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Arachidonate lipoxygenase 3

ALOXE3, eLOX3, epidermal lipoxygenase, epidermal lipoxygenase-3
This gene is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin. This gene is part of a cluster of lipoxygenase genes on 17p13.1. Mutations in this gene result in nonbullous congenital ichthyosiform erythroderma (NCIE). Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: ALOX12B, ACID, lysyl oxidase, CAN, Transglutaminase
Papers on ALOXE3
Two Cases of Autosomal Recessive Congenital Ichthyosis due to CYP4F22 Mutations: Expanding the Genotype of Self-Healing Collodion Baby.
New
Torrelo et al., Madrid, Spain. In Pediatr Dermatol, Jan 2016
However, some cases showing ALOX12B and ALOXE3 gene mutations have also been reported.
The role of lipoxygenases in pathophysiology; new insights and future perspectives.
Review
New
Okuyama et al., Tokyo, Japan. In Redox Biol, Dec 2015
Similarly, eLOX-3, which is also expressed in the skin epithelial cells acting downstream 12R-LOX, is another causative factor for ichthyosis.
Novel mutations in the genes TGM1 and ALOXE3 underlying autosomal recessive congenital ichthyosis.
New
Ahmad et al., Islamabad, Pakistan. In Int J Dermatol, Dec 2015
Sequencing of the two genes TGM1 and ALOXE3 was performed by the dideoxy chain termination method.
Update on autosomal recessive congenital ichthyosis: mRNA analysis using hair samples is a powerful tool for genetic diagnosis.
Review
New
Akiyama et al., Nagoya, Japan. In J Dermatol Sci, Jul 2015
The known causative molecules underlying ARCI include ABCA12, TGM1, ALOXE3, ALOX12B, NIPAL4, CYP4F22, PNPLA1, CERS3, and LIPN.
Triallelic Inheritance of TGM1 and ALOXE3 Mutations Associated with Severe Phenotype of Ichtyosis in an Iranian Family - A Case Report.
New
Ataei-Kachoui et al., Tehrān, Iran. In Iran J Public Health, Jul 2015
A novel homozygous mutation (p.D414V) in TGM1 and rs3027232 in ALOXE3 gene in heterozygous form were identified which segregated with disease status in the family.
Autosomal recessive congenital ichthyoses in the Czech Republic.
New
Fajkusová et al., Brno, Czech Republic. In Br J Dermatol, Jun 2015
Nine genes have been identified to be causative of ARCI, including TGM1 (1,2) , ABCA12 (3) , NIPAL4 (4) , CYP4F22 (5) , ALOX12B, ALOXE3 (6) , PNPLA1 (7) , LIPN (8) , and CERS3 (9) .
Leukotriene signaling in the extinct human subspecies Homo denisovan and Homo neanderthalensis. Structural and functional comparison with Homo sapiens.
Heydeck et al., Berlin, Germany. In Arch Biochem Biophys, 2015
For this study we extracted the nucleotide sequences of selected eicosanoid relevant genes (ALOX5, ALOX15, ALOX12, ALOX15B, ALOX12B, ALOXE3, COX1, COX2, LTA4H, LTC4S, ALOX5AP, CYSLTR1, CYSLTR2, BLTR1, BLTR2) from the corresponding databases.
A mouse organotypic tissue culture model for autosomal recessive congenital ichthyosis.
Krieg et al., Heidelberg, Germany. In Br J Dermatol, 2014
Mutations in the genes encoding the lipoxygenases 12R-LOX and eLOX-3 are the second most common cause of ARCIs.
Homozygous ALOXE3 Nonsense Variant Identified in a Patient with Non-Bullous Congenital Ichthyosiform Erythroderma Complicated by Superimposed Bullous Majocchi's Granuloma: The Consequences of Skin Barrier Dysfunction.
Lian et al., Beijing, China. In Int J Mol Sci, 2014
We identified a homozygous nonsense variant c.814C>T (p.Arg272*) in ALOXE3 (NM_001165960.1) in the proband and discovered that his parents are both heterozygous carriers of the variant.
