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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Alkaline ceramidase 1

alkaline ceramidase
Top mentioned proteins: ACID, HAD, CAN, fibrillin-1, V1a
Papers on alkaline ceramidase
Saccharomyces cerevisiae Is Dependent on Vesicular Traffic between the Golgi Apparatus and the Vacuole When Inositolphosphorylceramide Synthase Aur1 Is Inactivated.
Conzelmann et al., Fribourg, Switzerland. In Eukaryot Cell, Dec 2015
Overexpression of the alkaline ceramidase YPC1 rescues cells under this condition.
Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain.
Mao et al., Stony Brook, United States. In Plos Genet, Oct 2015
Mouse alkaline ceramidase 3 (Acer3), which preferentially catalyzes the hydrolysis of C18:1-ceramide, a major unsaturated long-chain ceramide species in the brain, is upregulated with age in the mouse brain.
Activity of neutral and alkaline ceramidases on fluorogenic N-acylated coumarin-containing aminodiols.
Fabrias et al., Barcelona, Spain. In J Lipid Res, Oct 2015
On the other hand, microsomes from alkaline ceramidase (ACER)3 knockdown cells were less competent at hydrolyzing RBM14C12, RBM12C14, and RBM14C16 than controls, while microsomes from ACER2 and ACER3 overexpressing cells showed no activity toward the RBM14 substrates.
Hippocampal transcriptional and neurogenic changes evoked by combination yohimbine and imipramine treatment.
Vaidya et al., Mumbai, India. In Prog Neuropsychopharmacol Biol Psychiatry, Sep 2015
Further, we noted a regulation of signaling pathway genes like inositol monophosphatase 2 (Impa2), iodothyronine deiodinase 3 (Dio3), regulator of G-protein signaling 4 (Rgs4), alkaline ceramidase 2 (Acer2), doublecortin-like kinase 2 (Dclk2), nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (Nfkbia) and serum/glucocorticoid-regulated kinase 1 (Sgk1), several of which are implicated in the pathophysiology of mood disorders.
p38 mitogen-activated protein kinase/activator protein-1 involved in serum deprivation-induced human alkaline ceramidase 2 upregulation.
Jin et al., Guilin, China. In Biomed Rep, Mar 2015
UNASSIGNED: Our previous study revealed that serum deprivation upregulated human alkaline ceramidase 2 (haCER2) activity and mRNA in HeLa cells, but the mechanism remains unknown.
The Arabidopsis alkaline ceramidase TOD1 is a key turgor pressure regulator in plant cells.
Yang et al., Beijing, China. In Nat Commun, 2014
We demonstrate that TOD1 is a Golgi-localized alkaline ceramidase.
The dietary ingredient, genistein, stimulates cathelicidin antimicrobial peptide expression through a novel S1P-dependent mechanism.
Uchida et al., San Francisco, United States. In J Nutr Biochem, 2014
Genistein treatment increased acidic and alkaline ceramidase expression and cellular S1P levels in parallel with increased S1P lyase inhibition, accounting for increased CAMP production.
Regulation of alkaline ceramidase activity by the c-Src-mediated pathway.
Murayama et al., Chiba, Japan. In Arch Biochem Biophys, 2014
The ceramidase sensitivity to substrates, pH, and Ca(2+) suggest that the c-Src- and SU6656-sensitive ceramidase is alkaline ceramidase (ACER), possibly Ca(2+)-activated ACER2.
Membrane topology of yeast alkaline ceramidase YPC1.
Conzelmann et al., Fribourg, Switzerland. In Biochem J, 2013
The data allow the inference that all of the amino acids of Ypc1p that are conserved in the Pfam PF05875 ceramidase motif and the CREST {alkaline ceramidase, PAQR [progestin and adipoQ (adiponectin) receptor] receptor, Per1 (protein processing in the ER 1), SID-1 (sister disjunction 1) and TMEM8 (transmembrane protein 8)} superfamily are located in or near the ER lumen.
Metabolic engineering of the non-conventional yeast Pichia ciferrii for production of rare sphingoid bases.
Schaffer et al., Hanau am Main, Germany. In Metab Eng, 2012
Several canonical genes encoding ceramide synthase (encoded by PcLAG1 and PcLAF1), alkaline ceramidase (PcYXC1) and sphingolipid C-4-hydroxylase(PcSYR2), as well as structural genes for dihydroceramide Δ(4)-desaturase (PcDES1) and sphingolipid Δ(8)-desaturase (PcSLD1) were identified, indicating that P. ciferrii would be capable of synthesizing desaturated sphingoid bases, a property not ubiquitously found in yeasts.
Non-genomic progesterone signalling and its non-canonical receptor.
Lyons et al., Gainesville, United States. In Biochem Soc Trans, 2012
Instead, they more closely resemble proteins in the alkaline ceramidase family and they may possess enzymatic activity.
Acid ceramidase expression modulates the sensitivity of A375 melanoma cells to dacarbazine.
Levade et al., Toulouse, France. In J Biol Chem, 2011
Down-regulation of acid but not neutral or alkaline ceramidase 2 resulted in elevated levels of ceramide and sensitization to the toxic effects of DTIC.
CDase is a pan-ceramidase in Drosophila.
Acharya et al., Frederick, United States. In Mol Biol Cell, 2011
Several genes encode for variants of alkaline ceramidase in mammals.
CREST--a large and diverse superfamily of putative transmembrane hydrolases.
Grishin et al., Dallas, United States. In Biol Direct, 2010
They were unified into a large and diverse superfamily of putative membrane-bound hydrolases called CREST (alkaline ceramidase, PAQR receptor, Per1, SID-1 and TMEM8).
Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate.
Obeid et al., Charleston, United States. In Biochim Biophys Acta, 2008
Presently, 5 human ceramidases encoded by 5 distinct genes have been cloned: acid ceramidase (AC), neutral ceramidase (NC), alkaline ceramidase 1 (ACER1), alkaline ceramidase 2 (ACER2), and alkaline ceramidase 3 (ACER3).
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