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Adrenergic, alpha-1B-, receptor

alpha 1B-adrenoceptor, alpha 1B-adrenergic receptor, alpha 1B-adrenergic receptor gene
couples with G alpha(h) (transglutaminase II) to activate phospholipase C; facilitates Ca2+ release and capacitative Ca2+ entry [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: HAD, CAN, V1a, Arginine Vasopressin, ACID
Papers on alpha 1B-adrenoceptor
The eukaryotic translation initiation factor 3f (eIF3f) interacts physically with the alpha 1B-adrenergic receptor and stimulates adrenoceptor activity.
Pardo-Galván et al., Morelia, Mexico. In Bmc Biochem, 2014
RESULTS: We here report that, in native conditions, eIF3f physically interacts with the alpha 1B-adrenergic receptor, a plasma membrane protein considered as a proto-oncogene, and involved in vasoconstriction and cell proliferation.
Epinephrine-dependent control of glucose metabolism in white adipose tissue: the role of α- and β-adrenergic signalling.
GeneRIF
Kazdova et al., Praha, Czech Republic. In Exp Biol Med (maywood), 2012
alpha- and beta-adrenergic signalling has a role in epinephrine-dependent control of glucose metabolism in white adipose tissue
NOX2 activated by α1-adrenoceptors modulates hepatic metabolic routes stimulated by β-adrenoceptors.
GeneRIF
Piña et al., Mexico. In Free Radic Res, 2011
NOX2 activated by alpha1-adrenoceptors modulates hepatic metabolic routes stimulated by beta-adrenoceptors
The contribution of α1B-adrenoceptor subtype in the renal vasculature of fructose-fed Sprague-Dawley rats.
GeneRIF
Johns et al., George Town, Malaysia. In Eur J Nutr, 2011
Data indicate that Adra1b is the functional subtype that mediates renal cortical vasoconstriction in control rats; high fructose feeding [inducing hyperinsulinemia] influences functionality of Adra1b in mediating renal cortical hemodynamic changes.
Influence of high dietary sodium intake on the functional subtypes of alpha-adrenoceptors in the renal cortical vasculature of Wistar-Kyoto rats.
GeneRIF
Johns et al., George Town, Malaysia. In Auton Autacoid Pharmacol, 2009
Irrespective of dietary sodium content, in Wistar-Kyoto rats, alpha(1A)- and alpha(1D)-subtypes are the major alpha(1)-adrenoceptors in renal cortical vasculature. Alpha(1B)-adrenoceptors appear also to be involved in high dietary sodium rats.
Lack of alpha 1b-adrenergic receptor protects against epileptic seizures.
Fornai et al., Pisa, Italy. In Epilepsia, 2009
PURPOSE: The role of alpha 1b-adrenergic receptor (alpha 1b-AR) in relation with neuronal degeneration, drug addiction, and seizure susceptibility has recently emerged.
Gene expression of adrenoceptors in the hearts of cold-acclimated rats exposed to a novel stressor.
GeneRIF
Kvetnanský et al., Bratislava, Slovakia. In Ann N Y Acad Sci, 2008
Results show that expression of different adrenoceptor subtypes in the heart is regulated differently by various stressors, and suggest a protective role of beta(2)-, beta(3)-AR, and alpha(1B)-AR in the process of heart adaptation to chronic stress.
Wheel running alters serotonin (5-HT) transporter, 5-HT1A, 5-HT1B, and alpha 1b-adrenergic receptor mRNA in the rat raphe nuclei.
Fleshner et al., Boulder, United States. In Biol Psychiatry, 2005
BACKGROUND: Altered serotonergic (5-HT) neurotransmission is implicated in the antidepressant and anxiolytic properties of physical activity.
Peroxovanadate induces alpha 1B-adrenoceptor phosphorylation and association with protein kinase C.
García-Sáinz et al., Mexico. In Eur J Pharmacol, 2004
Peroxovanadate induced a marked increase in the phosphorylation state of alpha(1B)-adrenoceptors.
Oligomerization of the alpha 1a- and alpha 1b-adrenergic receptor subtypes. Potential implications in receptor internalization.
Cotecchia et al., Lausanne, Switzerland. In J Biol Chem, 2003
We combined biophysical, biochemical, and pharmacological approaches to investigate the ability of the alpha 1a- and alpha 1b-adrenergic receptor (AR) subtypes to form homo- and hetero-oligomers.
The adaptor complex 2 directly interacts with the alpha 1b-adrenergic receptor and plays a role in receptor endocytosis.
