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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Adrenergic, alpha-1D-, receptor

Alpha-1, alphaI
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, AGE, CD45
Papers on Alpha-1
Exome Sequencing Analysis in Severe, Early-Onset Chronic Obstructive Pulmonary Disease.
New
Lung GO et al., Boston, United States. In Am J Respir Crit Care Med, Feb 2016
Alpha-1 antitrypsin deficiency shows that rare coding variants of large effect also influence COPD susceptibility.
Historical role of alpha-1-antitrypsin deficiency in respiratory and hepatic complications.
New
Chuang et al., Columbus, United States. In Gene, Feb 2016
UNASSIGNED: Alpha-1-antitrypsin (AAT) deficiency is a heritable disease that is commonly associated with complications in the respiratory and hepatic systems.
Identification of candidate synovial membrane biomarkers after Achyranthes aspera treatment for rheumatoid arthritis.
New
Tian et al., Hangzhou, China. In Biochim Biophys Acta, Jan 2016
Furthermore, Alpha-1-antiproteinase and manganese superoxide dismutase were both increased in drug-treated synovial tissues.
Luminal Angiotensin II Stimulates Rat Medullary Thick Ascending Limb Chloride Transport in the in the Presence of Basolateral Norepinephrine.
New
Baum, Dallas, United States. In Am J Physiol Renal Physiol, Jan 2016
Alpha1 adrenergic stimulation prevents the inhibition of chloride transport by luminal angiotensin II.
Characteristics of Alpha-1 Antitrypsin-Deficient Individuals in the Long-term Oxygen Treatment Trial and Comparison with Other Subjects with Chronic Obstructive Pulmonary Disease.
New
LOTT Research Group * et al., Baltimore, United States. In Ann Am Thorac Soc, Dec 2015
RATIONALE: Alpha-1 antitrypsin deficiency (AATD) predisposes to chronic obstructive pulmonary disease, but is underrecognized.
[Alpha-1 antitrypsin deficiency: A model of alteration of protein homeostasis or proteostasis].
Review
New
Bouchecareilh et al., Bordeaux, France. In Rev Mal Respir, Dec 2015
Risk factors for COPD include exposure to tobacco, dusts and chemicals, asthma and alpha-1 antitrypsin deficiency.
Alpha1-Adrenoceptor Antagonists Improve Memory by Activating N-methyl-D-Aspartate-Induced Ion Currents in the Rat Hippocampus.
New
Kim et al., Inch'ŏn, South Korea. In Int Neurourol J, Dec 2015
PURPOSE: Alpha1 (α1)-adrenoceptor antagonists are widely used to treat lower urinary tract symptoms.
Neutrophilic Panniculitis Associated with Alpha-1 Antitrypsin Deficiency: an Update.
Review
New
Janciauskiene et al., Barcelona, Spain. In Br J Dermatol, Dec 2015
UNASSIGNED: Neutrophilic panniculitis associated with alpha-1 antitrypsin deficiency (AATD) is a very rare disease with an estimated prevalence of 1 in 1,000 subjects with severe AATD (usually Caucasians with a Pi*ZZ genotype).
The use of alpha-1 adrenergic blockers in children with distal ureterolithiasis: a systematic review and meta-analysis.
Review
New
Bernardo et al., Santos, Brazil. In Int Braz J Urol, Nov 2015
However, literature about the use of alpha-1 adrenergic blockers in pediatric population with distal ureterolithiasis is still scarce.
Neutrophil elastase inhibitors for the treatment of (cardio)pulmonary diseases: Into clinical testing with pre-adaptive pharmacophores.
Review
New
Li et al., Berlin, Germany. In Bioorg Med Chem Lett, Nov 2015
Alpha-1 antitrypsin deficiency is linked with an increased risk of suffering from lung emphysema.
[Alpha-1 antitrypsin deficiency 50 years later].
