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Programmed cell death 6

ALG-2, apoptosis-linked gene 2
This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is also located on the short arm of chromosome 5. [provided by RefSeq, May 2012] (from NCBI)
Top mentioned proteins: ACID, AIP1, CAN, TSG101, Calpain
Papers on ALG-2
Differential Recognition Preferences of the Three Src Homology 3 (SH3) Domains from the Adaptor CD2-associated Protein (CD2AP) and Direct Association with Ras and Rab Interactor 3 (RIN3).
New
Feller et al., Oxford, United Kingdom. In J Biol Chem, Nov 2015
CD2AP SH3 domains 1 and 2 generally bound with similar characteristics and specificities, whereas the SH3-3 domain bound more weakly to most peptide ligands tested yet recognized an unusually extended sequence in ALG-2-interacting protein X (ALIX).
Syntenin and syndecan in the biogenesis of exosomes.
Review
New
Zimmermann et al., Marseille, France. In Biol Cell, Oct 2015
SDC-syntenin-associated regulators include the endosomal sorting complex required for transport accessory component ALG-2-interacting protein X, the small GTPase adenosine 5'-diphosphate-ribosylation factor 6, the lipid-modifying enzyme phospholipase D2 and the endoglycosidase heparanase.
Calcium signaling in membrane repair.
Review
New
Xu et al., Ann Arbor, United States. In Semin Cell Dev Biol, Sep 2015
Multiple calcium sensors, including synaptotagmin (Syt) VII, dysferlin, and apoptosis-linked gene-2 (ALG-2), are involved in PM resealing, suggesting that Ca(2+) may regulate multiple steps of the repair process.
Mutations in GMPPB cause congenital myasthenic syndrome and bridge myasthenic disorders with dystroglycanopathies.
New
Beeson et al., Eşfahān, Iran. In Brain, Sep 2015
Four of these, ALG2, ALG14, DPAGT1 and GFPT1, are involved in glycosylation.
Dicaine represses apoptosis-linked gene 2-interacting protein X expression to induce airway epithelial barrier dysfunction.
New
Yan et al., Wuhan, China. In Mol Med Report, Jul 2015
Expression of apoptosis-linked gene 2-interacting protein X (Alix) in Rpc cells was assessed using quantitative reverse transcription‑polymerase chain reaction and western blotting.
Drosha, Dicer-1 and Argonaute-1 in the desert locust: phylogenetic analyses, transcript profiling and regulation during phase transition and feeding.
New
Vanden Broeck et al., Leuven, Belgium. In J Insect Physiol, Apr 2015
Our data illustrate that insect Argonaute-1 proteins form a monophyletic group with ALG-1 and ALG-2 of Caenorhabditis elegans and with the four (non-Piwi) Argonaute proteins present in humans.
A new role for annexin A11 in the early secretory pathway via stabilizing Sec31A protein at the endoplasmic reticulum exit sites (ERES).
New
Maki et al., London, United Kingdom. In J Biol Chem, Mar 2015
We and others previously identified Sec31A, an outer cage component of COPII, as an interacting protein for the penta-EF-hand calcium-binding protein ALG-2.
Structural analysis of the complex between penta-EF-hand ALG-2 protein and Sec31A peptide reveals a novel target recognition mechanism of ALG-2.
Maki et al., Nagoya, Japan. In Int J Mol Sci, 2014
ALG-2, a 22-kDa penta-EF-hand protein, is involved in cell death, signal transduction, membrane trafficking, etc., by interacting with various proteins in mammalian cells in a Ca2+-dependent manner.
Apoptosis-linked gene-2 (ALG-2)/Sec31 interactions regulate endoplasmic reticulum (ER)-to-Golgi transport: a potential effector pathway for luminal calcium.
Hay et al., Utrecht, Netherlands. In J Biol Chem, 2014
Furthermore, we present several lines of evidence suggesting that luminal calcium affected transport at least in part through calcium-dependent interactions between apoptosis-linked gene-2 (ALG-2) and the Sec31A proline-rich region: 1) targeted disruption of ALG-2/Sec31A interactions caused severe defects in ER-to-Golgi transport in intact cells; 2) effects of luminal calcium and ALG-2/Sec31A interactions on transport mutually required each other; and 3) Sec31A function in transport required luminal calcium.
Annexin A11 in disease.
Review
Greenaway et al., Dalian, China. In Clin Chim Acta, 2014
In a variety of diseases, Anxa11 is most commonly reported to function through interactions with apoptosis-linked gene-2 protein (ALG-2) and/or calcyclin (S100A6).
Mechanism of Ca²⁺-triggered ESCRT assembly and regulation of cell membrane repair.
Jaiswal et al., Washington, D.C., United States. In Nat Commun, 2013
ALG-2 facilitates accumulation of ALG-2-interacting protein X (ALIX), ESCRT III and Vps4 complex at the injured cell membrane, which in turn results in cleavage and shedding of the damaged part of the cell membrane.
Programmed cell death 6 (PDCD6) as a prognostic marker for gastric cancers.
GeneRIF
Park et al., Seoul, South Korea. In Tumour Biol, 2012
PDCD6 may have a role in advanced gastric cancer
Evolutionary and physical linkage between calpains and penta-EF-hand Ca2+-binding proteins.
Review
Shibata et al., Nagoya, Japan. In Febs J, 2012
In addition to calpains, PEF domains are found in other Ca(2+)-binding proteins including ALG-2 that associates with ALIX (an ESCRT-III accessory protein) and TSG101 (an ESCRT-I subunit).
PDCD6 additively cooperates with anti-cancer drugs through activation of NF-κB pathways.
GeneRIF
Rho et al., Seoul, South Korea. In Cell Signal, 2012
PDCD6 exerts its anti-tumor potency by activating the p53-p21 protein for G1 phase of cell cycle progression and apoptosis
Programmed cell death 6 (PDCD6) inhibits angiogenesis through PI3K/mTOR/p70S6K pathway by interacting of VEGFR-2.
GeneRIF
Park et al., South Korea. In Cell Signal, 2012
programmed cell death 6 protein plays a significant role in modulating cellular angiogenesis
PDCD6 is an independent predictor of progression free survival in epithelial ovarian cancer.
GeneRIF
Qi et al., Hangzhou, China. In J Transl Med, 2011
PDCD6 seems to play an important role in ovarian cancer progression.
Structure and function of ALG-2, a penta-EF-hand calcium-dependent adaptor protein.
Review
Shibata et al., Nagoya, Japan. In Sci China Life Sci, 2011
ALG-2 (a gene product of PDCD6) is a 22-kD protein containing five serially repetitive EF-hand structures and belongs to the penta-EF-hand (PEF) family, including the subunits of typical calpains.
The ALG-2 binding site in Sec31A influences the retention kinetics of Sec31A at the endoplasmic reticulum exit sites as revealed by live-cell time-lapse imaging.
GeneRIF
Maki et al., Nagoya, Japan. In Biosci Biotechnol Biochem, 2009
the alg2 binding site is one of the key determinants of the retention kinetics of Sec31A at endoplasmic reticulum exit sites
Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing.
Impact
Mello et al., Worcester, United States. In Cell, 2001
Here we show that inactivation of genes related to RNAi pathway genes, a homolog of Drosophila Dicer (dcr-1), and two homologs of rde-1 (alg-1 and alg-2), cause heterochronic phenotypes similar to lin-4 and let-7 mutations.
Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3.
Impact
D'Adamio et al., Bethesda, United States. In Science, 1996
Two apoptosis-linked genes, named ALG-2 and ALG-3, were identified by means of a functional selection strategy.
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