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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Activin A receptor type II-like 1

ALK-1, Secretory Leukocyte Peptidase Inhibitor, SLPI, Secretory leukocyte protease inhibitor
This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ALK, SFRP1, CAN, HAD, endoglin
Papers using ALK-1 antibodies
Elafin prevents lipopolysaccharide-induced AP-1 and NF-kappaB activation via an effect on the ubiquitin-proteasome pathway
Supplier
Chung Whasun O. et al., In Journal of Oral Microbiology, 2005
... Anti-human SLPI was purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
De novo CD5+ diffuse large B-cell lymphoma: a clinicopathologic study of 109 patients
Supplier
Stein Harald et al., In Virchows Archiv, 2001
... ALK1Citrate1:20Dako ...
ClinicalTrials.gov: A Service of the U.S. National Institute of Health
Supplier
Winer Eric et al., In Journal of Hematology & Oncology, 1996
... Immunohistochemical analysis included a broad panel of antibodies against ALK1 (Dako, Carpinteria, CA; dilution 1:50), ...
Papillomavirus L1 major capsid protein self-assembles into virus-like particles that are highly immunogenic
Supplier
Zheng Zhi-Ming, In PLoS ONE, 1991
... from John Schiller, NIH); rabbit-anti-mouse HRP (Promega, Madison, WI); rabbit anti-goat HRP (Promega); goat anti-human SLPI (R&D Systems, Minneapolis, MN); AlexaFluor 680 goat-anti-rabbit IgG (Invitrogen) and IRDye 800 donkey-anti-mouse IgG (Rockland, Gilbertsville, PA) ...
Papers on ALK-1
Elevated concentration of secretory leukocyte protease inhibitor in the cervical mucus prior to delivery.
New
Fujii et al., Tokyo, Japan. In Am J Obstet Gynecol, Feb 2016
Secretory leukocyte protease inhibitor (SLPI) is a secretory protein that can function as an anti-microbial peptide, an anti-inflammatory molecule and a protease inhibitor.
Primary hepatic Epstein-Barr virus-associated CD30-positive peripheral T-cell lymphoma of cytotoxic phenotype.
New
Qing et al., Torrance, United States. In Exp Mol Pathol, Feb 2016
By immunohistochemistry, the lymphoma cells expressed CD2, CD3, CD8, CD30, CD43, CD45, granzyme B, TIA-1, and negative for CD4, CD5, CD7, CD56, βF1, ALK-1, and B-cell markers.
Secretory leukocyte protease inhibitor (SLPI), a multifunctional protein in the host defense response.
Review
New
Cichy et al., Kraków, Poland. In Cytokine Growth Factor Rev, Jan 2016
UNASSIGNED: Secretory leukocyte protease inhibitor (SLPI), a ∼12kDa nonglycosylated cationic protein, is emerging as an important regulator of innate and adaptive immunity and as a component of tissue regenerative programs.
Arteriovenous malformations in Hereditary Haemorrhagic Telangiectasia: looking beyond ALK1-NOTCH interactions.
Review
New
Jones et al., Leuven, Belgium. In Cardiovasc Res, Jan 2016
HHT is caused by mutations in ALK1 or Endoglin; however, the majority of arteriovenous malformations are idiopathic and arise spontaneously.
Osteopontin That Is Elevated in the Airways during COPD Impairs the Antibacterial Activity of Common Innate Antibiotics.
New
Kasetty et al., Lund, Sweden. In Plos One, Dec 2015
In vitro, OPN bound lactoferrin, secretory leukocyte peptidase inhibitor (SLPI), midkine, human beta defensin-3 (hBD-3), and thymic stromal lymphopoietin (TSLP) but showed low or no affinity for lysozyme and LL-37.
The soluble form of BMPRIB is a novel therapeutic candidate for treating bone related disorders.
New
Tomizuka et al., Machida, Japan. In Sci Rep, Dec 2015
Recently, several soluble BMP receptors, such as ActRIIA-Fc, ActRIIB-Fc, and ALK1-Fc, are undergoing clinical trials.
Hepatic inflammatory pseudotumor presenting in an 8-year-old boy: A case report and review of literature.
Review
New
Abu-Zaid et al., Riyadh, Saudi Arabia. In World J Gastroenterol, Aug 2015
Immunohistochemically, the cells stained negative for SMA, ALK-1, CD-21 and CD-23, diffusely positive for CD-68, and focally positive for IgG4.
A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis.
New
Impact
Knott et al., New York City, United States. In Nature, May 2015
Those clones that efficiently enter the vasculature express two secreted proteins, Serpine2 and Slpi, which were necessary and sufficient to program these cells for vascular mimicry.