Cotecchia et al., Lausanne, Switzerland. In J Biol Chem, 2003
Using the yeast two-hybrid system, we identified the mu 2 subunit of the clathrin adaptor complex 2 as a protein interacting with the C-tail of the alpha 1b-adrenergic receptor (AR).
Constitutive coupling of a chimeric dopamine D2/alpha 1B receptor to the phospholipase C pathway: inverse agonism to silent antagonism by neuroleptic drugs.
Pauwels et al., Saint-Pierre-des-Corps, France. In J Pharmacol Exp Ther, 2003
Marked inverse agonist responses with a series of dopamine antagonists were obtained by: 1) exchange of the D 2short receptor's 3ICL by that of the alpha 1B-adrenoceptor, 2) incorporation of an activating mutation (Ala 279 Glu) in the distal portion of its 3ICL, and 3) coexpression with a G alpha11 protein.
Systemic overexpression of the alpha 1B-adrenergic receptor in mice: an animal model of epilepsy.
Najm et al., Cleveland, United States. In Epilepsia, 2002
PURPOSE: A lack of selective alpha1-adrenergic receptor (alpha1-ARs) agonists and antagonists has made it difficult to clarify the precise function of these receptors in the CNS.
Effects of L-765,314, a selective and potent alpha 1B-adrenoceptor antagonist, on periarterial nerve electrical stimulation-induced double-peaked constrictor responses in isolated dog splenic arteries.
Chiba et al., Matsumoto, Japan. In Jpn J Pharmacol, 2002
The periarterial nerve electrical stimulation (PNS) at a frequency of 1 or 4 Hz (30-s trains of pulses) readily caused a double peaked vasoconstriction in the canine splenic artery.
Effective information transfer from the alpha 1b-adrenoceptor to Galpha 11 requires both beta/gamma interactions and an aromatic group four amino acids from the C terminus of the G protein.
Milligan et al., Glasgow, United Kingdom. In J Biol Chem, 2002
Co-expression of the alpha(1b)-adrenoreceptor and Galpha(11) in cells derived from a Galpha(q)/Galpha(11) knock-out mouse allows agonist-mediated elevation of intracellular Ca(2+) levels that is transduced by beta/gamma released from the G protein alpha subunit.
[NPY as a periarterial sympathetic transmitter in isolated vessel].
Review
Chiba, Matsumoto, Japan. In Nihon Yakurigaku Zasshi, 2001
The 2nd peaked response was significantly inhibited by treatment with chloroethylclonidine (CEC), an alpha 1B-adrenoceptor antagonist, but the 1st peaked response was not influenced.
Dicentrine is preferentially antagonistic to rat aortic than splenic alpha 1-adrenoceptor stimulation.
Achike et al., Kuala Lumpur, Malaysia. In Acta Pharmacol Sin, 2000
CONCLUSION: Dicentrine is an alpha 1-adrenoceptor antagonist which is more selective towards the putative alpha 1D-adrenoceptor subtype of the rat aorta than the alpha 1B-adrenoceptor of the spleen.
[Pharmacological properties of naftopidil, a drug for treatment of the bladder outlet obstruction for patients with benign prostatic hyperplasia].
Review
Ikegaki, Shizuoka, Japan. In Nihon Yakurigaku Zasshi, 2000
Using cloned human alpha 1-adrenoceptor subtypes (alpha 1a, alpha 1b and alpha 1d), naftopidil was selective for the alpha 1d-adrenoceptor with approximately 3- and 17-fold higher affinity than for the alpha 1a- and alpha 1b-adrenoceptor subtypes, respectively.
The alpha 1a and alpha 1b-adrenergic receptor subtypes: molecular mechanisms of receptor activation and of drug action.
Review
De Benedetti et al., Lausanne, Switzerland. In Pharm Acta Helv, 2000
In this chapter we summarize some aspects of the structure-functional relationship of the alpha 1a and alpha 1b-adrenergic receptor subtypes related to the receptor activation process as well as the effect of different alpha-blockers on the constitutive activity of the receptor.
Antagonism of catecholamine receptor signaling by expression of cytoplasmic domains of the receptors.
Impact
Lefkowitz et al., Durham, United States. In Science, 1993
Coexpression of the third intracellular loop of the alpha 1B-adrenergic receptor with its parent receptor inhibited receptor-mediated activation of phospholipase C. The inhibition extended to the closely related alpha 1C-adrenergic receptor subtype, but not the phospholipase C-coupled M1 muscarinic acetylcholine receptor nor the adenylate cyclase-coupled D1A dopamine receptor.
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