Pathogenesis of hepatic encephalopathy and brain edema in acute liver failure.
Montréal, Canada. In J Clin Exp Hepatol, Mar 2015
Neuropathologic investigations in acute liver failure (ALF) reveal significant alterations to neuroglia consisting of swelling of astrocytes leading to cytotoxic brain edema and intracranial hypertension as well as activation of microglia indicative of a central neuroinflammatory response.
G domain dimerization controls dynamin's assembly-stimulated GTPase activity.
Bethesda, United States. In Nature, 2010
Here we present the 2.0 A resolution crystal structure of a human dynamin 1-derived minimal GTPase-GED fusion protein, which was dimeric in the presence of the transition state mimic GDP.AlF(4)(-).The structure reveals dynamin's catalytic machinery and explains how assembly-stimulated GTP hydrolysis is achieved through G domain dimerization.
Regulation of ALF promoter activity in Xenopus oocytes.
Richardson, United States. In Plos One, 2008
The activity of ALF promoter constructs in oocytes and in transfected somatic Xenopus XLK-WG kidney epithelial cells was quite different, indicating that the two cell types are not functionally equivalent and are not interchangeable as assay systems