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proteins. Page last changed on 19 Dec 2016.
Adrenergic, alpha-1D-, receptor
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region. [provided by RefSeq, Jul 2008] (from
Janciauskiene et al., Barcelona, Spain. In Br J Dermatol, Dec 2015
UNASSIGNED: Neutrophilic panniculitis associated with alpha-1 antitrypsin deficiency (AATD) is a very rare disease with an estimated prevalence of 1 in 1,000 subjects with severe AATD (usually Caucasians with a Pi*ZZ genotype).
Ogura et al., Ōtsu, Japan. In Low Urin Tract Symptoms, 2013
OBJECTIVE: We investigated the effects of dutasteride on urination and quality of life (QOL) in patients diagnosed with benign prostatic hyperplasia (BPH) who showed poor improvement in lower urinary tract symptoms (LUTS) with alpha-1 blockers.
Krynetskiy et al., Philadelphia, United States. In Dig Dis Sci, 2011
Genetic characteristics associated with response to domperidone therapy included polymorphisms in the drug transporter gene ABCB1, the potassium channel KCNH2 gene, and alpha1D--adrenoceptor ADRA1D gene.
García-Sáinz et al., Mexico. In Naunyn Schmiedebergs Arch Pharmacol, 2009
Our data indicate that carboxyl terminus-truncated alpha(1D)-adrenoceptors are fully functional and subjected to regulation by phosphorylation. The roles of the carboxyl termini differ among alpha(1)-adrenoceptor subtypes.
Lee et al., Wilmington, United States. In Science, 1997
Time-resolved in situ x-ray absorption spectroscopy shows that when either alphaI-VOPO4/SiO2 or (VO)2P2O7/SiO2 catalysts are exposed to n-butane, the rate of maleic anhydride formation is proportional to the rate of decay of V5+ species in the catalyst.