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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Activin A receptor, type IC

ALK7, activin receptor-like kinase 7, ACVR1C
ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: SFRP1, ALK4, NODAL, Smad2, TGF-beta type I receptor
Papers on ALK7
Nodal promotes functional luteolysis via downregulation of progesterone and prostaglandins E2 and promotion of PGF2 alpha synthetic pathways in mare corpus luteum.
Ferreira-Dias et al., Olsztyn, Poland. In Endocrinology, Jan 2016
Expression pattern of Nodal and its receptors ACVR2B, Alk7 and Alk4, as well as Nodal physiological role, demonstrate the involvement of this pathway in functional luteolysis.
Overexpression of B2M and loss of ALK7 expression are associated with invasion, metastasis, and poor-prognosis of the pancreatic ductal adenocarcinoma.
Yuan et al., Changsha, China. In Cancer Biomark, Dec 2015
OBJECTIVE: In this study, we investigated the expression of B2M and ALK7 in 106 PDACs compared to precursor lesions of the pancreas.
NODAL secreted by male germ cells regulates the proliferation and function of human Sertoli cells from obstructive azoospermia and nonobstructive azoospermia patients.
Li et al., Shanghai, China. In Asian J Androl, Nov 2015
NODAL was found to be expressed in male germ cells but not in Sertoli cells, whereas its receptors ALK4, ALK7, and ACTR-IIB were detected in Sertoli cells and germ cells, suggesting that NODAL plays a regulatory role in Sertoli cells and germ cells via a paracrine and autocrine pathway, respectively.
ALK7 protects against pathological cardiac hypertrophy in mice.
Huang et al., Wuhan, China. In Cardiovasc Res, Nov 2015
AIMS: Activin receptor-like kinase 7 (ALK7), one of the type I transforming growth factor-β receptors, is expressed in various tissues, including the heart.
Growth differentiation factor 11 supports migration and sprouting of endothelial progenitor cells.
Strassburg et al., Freiburg, Germany. In J Surg Res, Sep 2015
RESULTS: pbEPCs express the TGF-β type-I receptors ALK4 and ALK5, but not ALK7.
Silencing of activin receptor-like kinase 7 alleviates aortic stiffness in type 2 diabetic rats.
Tang et al., Jinan, China. In Acta Diabetol, Aug 2015
Activin receptor-like kinase 7 (ALK7), a member of type I transforming growth factor-β (TGF-β) receptors, is correlated with pathogenic risks of type 2 diabetes mellitus and cardiovascular diseases and may be involved in cardiovascular remodeling.
A novel crosstalk between Alk7 and cGMP signaling differentially regulates brown adipocyte function.
Pfeifer et al., Bonn, Germany. In Mol Metab, Aug 2015
The type I transforming growth factor β (TGFβ) receptor Activin receptor-like kinase 7 (Alk7) is highly expressed in adipose tissues and is down-regulated in obese patients.
Conformational features and binding affinities to Cripto, ALK7 and ALK4 of Nodal synthetic fragments.
Ruvo et al., Napoli, Italy. In J Pept Sci, Apr 2015
Recently, we reported the molecular models of Nodal in complex with its type I receptors (ALK4 and ALK7) as well as with Cripto, as obtained by homology modeling and docking simulations.
The multifaceted role of the embryonic gene Cripto-1 in cancer, stem cells and epithelial-mesenchymal transition.
Salomon et al., Frederick, United States. In Semin Cancer Biol, 2014
As a member of the epidermal growth factor (EGF)/Cripto-1-FRL-1-Cryptic (CFC) family, CR-1 functions as an obligatory co-receptor for the transforming growth factor-β (TGF-β) family members, Nodal and growth and differentiation factors 1 and 3 (GDF1/3) by activating Alk4/Alk7 signaling pathways that involve Smads 2, 3 and 4. In addition, CR-1 can activate non-Smad-dependent signaling elements such as PI3K, Akt and MAPK.
