New developments in steroid-resistant nephrotic syndrome.
Bristol, United Kingdom. In Pediatr Nephrol, 2013
Key genes that have been identified from the study of inherited nephrotic syndromes include those encoding nephrin, podocin, TRPC6 (transient receptor potential canonical channel-6) and α-actinin-4, and more remain to be found.
Alpha-actinin 4 and tumorigenesis of breast cancer.
Cleveland, United States. In Vitam Horm, 2012
Notably, unlike other ACTNs, alpha-actinin 4 (ACTN4) displays unique characteristics in signaling transduction, nuclear translocation, and gene expression regulation.
MDM2 binding protein, a novel metastasis suppressor.
Kansas City, United States. In Cancer Metastasis Rev, 2012
Furthermore, overexpression of MTBP suppresses cell migration and filopodia formation, in part, by inhibiting function of an actin crosslinking protein α-actinin-4.
Pathogenesis of nonimmune glomerulopathies.
Saint Louis, United States. In Annu Rev Pathol, 2005
In addition, we review our current understanding of the slit diaphragm (a specialized cell junction found in the kidney), slit diaphragm-associated proteins (including nephrin, podocin, alpha-actinin-4, CD2-associated protein, and transient receptor potential channel 6), and the role of these proteins in glomerular disease.