Activin Receptor-Like Kinase Receptors ALK5 and ALK1 Are Both Required for TGFβ-Induced Chondrogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells.
van der Kraan et al., Nijmegen, Netherlands. In Plos One, 2014
Transforming Growth Factor β (TGFβ) is crucial for inducing chondrogenic differentiation of BMSCs and is known to signal via Activin receptor-Like Kinase (ALK) receptors ALK5 and ALK1.
Looking downstream: the role of cyclic AMP-regulated genes in axonal regeneration.
Review
Hannila et al., New York City, United States. In Front Mol Neurosci, 2014
In this review, we will highlight the pro-regenerative effects of arginase I (ArgI), interleukin (IL)-6, secretory leukocyte protease inhibitor (SLPI), and metallothionein (MT)-I/II, and discuss their potential for therapeutic use in spinal cord injury.
A novel channelopathy in pulmonary arterial hypertension.
Impact
Chung et al., New York City, United States. In N Engl J Med, 2013
METHODS: We studied a family in which multiple members had pulmonary arterial hypertension without identifiable mutations in any of the genes known to be associated with the disease, including BMPR2, ALK1, ENG, SMAD9, and CAV1.
Secretory leukocyte proteinase inhibitor-competent DNA deposits are potent stimulators of plasmacytoid dendritic cells: implication for psoriasis.
GeneRIF
Cichy et al., Kraków, Poland. In J Immunol, 2012
SLPI may contribute to psoriasis by enabling pDCs to sense extracellular DNA and produce IFN type I.
Structure of the Alk1 extracellular domain and characterization of its bone morphogenetic protein (BMP) binding properties.
GeneRIF
Hinck et al., San Antonio, United States. In Biochemistry, 2012
Alk1 extracellular domain binds with high affinity to BMP-9.
Specificity and structure of a high affinity activin receptor-like kinase 1 (ALK1) signaling complex.
GeneRIF
Grinberg et al., Cambridge, United States. In J Biol Chem, 2012
The structure reveals that the high specificity of ALK1 for BMP9/10 is determined by a novel orientation of ALK1 with respect to BMP9, which leads to a unique set of receptor-ligand interactions
Secretory leukocyte protease inhibitor binds to Neisseria gonorrhoeae outer membrane opacity protein and is bactericidal.
GeneRIF
Jarvis et al., Springfield, United States. In Am J Reprod Immunol, 2012
SLPI is bactericidal for gonococci and is expressed by reproductive tract epithelial cells and thus is likely to play a role in the pathogenesis of gonococcal infection.
Anti-human activin receptor-like kinase 1 (ALK1) antibody attenuates bone morphogenetic protein 9 (BMP9)-induced ALK1 signaling and interferes with endothelial cell sprouting.
GeneRIF
ten Dijke et al., Leiden, Netherlands. In J Biol Chem, 2012
data suggest that both the VEGF/VEGF receptor and the BMP9/ALK1 pathways are essential for stimulating angiogenesis, and targeting both pathways simultaneously may be an attractive strategy to overcome resistance to antiangiogenesis therapy
Thymic stromal lymphopoetin-induced expression of the endogenous inhibitory enzyme SLPI mediates recovery from colonic inflammation.
Impact
Mak et al., Toronto, Canada. In Immunity, 2011
Increased localized neutrophil elastase (NE) activity during overt inflammation was observed in Tslp(-/-) mice and was paralleled by reduced expression of an endogenous inhibitor, secretory leukocyte peptidase inhibitor (SLPI).
Epithelial cells trigger frontline immunoglobulin class switching through a pathway regulated by the inhibitor SLPI.
Impact
Cerutti et al., New York City, United States. In Nat Immunol, 2007
The resulting class switching was amplified by thymic stromal lymphopoietin, an epithelial interleukin 7-like cytokine that enhanced the B cell 'licensing' function of dendritic cells, and was restrained by secretory leukocyte protease inhibitor, an epithelial homeostatic protein that inhibited AID induction in B cells.
Proteins with whey-acidic-protein motifs and cancer.
Review
Impact
Tremblay et al., Québec, Canada. In Lancet Oncol, 2006
Most notably, the genes coding for elafin, antileukoproteinase 1 (previously called secretory leucocyte proteinase inhibitor, SLPI), WAP four disulphide core domain protein 1 (previously called prostate stromal protein 20 kDa, PS20), and WAP four disulphide core domain protein 2 (previously called major human epididymis-specific protein E4, HE4), have been identified as candidate molecular markers for several cancers.
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