Review
Mornex, In Bull Acad Natl Med, 2014
Alpha-1 antitrypsin deficiency is a frequent genetic disorder associated with pulmonary emphysema in smokers and with liver cirrhosis.
Efficacy of Additional Dutasteride on Lower Urinary Tract Symptoms in Patients with Alpha-1 Blocker-Resistant Benign Prostatic Hyperplasia.
Ogura et al., Ōtsu, Japan. In Low Urin Tract Symptoms, 2013
OBJECTIVE: We investigated the effects of dutasteride on urination and quality of life (QOL) in patients diagnosed with benign prostatic hyperplasia (BPH) who showed poor improvement in lower urinary tract symptoms (LUTS) with alpha-1 blockers.
Correlation Between Bladder Mucosal Alpha-1D/Alpha-1A Adrenoceptor mRNA Ratio and Lower Urinary Tract Function in Benign Prostatic Obstruction Patients.
Nishizawa et al., Matsumoto, Japan. In Low Urin Tract Symptoms, 2013
OBJECTIVES: Alpha-1 adrenoceptor (AR) antagonists are commonly used as therapeutic agents for patients with benign prostatic obstruction (BPO).
Domperidone treatment for gastroparesis: demographic and pharmacogenetic characterization of clinical efficacy and side-effects.
GeneRIF
Krynetskiy et al., Philadelphia, United States. In Dig Dis Sci, 2011
Genetic characteristics associated with response to domperidone therapy included polymorphisms in the drug transporter gene ABCB1, the potassium channel KCNH2 gene, and alpha1D--adrenoceptor ADRA1D gene.
Alpha-dystrobrevin-1 recruits alpha-catulin to the alpha1D-adrenergic receptor/dystrophin-associated protein complex signalosome.
GeneRIF
Hague et al., Seattle, United States. In Proc Natl Acad Sci U S A, 2011
Data show that alpha-dystrobrevin-1 recruits alpha-catulin, which supersensitizes alpha(1D)-AR functional responses by recruiting effector molecules to the signalosome.
Signaling properties of human alpha(1D)-adrenoceptors lacking the carboxyl terminus: intrinsic activity, agonist-mediated activation, and desensitization.
GeneRIF
García-Sáinz et al., Mexico. In Naunyn Schmiedebergs Arch Pharmacol, 2009
Our data indicate that carboxyl terminus-truncated alpha(1D)-adrenoceptors are fully functional and subjected to regulation by phosphorylation. The roles of the carboxyl termini differ among alpha(1)-adrenoceptor subtypes.
The alpha1D-adrenergic receptor induces vascular smooth muscle apoptosis via a p53-dependent mechanism.
GeneRIF
Piascik et al., Lexington, United States. In Mol Pharmacol, 2008
ADRA1D induces vascular smooth muscle apoptosis via a p53-dependent mechanism.
Evidence of alpha1-adrenoceptor functional changes in omental arteries of patients with end-stage renal disease.
GeneRIF
Castillo-Henkel et al., Mexico. In Auton Autacoid Pharmacol, 2008
ADRA1A expression was decreased in end stage renal disease. Functional receptor changes mediated vascular hypersensitivity to phenylephrine.
The Kinetic Significance of V5 in n-Butane Oxidation Catalyzed by Vanadium Phosphates
Impact
Lee et al., Wilmington, United States. In Science, 1997
Time-resolved in situ x-ray absorption spectroscopy shows that when either alphaI-VOPO4/SiO2 or (VO)2P2O7/SiO2 catalysts are exposed to n-butane, the rate of maleic anhydride formation is proportional to the rate of decay of V5+ species in the catalyst.
Alpha-1-antitrypsin deficiency, emphysema, cirrhosis, and intestinal mucosal atrophy.
Impact
Randa et al., In Jama, 1975
He had very low levels of serum alpha1-antitrypsin, hepatic cirrhosis, and intestinal mucosal atrophy.
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