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AlkB, alkylation repair homolog 8

Papers on ALKBH8
ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA.
Falnes et al., Oslo, Norway. In Nat Commun, 2010
The AlkB domain of ALKBH8 specifically hydroxylates mcm(5)U into (S)-mchm(5)U in tRNA-Gly(UCC).
Human AlkB homolog ABH8 Is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival.
Samson et al., Cambridge, United States. In Mol Cell Biol, 2010
Data show that human AlkB homolog 8 (ABH8) catalyzes tRNA methylation to generate 5-methylcarboxymethyl uridine (mcm(5)U) at the wobble position of certain tRNAs, a critical anticodon loop modification linked to DNA damage survival.
Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding.
Klungland et al., Oslo, Norway. In Mol Cell Biol, 2010
Data show that ALKBH8 is a tRNA methyltransferase required for the final step in the biogenesis of mcm5U.
A novel human AlkB homologue, ALKBH8, contributes to human bladder cancer progression.
Konishi et al., Kashihara, Japan. In Cancer Res, 2009
Findings indicate a role for ALKBH8 in urothelial carcinoma cell survival mediated by NOX-1-dependent ROS signals, further suggesting therapeutic strategies in human bladder cancer by inducing JNK/p38/gammaH2AX-mediated cell death by silencing of ALKBH8.
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