, alpha-actinin, a
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Actin, CAN, alpha-actinin-4, ACID, HAD
Papers on alpha-Actinin
Three-Dimensional Cultures of Human Subcutaneous Adipose Tissue-Derived Progenitor Cells Based on RAD16-I Self-Assembling Peptide.
New
Semino et al., Barcelona, Spain. In Tissue Eng Part C Methods, Feb 2016
Additionally, it has been observed that chemical induction can induce upregulation of cardiac markers, such as TBX5, MEF2C, ACTN1, and GJA1.
Comparative proteome analysis of saccular intracranial aneurysms with iTRAQ quantitative proteomics.
New
Zhao et al., Beijing, China. In J Proteomics, Feb 2016
Furthermore, Integrin β3, Secreted frizzled-related protein 2 were significantly up-regulated (2.3 fold and 2.1 fold, respectively), whereas MyosinIIb, Alpha-actinin-1, Laminin β2, and Carboxypeptidase A3 were down-regulated (3.01 fold, 2.1 fold, 2.07 fold, and 2.01 fold, respectively) in sIAs.
ACTN1 rod domain mutation associated with congenital macrothrombocytopenia.
New
Ohshima et al., Fukui, Japan. In Ann Hematol, Jan 2016
Mutations in ACTN1, the gene encoding the actin-crosslinking protein α-actinin-1, cause autosomal dominant macrothrombocytopenia.
A translocation t(6;14) in two cases of leiomyosarcoma: Molecular cytogenetic and array-based comparative genomic hybridization characterization.
New
Szuhai et al., Leiden, Netherlands. In Cancer Genet, Nov 2015
A small homozygous deletion was also found in the breakpoint region of chromosome 14q24.1 involving ACTN1.
The actinin family of actin cross-linking proteins - a genetic perspective.
Young et al., Cork, Ireland. In Cell Biosci, 2014
Invertebrates have a single actinin-encoding ACTN gene, while mammals have four.
Update on the causes of platelet disorders and functional consequences.
Review
van Geet et al., Leuven, Belgium. In Int J Lab Hematol, 2014
A major step forward was made during the last 3 years using new-generation genetic approaches that resulted in the discovery of novel genes such as NBEAL2, RBM8A, ACTN1, and GFI1B for the well-known IPD that cause gray platelet syndrome, thrombocytopenia-absent radius syndrome, and autosomal dominant thrombocytopenias, respectively.
Novel insight into the role of α-actinin-1 in rheumatoid arthritis.
Review
Burgering et al., Guangzhou, China. In Discov Med, 2014
Recently we demonstrated that α-actinin-1 (ACTN1) gene is significantly increased in synovial tissues obtained from RA, as compared to osteoarthritis (OA).
Pathogenesis and management of inherited thrombocytopenias: rationale for the use of thrombopoietin-receptor agonists.
Review
Pecci, Pavia, Italy. In Int J Hematol, 2013
In the last 5 years, nine new genes whose mutations are responsible for thrombocytopenia have been identified, and this also led to the recognition of several novel nosographic entities, such as thrombocytopenias deriving from mutations in CYCS, TUBB1, FLNA, ITGA2B/ITGB3, ANKRD26 and ACTN1.
Alpha-actinin 4 and tumorigenesis of breast cancer.
Review
Kao et al., Cleveland, United States. In Vitam Horm, 2012
Notably, unlike other ACTNs, alpha-actinin 4 (ACTN4) displays unique characteristics in signaling transduction, nuclear translocation, and gene expression regulation.
CLP36 and RIL recruit α-actinin-1 to stress fibers and differentially regulate stress fiber dynamics in F2408 fibroblasts.
GeneRIF
Sato et al., Hamamatsu, Japan. In Exp Cell Res, 2012
The alpha-actinin-1 form a complex with CLP36 and RIL.
EWI-2 association with α-actinin regulates T cell immune synapses and HIV viral infection.
GeneRIF
Yáñez-Mó et al., Madrid, Spain. In J Immunol, 2012
The alpha-actinin/EWI motif-containing protein 2 (EWI-2) complex is involved in regulation of the actin cytoskeleton at T cell immune and virological synapses, providing a link between membrane microdomains and structures involved in T cell recognition.
Desmin and α-actinin-2 content in rat soleus muscle in the dynamics of gravitational unloading and subsequent reloading.
GeneRIF
Ogneva et al., Moscow, Russia. In Dokl Biochem Biophys, 2012
Desmin and alpha-actinin-2 content in rat soleus muscle in the dynamics of gravitational unloading and subsequent reloading.
Alpha-actinin: a multidisciplinary protein with important role in B-cell driven autoimmunity.
Review
Dalekos et al., Lárisa, Greece. In Autoimmun Rev, 2011
Alpha-actinin (α-actinin) is a ubiquitous cytoskeletal protein, which belongs to the superfamily of filamentous actin (F-actin) crosslinking proteins.
HAMLET binding to α-actinin facilitates tumor cell detachment.
GeneRIF
Svanborg et al., Lund, Sweden. In Plos One, 2010
The results suggest that the interaction between HAMLET and alpha-actinins promotes tumor cell detachment.
Localization of the invadopodia-related proteins actinin-1 and cortactin to matrix-contact-side cytoplasm of cancer cells in surgically resected lung adenocarcinomas.
GeneRIF
Eishi et al., Tokyo, Japan. In Pathobiology, 2010
Actinin-1 and cortactin showed matrix-contact-side localization in adenocarcinoma cells.
Actin and alpha-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner.
Impact
GeneRIF
Horwitz et al., Charlottesville, United States. In Nat Cell Biol, 2008
Alpha-Actinin mediates the formation of the template and organization of adhesions associated with actin filaments, suggesting that actin crosslinking has a major role in this process.
Competitive binding of alpha-actinin and calmodulin to the NMDA receptor.
Impact
Sheng et al., Boston, United States. In Nature, 1997
alpha-Actinin-2, a member of the spectrin/dystrophin family of actin-binding proteins, is identified here as a brain postsynaptic density protein that colocalizes in dendritic spines with NMDA receptors and the putative NMDA receptor-clustering molecule PSD-95.
alpha-Actinin-containing branched microvilli isolated from an ascites adenocarcinoma.
Impact
Carraway et al., In Nature, 1980
Immunofluorescence studies with anti-alpha-actinin have suggested that alpha-actinin is concentrated at the tips of intestinal brush border microvilli and might link actin microfilaments and the plasma membrane.
The existence of an insoluble Z disc scaffold in chicken skeletal muscle.
Impact
Lazarides et al., In Cell, 1978
SDS-polyacrylamide gel electrophoresis reveals that this framework consists primarily of actin and desmin, with lesser amounts of a few proteins including alpha-actinin, myosin and tropomyosin.
Alpha-actinin: immunofluorescent localization of a muscle structural protein in nonmuscle cells.
Impact
Burridge et al., In Cell, 1975
Antibodies specific for the skeletal muscle structural protein alpha-actinin are used to localize this protein by indirect immunofluorescence in nonmuscle cells.
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