Surprising prenatal toxicity of epidermal lipoxygenase-3.
Schneider et al., Erlangen, Germany. In Placenta, 2014
Metabolites of the epidermal lipoxygenase-3 (eLOX-3) are involved in various metabolic pathways.
The importance of the lipoxygenase-hepoxilin pathway in the mammalian epidermal barrier.
Review
Brash et al., Nashville, United States. In Biochim Biophys Acta, 2014
This review covers the background to discovery of the two key lipoxygenases (LOX) involved in epidermal barrier function, 12R-LOX and eLOX3, and our current views on their functioning.
The role of lipoxygenases in epidermis.
Review
Fürstenberger et al., Heidelberg, Germany. In Biochim Biophys Acta, 2014
Loss-of-function mutations in the LOX genes ALOX12B and ALOXE3 have been found to represent the second most common cause of autosomal recessive congenital ichthyosis and targeted disruption of the corresponding LOX genes in mice resulted in neonatal death due to a severely impaired permeability barrier function.
Successful nucleofection of rat adipose-derived stroma cells with Ambystoma mexicanum epidermal lipoxygenase (AmbLOXe).
Radtke et al., In Stem Cell Res Ther, 2013
Therefore, we used this technique to transfect ASCs with a vector encoding for Ambystoma mexicanum epidermal lipoxygenase (AmbLOXe) which is a promising bioactive enzyme in regenerative processes.
Autosomal recessive congenital ichthyosis.
Review
Toribio et al., Santiago de Compostela, Spain. In Actas Dermosifiliogr, 2013
ARCI is genetically highly heterogeneous and has been associated with 6 genes to date: TGM1, ALOXE3, ALOX12B, NIPAL4, CYP4F22, and ABCA12.
Control of somatic tissue differentiation by the long non-coding RNA TINCR.
Impact
Khavari et al., Stanford, United States. In Nature, 2013
TINCR is required for high messenger RNA abundance of key differentiation genes, many of which are mutated in human skin diseases, including FLG, LOR, ALOXE3, ALOX12B, ABCA12, CASP14 and ELOVL3.
Dioxygenase activity of epidermal lipoxygenase-3 unveiled: typical and atypical features of its catalytic activity with natural and synthetic polyunsaturated fatty acids.
GeneRIF
Brash et al., Nashville, United States. In J Biol Chem, 2011
Dioxygenase activity of epidermal lipoxygenase-3 unveiled: typical and atypical features of its catalytic activity with natural and synthetic polyunsaturated fatty acids.
On the role of molecular oxygen in lipoxygenase activation: comparison and contrast of epidermal lipoxygenase-3 with soybean lipoxygenase-1.
GeneRIF
Brash et al., Nashville, United States. In J Biol Chem, 2011
On the role of molecular oxygen in lipoxygenase activation: comparison and contrast of epidermal lipoxygenase-3 with soybean lipoxygenase-1.
Epidermis-type lipoxygenase 3 regulates adipocyte differentiation and peroxisome proliferator-activated receptor gamma activity.
GeneRIF
Kristiansen et al., Odense, Denmark. In Mol Cell Biol, 2010
expression of eLOX3 or addition of eLOX3 products stimulated adipogenesis under conditions that normally require an exogenous PPAR gamma ligand for differentiation
Genotypic and clinical spectrum of self-improving collodion ichthyosis: ALOX12B, ALOXE3, and TGM1 mutations in Scandinavian patients.
GeneRIF
Fischer et al., Uppsala, Sweden. In J Invest Dermatol, 2010
ALOX12B mutations are the leading cause of self-improving collodion ichthyosis in Scandinavia, followed by ALOXE3 mutations, and TGM1 mutations
Molecular analysis of 250 patients with autosomal recessive congenital ichthyosis: evidence for mutation hotspots in ALOXE3 and allelic heterogeneity in ALOX12B.
GeneRIF
Hennies et al., Köln, Germany. In J Invest Dermatol, 2009
mutation hotspots in ALOXE3 and allelic heterogeneity in ALOX12B may have roles in autosomal recessive congenital ichthyosis
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