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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Actin, alpha 1, skeletal muscle

alpha-actin, ActA
The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Actin, CAN, HAD, V1a, SM22alpha
Papers using alpha-actin antibodies
Automated structure prediction of weakly homologous proteins on a genomic scale
Supplier
Linstedt Adam D. et al., In The Journal of Cell Biology, 2003
... For GFP-ActA, residues 599–624 of the ActA protein from Listeria monocytogens were cloned into the HindIII and BamHI sites of pEGFP-C1 (Clontech Laboratories, Inc.) ...
Mitochondrial disorders
Supplier
Zeviani Massimo et al., In Cell Metabolism, 2003
... MCK-PGC-1α and ACTA-Cre transgenic mice were obtained from ...
Papers on alpha-actin
AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy irrespective of expression levels and the subcellular localization of Bcl-xL and Bcl-2 in MCF7 cells.
New
Kögel et al., Frankfurt am Main, Germany. In Biochim Biophys Acta, Jan 2016
This was also observed with the organelle-specific variants Bcl-xL-ActA and Bcl-2-ActA (mitochondrial) as well as Bcl-xL-cb5 and Bcl-2-cb5 (ER) which all reduced AT-101-induced cell death, but did not affect the death-enhancing effects of 3-MA.
[Treatment of Anovulatory Infertility with Shen Deficiency Syndrome by ZHU's Tiaojing Cuyun Recipe: a Clinical Evaluation].
New
Dong et al., In Zhongguo Zhong Xi Yi Jie He Za Zhi, Oct 2015
Serum levels of activin A (ACTA), inhibin B (INHB), and follistatin (FS) were detected using double antibody sandwich ELISA.
Increase of Th17 Cell Phenotype in Kidney Transplant Recipients with Chronic Allograft Dysfunction.
Yang et al., Seoul, South Korea. In Plos One, 2014
In vitro study revealed that IL-17 increased production of IL-6 and IL-8 and up-regulated profibrotic gene expression such as ACTA-2 and CTGF in HPRTEpiC in a dose-dependent manner, which suggests that IL-17 has a role in the development of renal tubular cell injury.
Genetic profile of hypertrophic cardiomyopathy in Tunisia: Is it different?
Olivotto et al., Monastir, Tunisia. In Glob Cardiol Sci Pract, 2014
Using the Illumina platform, a panel of 12 genes was analyzed including myosin binding protein C (MYBPC3), beta-myosin heavy chain (MYH7), regulatory and essential light chains (MYL2 and MYL3), troponin-T (TNNT2), troponin-I (TNNI3), troponin-C (TNNC1), alpha-tropomyosin (TPM1), alpha-actin (ACTC1), alpha-actinin-2 (ACTN2) as well as alfa-galactosidase (GLA), 5'-AMP-activated protein (PKRAG2), transthyretin (TTR) and lysosomal-associated membrane protein-2 (LAMP2) for exclusion of phenocopies.
Nuclear factor-κB mediates the phenotype switching of airway smooth muscle cells in a murine asthma model.
Fan et al., Shenzhen, China. In Int J Clin Exp Pathol, 2014
We found that chronic asthma increased the activation of NF-κB in the primary murine ASM cells with a concomitant marked decrease in the expression of contractile phenotypic marker protein including smooth muscle alpha-actin (α-SMA).
Role of host GTPases in infection by Listeria monocytogenes.
Review
Dowd et al., Dunedin, New Zealand. In Cell Microbiol, 2014
After bacterial-induced destruction of the phagosome, cytosolic Listeria uses the surface protein ActA to stimulate actin-based motility.
Listeria monocytogenes exploits efferocytosis to promote cell-to-cell spread.
Impact
Brumell et al., Toronto, Canada. In Nature, 2014
Expression of the cell surface protein ActA allows L. monocytogenes to activate host actin regulatory factors and undergo actin-based motility in the cytosol, eventually leading to formation of actin-rich protrusions at the cell surface.
Listeria monocytogenes ActA: a new function for a 'classic' virulence factor.