Genome-wide transcriptome directed pathway analysis of maternal pre-eclampsia susceptibility genes.
Moses et al., Melbourne, Australia. In Plos One, 2014
We examined ten candidate genes, which are from these functional groups: activin/inhibin signalling-ACVR1, ACVR1C, ACVR2A, INHA, INHBB; structural components-COL4A1, COL4A2 and M1 family aminopeptidases-ERAP1, ERAP2 and LNPEP.
Growth differentiation factor 11 is an encephalic regionalizing factor in neural differentiated mouse embryonic stem cells.
Leyns et al., Brussels, Belgium. In Bmc Res Notes, 2013
In addition, inhibition of the TGF-β type I receptors Alk4, Alk5 and Alk7 by the pharmacological inhibitor SB431542 caused a strong anteriorization of the cells.
Activin receptor antagonists for cancer-related anemia and bone disease.
Terpos et al., North Bay Shore, United States. In Expert Opin Investig Drugs, 2013
Antitumor activity has been observed preclinically with small-molecule inhibitors of transforming growth factor-β receptor type I (ALK5) that also antagonize the closely related activin receptors ALK4 and ALK7.
Nodal induces apoptosis through activation of the ALK7 signaling pathway in pancreatic INS-1 β-cells.
Wang et al., Toronto, Canada. In Am J Physiol Endocrinol Metab, 2012
Data suggest that up-regulation of Nodal expression increases apoptosis of beta cells and is associated with increased Alk7 expression, activation of Smad3 signaling, and down-regulation of apoptosis regulatory proteins.
Activin receptor signaling: a potential therapeutic target for osteoporosis.
Baron et al., Boston, United States. In Curr Mol Pharmacol, 2012
The binding of activins to activin type IIA (ActRIIA) or type IIB (ActRIIB) receptors induces the recruitment and phosphorylation of an activin type I receptor (ALK4 and/or ALK7), which then phosphorylates the Smad2 and Smad3 intracellular signaling proteins.
Nodal/Activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy.
Heeschen et al., Madrid, Spain. In Cell Stem Cell, 2011
Knockdown or pharmacological inhibition of the Nodal/Activin receptor Alk4/7 in cancer stem cells virtually abrogated their self-renewal capacity and in vivo tumorigenicity
Nodal signals through activin receptor-like kinase 7 to inhibit trophoblast migration and invasion: implication in the pathogenesis of preeclampsia.
Peng et al., Toronto, Canada. In Am J Pathol, 2011
These findings suggest that the Nodal/ALK7 pathway plays important roles in human placentation and that its abnormal signaling may contribute to the development of preeclampsia.
Activin receptor-like kinase and the insulin gene.
Watanabe, Kyoto, Japan. In Vitam Horm, 2010
A type I receptor, which is a component of the complex, is known as an activin receptor-like kinase (ALK); currently seven ALKs (ALK1-ALK7) have been identified in humans.
ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease.
Sjöholm et al., Göteborg, Sweden. In Biochem Biophys Res Commun, 2009
Microarray analysis showed that adipose tissue expressed activin type I and II receptors and that the expression of activin receptor-like kinase 7 was adipose tissue specific.
Insulin gene is a target in activin receptor-like kinase 7 signaling pathway in pancreatic beta-cells.
Yamada et al., Kyoto, Japan. In Biochem Biophys Res Commun, 2009
One of the direct target genes in the ALK7 signaling pathway is the insulin gene in pancreatic beta-cells, and that PDX-1 is directly involved in this pathway through interaction with Smad2 and Smad3.
Signal transduction pathway through activin receptors as a therapeutic target of musculoskeletal diseases and cancer.
Cui et al., Japan. In Endocr J, 2008
In the case of activins and nodal, activin receptor-like kinases 4 and 7 (ALK4 and ALK7) are the authentic type I receptors.
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