Review
Lecuit et al., Paris, France. In Curr Opin Microbiol, 2014
We have recently shown that ActA also acts extracellularly.
[Role of Activin A and Myostatin in cancer cachexia].
Review
Loumaye et al., Brussels, Belgium. In Ann Endocrinol (paris), 2013
Recent works suggest that Activin A (ActA) and Myostatin (Mstn), two members of the TGFβ superfamily, could contribute to skeletal muscle atrophy observed in some cancers.
Immunohistochemistry in diagnosis of extranasopharyngeal angiofibroma originating from nasal cavity: case presentation and review of the literature.
Review
Zivić et al., In Acta Medica (hradec Kralove), 2012
The staining was positive for CD34, CD31, factor VIII, vimentin and smooth muscle alpha-actin, and negative for desmin.
Eye features in three Danish patients with multisystemic smooth muscle dysfunction syndrome.
GeneRIF
Ostergaard et al., Viborg, Denmark. In Br J Ophthalmol, 2012
Congenital mydriasis is an extremely rare pupil anomaly and is the feature for the early diagnosis of this new syndrome with ACTA2 mutation.
A novel distinctive cerebrovascular phenotype is associated with heterozygous Arg179 ACTA2 mutations.
GeneRIF
Ganesan et al., London, United Kingdom. In Brain, 2012
Neuroimaging phenotype of ACTA2 mutations highlights differences compared with moyamoya disease and emphasizes clinical features that should lead to consideration of this diagnosis and recognition of the importance of the cerebrovascular patterns.
Scleraxis modulates bone morphogenetic protein 4 (BMP4)-Smad1 protein-smooth muscle α-actin (SMA) signal transduction in diabetic nephropathy.
GeneRIF
Doi et al., Tokushima, Japan. In J Biol Chem, 2012
Scx and Id1 are involved in the BMP4-Smad1-SMA signal transduction pathway besides the TGFbeta1-Smad1-SMA signaling pathway and modulate phenotypic changes in MCs in diabetic nephropathy.
Smooth muscle actin expression in primary bone tumours.
GeneRIF
Athanasou et al., Oxford, United Kingdom. In Virchows Arch, 2012
Our findings show that there is differential expression of the alpha isoform of smooth muscle actin in primary bone tumours
The interstitial expression of alpha-smooth muscle actin in glomerulonephritis is associated with renal function.
GeneRIF
Vukojevic et al., Split, Croatia. In Med Sci Monit, 2012
Interstitial expression of ASMA is associated with reduced renal function at time of biopsy.
Cyanotic congenital heart disease the coronary arterial circulation.
Review
Perloff, Los Angeles, United States. In Curr Cardiol Rev, 2012
Immunostaining against SM alpha-actin permitted microcirculatory morphometric analysis.
Listeria monocytogenes ActA-mediated escape from autophagic recognition.
Impact
Sasakawa et al., Tokyo, Japan. In Nat Cell Biol, 2009
We show here that recruitment of the Arp2/3 complex and Ena/VASP, via the bacterial ActA protein, to the bacterial surface disguises the bacteria from autophagic recognition, an activity that is independent of the ability to mediate bacterial motility.
Mutations in smooth muscle alpha-actin (ACTA2) lead to thoracic aortic aneurysms and dissections.
Impact
GeneRIF
Milewicz et al., Houston, United States. In Nat Genet, 2007
Study shows that missense mutations in ACTA2 are responsible for 14% of inherited ascending thoracic aortic aneurysms and dissections (TAAD).
Human tissue-engineered blood vessels for adult arterial revascularization.
Impact
McAllister et al., Novato, United States. In Nat Med, 2006
A smooth muscle-specific alpha-actin-positive cell population developed within the TEBV, suggesting regeneration of a vascular media.
The RickA protein of Rickettsia conorii activates the Arp2/3 complex.
Impact
Cossart et al., Paris, France. In Nature, 2004
Arp2/3 requires activation by proteins such as the WASP-family proteins or ActA of Listeria.
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